• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.13 no.1
• /
• pp.37-49
• /
• 2000

This paper is for the first essential study on the development of unified finite element formulations for solving problems related to the dynamics/thermoelastics behavior of solids. In the first part of formulations, the finite element method is based on the introduction of a new quantity defined as heat displacement, which allows the heat conduction equations to be written in a form equivalent to the equation of motion, and the equations of coupled thermoelasticity to be written in a unified form. The equations obtained are used to express a variational formulation which, together with the concept of generalized coordinates, yields a set of differential equations with the time as an independent variable. Using the Laplace transform, the resulting finite element equations are described in the transform domain. In the second, the Laplace transform is applied to both the equation of heat conduction derived in the first part and the equations of motions and their corresponding boundary conditions, which is referred to the transformed equation. Selections of interpolation functions dependent on only the space variable and an application of the weighted residual method to the coupled equation result in the necessary finite element matrices in the transformed domain. Finally, to prove the validity of two approaches, a comparison with one finite element equation and the other is made term by term.

• Human Ecology Research
• /
• v.62 no.2
• /
• pp.233-248
• /
• 2024

The purpose of this study was to describe the family life and relationships of national family center users in 2023. A sample of 1,086 adults was recruited from 48 family centers across South Korea. Participants, both online and offline, reported on various aspects of family life, including satisfaction, gender equality, work-home-life balance, family leisure, and internet usage for family and household purposes. Additionally, family relationships were explored in terms of dynamics with a spouse, children, and adult children. Data were analyzed using descriptive statistics and t-tests. In the family life domain, center users reported a high level of satisfaction, with women exhibiting greater awareness of gender equality and higher engagement in household chores than men. Furthermore, although a moderate balance among work, home, and life was reported, time emerged as a significant challenge for family leisure. Regarding technology, center users frequently utilized the internet for family communication, leisure, shopping, and household management. In the family relationships domain, men were more satisfied with spousal relationships than women. Center users reported high satisfaction with parent-child relationships. Parents of school-aged children perceived economic burdens, while those with adult children frequently provided psychological and instrumental support. These findings suggest the need for program modification and the development of new initiatives within national family centers to better support the diverse needs of families in terms of life satisfaction and relationship dynamics.

• Journal of Korean Society on Water Environment
• /
• v.32 no.1
• /
• pp.60-69
• /
• 2016

In this study, we estimated root zone soil moisture dynamics using remotely sensed (RS) data. A soil moisture data assimilation scheme was used to derive the soil and root parameters from MODerate resolution Imaging Spectroradiometer (MODIS) data. Based on the estimated soil/root parameters and weather forcings, soil moisture dynamics were simulated at spatio-temporal scales based on a hydrological model. For calibration/validation, the Little Washita (LW13) in Oklahoma and Chungmi-cheon/Seolma-cheon sites were selected. The derived water retention curves matched the observations at LW 13. Also, the simulated soil moisture dynamics at these sites was in agreement with the Time Domain Reflectrometry (TDR)-based measurements. To test the applicability of this approach at ungauged regions, the soil/root parameters at the pixel where the Seolma-cheon site is located were derived from the calibrated MODIS-based (Chungmi-cheon) soil moisture data. Then, the simulated soil moisture was validated using the measurements at the Seolma-cheon site. The results were slightly overestimated compared to the measurements, but these findings support the applicability of this proposed approach in ungauged regions with predictable uncertainties. These findings showed the potential of this approach in Korea. Thus, this proposed approach can be used to assess root zone soil moisture dynamics at spatio-temporal scales across Korea, which comprises mountainous regions with dense forest.

