• Steel and Composite Structures
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• 제19권1호
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• pp.153-171
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• 2015

Twelve large-scale composite deck slabs were instrumented and tested in a cantilever diaphragm configuration to assess the effect of fibers and welded wire mesh (WWM) on the in-plane shear capacity of composite deck slabs. The slabs were constructed with reentrant decking profile and reinforced with different types and dosages of secondary reinforcements: Conventional welded wire mesh (A142 and A98); synthetic macro-fibers (dosages of $3kg/m^3$ and $5.3kg/m^3$); and hooked-end steel fibers with a dosage of $15kg/m^3$. The deck orientation relative to the main beam (strong and weak) was also considered in this study. Fibers and WWM were found efficient in distributing the applied load to the whole matrix, inducing multiple cracking, thereby enhancing the strength and ductility of composite deck slabs. The test results indicate that fibers increased the slab's ultimate in-plane shear capacity by up to 29% and 50% in the strong and weak directions, respectively. WWM increased the ultimate in-plane shear capacity by up to 19% in the strong direction and 9% in the weak direction. The results suggest that discrete fibers can provide comparable diaphragm behavior as that with the conventional WWM.

• Computers and Concrete
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• 제15권6호
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• pp.935-950
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• 2015

The aim of this study is to provide experimental data regarding the compressive, shear and torsional strength of self-compacting concrete (SCC) used in rectangular beams, and then comparing the results with the equations presented by the CSA A23.3-04 and ACI 318-11. In fact, the gathered information in this field is quite useful for calibrating the computer models of other researchers. The other goal of this study was to investigate the effects of silica fume and superplasticizer dosages on the mechanical properties of SCC. In this research, SCC is made based on 16 different type mixing layout. Also two normal concrete (NC) or vibrating concrete are constructed to compare the results of SCC and NC. This work concentrated on concrete mixes having water/binder ratios of 0.45 and 0.35, which contained constant total binder contents of $400kg/m^3$ and $500kg/m^3$, respectively. The percentages of silica fume that replaced cement were 0% and 10%. The superplasticizer dosages utilized in the mixtures were 0.4%, 0.8%, 1.2% and 1.6% of the weight of cement. Beam dimensions used in this test were $30{\times}30{\times}120cm^3$. The results of this research indicated that shear and torsional strength of SCC beams to be used in computer models can be calculated utilizing the equations presented in CSA A23.3-04 and ACI 318-11.

• 한국임상수의학회지
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• 제10권2호
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• pp.215-220
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• 1993

The anesthetic effects by dosages of Tiletamlne-Zolazepam in the dogs were investigated and then the optimal dosages for the operation of patients were suggested. 1. In groups of T+Z 20, 10 and 5 mg/kg administration, anesthetic periods are 180~300, 33~47 and 40~50 minutes, respectively and complete recovery from anesthesia was shorted with taking 53~72 minutes in the group of 5 mg/kg administration. 2. Reflex responses to eyelids, cornea and pharyngolarynx were maintained but pedal reflexes became considerably sluggish 3. It showed tachycardias on ECG but there were no specific dysrhythmias. On EEG, it showed low voltage-fast waves before anesthesia, high voltage-fast waves in induction stage, low voltage-slow waves in anesthetic stage and high voltage-fast waves again in recovery stage. 4. Surgical procedures could be performed satisfactorily in 6 cases of the 10 mg/kg administration group, but in 3 of 5 cases of 5 mg/kg administration group it could be completed after additional administration. 5. In conclusion, it was considered desirable for anesthetizing dogs that for healthy cases T+Z at the level of 10 mg/kg B.W. was administered, and for poor risk patients, 5 mg/kg B.W., followed by an additional administration in unsatisfied cases.

