• Journal of Integrative Natural Science
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• v.13 no.4
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• pp.170-180
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• 2020

Abnormal regulation, hyperphosphorylation, and aggregation of the tau protein are the hallmark of several types of dementia, including Alzheimer's Disease. Increased activity of Glycogen Synthase Kinase-3β (GSK-3β) in the Central Nervous System (CNS), increased the tau hyperphosphorylation and caused the neurofibrillary tangles (NFTs) formation in the brain cells. Over the last two decades, numerous adenosine triphosphate (ATP) competitive inhibitors have been discovered that show inhibitory activity against GSK-3β. But these compounds exhibited off-target effects which motivated researchers to find new GSK-3β inhibitors. In the present study, we have collected the dataset of 31 C-Glycosylflavones derivatives that showed inhibitory activity against GSK-3β. Among the dataset, the most active compound was docked with the GSK-3β and molecular dynamics (MD) simulation was performed for 50 ns. Based on the 50 ns MD pose of the most active compound, the other dataset compounds were sketched, minimized, and aligned. The 3D-QSAR based Comparative Molecular Field Analysis (CoMFA) model was developed, which showed a reasonable value of q2=0.664 and r2=0.920. The contour maps generated based on the CoMFA model elaborated on the favorable substitutions at the R2 position. This study could assist in the future development of new GSK-3β inhibitors.

• Journal of Astronomy and Space Sciences
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• v.41 no.2
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• pp.61-78
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• 2024

This study developed a real-time spacecraft pose estimation algorithm that combined a deep learning model and the least-squares method. Pose estimation in space is crucial for automatic rendezvous docking and inter-spacecraft communication. Owing to the difficulty in training deep learning models in space, we showed that actual experimental results could be predicted through software simulations on the ground. We integrated deep learning with nonlinear least squares (NLS) to predict the pose from a single spacecraft image in real time. We constructed a virtual environment capable of mass-producing synthetic images to train a deep learning model. This study proposed a method for training a deep learning model using pure synthetic images. Further, a visual-based real-time estimation system suitable for use in a flight testbed was constructed. Consequently, it was verified that the hardware experimental results could be predicted from software simulations with the same environment and relative distance. This study showed that a deep learning model trained using only synthetic images can be sufficiently applied to real images. Thus, this study proposed a real-time pose estimation software for automatic docking and demonstrated that the method constructed with only synthetic data was applicable in space.

• The Journal of Korea Robotics Society
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• v.1 no.2
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• pp.117-124
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• 2006

In this paper, we develope the navigation system for patrol robots in indoor environment. The proposed system consists of PDA map modelling, a localization algorithm based on a global position sensor and an automatic charging station. For the practical use in security system, the PDA is used to build object map on the given indoor map. And the builded map is downloaded to the mobile robot and used in path planning. The global path planning is performed with a localization sensor and the downloaded map. As a main controller, we use PXA270 based hardware platform in which embedded linux 2.6 is developed. Data handling for various sensors and the localization algorithm are performed in the linux platform. Also, we implemented a local path planning algorithm for object avoidance with ultra sonar sensors. Finally, for the automatic charging, we use an infrared ray system and develop a docking algorithm. The navigation system is experimented with the two-wheeled mobile robot using North-Star localization system.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.33B no.3
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• pp.38-46
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• 1996

In this paper, a multi-velocity log system which uses ultrasonic pulsed doppler signal is developed. The output of the system is the absoluted velcocity of the ship. By using digitral signal processing, we get the vector velocity which displays the ship's speed about fore, aft, port and starboard. And this system give us the information about depth. This multi-velocity system has a large merit that is bottom and water track velocity. In addition, this has the high accuracy and can measure the water-depth according to the deep mode. And the fish finder, echo sounder or docking system will be made by applying the speed log system.