• BMB Reports
• /
• v.35 no.4
• /
• pp.389-394
• /
• 2002

$[Ru(bpy)_2(dppz)]^2+$ (bpy=2,2'-bipyfidine, dppz=dipyrido[3,2-a:2',3'-c]phenazine) (RuBD), a long-lifetime metal-ligand complex, displays favorable photophysical properties. These include long lifetime, polarized emission, but no significant fluorescence from the complex that is not bound to DNA. To show the usefulness of this luminophore (RuBD) for probing the bending and torsional dynamics of nucleic acids, its intensity and anisotropy decays when intercalated into supercoiled and relaxed pTZ18U plasmids were examined using frequency-domain fluorometry with a blue light-emitting diode (LED) as the modulated light source. The mean lifetimes for the supercoiled plasmids (< $\tau$ >=148 ns) were somewhat shorter than those for the relaxed plasmids (< $\tau$ >=160 ns). This suggests that the relaxed plasmids were shielded more efficiently from water. The anisotropy decay data also showed somewhat shorter slow rotational correlation times for supercoiled plasmids (288 ns) than for the relaxed plasmids (355 ns). The presence of two rotational correlation times suggests that RuBD reveals both the bending and torsional motions of the plasmids. These results indicate that RuBD can be useful for studying both the bending and torsional dynamics of mucleic acids.

• Journal of Photoscience
• /
• v.11 no.3
• /
• pp.133-139
• /
• 2004

The metal-ligand complex, $[Ru(phen)_2(dppz)]^{2+}$ (phen=1,10-phenanthroline, dppz=dipyrido[3,2-a:2',3'-c]phenazine) (RuPD), was used as a spectroscopic probe for studying nucleic acid dynamics. The RuPD complex displays a long lifetime and a molecular light switch property upon DNA binding due to shielding of its dppz ligand from water. To show the usefulness of this luminophore (RuPD) for probing nucleic acid dynamics, we compared its intensity and anisotropy decays when intercalated into the $tRNA^{val}$ and pBluescript (pBS) II SK(+) phagemid through a comparison with ethidium bromide (EB), a conventional nucleic acid probe. We used frequency-domain fluorometry with a blue light-emitting diode (LED) as the modulated light source. The mean lifetime for the $tRNA^{val}$ (<${\tau}$> = 166.5 ns) was much shorter than that for the pBS II SK(+) phagemid (<${\tau}$> = 481.3 ns), suggesting a much more efficient shielding from water by the phagemid. Because of their size difference, the anisotropy decay data showed a much shorter rotational correlation times for the $tRNA^{val}$ (99.9 and 23.6 ns) than for the pBS II SK(+) phagemid (968.7 and 39.5 ns). These results indicate that RuPD can be useful for studying nucleic acid dynamics.

• Molecules and Cells
• /
• v.44 no.2
• /
• pp.88-100
• /
• 2021

Anoctamin 6/TMEM16F (ANO6) is a dual-function protein with Ca2+-activated ion channel and Ca2+-activated phospholipid scramblase activities, requiring a high intracellular Ca2+ concentration (e.g., half-maximal effective Ca2+ concentration [EC50] of [Ca2+]i > 10 μM), and strong and sustained depolarization above 0 mV. Structural comparison with Anoctamin 1/TMEM16A (ANO1), a canonical Ca2+-activated chloride channel exhibiting higher Ca2+ sensitivity (EC50 of 1 μM) than ANO6, suggested that a homologous Ca2+-transferring site in the N-terminal domain (Nt) might be responsible for the differential Ca2+ sensitivity and kinetics of activation between ANO6 and ANO1. To elucidate the role of the putative Ca2+-transferring reservoir in the Nt (Nt-CaRes), we constructed an ANO6-1-6 chimera in which Nt-CaRes was replaced with the corresponding domain of ANO1. ANO6-1-6 showed higher sensitivity to Ca2+ than ANO6. However, neither the speed of activation nor the voltage-dependence differed between ANO6 and ANO6-1-6. Molecular dynamics simulation revealed a reduced Ca2+ interaction with Nt-CaRes in ANO6 than ANO6-1-6. Moreover, mutations on potentially Ca2+-interacting acidic amino acids in ANO6 Nt-CaRes resulted in reduced Ca2+ sensitivity, implying direct interactions of Ca2+ with these residues. Based on these results, we cautiously suggest that the net charge of Nt-CaRes is responsible for the difference in Ca2+ sensitivity between ANO1 and ANO6.

