• Progress in Medical Physics
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• v.9 no.4
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• pp.247-257
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• 1998

For effective radiotherapy, it should always be considered that calculation of different dose distribution in heterogenous tissue is important particularly on lung which has low density and large volume. To take precise dose distribution of 6MV X-ray in the thoracic cage, the authors had made a tissue equivalent phantom for thorax, measured dose distribution by thermoluminescent dosimeter and mm dosimeter, and derived methmetical equation coincided with provided theoretical formula. In comparision with isodose curve on case of homogeneous soft tissue, dose of heterogeneous lung tissue had been shown increase about 4% per cm depth on one and multiportal field, less than 15% difference on rotation field for esophagus, and around 20% difference on rotation field for lung according to the degree of rotation angle that must be corrected by dose compensation.

• Journal of radiological science and technology
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• v.40 no.4
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• pp.621-626
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• 2017

In this paper, an optical dosimetric system for radiation dose measurement is developed and characterized for 100 MeV proton beams in KOMAC(Korea Multi-Purpose Accelerator Complex). The system consists of 10 wt% Ultima GoldTM liquid organic scintillator in the ethanol, a camera lens(50 mm / f1.8), and a high sensitivity CMOS(complementary metal-oxide-semiconductor) camera (ASI120MM, ZWO Co.). The FOV(field of view) of the system is designed to be 150 mm at a distance of 2 m. This system showed sufficient linearity in the range of 1~40 Gy for the 100 MeV proton beams in KOMAC. We also successfully got the percentage depth dose and the isodose curves of the 100 MeV proton beams from the captured images. Because the solvent is not a human tissue equivalent material, we can not directly measure the absorbed dose of the human body. Through this study, we have established the optical dosimetric procedure and propose a new volume dose assessment method.

• Journal of Radiation Protection and Research
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• v.46 no.3
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• pp.106-111
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• 2021

Background: Crookes tube is utilized in junior high and high schools in Japan to study the character of electrons and current, and not for radiological education. There is no official guideline or regulation for these radiation source to the public. Therefore, most teachers have no information about the leakage of X-rays from Crookes tube. The peak energy of X-rays is approximately 20 keV, and it is impossible to measure using conventional survey meters. Materials and Methods: Each leakage dose of low energy X-rays from 38 Crookes tube in the education field, such as junior and senior high schools in Japan, was explored by the teachers in the school using radio-photoluminescence (RPL) dosimeters. Before and after the measurements, the dosimeters were sent by postal mails. Results and Discussion: At the exploration in this study, it was estimated that the 70 ㎛ dose equivalent, H_p(0.07) of X-rays from 31 Crookes tubes were smaller than 100 µSv in 10 minutes, at the distance of 1 m, where the Crookes tube was usually observed. However, the highest dose was estimated as 0.69 mSv by an equipment with the full power. Furthermore, one Crookes tube exhibited 0.62 mSv with minimum output power of the induction coil. This relatively large dose was reduced by the shorter distance of discharge electrodes of the induction coil. Conclusion: The leakage dose of low energy X-rays from 38 Crookes tube was explored using RPL dosimeters. It was estimated that the H_p(0.07) of X-rays from 31 Crookes tubes were smaller than 100 µSv in 10 minutes at the distance of 1 m, while some equipment radiated a higher dose. With this study, the provisional guideline for the safety operation of Crookes tube is established.

• The Korea Journal of Herbology
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• v.33 no.4
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• pp.53-58
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• 2018

Objectives : Kaempferia parviflora Rhizome is black ginger indigenous to Laos and Thailand. It has been used as a folk medicine to improve blood flow and promote vitality and longevity with good health and well being. For these reasons, Kaempferia parviflora Rhizome has been focused on developing it as a food or food supplement. In addition, Kaempferia parviflora Rhizome could be under consideration of new prescription based on its characteristic compounds, polymethoxyflavonoids. However, it needs to be certified as safe before it can be used. Here, a single-oral toxicity test and safety classification was carried out to identity acute information of the toxicity of Kaempferia parviflora Rhizome powder and to make sure of its safety in clinical applications. Methods : Test substance was orally administered to male and female SD-rat at dose levels of 5000 mg/kg to estimate approximate lethal dose(ALD). Based on the acute information of the toxicity, the safety classification was estimated using the HED(human equivalent dose)-based MOS(margin of safety). Results : At 14 days after treatment with test substance. there were no of test substance related with mortalities and clinical signs. In addition, no changes in the body or organ weights and no gross or histopathological findings were observed. Thus, the ALD of Kaempferia parviflora Rhizome powder was considered over 5,000 mg/kg in both female and male mice. Conclusions : Based on the single oral toxicity test using the highest and limit dose, 5,000 mg/kg and the decision guideline for safety classification based on HED-based MOS, it was estimated that Kaempferia parviflora Rhizome powder is classified as "Specified class B" indicating that clinical dose is not limited to patients as safe as food.

