• International Journal of Stem Cells
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• v.17 no.2
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• pp.130-140
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• 2024

Cardiac organoids have emerged as invaluable tools for assessing the impact of diverse substances on heart function. This report introduces guidelines for general requirements for manufacturing cardiac organoids and conducting cardiac organoid-based assays, encompassing protocols, analytical methodologies, and ethical considerations. In the quest to employ recently developed three-dimensional cardiac organoid models as substitutes for animal testing, it becomes imperative to establish robust criteria for evaluating organoid quality and conducting toxicity assessments. This guideline addresses this need, catering to regulatory requirements, and describes common standards for organoid quality and toxicity assessment methodologies, commensurate with current technological capabilities. While acknowledging the dynamic nature of technological progress and the potential for future comparative studies, this guideline serves as a foundational framework. It offers a comprehensive approach to standardized cardiac organoid testing, ensuring scientific rigor, reproducibility, and ethical integrity in investigations of cardiotoxicity, particularly through the utilization of human pluripotent stem cell-derived cardiac organoids.

• Journal of Information Display
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• v.13 no.2
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• pp.83-89
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• 2012

The crosstalk evaluation of multiview autostereoscopic three-dimensional (3D) displays is discussed, with both the human and technical factors investigated via image quality assessment. In the imaging performance measurements and analysis for a multiview autostereoscopic display prototype equipment, it was inferred that crosstalk would have both a positive and a negative effect on the imaging performance of the equipment. The importance of the attached diaphragm in the crosstalk evaluation was proposed and then experimentally verified, using the developed prototype equipment. The luminance distribution and crosstalk situation were given, with two different diaphragm arrays applied. The analysis results showed that the imaging performance of this 3D display system can be improved with minimum changes to the system structure.

• Clinics in Shoulder and Elbow
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• v.18 no.2
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• pp.86-90
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• 2015

Background: Although there are several methods for evaluating bone quality, Hounsfield units (HU), a standardized computed tomography (CT) attenuation coefficient, provide a useful tool for estimating focal bone mineral density (BMD). The aim of this study is to investigate the HU for evaluating the degree of osteoporosis in greater tuberosity with regard to anchor positioning. Methods: Forty patients diagnosed as normal on shoulder CT were included and categorized according to age and gender. Axially sectioned CT images were processed to 3-dimensional models containing information about bone quality using Mimics (14.11 platform v14.1.1.1 Materialise). Three-dimensional anchors were simulated and positioned according to 6 regions of interest (ROI) in the greater tuberosity classified using Tingart's system. Mean HU of intra-anchor volumes in the 6 regions was measured. Results: A significant decrease in HU was observed with increasing age (p=0.0001) and menopause (p<0.001). A significant difference in HU was found between male and female groups with males showing the higher values (p=0.0001). HU of proximal areas of ROI was higher than those of distal areas (p<0.005). However, although mean HU of distal posterior ROI showed the lowest values, no statistically significant difference was found between anterior, middle, and posterior regions (p=0.087). Conclusions: Mean HU of ROIs provides a tool for preoperative assessment of focal BMD, which is a factor of suture anchor stability and can be used to aid decision-making regarding secure anchor positioning for rotator cuff repair. Our data support that the most secure point is the proximal regions of ROI.

• Journal of Environmental Impact Assessment
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• v.18 no.4
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• pp.229-234
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• 2009

A lot of research on the application of GIS has been conducted in the field of water quality management. The function of a geometric data acquisition for reservoir and river models, however, is not enough to satisfy multiuser' convenience. CE-QUAL-W2 is a two-dimensional(2D) longitudinal/vertical hydrodynamic and water quality model for surface water bodies, modeling eutrophication processes such as temperature-nutrient-algae and sediment relationships. The purpose of this study is to analyzing which bathymetry information affects hydraulic results. There are consisted of three scenarios under consideration. The first scenario takes into account only tribatary type data such as Heoin and Okchen river. The second scenario, Heoin river constructs to tributary and Okchen river constructs by branch. Last scenario constructs Heoin and Okchen river by branch. The RMSE error results for the first, second and third scenarios are 0.61, 0.36 and 0.28 respectively.

• Journal of Environmental Impact Assessment
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• v.17 no.6
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• pp.349-356
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• 2008

This paper aims to understand the effects of a turbidity flow intrusion on eutrophication in Daecheong Dam Reservoir. CE-QUAL-W2, a two-dimensional hydrodynamic and water quality model, is applied. The elevation of the reservoir water surface is used to validate the hydrodynamic model parameters and maximum fluctuations in the water surface elevations reaches about 1 m in the reservoir. During the heavy storm season, July, the thermocline submerged to less than 30 m below the surface. The thickness of the thermocline also reduced to 10 to 15 m. While the average TSS in June, the beginning of the monsoon was still low but it peaked in July due to heavy rainfall. Vertical profiles of the TSS regime in July indicated higher concentration in upper water layers and then the regime moves gradually downward in accordance with the time lapse. Due to the dam spillway opening, high concentrations of TSS attributed to storm turbidity ascended to the upper water layer by following the upward current movement and then, the regime precipitated to a layer below 30 to 40 m after September.

• Journal of Korean Society of Rural Planning
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• v.25 no.2
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• pp.23-33
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• 2019

The study aims to measure the quality of consulting services for village-building projects in rural areas. To this end, the government wanted to analyze the impact of the quality of service on residents' satisfaction and business performance in villages that are receiving consulting services. As a result of the empirical analysis of the case areas, the five-dimensional tangibles, reliability, assurance and empathy of the quality of consulting services in rural villages had a defining influence on the residents' satisfaction. And the residents' satisfaction of consulting services had a defining influence on the business performance of the village with tangibles, reliability, and assurances. The main implications presented on the basis of these results were analyzed that it was necessary to universalize the assessment of service quality, to strengthen the burden of the village on the cost of consulting services, and to induce participation through a sufficient understanding of the villagers' business.

