• 사상체질의학회지
• /
• 제24권2호
• /
• pp.61-70
• /
• 2012

1. Objectives : The aim of this study was to report significant improvement of chronic diarrhea and hematochezia after treatment with Dojeokgangki-tang in a Soyangin Patient with Crohn's Disease. 2. Methods : The patient's subjective and objective symptoms were observed daily throughout the hospitalization period, and the Crohn's disease activity index(CDAI) was calculated to gauge the progress or lack of progress. 3. Results : The symptoms of diarrhea and hematochezia disappeared by the end of the hospitalization period without recurrence, and the CDAI score dropped from 92.5 to 47. 4. Conclusions : A patient with Crohn's disease, who was in the state of repetitive relapse and remission after long term clinical courses was treated with Dojeokgangki-tang in a short period and the the symptoms of diarrhea and hematochezia disappeared without recurrence. Then the patient could stop taking corticosteriods and taper off immune-suppressing drugs.

• 한국컴퓨터정보학회논문지
• /
• 제26권2호
• /
• pp.39-44
• /
• 2021

본 논문에서는 가정에서 많이 기르는 반려견을 바탕으로 반려견 질병에 대한 전문적인 수의학 지식이 부족한 일반인들을 대상으로 자신의 반련견의 건강 상태를 파악할 수 있는 진단 시스템을 제안한다. 제안된 진단 시스템은 50가지 질병과 각 질병의 증상을 데이터베이스에 구축하여 입력된 증상을 통해서 반려견의 질병을 도출한다. 각 질병 데이터베이스에는 질병에 해당하는 증상 코드들을 가지고 있으며, 이러한 질병에 대한 데이터베이스를 이용하여 군집화 기법인 FCM 클러스터링 기법을 적용하여 질병을 클러스터링하고 그 결과 값인 소속도를 바탕으로 입력된 증상과 가까운 질병들을 도출하여 반려견의 진단 결과를 제공한다. 제안된 반려견 진단의 구현 결과에서는 선택한 증상들의 개수와 선택된 증상들이 포함된 질병들의 가능성 값을 구하여 내림차순으로 정렬하여 반려견의 증상과 가장 가까운 질병 상위 3가지를 도출하였다.

• Journal of Yeungnam Medical Science
• /
• 제38권3호
• /
• pp.245-250
• /
• 2021

Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a self-limiting lymphadenitis. It is a benign disease mainly characterized by high fever, lymph node swelling, and leukopenia. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease with clinical symptoms similar to those of KFD, but it requires a significantly more aggressive treatment. A 19-year-old Korean male patient was hospitalized for fever and cervical lymphadenopathy. Variable-sized lymph node enlargements with slightly necrotic lesions were detected on computed tomography. Biopsy specimen from a cervical lymph node showed necrotizing lymphadenitis with HLH. Bone marrow aspiration showed hemophagocytic histiocytosis. The clinical symptoms and the results of the laboratory test and bone marrow aspiration met the diagnostic criteria for HLH. The patient was diagnosed with macrophage activation syndrome-HLH, a secondary HLH associated with KFD. He was treated with dexamethasone (10 mg/m²/day) without immunosuppressive therapy or etoposide-based chemotherapy. The fever disappeared within a day, and other symptoms such as lymphadenopathy, ascites, and pleural effusion improved. Dexamethasone was reduced from day 2 of hospitalization and was tapered over 8 weeks. The patient was discharged on day 6 with continuation of dexamethasone. The patient had no recurrence at the 18-month follow-up.

• 대한유전성대사질환학회지
• /
• 제22권1호
• /
• pp.1-8
• /
• 2022

Long-chain fatty acid oxidation disorders (LC-FAOD) are an autosomal recessive inherited rare disease group that result in an acute metabolic crisis and chronic energy deficiency owing to the deficiency in an enzyme that converts long-chain fatty acids into energy. LC-FAOD includes carnitine palmitoyltransferase type 1 (CPT1), carnitine-acylcarnitine translocase (CACT), carnitine palmitoyltransferase type 2 (CPT2), very long-chain acyl-CoA dehydrogenase (VLCAD), long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD), and trifunctional protein (TFP) deficiencies. Common symptoms of LC-FAOD are hypoketotic hypoglycemia, cardiomyopathy, and myopathy. Depending on symptom onset, the disease can be divided as neonatal period, late infancy and early childhood, adolescence, or adult onset, but symptoms can appear at any time. The neonatal screening test (NBS) can be used to identify the characteristic plasma acylcarnitine profiles for each disease and confirmed by deficient enzyme analysis or molecular testing. Before introduction of NBS, the mortality rate of LC-FAOD was very high. With NBS implementation as routine neonatal care, the mortality rate was dramatically decreased, but severe symptoms such as rhabdomyolysis recur frequently and affect the quality of life. Triheptanoin (Dojolvi^®), the first drug for pediatric and adult patients with molecularly confirmed LC-FAOD, has recently been approved by the US Food and Drug Administration in 2020. In this review, the diagnosis of LC-FAOD and treatment including triheptanoin are summarized.