• Journal of radiological science and technology
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• v.31 no.1
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• pp.83-87
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• 2008

The purpose of this study is to get the correction factor to correct the measured values of the absolute absorbed dose proportional to the water equivalent depth. The measurement conditions in white polystyrene and water phantoms for 10MV X-ray beam are that the distance of source to center of ionization chamber is fixed at SAD 100 cm, the field sizes are $10{\times}10\;cm^2$, $20{\times}20\;cm^2$ and the depths are 2.3 cm, 5 cm, 10 cm, and 15 cm, respectively. The mean value of ionization was obtained by three times measurements in each field size and depths after delivering 100 MU from linear accelerator with output of 400 MU per min to the two phantoms. The correction factor and the percentage deviation in TPR were obtained below 0.97% and 0.53%, respectively. Therefore, we can get high accuracy by using the correction factor and the percentage deviation in TPR in measuring the absolute absorbed dose with the solid water equivalent phantom.

• Biomolecules & Therapeutics
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• v.6 no.3
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• pp.242-246
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• 1998

The inhibitory activities of Amberlite active fraction, which was obtained from methanol soluble fraction of freeze dried slikworm urine, on the rat intestinal glycosidase-catalyzed enzymatic reaction were examined in in viro and in vivo experiments. Amberlite active fraction showed significant inhibitory effects on the hydrolysis of o-glycosidic bond, especially $\alpha$-1,4 bond. On the other hand, the inhibition on the hydrolysis of $\beta$-glycosidic bond was very weak. Oral administration of Amberlite active fraction resulted in a dose-dependent decrease in the blood glucose after an oral maltose load, and postprandial hyperglycemia in carbohydrate-loaded mice was suppressed by Amberlite active fraction at 60 mgHg in decreasing order of maltose, starch, sucrose and lactose. 60 mg/kg of Amberlite active fraction lowered the blood glucose level markedly after 18, 35, and 60 min after an oral maltose load and the antihyperglycemic activity was maintained upto 90 min. In alloxan-induced hyperglycemic mice, Amberlite active fraction at a dose of 100 mg/kg also significantly lowered blood glucose after an oral maltose load, and its efficacy was almost equivalent to that of acarbowe.

• Journal of radiological science and technology
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• v.23 no.2
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• pp.69-73
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• 2000

This paper studied a C-arm's exposure condition and measured scatter rays by thickness and distance. This study reached the following conclusion. 1. Approrimately exposure dose for a patient using fluoroscopy is as follows : 2. Mostly, an operating room was not shielding by lead and operator put on only apron without thyroid and facial part protection. 3. 0.5 mmPb equivalent's apron shielded about 99% of scattered rays at 60 cm from x-ray tube. 4. Scattered rays are depended on distance and thickness so operators are should be careful when using fluoroscopy by C-arm and if possible use high frequency equipment that has a large output.

• Journal of Sensor Science and Technology
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• v.25 no.1
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• pp.41-45
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• 2016

In this study, LET (Linear Energy Transfer) calibration of CR-39 SSNTD (Solid State Nuclear Track Detector) was performed using 500 MeV/u Fe heavy ions in HIMAC (Heavy Ion Medical Accelerator) for high LET radiation dosimetry. The irradiated CR-39 SSNDT were etched according JAXA (Japan Aerospace Exploration Agency) etching conditions. And the etched SSNTD were analyzed by using Image J. Determined dose-mean lineal energy ($\overline{y_D}$) of 500 MeV/u Fe is about 283.3 keV/um by using the CR-39 SSNTD. This value is very similar result compare to the results calculated by GEANT4 Monte Carlo simulation and measured with TEPC active radiation detector. We confirmed that the CR-39 SSNTD was useful for high LET radiation dosimetry such as heavy iron ions.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.5 no.2
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• pp.128-136
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• 1995

