• Title/Summary/Keyword: direct test

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Prevalence-based Interpretation of Predictive Values of Diagnostic Tests: An Example for Detection of Canine Heartworm Infection (진단키트 검사결과에 대한 유병율 위주 해석: 개 심장사상충의 예)

  • Park, Choi-Kyu;Pak, Son-Il
    • Journal of Veterinary Clinics
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    • v.26 no.2
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    • pp.130-133
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    • 2009
  • The use of screening tests as part of a diagnostic work-up is common in domestic canine practice, but understanding of the diagnostic test characteristics and factors affecting diagnostic accuracy is not clear among clinicians. This article was aimed to provide clinicians with a better understanding on the selection of test kits and with a proper interpretation of test results using an example from heartworm(Dirofilaria immitis) studies. From the literatures, diagnostic accuracy varied depending on the kits: percent average sensitivity and specificity of ELISA antigen-detecting kits were DiroChek(Synbiotics, USA) 78.1 and 95.2, SNAP(IDEXX, USA) 66.3 and 98.1, and Solo Step(Heska, Switzerland) 69.5 and 97.5, respectively, while the values for three hematological methods(Modified Knott's, direct smear and capillary tube) ranged from 38.4 to 81.8% and from 96.9 to 100%, respectively. Furthermore, it was also reported that the prevalence of heartworm disease in domestic dog populations varied depending on the regions studied: 2.5-22.8% for microfilarial test and 2.2-66.3% by ELISA. The values of predictive values for positive(PPV) and negative(NPV) provide useful information to clinicians on the probability of heartworm infection, but the PPV and NPV are greatly dependent on the heartworm prevalence. This suggests that PPV or NPV values of a test should be interpreted carefully in different clinical settings. Practical methods on the interpretation taking into account heartworm prevalence were discussed.

Assessment of Sensitivity of Photo-Chromosomal Assay in the Prediction of Photo-carcinogenicity (광염색체이상시험의 광발암성 예측능력에 대한 평가)

  • Hong Mi-Young;Kim Ji-Young;Lee Young Mi;Lee Michael
    • Toxicological Research
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    • v.21 no.2
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    • pp.99-105
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    • 2005
  • Photo-mutagenic compounds have been known to alter skin cancer rates by acting as initiators or by affecting subsequent steps in carcinogenesis. The objectives of this study are to investigate the utility of photo-chromosomal aberration (photo-CA) assay for detecting photo-clastogens, and to evaluate its ability to predict rodent photocarcinogenicity. Photo-CA assay was performed with five test substances that demonstrated positive results in photo-carcinogenicity tests: 8-Methoxypsoralen (photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation), chlorpromazine (an aliphatic phenothiazine an alpha-adrenergic blocking agent), lomefloxacin (an antibiotic in a class of drugs called fluoroquinolones), anthracene (a tricyclic aromatic hydrocarbon a basic substance for production of anthraquinone, dyes, pigments, insecticides, wood preservatives and coating materials) and Retinoic acid (a retinoid compound closely related to vitamin A). For the best discrimination between the test substance-mediated genotoxicity and the undesirable genotoxicity caused by direct DNA absorption, a UV dose-response of the cells in the absence of the test substances was firstly analyzed. All 5 test substances showed a positive outcome in photo-CA assay, indicating that the photo-CA test is very sensitive to the photo-genotoxic effect of UV irradiation. With this limited data-set, an investigation into the predictive value of this photo-CA test for determining the photo-carcinogenicity showed that photo-CA assay has the high ability of a test to predict carcinogenicity. Therefore, the photo-CA test using mammalian cells seems to be a sensitive method to evaluate the photo-carcinogenic potential of new compounds.

Effect of Coarse mateflal on the mechanical properties of Soil (조립재가 흙의 역학적 성질에 미치는 영향)