• Korean Journal of Microbiology
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• v.39 no.3
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• pp.141-147
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• 2003

The simultaneous expression levels of antifungal activity related genes was analyzed by DNA microarray. We constructed DNA chips contained 2,000 randomly digested genome spots of the antifungal bacterium of Bacillus lentimorbus WJ5 and compared its quantitative aspect with 7 antifungal activity deficient mutants induced by gamma radiation ($^{60}Co$). From the analysis of microarray hybridization by the Gene Cluster (Michael Eisen, Stanford Univ.), totally 408 genes were expressed and 20 genes among them were significantly suppressed in mutants. pbuX (xanthine permease, K222), ywbA (phosphotransferase system enzyme II, K393), ptsG (PTS glucose specific enzyme II ABC component, K877), yufO (ABC transporter (ATP-binding protein), K130l), and ftsY (signal recognition particle (docking protein), K868) were simultaneously down-regulated in all mutants. It suggested that they were supposed to be related to the antifungal activity of B. lentimorbus WJ5.

• Korean Management Science Review
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• v.34 no.1
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• pp.1-13
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• 2017

The percentage of 3PL (Third-party Logistics), which uses third party businesses to outsource elements of the company's distribution and fulfillment services, is increasing steadily. To provide 3PL service to the customers, it is needed to estimate the total transportation cost and propose the unit cost to the customers. In this paper, we develop a decision support system for estimation of transportation cost of 3PL provider considering various transportation services, such as direct transportation, multi point visiting transportation, and cross docking. The system supports route planning of vehicles by using algorithms based on tabu search and dynamic programming.

• Proceedings of the KSR Conference
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• 2007.05a
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• pp.1937-1942
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• 2007

Bimodal tram is being developed to be completed in 2010 and the infrastructure needs to be developed to make the operation in time. Through the study of infrastructure reflecting domestic condition, dedicated lane, station, connection center, automated operation, precise docking, ticketing system, information system, management system for operation and maintenance, and refueling station will be developed and their performances will be also verified through the construction of test bed. The economical, safe and environment-friendly operation of the bimodal tram will be established through the present study.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.11
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• pp.2074-2079
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• 2008

This paper presents a software toolbox with $Matlab^{(R)}$ developed for the various performance analysis of an automatic guidance system of the Bimodal Tram. The Bimodal Tram is a new kind of transportation vehicle which could be an all-wheel steered multiple-articulated vehicle. This vehicle has to be equipped with an automatic guidance, traction/braking, and docking system, In the stage of developing such a system, its validities and performances should be verified under various operation conditions. For the purpose of doing these things through simulation, this toolbox has been developed and demonstrated well by applying it to the KRRI model.

• The Journal of Korea Robotics Society
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• v.18 no.3
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• pp.233-240
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• 2023

In this paper, we proposed a hybrid type robot that simultaneously surveillance and reconnaissance on the ground and in the air. It was possible to expand the surveillance and reconnaissance range by expanding the surveillance and reconnaissance area of the ground robot and quickly moving to the hidden area through the drone. First, ground robots go to mission areas through drones and perform surveillance and reconnaissance missions for urban warfare or mountainous areas. Second, drones move ground robots quickly. It transmits surveillance and reconnaissance images of ground robots to the control system and performs reconnaissance missions at the same time. Finally, in order to secure the interoperability of these hybrid robots, basic performance and environmental performance were verified. The evaluation method was tested and verified based on the KS standards.

• Proceedings of the KSR Conference
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• 2003.10b
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• pp.58-63
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• 2003

This study shows the functional contribution into the public transportation system for congestion area. And there is a introduction for the rapid bus transit developed in Europe community. It can be classified the public transportation as urban transit, subway and bus. For a few years, it has been introduced the AGT system as a role of the alternative and lengthening system of subway line. Recently, there is going on construction of AGT system in some regional cities. The AGT system has advantages in terms of accessibility and cost-effective rather than subway. But the bus system is advantageous at the points rather than AGT system. It is obvious that the bus system is most cost-effective for infrastructure and system rather than any other public transports. If the bus system has punctuality and precise docking, that becomes best choice for public transportation scheme. There are tries to develop new systems by means of the f1les up the advantages in bus and AGT system, which can be classified as BRT(Bus Rapid Transit}. The idea is simple; 'Thirik rail, use advanced buses.' It is introduced the IRISBUS system at this article, which was developed in Europe community. And it is introduced the project architecture to develop the similar system to IRISBUS in KRRI through National Transportation Key Technology R&D Project