• Mycobiology
• /
• 제51권3호
• /
• pp.186-194
• /
• 2023

In July 2021, wilting symptoms were observed in adult and seedling hemp (Cannabis sativa L. cv. Cherry Blossom) plants grown in a greenhouse. As the disease progressed, yellowing and wilting symptoms on the leaves developed, resulting in whole plant death. In seedling plants, typical damping-off symptoms were observed. To identify the pathogen, the roots of diseased plants were sampled, surface sterilized, and cultured on potato dextrose agar (PDA) media. From the culture, 4 different fungal isolates were recovered and purely cultured. Each fungal isolate showed distinct growth shapes and color development on malt extract agar, oatmeal agar, sabouraud dextrose agar, and PDA media. Microscopic observation and molecular identification using ribosomal DNA internal transcribed spacer sequencing identified them as 3 Fusarium spp. and 1 Thielaviopsis paradoxa. Additional sequencing of elongation factor 1-alpha and b-tubulin regions of 3 Fusarium spp. revealed that 2 of them are Fusarium solani, and the other one is Fusarium proliferatum. To examine which isolate can act as a causal agent of wilt disease of hemp, each isolate was tested for their pathogenicity. In the pathogenicity test, F. solani AMCF1 and AMCF2, and F. proliferatum AMCF3, but not T. paradoxa AMCF4, were able to cause wilting disease in hemp seedlings. Therefore, we report that F. solani AMCF1 and AMCF2, and F. proliferatum AMCF3 as causal agents of Fusarium wilt of hemp plants. To our knowledge, this is the first report of the wilt disease of C. sativa L. caused by Fusarium spp. in Korea.

• 대한한의학원전학회지
• /
• 제27권1호
• /
• pp.99-109
• /
• 2014

Objectives : The concepts of many Korean medicine terms have changed for a long time and cumulatively been recorded in later medicine literatures. And, the same terms have very often been used for different meanings depending on context. Methods : This study was performed so that conceptual magnitude of Korean medicine terms could intuitively be recognized for the purpose of quantization. Results : This study was performed under the premise that terms used in old literatures of Korean medicine are related mostly to treatments that could immediately be reverted to types of medical herbs used. Through this, conceptual magnitude of terms was quantified by the method that frequency of medical herbs used for treatment was changed to numerical values. For this, data of "Compilation of Formulas and Medicinals Addendum" were used. First, after 'specificity' of each medicine herb corresponding to representative disease symptoms was calculated, medians in the set were selected, and 'values of conceptual magnitude' for representative disease symptoms were calculated. Conclusions : As a result, if disease symptoms are diverse, concept range is diachronically changed greatly, and specific disease symptoms of great conceptual difference are included, value of conceptual magnitude was great. Meanwhile, if disease factor and treatment are singular or limited to several types, and many medical herbs with high specificity are used, value of conceptual magnitude was less.

• 대한한방내과학회지
• /
• 제36권2호
• /
• pp.122-152
• /
• 2015

Objectives: This study was designed to develop a standard tool for pattern identification of gastroesophageal reflux disease (GERD) patients. Methods: Korean and Chinese literature was selected that mentioned pattern identification of GERD. We gathered the pattern identification and their symptoms and a Chinese medical doctor proficient in Korean translated the Chinese characters into Korean. A Korean linguist then confirmed the translation results to develop a draft of the standard tool for pattern identification of gastroesophageal reflux disease (PIGERD). The final PIGERD was developed after assessment by an expert committee composed of professors from the Korean Medicine University, using the following items: inclusion of the pattern identification and its symptoms, importance of items, and validity of translation. Results: Six pattern identifications and 94 symptoms were selected from 45 references and translated into Korean. Four pattern identifications [pattern/syndrome of liver qi invading the stomach (肝胃不和), spleen-stomach weakness (脾胃虛弱), spleen-stomach dampness-heat (脾胃濕熱), and stomach yin deficiency (胃陰不足)] and 49 symptoms were then selected through the Delphi method by the expert committee. The final standard PIGERD tool was completed after the assessment of translation validity and reflection of individual opinions by the expert committee. This tool consists of 40 items including tongue and pulse diagnosis. The weighted value was also computed from assessment of the importance of items. Conclusions: We developed a standard tool for pattern identification of gastroesophageal reflux disease (PIGERD) to clarify the pattern identification of patients with gastroesophageal reflux disease for standardized diagnosis.