  • 윤충섭;김호일
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.31 no.3
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    • pp.57-69
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    • 1989
  • The study was carried out for the strength parameter of coarse grained Soil and slope stability analysis of earth dam. The test samples were taken fifteen kinds of soil from cohesive soil to coarse gravel. The degree of compaction of test samples for shear test and permeability test was chosen 95 percentage of maximum dry density. The results of this study are as follows ; 1.The maximum dry density(Yd) of coarse grained soil increase in proportion to coarse particles(P) with the relation of Y d= 1.609+0.0043P. 2.The coefficients of permeability(k) decrease by the increase of fine particles(n) with the relation of k=0.0426e-0 185n. 3.The cohesions of soil decrease by the increase of coarse particles, but internal friction angles are more increased in same condition. 4.The internal friction angles(${\Phi}$) decrease in inverse proportion to void ratio(e) with the relation of ${\Phi}$ = 73.068 - 69.268e. 5.The strength parameters( Ct ${\Phi}$t) by triaxial compression test are clearly smaller than that (Cd, ${\Phi}$d) by direct shear test in fine grained soil, but the differences between both parameters are a little in coarse grained soil.The relations of both parameters are as follows; Ct = O.544Cd + 0.04 ${\Phi}$t= 1.282${\Phi}$d-2306 6.In cohesive soil, the strength parameters( Cl ${\Phi}$l) by large size shear test apparatus are similar to the strength parameters(Cs , ${\Phi}$s) by small size shear test appratus, but Cs and ${\Phi}$s values are larger than Cl and ${\Phi}$l values from 10 percentage to 20 percentage in coarse grained soil. 7.The fine grained soil is inappropriate to high dam more than 20 meters and it must be taken coarse grained soil with high internal friction angle for high dam.

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Characterization of In-plane Shear Behaviors of Woven Fabrics by Bias-extension and Trellis-frame Tests (편향 인장 및 트렐리스 시험에 의한 직물 복합재료의 면내 전단 물성 평가)

  • Lee, Won-Oh;Um, Moon-Kwang;Byun, Joon-Hyung;Cao, Jian
    • Composites Research
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    • v.23 no.5
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    • pp.8-14
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    • 2010
  • Three types of glass woven fabrics (plain, balanced twill, and unbalanced twill) having various sample sizes and aspect ratios were tested using the bias-extension tests. Real-time deformation images, force, and displacement data were collected. For the bias-extension test, the shear angle of the fabrics from the equation based on the crosshead displacement and fabric size was compared with direct manual measurements of the warp and weft angles as well as the optical measurement software. To determine the shear force, an analytical equation was introduced considering the kinematics of the bias-extension test. The obtained shear behaviors were further compared with the results by the trellis-frame test. The optical measurement methods showed that the mathematical method was reasonable before the shear angle of the fabrics reaches $30^{\circ}$ in the bias-extension tests. Also, the bias-extension test gave consistent behaviors with the trellis-frame test only for isotropic and homogeneous fabrics such as balanced plain and twill weaves.

Development of Stress Intensity Factor Equation for the Notched Ring Test (NRT) Specimen (Notched Ring Test 저속균열 시험편의 응력확대계수정식화)

  • Pyo, Sooho;Choi, Sunwoong
    • Korean Journal of Materials Research
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    • v.24 no.2
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    • pp.87-92
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    • 2014
  • The Notched Ring Test(NRT) has proven to be very useful in determining the slow crack growth behavior of polyethylene pressure pipes. In particular, the test is simple and an order of magnitude shorter in experimental times as compared to the currently used Notched Pipe Test(NPT), which makes this method attractive for use as the accelerated slow crack growth test. In addition, since the NRT specimen is taken directly from the pipe, having maintained the cross-section, processing induced artifacts that would affect the slow crack growth behavior are not altered. This makes the direct comparison to the slow crack growth specimen in pipe from more meaningful. In this study, for comparison with other available slow crack growth methods, including the NPT, the stress intensity factor equation for NRT specimen was developed and demonstrated of its accuracy within 3% of that obtained from the finite element analysis. The equation was derived using a flexure formula of curved beam bending along with numerically determined geometric factors. The accuracy of the equation was successfully tested on 63, 110, 140, 160, 250, and 400 mm nominal pipe diameters, with crack depth ranging from 15 % to 45 % of the pipe wall thickness, and for standard dimensional ratio(SDR) of 9, 11, and 13.6. Using this equation the slow crack results from 110SDR11 NRT specimen were compared to that from the NPT specimen, which demonstrated that the NRT specimen was equivalent to the NPT specimen in creating the slow crack, however in much shorter experimental times.

Predicting Uniaxial Compressive Strength and Elastic Modulus Using Brazilian Test (Brazilian시험을 이용한 일축압축강도, 탄성계수의 추정 (I))

  • Min, Tuk-Ki;Moon, Jong-Kyu;Ro, Jai-Sool
    • Journal of the Korean Geotechnical Society
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    • v.24 no.10
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    • pp.131-146
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    • 2008
  • Many attempts have been made to determine the uniaxial compressive strength and elastic modulus of regular specimens of rock indirectly. But little experimental work has been done to find above two parameters using Brazilian test value up to date. This paper employs Brazilian test value to estimate uniaxial compressive strength and elastic modulus of sedimentary (sand stone, shale) and metamorphic (gneiss) rocks. High reliability of Brazilian test has been supported by the established conclusions drawn from point load test and Schmidt hammer strike values. It has also been found that this method can be applied easily and rapidly to the estimation of uniaxial compressive strength and elastic modulus of rock cores when direct tests are not available.