• Journal of computational fluids engineering
• /
• v.20 no.2
• /
• pp.1-6
• /
• 2015

In this study, a numerical prediction on propulsive performance of a ducted propeller in open water condition was carried out by solving Reynolds averaged Navier-Stokes(RANS) equation using computational fluid dynamics(CFD). A configuration of propeller Ka-470 inside duct 19A was considered. Hexahedral grid system was generated by dividing whole computational domain into three separate regions; propeller, duct and outer flow region. A commercial CFD software, ANSYS-CFX was used for numerical simulations. Results were compared with experimental data and showed considerable improvement in accuracy, in comparison to those from surface panel method which is based on potential flow assumption. The results also exhibited the importance of grid system within the gap between the inner surface of duct and blade tip for accurate prediction of propulsive performance of ducted propeller.

• Journal of the Korean Society of Safety
• /
• v.30 no.4
• /
• pp.142-150
• /
• 2015

A portable recoilless guided missile generates a strong back blast and impulsive noise at the nozzle when it launches. In the case of indoor operations, the hazard of the blast noise from a recoilless weapon increases due to limited indoor spaces. Also, the noise levels determine the operational feasibility of a weapon; therefore, it is important to predict the blast noise levels distribution in the indoor space in advance. In addition, computational fluid dynamics (CFD) method generally used for fluid related simulations, requires high computing cost and time to simulate the whole domains. The domain includes both blast wave region and large and various indoor space region. Therefore, an efficient method for predicting the far-field noise level within a short time should be developed. This paper describes an analysis model for predicting the indoor noise distributions by considering the shape effect of the building within a short time. A new developed blast wave model was implemented using the noise source. Additionally, noise reflections at the closed surfaces such as walls and noise transmissions at the opened surfaces such as windows and doors were considered in calculating the noise levels. The predicted noise levels were compared with the experimental data obtained from the indoor launch test to validate the reliability of program.

• BMB Reports
• /
• v.43 no.2
• /
• pp.127-132
• /
• 2010

Phosphatidylinositol (3,4,5)-triphosphate ($PIP_3$) is a lipid second messenger that employs a wide range of downstream effector proteins for the regulation of cellular processes, including cell survival, polarization and proliferation. One of the most well characterized cytoplasmic targets of $PIP_3$, serine/threonine protein kinase B (PKB)/Akt, promotes cell survival by directly interacting with nucleophosmin (NPM)/B23, the nuclear target of $PIP_3$. Here, we report that nuclear $PIP_3$ competes with Akt to preferentially bind B23 in the nucleoplasm. Mutation of Arg23 and Arg25 in the PH domain of Akt prevents binding to $PIP_3$, but does not disrupt the Akt/B23 interaction. However, treatment with phosphatases PTEN or SHIP abrogates the association between Akt and B23, indicating that nuclear $PIP_3$ regulates the Akt/B23 interaction by controlling the concentration and subcellular dynamics of these two proteins.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2007.11a
• /
• pp.1354-1359
• /
• 2007

This paper discusses the acoustic performance of simple expansion chamber using computational fluid dynamics(CFD). The CFD model consists of an axisymmetric grid with a single period sinusoid of acceptable amplitude and duration imposed at the inlet boundary condition. The time history of the static pressure is recorded at two points, one in the inlet pipe and one point in outlet pipe. The time history of the static pressure is converted to the frequency domain using Fourier Transform and the transmission loss (TL) of the muffler is obtained from the ratio of the static pressure at the inlet and outlet pipe. The transmission loss of CFD result is compared with that of the computational acoustic analysis using the boundary element method (BEM). There are some differences in two results due to the pressure drop according to the inlet and outlet pipe length. Therefore, the effects of the pressure drop to the transmission loss have to be considered.