• Smart Structures and Systems
• /
• 제2권4호
• /
• pp.313-320
• /
• 2006

The reliability analysis of structures subjected to stochastic loading involves evaluation of time and probability of the system's residence in a reference domain. In this paper, we derive an asymptotic estimate of exit time for multi-degrees-of-freedom structural systems. The system's dynamics is governed by the Lagrangian equations with linear dissipation and fast additive noise. The logarithmic asymptotic of exit time is found explicitly as a sum of two terms dependent on kinetic and potential energy of the system, respectively. As an example, we estimate exit time and an associated structural performance for a rocking structure.

• 한국자기학회:학술대회 개요집
• /
• 한국자기학회 2008년도 Asian Magnetics Conference
• /
• pp.200.2-200.2
• /
• 2008

• 대한수학회지
• /
• 제56권6호
• /
• pp.1641-1654
• /
• 2019

In this paper we study the quasi-neutral limit of the compressible magnetohydrodynamic flows in the periodic domain ${\mathbb{T}}^3$ with the well-prepared initial data. We prove that the weak solution of the compressible magnetohydrodynamic flows governed by the Poisson equation converges to the strong solution of the compressible flow of magnetohydrodynamic flows as long as the latter exists.

• 한국자기공명학회논문지
• /
• 제20권2호
• /
• pp.56-60
• /
• 2016

Adenylate kinase (AK) enzyme which acts as the catalyst of reversible high energy phosphorylation reaction between ATP and AMP which associate with energetic metabolism and nucleic acid synthesis and signal transmission. This enzyme has three distinct domains: Core, AMP binding domain (AMPbd) and Lid domain (LID). The primary role of AMPbd and LID is associated with conformational changes due to flexibility of two domains. Three dimensional structure of human AK1 has not been confirmed and various mutation experiments have been done to determine the active sites. In this study, AK1R138A which is changed arginine[138] of LID domain with alanine[138] was made and conducted with NMR experiments, backbone dynamics analysis and mo-lecular docking dynamic simulation to find the cause of structural change and substrate binding site. Synthetic human muscle type adenylate kinase 1 (hAK1) and its mutant (AK1R138A) were re-combinded with E. coli and expressed in M9 cell. Expressed proteins were purified and finally gained at 0.520 mM hAK1 and 0.252 mM AK1R138A. Multinuclear multidimensional NMR experiments including HNCA, HN(CO)CA, were conducted for amino acid sequence analysis and signal assignments of $^1H-^{15}N$ HSQC spectrum. Our chemical shift perturbation data is shown LID domain residues and around alanine[138] and per-turbation value(0.22ppm) of valine[179] is consid-ered as inter-communication effect with LID domain and the structural change between hAK1 and AK1R138A.

• International Journal of Molecular Medicine
• /
• 제43권2호
• /
• pp.1105-1113
• /
• 2019

Epigenetic modifier lysine demethylase 3a (Kdm3a) specifically demethylates mono- and di-methylated ninth lysine of histone 3 and belongs to the Jumonji domain-containing group of demethylases. Kdm3a serves roles during various biological and pathophysiological processes, including spermatogenesis and metabolism, determination of sex, androgen receptor-mediated transcription and embryonic carcinoma cell differentiation. In the present study, physiological functions of Kdm3a were evaluated during embryogenesis of Xenopus laevis. Spatiotemporal expression pattern indicated that kdm3a exhibited its expression from early embryonic stages until tadpole stage, however considerable increase of kdm3a expression was observed during the neurula stage of Xenopus development. Depleting kdm3a using kdm3a antisense morpholino oligonucleotides induced anomalies, including head deformities, small-sized eyes and abnormal pigmentation. Whole-mount in situ hybridization results demonstrated that kdm3a knockdown was associated with defects in neural crest migration. Further, quantitative polymerase chain reaction revealed abnormal expression of neural markers in kdm3a morphants. RNA sequencing of kdm3a morphants indicated that kdm3a was implicated in mesoderm formation, cell adhesion and metabolic processes of embryonic development. In conclusion, the results of the present study indicated that Kdm3a may serve a role in neural development during Xenopus embryogenesis and may be targeted for treatment of developmental disorders. Further investigation is required to elucidate the molecular mechanism underlying the regulation of neural development by Kdm3a.