Multiple-Hole Effect on the Performance of a Sparger During Direct Contact Condensation of Steam

  • Seok Cho;Song, Chul-Hwa;Chung, Heung-June;Chun, Se-Young;Chung, Moon-Ki
    • Journal of Mechanical Science and Technology
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    • v.15 no.4
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    • pp.482-491
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    • 2001
  • An experimental study has been carried out to investigate an I-type sparger-performance in view of pressure oscillation and thermal mixing in a pool. Its pitch-to-hole diameter, P/D, varies from 2 to 5. The test conditions are restricted to the condensation oscillation regime. In the present study, two different hole patterns, staggered and parallel types, are employed under various test conditions. The amplitude of the pressure pulse shows a peak for pool temperatures of 45∼85$\^{C}$, which depends on P/D and the steam mass flux. The effect of hole pattern on the pressure load is smaller than that of P/D. The dominant frequency increases with the subcooling temperature of pool water and P/D. A correlation for the dominant frequency is proposed in terms of the pitch-to-hole diameter ratio and other dimensionless thermal hydraulic parameters.

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The Characteristics of Exhaust Emissions by Durability Test with Biodiesel Fuel (20%) in a Commercial CRDI Diesel Engine (상용 CRDI 디젤기관에서 바이오디젤유 20% 적용시 내구시험에 따른 배기배출물 특성)

  • Choi, Seung-Hun;Oh, Young-Taig
    • Journal of Biosystems Engineering
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    • v.33 no.6
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    • pp.379-383
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    • 2008
  • A CRDI diesel engine used to commercial vehicle was fueled with diesel fuel and 20% biodiesel blended fuel (BDF 20%) and tested at the Seoul-10 mode for 150 hours. Engine dynamometer testing was completed at regularly scheduled intervals to monitor the engine performance and exhaust emissions. To check the engine parts (valve, injector), the engine was inspected after 150 hours running test. It was concluded that there was no unusual deterioration of the engine, or the changes in engine power (below 1.9%), smoke (below 4.1%), NOx (below 3.7%) and durability characteristics in spite of operation of 150 hours run with BDF 20%. The difference of kinetic viscosity for engine oil (before and after durability testing) was below 0.19% at $100^{\circ}C$.

A study of sea level measurement using GPS buoy (GPS 부의를 이용한 해수면 관측에 관한 연구)

  • Park, Un-Yong;Oh, Chang-Soo;Lee, Dong-Rak;Hong, Jung-Soo
    • Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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    • 2007.04a
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    • pp.85-88
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    • 2007
  • Sea level fluctuation present a direct influence to those who live near the coast. The importance of monitoring sea level is evident. Therefore, various techniques have been employed for sea level measurements such as the coastal water level gauges, satellite altimetry and GPS buoy. Especially, GPS buoys have been used to measure water levels, atmospheric parameter and other physical conditions in sea, tide correction, the altimeter range calibration, ocean environment. In this paper, we will mainly concentrate on the kinematic technique for GPS buoy to measure the sea level. A test was carried out to test the method proposed in this paper, which made use of a GPS buoy equipped to monitor the sea level in Busan. We have executed to analysis about applications of GPS buoy.

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A Study on Flame and Dynamic Characteristics of Injectors in Liquid Rocket Engine (액체로켓엔진 분사기의 화염 및 동적 특성 연구)

  • Song, Ju-Young;Lee, Kwang-Jin;Seo, Seong-Hyeon;Han, Yeoung-Min;Seol, Woo-Seok
    • 한국연소학회:학술대회논문집
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    • 2004.11a
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    • pp.141-145
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    • 2004
  • The objective of the present study is to conduct model combustion tests for various injectors to identify their combustion stability characteristics. Three different double swirl coaxial injectors with variation of a recess length have been tested for the comparative study of CH flame structure and dynamic characteristics. Gaseous oxygen and mixture of gaseous methane and propane have been employed for simulating actual propellants used for a full-scale thrust chamber. Upon test results, the direct comparison between various types of injectors can be realized for the selection of the best design among prospective injectors.

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