• Bulletin of the Korean Chemical Society
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• v.31 no.8
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• pp.2422-2423
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• 2010

• Bulletin of the Korean Chemical Society
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• v.29 no.11
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• pp.2267-2269
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• 2008

• 한국약용작물학회:학술대회논문집
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• 2009.05a
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• pp.343-344
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• 2009

• Journal of Korean Society of Forest Science
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• v.96 no.1
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• pp.65-69
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• 2007

Essential oils which were isolated from leaves and twigs of Lindera obtusiloba Blume by steam distillation method were analyzed by the NIST and Wiley 6 Library method, using GC-MS. 24 components from the experiment were identified, and sesquiterpenoids were major of the components. The main constituents in the leaves were germacrene B (17.78%), ${\beta}-caryophyllene$ (17.50%), phytol isomaer (13.36%) and $(-)-{\beta}-elemene$ (11.07%), and the main in the twigs were ${\beta}-elemol$ (24.47%), ${\alpha}-cadinol$ (13.73%), camphor (9.83%) and ${\beta}-citronellol$ (9.54%). Acyclic diterpene such as phytone, phytol and phytol isomer were isolated for the first time in the leaves of L. obtusiloba.

• Natural Product Sciences
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• v.6 no.2
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• pp.66-69
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• 2000

Salvia bucharica belonging to the family Lamiaceae (Labiatae), afforded a novel terpenoid (1) named as salvatrione. The structure of 1 was elucidated through extensive 2-D NMR experiments and the biogenetic pathway of 1 has also been proposed. On biogenetic grounds, 1 may be considered to be a pseudo-triterpenoid as it is derived from the coupling of mono/ diterpenic units and not from squalene.

• Korean Journal of Pharmacognosy
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• v.3 no.1
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• pp.21-22
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• 1972

우리 나라 한방요법(漢方療法)에서 고혈압치료(高血壓治療)에 널리 쓰이고 있는 희염은 털진득찰 Siegesbeckia pubescens의 전초(全草)로서 그 유효성분(有成分)으로서는 이미 물질(物質) $A\;C_{20}H_{34}O_4\;mp\;192{\sim}193^{\circ}\;[{\alpha}]^{20}_D\;-22\;(in\;dioxane),\;B\;C_{20}H_{32}O_4\;260.2^{\circ}[{\alpha}]^{20}_D\;-88\;(in{\;}pyridine)$의 화학구조(化學構造) 및 생리작용(生理作用)을 밝힌 바 있다. 본 연구에서는 또하나의 새로운 배당체(配糖體) $compound(I)\;C_{26}H_{44}O_8\;mp\;225{\sim}6^{\circ}[{\alpha}]^{20}_D\;-40$을 얻어 그의 이화학적(理化學的) 성상(性狀) 및 유도체(誘導體)의 합성(合成)으로서 화학구조(化學構造)를 구명(究明)하였다.

• Natural Product Sciences
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• v.6 no.1
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• pp.36-39
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• 2000

Acorenone, a diterpene isolated from Acorus gramineus, showed strong resistance inhibitory activity against multi-drug resistant microorganisms such as Staphylococcus aureus SA2, which has resistance to 10 usual antibiotics including chloramphenicol (Cm). At the level of $5\;{\mu}g/ml$ when combined with $50\;{\mu}g/ml$ of Cm. Bacterial resistance to Cm is due to the presence in resistant bacteria of an enzyme, chloramphenicol acetyltransferase (CAT), which catalyses the acetyl-CoA dependent acetylation of the antibiotic at C-3 hydroxyl group. To elucidate the mechanism of resistant inhibitory effect, the acorenone which had the strongest resistant inhibitory activity, was investigated on the CAT assay. As the result, the combination of Cm and acorenone showed the strongest inhibitory activity on CAT as noncompetitive and dose dependent manner.

• Journal of The Korean Society of Clinical Toxicology
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• v.4 no.2
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• pp.180-186
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• 2006

The various species of aconitum contain diterpene (C-20) and norditerpene (C-19) forms of the natural alkaloid aconitine that cause neurologic, gastrointestinal, cardiovascular symptoms. In chinese medicine, these plants has been used as drugs to treat pain, dyspepsia, cerebrovascular disease, and so on. Because the therapeutic window is narrow, poisoning may occur from unintentional exposure, with a variety of toxic effects such as arrhythmia, hypotension, paresthesia, paralysis, nausea, vomiting, and abdominal pain. Aconitine-containing folk remedies are widely used in Korea. We encountered two cases of ventricular arrhythmia in patients who ingested tablets, known as 'Wha-Pung-Dan' made with aconitine extracts and were subsequently admitted to the ED. A 42 year-old man who took 35 tablets presented with ventricualr tarchycardia, and 40 year-old woman who took 40 tablets showed premature ventricular contractions. Both patients were discharged normally without any complications after three days.

• YAKHAK HOEJI
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• v.40 no.6
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• pp.720-726
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• 1996

The neurotoxicity induced by L-glutamate in primary cultures of rat cortical cells could be attenuated by diterpene constituents of Ginkgo biloba leaves, ginkgolides A, B and C. At the concentration of 100 nM, ginkgolides up-regulated the activity of glutathione reductase in primary cultures of rat cortical cells exposed to 100 ${\mu}$M glutamate. Furthermore, ginkgolides increased the content of reduced glutathione in glutamate-treated cortical cells. However, ginkgolides showed little effect in reducing superoxide dismutase activity. Ginkgolides did, however, markedly block the production of malondialdehyde, a byproduct of lipid peroxidation in glutamate-treated rat cortical cells.

• Natural Product Sciences
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• v.9 no.3
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• pp.161-166
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• 2003

In the course of our studies for new anticancer medicinal plants, we evaluated the effects of an alcohol-water (1:1, V/V) extract of Dendrostellera lesserii (Thymelaeaceae) leaves on the growth rates of breast tumors of rats. The breast tumors were induced in a group of rats by Dimethylbenz[a]anthracene (DMBA) injection. Our data showed that daily oral feeding of the crude extract to the rats, for 20 consecutive weeks, significantly repressed the growth rates of the breast tumors. In addition, the probable effect of D. lessertii crude extract or one of its purified active components on metastasis was evaluated using wehi-164 cells. Treatment of the cells with a single nontoxic dose of the purified active component for 48 hours inhibited the adhesion of the cells to the immobilized fibronectin molecules by almost 80% compared to the untreated control cells.