• The Journal of Korean Physical Therapy
• /
• 제31권2호
• /
• pp.122-128
• /
• 2019

Purpose: This study examined the effects of sagittal spinopelvic alignment on the clinical parameters, motor symptoms, and respiratory function in patients with mild to moderate Parkinson's disease (PD). Methods: This study was a prospective assessment of treated patients (n=28, Hoehn and Yahr (H&Y) stage 2-3) in a PD center. Twenty-eight subjects ($68.5{\pm}5.7yrs$) participated in this study. The clinical and demographic parameters, including age, sex, symptoms duration, treatment duration, and H&Y stage, were collected. Kinematic analysis was conducted in the upright standing posture with a motion capture system. A pulmonary function test (PFT) was performed in the sitting position using a spirometer. The motor symptoms were assessed on part III of the movement disorder society sponsored version of the unified Parkinson's disease rating scale (MDS-UPDRS). SPSS 18.0 was used to analyze the collected data. Results: The exceeding 12 degrees group of the lower trunk showed significantly higher on the clinical parameters than the below 12 degrees group. In addition, the exceeding 12 degrees group of the lower trunk showed a significantly lower forced expiratory volume at one second (FEV1) / forced vital capacity (FVC) (%) and 25-75% forced mid-expiratory flow (FEF) (L/s) than in the below group. On the other hand, there was no difference in the upper trunk and the cervical pelvis between the groups. Conclusion: These findings suggest that the sagittal balance in the lower trunk is related to the clinical parameters and respiratory function, but not the motor symptoms in patients with mild to moderate PD.

• 대한간호학회지
• /
• 제50권5호
• /
• pp.714-727
• /
• 2020

Purpose: The aim of this study was to develop a situation-specific theory to explain the disease management experience of patients with asthma. Methods: Twenty participants with asthma were selected using the theoretical sampling method. The data were acquired through in-depth interviews conducted from June to October 2018 and analyzed using the grounded theory approach of Strauss and Corbin. Results: In total, 69 concepts, 30 subcategories, and 13 categories were generated to explain the disease management experience of patients with asthma. The core category of the disease management experience of patients with asthma was 'management of the disease to prevent aggravation of symptoms over the lifetime'. The disease management process of asthma patients included three steps: the 'cognition phase', the 'adjustment phase', and the 'maintenance phase'. However, some patients remained in the 'stagnation phase' of disease management, which represents the result of the continual pursuit of risky health behavior. There were three types of disease management experiences among patients with asthma: 'self-managing', 'partially self-managing', and 'avoidant'. Conclusion: This study shows that patients with asthma must lead their disease management process to prevent exacerbation of their symptoms. It is imperative to develop nursing strategies and establish policies for effective disease management of patients with asthma based on their individual disease management processes and types.

• 사상체질의학회지
• /
• 제14권1호
• /
• pp.34-50
• /
• 2002

1. Background and Purpose At the year of 2000, the society of sasang constitutional medicine acqired ${\ulcorner}$HamsanSachon DongyiSuseBowon GoboGubon${\lrcorner}$ which is presumed as the copy of ${\ulcorner}$GoboGubon${\lrcorner}$. According to Lee Sung-Su who is the great-grandson of DongMu's older brother, $[\ulcorner}$HamsanSachon DongyiSuseBowon GoboGubon${\lrcorner}$ was worked by Lee Jin-Yoon who is the grandson of DongMu's older brother and it was copied by Han Min-Gab and now is owned by Lee Sung-Su who is the son of Lee Jin-Yoon. 2. Method This paper was written in order to understand the character of the discourse on the constitutional symp toms and diseases of ${\ulcorner}$HamsanSachon DongyiSuseBowon GoboGubon${\lrcorner}$. 3. Result and Conclusion 1) Each constitutional symptoms and diseases is classed as that of exterior and interior and then classsed again as that of exterior's exterior, exterior's interior, interior's exterior and interior's interior. 2) The degree of completion is high at the chapter of Soeumin and Soyangin comparing with that of Taeeumin and Taeyangin which don't exist as the contrasted explanation. 3) Soeumin's exterior-disease is divided Taiyang(太陽) and Yangmyung(陽明)'s disease by the sweating, that's interior-disease is same to Sinchukbon(辛丑本). BaboBon already have the concept of UlKwang(鬱狂) and mangYang(亡陽), so the discourse on the constitutional symptoms and diseases of Soyangin is early establish comparing with other constitution. 4) The Cold and Hot, the constitutional symptoms and diseases, the disease theory of Soyangin can be accessible to opposite side of Soeumin's that. The disease of exterior's exterior is only explained abdominal pain and diarrhea without the concept of Mangeum(亡陰) disease, but at the time of SinchukBon the concept of Mangeum-disease is invented. 5) There is many different with SinchukBon that the classification of symptoms and diseases of Taeeumin, and not mentioned the physiology and pathlogy of the airs and fluids metabolism. 6) Healthy Energy(保命之主) show us that JungKi(正氣) is key-point of the utility of the symptoms and diseases.