The purpose of this study is to evaluate the difference of noise level according to noise measuring methods in the noisy working environments. Sound pressure level(SPL), equivalence sound level(Leq) and personal noise exposure dose(Dose) in the fifty-nine unit workplaces of the twenty-eight industries were measured and relating factors which were affected noise level were investigated. The results were as follows ; 1. The noise levels were $88.70{\pm}5.68dB(A)$ by SPL, $89.07{\pm}5.41dB(A)$ by Leq and $89.07{\pm}5.69$ by Dose. The differences of noise levels by three measuring methods were statistically significant(P<0.001) by repeated measure ANOV A. 2. Comparing with noise levels by general classes of noise exposure, noise levels of continuous noise were $89.14{\pm}5.19dB(A)$ by SPL, $89.45{\pm}4.65dB(A)$ by Leq and $90.04{\pm}5.09$ by Dose. Noise levels of intermittent noise were $87.90{\pm}6.52dB(A)$ by SPL, $88.40{\pm}6.63dB(A)$ by Leq and $90.10{\pm}6.80$ by Dose. The differences noise level of noise measuring methods by general classese of noise exposure were statistically not significant by repeated measure ANOV A. 3. Interaction between general classese of noise exposure and noise measuring methods for noise level was not statistically significant by repeated measure ANOVA. And the noise level by noise measuring methods were statistically significant by repeated measure ANOV A(P<.001) 4. Comparing with noise levels by unit workplace size, noise levels of large unit workplace were $90.73{\pm}5.87dB(A)$ by SPL, $91.32{\pm}5.50dB(A)$ by Leq and $91.82{\pm}6.06$ by Dose and noise levels of middle unit workplace were $88.31{\pm}5.26dB(A)$ by SPL, $88.41{\pm}4.83dB(A)$ by Leq and $89.69{\pm}5.05$ by Dose. And noise levels of small unit workplace were $94.89{\pm}4.10dB(A)$ by SPL, $85.35{\pm}4.11dB(A)$ by Leq and $86.87{\pm}4.98$ by Dose. The noise level differences of noise measuring methods by unit workplace size were statistically significant by repeated measure ANOV A(P<.05). 5. The noise level by noise measuring methods were statistically significant by repeated measure ANOV A(P<.001). But Interaction between workplace size and noise level measuring methods for noise level was not statistically significant by repeated measure ANOVA. According to the above results, there was a difference of the noise level among the three measuring methods. Therefore we must use the personal noise exposure dose using by noise dose meter, possible, to prvent occupational hearing loss in noisy working environment.

• Journal of the Korean Society of Radiology
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• v.17 no.3
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• pp.367-373
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• 2023

Aircrews and passengers are exposed to radiation from cosmic rays and secondary scattered rays generated by reactions with air or aircraft. For aircrews, radiation safety management is based on the exposure dose calculated using a space-weather environment simulation. However, the exposure dose varies depending on solar activity, altitude, flight path, etc., so measuring by route is more suggestive than the calculation. In this study, we developed an instrument to measure the cosmic radiation dose using a general-purpose Si sensor and a multichannel analyzer. The dose calculation applied the algorithm of CRaTER (Cosmic Ray Telescope for the Effects of Radiation), a space radiation measuring device of NASA. Energy and dose calibration was performed with Cs-137 662 keV gamma rays at a standard calibration facility, and good dose rate dependence was confirmed in the experimental range. Using the instrument, the dose was directly measured on the international line between Dubai and Incheon in May 2023, and it was similar to the result calculated by KREAM (Korean Radiation Exposure Assessment Model for Aviation Route Dose) within 12%. It was confirmed that the dose increased as the altitude and latitude increased, consistent with the calculation results by KREAM. Some limitations require more verification experiments. However, we confirmed it has sufficient utilization potential as a cost-effective measuring instrument for monitoring exposure dose inside or on personal aircraft.