• Korean Journal of Applied Biomechanics
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• v.28 no.1
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• pp.61-67
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• 2018

Objective: The human body is often modelled as a spring-mass system. Lower extremity stiffness has been considered to be one of key factor in the performance enhancement of running, jumping, and hopping involved sports activities. There are several different classification of lower extremity stiffness consisting of vertical stiffness, leg stiffness, joint stiffness, as well as muscle and tendon stiffness. The primary purpose of this paper was to review the literature and describe different stiffness models and discuss applications of stiffness models while engaging in sports activities. In addition, this paper provided a current update of the lower extremity literature as it investigates the relationships between lower extremity stiffness and both functional performance and injury. Summary: Because various methods for measuring lower extremity stiffness are existing, measurements should always be accompanied by a detailed description including type of stiffness, testing method and calculation method. Moreover, investigator should be cautious when comparing lower extremity stiffness from different methods. Some evidence highlights that optimal degree of lower extremity stiffness is required for successful athletic performance. However, the actual magnitude of stiffness required to optimize performance is relatively unexplored. Direct relationship between lower extremity stiffness and lower extremity injuries has not clearly been established yet. Overall, high stiffness is potentially associate risk factors of lower extremity injuries although some of the evidence is controversial. Prospective injures studies are necessary to confirm this relationship. Moreover, further biomechanical and physiological investigation is needed to identify the optimal regulation of the lower limb stiffness behavior and its impact on athletic performance and lower limb injuries.

• Biomolecules & Therapeutics
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• v.10 no.4
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• pp.230-235
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• 2002

Gold sodium thiomalate (GST, gold compound) is a widely used anti-arthritic, anti-rheumatic and anti-inflammatory drug that is considered a good alternative to sodium salicylate (NaSA) for individuals who cannot tolerate salicylates. Nitric oxide (NO) synthesized by inducible nitric oxide synthase (iNOS) has been implicated as a mediator of inflammation. Recent evidence suggests that anti-inflammatory effect of NaSA lies in the inhibition of iNOS, but nothing has been reported about the direct effect of iNOS expression by GST. The present study was designed to elucidate sequentially the action mechanisms of GST and NaSA on lipopolysaccharide (LPS) plus interferon-gamma (IFN-$\gamma$) induced iNOS expression in RAW 264.7 macrophages. Both GST and NaSA inhibited NO production and iNOS protein expression in a dose dependent manner. GST inhibited iNOS mRNA expression induced by LPS plus IFN-$\gamma$, whereas NaSA did not. These findings suggest that GST may exert anti-arthritic, anti-rheumatic and anti-inflammatory effect by inhibiting iNOS expression induced by LPS plus IFN-$\gamma$ at transcriptional level, whereas NaSA exert its effect by inhibiting iNOS expression at the translational or posttranslational level.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.54 no.5
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• pp.585-595
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• 2021

Even though most of aquatic animal pathogens are considered opportunistic and many pose a low direct risk to personnel, all personnel working with aquatic pathogens and facilities using these organisms must comply with the regulation to prevent the release of the pathogen into the environment and causing disease in aquatic animals. First of all, in order to establish a biosafety system for aquatic pathogen, the list of microorganisms that can infect aquatic animals and humans should be drawn up according to the microorganisms encountered within national boundaries. Second, risk assessment guideline for diseases of livestock and aquatic environment is desperately needed. Third, microorganisms should be classified into risk group based on their potential impact on human and aquatic environment. Fourth, facilities handling aquatic pathogens should ensure that these pathogens are securely contained and safely handled for experimental or commercial development purposes. In conclusion, classification is based on the pathogenicity, mode of transmission and host range of the aquatic microorganisms, availability of effective preventative measures and treatments. Furthermore, risk group of aquatic pathogens should be correlated with physical containment facility requirements according to domestic characteristics.

• Molecules and Cells
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• v.42 no.2
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• pp.175-182
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• 2019

microRNAs regulate a diverse spectrum of cancer biology, including tumorigenesis, metastasis, stemness, and drug resistance. To investigate miRNA-mediated regulation of drug resistance, we characterized the resistant cell lines to 5-fluorouracil by inducing stable expression of miRNAs using lenti-miRNA library. Here, we demonstrate miR-551a as a novel factor regulating cell survival after 5-FU treatment. miR-551a-expressing cells (Hep3B-lenti-miR-551a) were resistant to 5-FU-induced cell death, and after 5-FU treatment, and showed significant increases in cell viability, cell survival, and sphere formation. It was further shown that myocyte-specific factor 2C is the direct target of miR-551a. Our results suggest that miR-551a plays a novel function in regulating 5-FU-induced cell death, and targeting miR-551a might be helpful to sensitize cells to anti-cancer drugs.

• International journal of advanced smart convergence
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• v.8 no.1
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• pp.153-158
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• 2019

Language and letter are represented by a combination of its signifier and signified. All symblos are commonly calling direct attention to people who are living in the physical world. However, in cyberspace, the image takes control once inhabited by the language. Cyberspace with anonymity and deoent physical nature has something with physical laws. In this space the statue transcends the imaginary realm. Ideology gives a greater connotation by giving a series of regulation to images floating in cyberspace. Even if various media have the same image, the meaning of the image changes depending on which ideology is used. The impact of this on the public is great. In this study, I discuss the ideology in cyberspace where is supposedly wide open to who visits and spreads all the thoughts without suppression and the human body. The main ideas would be who owns the ideology and what does it want to control and how the people would react to the ideology. This paper would eventually head the prototype that visualizes above ideas. Though the interactive media it will also show the subject in the real world is accept the images floating in the cyberspace without any doubts.