• Journal of the Korea Society of Computer and Information
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• v.22 no.6
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• pp.109-114
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• 2017

In this paper, I propose the effects of food therapy on subjects' health and happiness. The result has come out that food therapy enhances subjects' multi-dimensional health(medical, functional, self-evaluative) and their happiness. The participants were 230 adults over 30 years old living in Seoul and Gyeonggi district. To examine the effect of food therapy, the study sampled 220 questionnaire out of 230. By the non-equivalent control group design, the health levels were measured in three concepts: medical dimension, functional dimension and self-evaluative dimension. The results are as follows: First, participants who had taken food therapy for 3 months have been enhanced in their subjective and functional health level. Their subjective health enhanced from $2.80{\pm}.44$ to $4.07{\pm}.27$ (p=.000). And their functional health enhanced from $.92{\pm}.07$ to $.94{\pm}.07$(p=.035). Second, participants' happiness has enhanced significantly. Cognitive happiness enhanced from $3.39{\pm}.50$ to $3.84{\pm}.44$(p=.000). And emotional happiness enhanced from $2.76{\pm}.44$ to $3.07{\pm}.34$(p=.000). With this results, in case that people apply food therapy based on Yaksun, they are able to expect their enhancement of health level and happiness. Therefore study shows that Food therapy helps people to pursue their health and happiness improvement and suggest valuable information of a way to enhance quality of life.

• Journal of Environmental Impact Assessment
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• v.18 no.6
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• pp.331-346
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• 2009

The serious problem facing two-dimensional finite element hydraulic model is the treatment of wet and dry areas. This situation is encountered in most practical river and coastal engineering problems, such as flood propagation, dam break analysis and so on. Especially, dry areas result in mathematical complications and require special treatment. The objective of this study is to investigate the wet and dry parameters that have direct relevance to model performance in situations where inundation of initially dry areas occurs. Several numerical simulations were carried out, which examined the performance of the marsh porosity method of RMA-2 model to investigate for application of parameters. Experimental channel with partly dry side slopes, straight channel with irregular geometry and Han river were performed for tests. As a result of this study, effectively applied marsh porosity method provide a reliable results for flow distribution of wet and dry area, it could be further developed to basis for extending to water quality and sediment transport analysis.

• Journal of Ocean Engineering and Technology
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• v.20 no.1 s.68
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• pp.55-62
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• 2006

Recently, pollution by development in coastal areas is going from bad to worse. The Korean government is attempting to make policies that prevent water pollution, but it is still difficult to say whether such measures are lowering pollution to an acceptable level. More specifically, the general investigation that has been done in KOREA does not accurately reflect the actual conditions of pollution in coastal areas. An investigation that quantitatively assesses water quality management using rational prediction technology must be attempted, and the ecosystem model, which incorporates both the 3-dimensional hydrodynamic and material cycle models, is the only one with a broad enough scope to obtain accurate results. The hydrodynamic model, which includes advection and diffusion, accounts for the ever-changing flow and (quality) of water in coastal areas, while the material cycle model accounts for pollutants and components of decomposition as sources of the carbon, phosphorus, and nitrogen cycles. In this paper, we simulated the rates of dissolved oxygen (DO), chemical oxygen demand (COD), total nitrogen(T-N) and total-phosphorous(T-P) in Korea's Ulsan Area. Using the ecosystem model, we did simulations using a specific set of parameters and did comparative analysis to determine those most appropriate for the actual environmental characteristics of Ulsan Area. The simulation was successful, making it now possible to predict the likelihood of coastal construction projects causing ecological damage, such as eutrophication and red tide. Our model can also be used in the environmental impact assessment (EIA) of future development projects in the ocean.

• Journal of Korean Neurosurgical Society
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• v.42 no.2
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• pp.103-111
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• 2007

Objective : We evaluated the accuracy of multislice computerized tomographic angiography (MCTA) in the postoperative evaluation of clipped aneurysms by comparising it with three dimensional digital subtraction angiography (3D-DSA). Methods : Between May 2004 and September 2006, we included patients with ruptured cerebral aneurysm of the anterior circulation that was surgically clipped and evaluated by both postoperative MCTA and postoperative 3D-DSA. We measured the diagnostic performance and calculated the sensitivity and specificity of postoperative MCTA compared to 3D-DSA in the detection of aneurysm remnants. Results : A total of 11 neck remnants among the 92 clipped aneurysms (11.9%) were confirmed by 3D-DSA. According to Sindou's classification of aneurysm remnants, 8.7% of clipped aneurysms (8/92) had only neck remnant on 3D-DSA and 3.2% (3/92 aneurysms) had residuum of the neck and sac on 3D-DSA. There were 12 (13.04%) equivocal cases that were difficult to interpret based on the postoperative MCTA. The reasons for the equivocal cases included multiple clips (6 cases, 50.0%). beam-hardening effect (4 cases, 33.3%), motion artifact (1 case, 8.3%), fenestrated clip (1 case, 8.3%) and other combined causes. The sensitivity and specificity of the postoperative MCTA was 81.8% and 88.9%, respectively by ROC curve (p=0.000). Conclusion : MCTA is an accurate noninvasive imaging method used for the assessment of clipped aneurysms in the anterior circulation. If the image quality of postoperative MCTA is good quality and the patient has been treated with a single titanium clip, except a fenestrated clip, the absence of an aneurysm remnant can be diagnosed by MCTA alone and the need for postoperative DSA can be reduced in a large percentage of cases.