• Journal of Photoscience
• /
• 제7권4호
• /
• pp.155-159
• /
• 2000

[Ru(bpy)$_2$(dppz)]$^2$$^{+}$ (bpy = 2,2'-bipyridine, dppz = dipyrido[3,2-a:2',3'-c]phenazine)(RuBD), a long-lifetime metal-ligand complex displays photophysical properties including long lifetime, polarized emission, and very little background fluorescence. To further show the usefulness of this luminophore(RuBD) for probing nucleic acid dynamics, its intensity and anisotropy decays when bound to tRN $A^{val}$ were examined using frequency-domain fluorometry with a blue light-emitting diode(LED)as the modulated light source. Unexpectedly much longer mean lifetime was obtained at 4$^{\circ}C$(<$\tau$>=178.3 ns) as compared to at $25^{\circ}C$(<$\tau$>=117.0 ns), suggesting more favorable conformation of tRN $A^{val}$ for RuBD when intercalated at 4$^{\circ}C$. The anisotropy decay data showed longer rotational correlation times at 4$^{\circ}C$(52.7 and 13.0 ns) than at $25^{\circ}C$ (32.9 and 10.3 ns). The presence of two rotational correlation times suggests that RuBD reveals both local and overall rotational motion of tRN $A^{val}$. Due to long lifetime of RuBD and small size of tRN $A^{val}$, very low steady-state anisotropy values were observed, 0.048 and 0.036 at 4 and $25^{\circ}C$, respectively. However, a clear difference in the modulated anisotropy values was seen between 4 and $25^{\circ}C$. These results indicate that RuBD can be useful for studying hydrodynamics of small nucleic acids such as tRN $A^{val}$.^{val}$.>.$.>.

• 한국전자파학회논문지
• /
• 제24권3호
• /
• pp.331-336
• /
• 2013

본 논문은 유체 역학적 관점에서 플라즈마 모델링을 통하여 전자 밀도를 계산하는 방식을 제안하였다. 그럼으로써 기존 논문들에서 사용된 단순화된 플라즈마 모델링의 한계를 극복하였다. 계산된 전자 밀도를 finite-difference time-domain(FDTD) 기법에 기반한 맥스웰-볼츠만 시스템에 연계하여 다양한 각도에서 입사하는 전자기파에 대한 산란파 계산을 수행하였다. 전반부에서는 유전체 장벽 방전(dielectric barrier discharge: DBD) 구조에서 발생되는 플라즈마를 모델링하였다. 다수의 모델링 방식 중, 시간 독립적인 변수를 도입하여 정지계의 전위 분포와 전자 밀도 분포를 계산하는 Suzen-Huang 모델을 이용하였다. 후반부에서는 변조된 가우시안 펄스를 플라즈마에 입사시켜 발생하는 산란파를 FDTD 기법을 이용하여 계산하였으며, 이를 바탕으로 레이더 단면적(radar cross section: RCS)을 관찰하였다. 모의실험 결과, DBD 플라즈마에 의해 1~2 dB 감소하는 것을 관찰할 수 있었다. 이는 기존의 논문에서 알려진 RCS 측정 결과와 유사한 양상을 보이며, 본 논문에서 제안한 모델링의 유효성을 확인하였다.