• Biomolecules & Therapeutics
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• 제16권3호
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• pp.237-242
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• 2008

The effect of Picrorrhiza Rhizoma (PR) aqueous extracts were evaluated on 2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis, type I allergic model. Contact dermatitis was induced by sensitization with dinitrophenyl-derivatized ovalbumin (DNP-OVA) and DNFB challenge as antigen. Three different concentrations of PR extracts (300,150 and 75mg/kg) were orally administered to DNP-OVA sensitization mice once a day for 7 days with reference materials; dexamethasone (15mg/kg, intraperitoneal treatment). End of 7 days oral administration of PR extracts or intraperitoneal treatment of dexamethasone, the changes on the edematous changes and scratching behavior were measured. Immediate after DNFB challenge on ear or paw of DNP-OVA sensitized mice, increases of ear and paw thicknesses and weights were detected with anterior ear skin (dermis to epidermis) thickness and paw scratching behavior increases. However, these DNFB-induced increases on ear and paw thicknesses, weights and scratching behaviors were decreased by treatment of all three different dosages of PR extracts and dexamethasone, respectively. In addition, the increases of anterior skin thicknesses were also dramatically inhibited by treatment of all three different dosages of PR extracts and dexamethasone at histopathological observations. The results obtained in this study suggest that oral treatment of PR extracts also has relatively favorable effects on allergic dermatitis.

• 한국물환경학회지
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• 제28권1호
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• pp.50-56
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• 2012

In this study, loess composites, loess with lanthanum and with aluminum, were made and evaluated for treatment of phosphorus removal in natural water system. Desiccation method for production of loess composite was superior to centrifugation method in obtaining high concentrated composites of lanthanum and aluminum. Washing of loess lanthanum composite by water did not deteriorat the lanthanum concentration in the composite, but this lowered the aluminum concentration of loess aluminum composite. Total of 15 and 37.5% of aluminum contents were removed after first washing treatment in aluminum loess of 0.05% and 0.1% respectively. However, no more aluminum loss was monitored with increase of washing times. Phosphorus removal efficiencies were not decreased with washed loess aluminum composite. Phosphorus removal was successfully achieved by adsorption of phosphate to loess composite at pH range of 5.0 ~ 8.0. Freundlich and Langmuir adsorption isotherm was observed in the adsorption of phosphate for loess composite. Dosages of 0.05% and 0.1% lanthanum composite for 95% of phosphorus removal could reduce its usage amount to 25% and 50%, respectively, comparing with dosage of loess alone. Dosages of 0.05% and 0.1% aluminum composite could reduce its usage amount to 48% and 63%, respectively.

• 대한한방내과학회지
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• 제32권2호
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• pp.278-287
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• 2011

Objectives : The object of this study was to observe the nephroprotective effects of Sojongchobisunki-tang (SCST), which has traditionally been used as Korean medicine for treating various renal diseases, on cisplatin-induced rat acute renal failure. Methods : Three different dosages of SCST were orally administered once a day for 23 days before cisplatin treatment (5 mg/kg, single intraperitoneally administered) and 5 days after cisplatin treatment (once a day for 28 days). 6 groups, of 8 rats per group were used in the present study after 7 days of acclimatization. Changes of the body weight, kidney weight, serum BUN and creatinine levels were observed, as well as changes of the kidney MDA and GSH contents. The results were compared with captopril 100 mg/kg of which the effects on cisplatin-induced acute renal failures are already confirmed. Results : Acute renal failure induced by cisplatin were induced by oxidative stress and related lipid peroxidation in the present study. However, these acute renal failures and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment at all three different dosages of SCST extracts. Conclusions : This study suggests that SCST extracts showed favorable effects on the cisplatin-induced rat ARF.

• 대한한방내과학회지
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• 제30권4호
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• pp.821-831
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• 2009

Purpose : This study was to observe the nephroprotective effects of the traditional prescription, Daebuncheong-eum (DBCE). DBCE has generally been used for treating various renal diseases, including renal failure. Methods : Three different dosages of DBCE extract were orally administered once a day for 28 days. At the 23rd day after DBCE extract treatment, cisplatin was also treated. Then, 5 days after cisplatin treatment, all rats (6 groups of 8 rats each) were sacrificed. Changes on the body weight, kidney weight, serum BUN and creatinine levels were observed, along with changes to the kidney MDA and GSH contents. The results were compared with captopril 100mg/kg, from which the effects on cisplatin-induced acute renal failures have already been confirmed. Results : Cisplatin induced ARF are induced by oxidative stress and related lipid peroxidation in the present study. However, these ARFs and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment of all three different dosages of DBCE extracts. Conclusion : This study suggests that DBCE extracts show favorable effects on cisplatin-induced rat ARF.