• Convergence Security Journal
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• v.21 no.2
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• pp.81-88
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• 2021

Officers and noncommissioned officers are the leaders of the military. Every year, more than 5,000 first-time officers are commissioned and perform their duties in various parts of the country. There is a conflict between officers and noncommissioned officers over the efficiency of experience. First-time officers are experiencing experience and a loss of authority from older noncommissioned officers and a failure to obey orders. Noncommissioned officers have complaints about first-time officers who want to direct only by class.Conflicts between officers and noncommissioned officers have existed in the past, but some first-time officers were resolved when they gained experience. Recently, the chief executives protested against the Chief of Staff's words and actions. I would like to study the cause of conflict between officers and noncommissioned officers and suggest solutions.

• Journal of Animal Reproduction and Biotechnology
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• v.36 no.1
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• pp.51-58
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• 2021

Kisspeptin, a neuropeptide and the master controller of reproductive axis upstream to GnRH neurons, and its receptor are also expressed in extra-hypothalamic tissues, such as ovaries. As systemic kisspeptin has been shown to modulate follicular dynamics in cattle, we hypothesized that kisspeptin has direct actions on the ovarian follicular development. We also hypothesized that kisspeptin regulation of primordial follicle development is via modulation of VEGF expression. In order to test these hypotheses, we cultured caprine ovarian cortical strips in vitro for 7 days with supplementation of kisspeptin at 1, 10 and 100 µM concentration and observed the development of primordial follicles into intermediate, primary and secondary follicles. We also studied the alteration in the expression profile of VEGF and VEGF transcript variant 2 mRNA during follicular development in the presence of kisspeptin. We confirmed the presence of GPR54 in goat ovaries in our preliminary studies. Supplementation of kisspeptin at 1 and 10 µM concentration facilitated the development of primordial follicles into intermediate, primary and secondary follicles with less number of degenerated follicles while the same at 100 µM resulted in degeneration of follicles. We observed a drastic increase in the expression profile of VEGF and VEGF transcript variant 2 mRNA upon culture which was independent of kisspeptin treatment. In conclusion, our studies show that kisspeptin facilitates ovarian primordial development in vitro.

• East Asian Journal of Business Economics (EAJBE)
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• v.10 no.2
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• pp.81-91
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• 2022

Purpose - This study explores the role played by the government in spreading corporate green IT. Indeed, a lot of evidence is emerging that governments acting independently are not in a position of attaining the far end economic and social changes need for the realization of green IT. As much as matters about green IT was initiated by many governments. Research design, Data, and methodology - This study selected the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) as a research design. The PRISMA is recognized for its standard evidence reporting system and can provide adequate systematic review among previous studies. Result - A lot of consensus leads to the acquisition of the value of corporate green IT concerning the effectiveness of the collaboration. This study could obtain six suggestions from the systematic review, such as 'Rebalancing Government and Public Duties', 'Direct Regulation', 'Marketing Tools and Fiscal or Economic Measures', 'VNRP', 'Education for Decision Making', 'Latest Policy Trends within the G8 Nations'. Conclusion - The most challenging aspect when it comes to ensuring corporate green IT is the separation of economic growth from the perspectives regarding life qualities. According to the study (Falcone, 2020), this needs a second policy-oriented wedge concerning re-socialization with the desire of encouraging the development of the culture associated with the corporate green IT.

• Journal of Microbiology and Biotechnology
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• v.32 no.8
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• pp.982-988
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• 2022

Licorice (Glycyrrhiza) has been used as preventive and therapeutic material for hyperpigmentation disorders. Previously, we isolated noble compounds including dehydroglyasperin C (DGC), dehydroglyasperin D (DGD) and isoangustone A (IAA) from licorice hexane/ethanol extracts. However, their anti-melanogenic effects and underlying molecular mechanisms are unknown. The present study compared effects of DGC, DGD and IAA on pigmentation in melan-a melanocytes and human epidermal melanocytes (HEMn). DGD exerted the most excellent anti-melanogenic effect, followed by DGC and IAA at non-cytotoxic concentrations. In addition, DGD significantly inhibited tyrosinase activity in vitro cell-free system and cell system. Western blot result showed that DGD decreased expression of microphthalmia-associated transcription factor (MITF), tyrosinase and tyrosinase-related protein-1 (TRP-1) in melan-a cells and HEMn cells. DGD induced phosphorylation of MITF, ERK and Akt signal pathway promoting MITF degradation system. However, DGD did not influence p38 and cAMP-dependent protein kinase (PKA)/CREB signal pathway in melan-a cells. These result indicated that DGD inhibited melanogenesis not only direct regulation of tyrosinase but also modulating intracellular signaling related with MITF level. Collectively, these results suggested a protective role for DGD against melanogenesis.

• Journal of Korea Multimedia Society
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• v.25 no.5
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• pp.721-729
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• 2022

The pandemic of COVID-19 has led "E-commerce+ Live streaming", the new form of retail business, development rapidly. And more and more consumers choose to buy commodities in E-commerce live streaming. According to the related investigation at home and abroad, the purchase intention and WOM intention are two important measuring factors of the effect of the direct transmission of e-commerce. In previous research, the author proved that IWOM has become an important reference for consumers to make online purchases. In this study, the author mainly focus on the impact of online WOM on consumer intention. Based on the Involvement Theory, this paper proposes a model of the influence of IWOM on WOM intention in e-commerce live broadcast which is adjusted by the product involvement degree. The results show that the characteristics of anchor, the quantity and quality of IWOM, the prescription of IWOM, the difference of IWOM and the intention of WOM are positively regulated by the product involvement. However, product involvement did not play a moderating role between relationship strength and WOM intention.