• Title/Summary/Keyword: dosing

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Modification of Linear Low Density Polyethylene by Irradiation of Electron Beam (전자선조사에 의한 선형저밀도폴리에틸렌의 개질)

  • 오장훈;천성득;황규면
    • The Korean Journal of Rheology
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    • v.10 no.4
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    • pp.256-258
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    • 1998
  • An experimental study was done to improve the processability and optical property of linear low density polyethylene(LLDPE) film. By modifying the molecular structure of LLDPE with electron beam we could get the improved processability and optical property of film. By appropriate dosing of electron beam and a small addition of UV-stabilizer it was possible to produce gel-free film with low haze. The proceassability was also improved.

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Atomic Layer Deposition of $Sb_2S_3$ Thin Films on Mesoporous $TiO_2$

  • Han, Gyu-Seok;Jeong, Jin-Won;Seong, Myeong-Mo
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.02a
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    • pp.282-282
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    • 2013
  • The antimony sulfide ($Sb_2S_3$) thin films were deposited using the gas phase method which known as atomic layer deposition (ALD) on mesoporous micro-films. Tris (dimethylamido) antimony (III[$(Me_2N)_3Sb$] and hydrogensulfide ($H_2S$) were used as precursors to deposit $Sb_2S_3$. Self-terminating nature of $(Me_2N)_3Sb$ and $H_2S$ reaction were demonstrated by growth rate saturation versus precursors dosing time. Absorption spectra and extinction coefficient were investigated by UV-VIS spectroscopy. Scanning electron microscopic analysis and X-ray photoelectron spectroscopy (XPS) depth profile were employed to determine the conformal deposition.

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Effects of Sustained-Release Formulation of Recombinant Human Growth Hormone on Body weight. Bone growth and Organs in Hypophysectomized Rats

  • Jo, Yeong-Woo;Park, Yong-Man;Lee, Ghun-Il;Park, Yong-Man;Yang, Hi-Chang;Kim, Mi-Ryang;Lee, Sung-Hee;Kwon, Jong-Won;Kim, Won-Bae
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.417.2-418
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    • 2002
  • The rhGH-loaded PLGA microsphere formulation was prepared using a double emulsion process from hydrophilic 0:50 poly(D.L-lactide-co-glycolide) (PLGA) polymers. To investigate the sustained efficacy of this formulation, ts pharmacodynamic characteristics were analyzed. It showed particle size of ca 53.1 $\mu\textrm{m}$ with high drug ncorporation efficiency and it was sucutaneously administrated to hypophysectomized rats and whole body rowth responses of this formulation were compared to those of the different dosing patterns of rhGH. (omitted)

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INVESTIGATIONS ON VARIABLE WELD PENETRATIONS IN GTA WELDING OF AUSTENITIC AND MARTENSITIC STAINLESS STEELS

  • Puybouffat, Sylvain;Chabenat, Alain;Boudot, Cecile;Marya, Surendar
    • Proceedings of the KWS Conference
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    • 2002.10a
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    • pp.752-756
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    • 2002
  • Variable weld bead penetrations related to the base metal chemistry of stainless steels in GTA welding have been under constant investigations due to their industrial implications. It has been proposed that among other elements, the sulfur content of steels determines the weld pool geometry, particularly its penetration. It is suggested that the surface tension temperature gradient of steels becomes positive with appropriate dosing in sulfur and results in inward melt flow, propitious for deeper welds. However, the chemistry of industrial steels is complex due to the presence of multiple minor elements either deliberately added or remnant impurity traces. With this in view, investigations on 41 austenitic and nine martensitic stainless steels were carried to see if there existed any possible relation between the weld profile and some of the designated elements. The results suggest no direct correlation between sulfur or any other major or trace element and weld penetration. At first glance the results are contradictory to what is often asserted.

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PHARMACOGENOMICS IN RELATION TO TAILOR-MADE DRUGS -INTRODUCTION-

  • Satoh, Tetsuo
    • 한국약용작물학회:학술대회논문집
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    • 2006.11a
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    • pp.51-66
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    • 2006
  • The field of cytochrome P450 pharmacogenomics has progressed rapidly during the past 25 years. Recently, conjugating enzymes including sulfotransferase, acetyltransferase, glucuronosyltransferase and glutathione transferase have been also extensively studied. All the major human drug-metabolizing P450 enzymes and some conjugating enzymes have been identified and cloned, and the major gene variants that cause inter-individual variability in drug response and are related to adverse drug reactions have been identified. This information now provides the basis for the use of predictive pharmacogenomics to yield drug therapies that are more efficient and safer. Today, we understand which drugs warrant dosing based on pharmacogenomics to improve drug treatment. It is anticipated that genotyping could be used to personalize drug treatment for vast numbers of subjects, decreasing the cost of drug treatment and increasing the efficacy of drugs and health in general. It is assumed that such personalized P450 gene-based treatment which is so-called tailor(order)-made drug therapy would be relevant for 10-20% of all drug therapy in the future.