• 대한한방내과학회지
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• 제35권2호
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• pp.208-221
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• 2014

Purpose : Banhasasim-tang (BHSST) has been applied for treating the symptom of gastric stuffiness, which is similar to dyspepsia. The object of this study was to observe the healing effect of BHSST on the indomethacin (IND)-induced gastric ulcer in rats. Methods : Three different dosages of BHSST (400, 200 and 100 mg/kg) were orally administered 30 min before IND treatment; 6 hrs after IND treatment, the changes on the gross lesion scores, fundic histopathology, myeloperoxidase (MPO) activity, lipid peroxidation and antioxidant defense system (glutathione contents, catalase (CAT) and superoxide dismutase (SOD) activities) were observed, and compared with the activity of the synthetic anti-ulcer drug, a representative proton pump inhibitor omeprazole (OME) 10 mg/kg. Results : All three different dosages of BHSST treatment in the IND-induced gastric ulcer rats, significant and dose dependent decreased gastric damages - hemorrhagic gross lesions, gastric mucosa MPO levels and histopathological gastric ulcerative lesions - were detected as compared with the IND treated control rats. BHSST also strengthened the antioxidant defense systems - decreased the level of lipid peroxidation and CAT activity but increased the level of GSH and SOD activity, and BHSST 200 mg/kg showed similar anti-ulcerative effect as compared with OME 10 mg/kg. Conclusions : The results obtained in this study suggest that BHSST has favorable effects against IND-induced gastric damages, through significant and dose-dependent decreasing gastric damages and the strengthening of the body's antioxidant defense systems with direct anti-inflammatory effects.

• International Journal of Industrial Entomology and Biomaterials
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• 제25권2호
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• pp.139-146
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• 2012

Botanicals have been regarded as sustainable solution of pest control because of their nominal effect on nontarget pest, biodegradability and other environment friendly properties. However, study on impact of botanicals against beneficial insects is less. In this investigation effort has been made to study the effect of essential oils of Ocimum sanctum, Ocimum gratissimum and Ageratum conyzoides against non-mulberry silkworm Antheraea assama in terms of percent mortality, total haemocyte count (THC) and phenol oxidase (PO) enzyme activity. After application of essential oil of the plants by contact residual film technique, age dependent decrease of percent mortality was recorded. Topical treatment of oil at higher dosages ($1{\mu}lg^{-1}$ and $0.5{\mu}lg^{-1}$) caused 100% mortality of late instar larvae at 24 hour but the lowest dose ($0.25{\mu}lg^{-1}$) did not cause any mortality till 48 hour of treatment. Initial increase of total haemocyte count (THC) was recorded at early hours of treatment (0.25 hour) at all dosages (1, 0.5, $0.25{\mu}lg^{-1}$) after topical treatment. A dose dependent increase was observed in phenol oxidase enzyme activity and this might indicate ability of the essential oils to cause induction of immune response in Antheraea assama larvae.

• Clinical and Experimental Pediatrics
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• 제48권5호
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• pp.476-480
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• 2005

Immunosuppressive therapy in pediatric renal transplant recipients is changing consequence of the increasing number of available immunosuppressive agents. The optimal use of immunosuppressive agents requires a thorough understanding of the pharmacokinetic characteristics, but the information on the pharmacokinetic characteristics of these drugs in pediatric transplant recipients is still limited. In general, patients younger than 5 years old show higher clearance rates, therefore the need for higher dosages in younger patients seems evident. By the therapeutic drug monitoring, trough($C_{min}$) and peak level($C_{max}$) are measured and the area under the blood concentration-time curve(AUC), which is taken as being representative of total systemic exposure can be calculated. Cyclosporine A (CSA) has poor bioavailability, which contributes to high inter- and intra-patient pharmacokinetic variability. CSA concentration measured 2 hours after administration($C_2$) has better correlation with the AUC than $C_{min}$ and is an alternative technique that predicts the AUC. Tacrolimus(Tac) has a great deal of inter-individual variability like CSA but intra-individual variability in systemic exposure is considered to be low. Both CSA and Tac are metabolized by a cytochrome P-450 enzyme isoform(CYP3A4). We should consider changing the dosages when CSA or Tac is used in combination with the medicines that inhibit or induce the CYP3A4. In case of steroid-free immunosuppressive therapy, the blood concentration of Tac should be frequently checked and dosage adjustment may be needed.