• 동력기계공학회지
• /
• 제17권3호
• /
• pp.72-81
• /
• 2013

Many articles have been published about a 2-degree of freedom model that includes the lateral and yaw motions for controller synthesis in intelligent transport system applications. In this paper, a 3-degree of freedom linear model that includes the roll motion is developed to design a robust steering controller for lane following maneuvers using ${\mu}$-synthesis. This linear perturbed system includes a set of parametric uncertainties in cornering stiffness and unmodelled dynamics in steering actuators. The state-space model with parametric uncertainties is represented in linear fractional transformation form. Design purpose can be obtained by properly choosing the frequency dependent weighting functions. The objective of this study is to keep the tracking error and steering input energy small in the presence of variations of the cornering stiffness coefficients. Furthermore, good ride quality has to be achieved against these uncertainties. Frequency-domain analyses and time-domain numerical simulations are carried out in order to evaluate these performance specifications of a given vehicle system. Finally, the simulation results indicate that the proposed robust controller achieves good performance over a wide range of uncertainty for the given maneuvers.

• 한국항해항만학회지
• /
• 제34권4호
• /
• pp.271-279
• /
• 2010

The Mobile Harbor(MH) is a new transportation platform that can load and unload containers to and from very large container ships in the sea. This loading and unloading by crane can be performed with only very small movements of the MH in waves because MH is operated outside of the harbor. For this reason, an anti-rolling tank(ART) and an active mass driving system(AMD) were designed to reduce MH's roll motion, especially at the natural frequency of MH. In the conceptual design stage, it is difficult to confirm the design result of theses anti-rolling devices without modeling and simulation tools. Therefore, the coupled MH and anti-rolling devices' dynamic equations in waves were derived and a simulation program that can analyze the roll reduction performance in various conditions, such as sea state, wave direction, and so on, was developed. The coupled equations are constructed as an eight degrees of freedom (DOF) motion that consists of MH's six DOF dynamics and the ART's and AMD's control variables. In order to conveniently include the ART's and AMD's control dynamics in the time domain, MH's radiated wave force was described by an impulse response function derived by the damping coefficient obtained in the frequency domain, and wave exciting forces such as Froude-Krylov force and diffraction force and nonlinear buoyancy were calculated at every simulation time interval. Finally, the roll reduction performances of the designed anti-rolling devices were successfully assessed in the various loading and wave conditions by using a developed simulation program.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2014년도 추계학술대회 논문집
• /
• pp.557-561
• /
• 2014

In this work, Altair Engineering's vibroacoustic modeling approach is used to simulate the acoustic signature of a simplified automobile in a wind tunnel. The modeling approach relies on a two step procedure involving simulation and extraction of acoustic sources using a high fidelity Computational Fluid Dynamics (CFD) simulation followed by propagation of the acoustic energy within the structure and passenger compartment using a structural dynamics solver. The tools necessary to complete this process are contained within Altair's HyperWorks CAE software suite. The CFD simulations are performed using AcuSolve and the structural simulations are performed using OptiStruct. This vibroacoustics simulation methodology relies on calculation of the acoustic sources from the flow solution computed by AcuSolve. The sources are based on Lighthill's analogy and are sampled directly on the acoustic mesh. Once the acoustic sources have been computed, they are transformed into the frequency domain using a Fast Fourier Transform (FFT) with advanced sampling and are subsequently used in the structural acoustics model. Although this approach does require the CFD solver to have knowledge of the acoustic simulation domain a priori, it avoids modeling errors introduced by evaluation of the acoustic source terms using dissimilar meshes and numerical methods. The aforementioned modeling approach is demonstrated on the Hyundai Simplified Model (HSM) geometry in this work. This geometry contains flow features that are representative of the dominant noise sources in a typical automobile design; namely vortex shedding from the passenger compartment A-pillar and bluff body shedding from the side view mirrors. The geometry also contains a thick poroelastic material on the interior that acts to reduce the acoustic noise. This material is modeled using a Biot material formulation during the structural acoustic simulation. Successful prediction of the acoustic noise within the HSM geometry serves to validate the vibroacoustic modeling approach for automotive applications.