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Determination of dosing rate for water treatment using fusion of genetic algorithms and fuzzy inference system (유전알고리즘과 퍼지추론시스템의 합성을 이용한 정수처리공정의 약품주입률 결정)

  • 김용열;강이석
    • 제어로봇시스템학회:학술대회논문집
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    • 1996.10b
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    • pp.952-955
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    • 1996
  • It is difficult to determine the feeding rate of coagulant in water treatment process, due to nonlinearity, multivariables and slow response characteristics etc. To deal with this difficulty, the fusion of genetic algorithms and fuzzy inference system was used in determining of feeding rate of coagulant. The genetic algorithms are excellently robust in complex operation problems, since it uses randomized operators and searches for the best chromosome without auxiliary information from a population consists of codings of parameter set. To apply this algorithms, we made the look up table and membership function from the actual operation data of water treatment process. We determined optimum dosages of coagulant (PAC, LAS etc.) by the fuzzy operation, and compared it with the feeding rate of the actual operation data.

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A Simultaneous Design of TSK - Linguistic Fuzzy Models with Uncertain Fuzzy Output

  • Kwak, Keun-Chang;Kim, Dong-Hwa
    • 제어로봇시스템학회:학술대회논문집
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    • 2005.06a
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    • pp.427-432
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    • 2005
  • This paper is concerned with a simultaneous design of TSK (Takagi-Sugeno-Kang)-linguistic fuzzy models with uncertain model output and the computationally efficient representation. For this purpose, we use the fundamental idea of linguistic models introduced by Pedrycz and develop their comprehensive design framework. The design process consists of several main phases such as (a) the automatic generation of the linguistic contexts by probabilistic distribution using CDF (conditional density function) and PDF (probability density function) (b) performing context-based fuzzy clustering preserving homogeneity based on the concept of fuzzy granulation (c) augment of bias term to compensate bias error (d) combination of TSK and linguistic context in the consequent part. Finally, we contrast the performance of the enhanced models with other fuzzy models for automobile MPG predication data and coagulant dosing process in a water purification plant.

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Pharmacokinetics of Furosemide in Rabbits with Renal Failure (신장장해 가토에서 Furosemide의 약물동태)

  • Choi, Jun-Shik;Choi, Tou-Ma;Lee, Jin-Hwan;Burm, Jin-Pil
    • YAKHAK HOEJI
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    • v.34 no.6
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    • pp.401-406
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    • 1990
  • The Pharmacokinetics of furosemide (5 mg/kg iv) was investigated in rabbits with folate (75 mg/kg, 150 mg/kg 300 mg/ug, iv) induced renal failure. The plasma concentration was increased and urinary excretion was decreased significantly compared with those of normal rabbits. ${\alpha},\;{\beta}\;and\;K_{12},\;K_{21},\;K_{10}$ were decreased, $t_{1/2}$ and AUC were increased significantly. Correlation of serum creatinine concentration and AUC, renal clearance have linear relationship respectively. In short, dosage regimen of furosemide is considered to be adjusted in the dose size and the dosing interval by degree of serum creatinine concentration.

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The decision of forming condition and design of injection mold by considering contraction rate of POM resin (POM 수지의 수축율을 고려한 사출금형설계 및 성형조건 선정)

  • Lee, K.Y.;Kim, H.M.;Park, S.S.;Park, H.Y.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2006.05a
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    • pp.180-183
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    • 2006
  • The contraction rate is a very important element that dominate quality of product in plastic injection molding. To get wanted products, the contraction rate of used resin must be considered necessarily when designing plastic injection molds, and suitable deform conditions must be chosen with this. In this paper, important parts used in LED department were produced by injection mold using POM resin, and dimension error that happened by contraction rate of resin was corrected and reflected in die design and suitable deform conditions were decided.

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Photobiomodulation and implants: implications for dentistry

  • Tang, Elieza;Arany, Praveen
    • Journal of Periodontal and Implant Science
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    • v.43 no.6
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    • pp.262-268
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    • 2013
  • The use of dental implants has become a mainstay of rehabilitative and restorative dentistry. With an impressive clinical success rate, there remain a few minor clinical issues with the use of implants such as peri-implant mucositis and peri-implantitis. The use of laser technology with implants has a fascinating breadth of applications, beginning from their precision manufacturing to clinical uses for surgical site preparation, reducing pain and inflammation, and promoting osseointegration and tissue regeneration. This latter aspect is the focus of this review, which outlines various studies of implants and laser therapy in animal models. The use of low level light therapy or photobiomodulation has demonstrated its efficacy in these studies. Besides more research studies to understand its molecular mechanisms, significant efforts are needed to standardize the clinical dosing and delivery protocols for laser therapy to ensure the maximal efficacy and safety of this potent clinical tool for photobiomodulation.