• Clinical and Experimental Pediatrics
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• v.59 no.3
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• pp.105-113
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• 2016

Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication in patients with hematologic malignancies or autoimmune disorders. The current treatment options, which include corticosteroids, transfusions, extracorporeal membrane oxygenation (ECMO), and immunosuppressants, have been limited and largely unsuccessful. Recombinant activated factor VII (rFVIIa) has been successfully administered, either systemically or bronchoscopically, to adults for the treatment of DAH, but there are few data on its use in pediatric patients. The current literature in the PubMed database was reviewed to evaluate the efficacy and risk of rFVIIa treatment for DAH in pediatric patients. This review discusses the diagnosis and treatment of DAH, as well as a new treatment paradigm that includes rFVIIa. Additionally, the risks and benefits of off-label use of rFVIIa in pediatric patients are discussed.

• Tuberculosis and Respiratory Diseases
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• v.42 no.2
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• pp.256-259
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• 1995

The diffuse nodular lung lesion has a diagnostic problem and should be made differential diagnosis. A chest X-ray of 62-year-old male patient with dyspnea showed small-sized scattered multinodular lesion on entire lung field. Bronchoalveolar lavage and transbronchial needle aspiration showed the non-specific findings, so open lung biopsy was done and revealed bronchioloalveolar cell carcinoma.

• Tuberculosis and Respiratory Diseases
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• v.74 no.4
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• pp.151-162
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• 2013

Diffuse alveolar hemorrhage (DAH) is a life-threatening and medical emergency that can be caused by numerous disorders and presents with hemoptysis, anemia, and diffuse alveolar infiltrates. Early bronchoscopy with bronchoalveolar lavage is usually required to confirm the diagnosis and rule out infection. Most cases of DAH are caused by capillaritis associated with systemic autoimmune diseases such as anti-neutrophil cytoplasmic antibody-associated vasculitis, anti-glomerular basement membrane disease, and systemic lupus erythematosus, but DAH may also result from coagulation disorders, drugs, inhaled toxins, or transplantation. The diagnosis of DAH relies on clinical suspicion combined with laboratory, radiologic, and pathologic findings. Early recognition is crucial, because prompt diagnosis and treatment is necessary for survival. Corticosteroids and immunosuppressive agents remain the gold standard. In patients with DAH, biopsy of involved sites can help to identify the cause and to direct therapy. This article aims to provide a general review of the causes and clinical presentation of DAH and to recommend a diagnostic approach and a management plan for the most common causes.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2006.04a
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• pp.365-372
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• 2006

A new meshfree formulation is developed for material discontinuity problems. A local interfacial jump function which is defined as hyperplane function is embedded in the meshless approximation and the approximation accurately models functions with jumps in the displacement and the derivative fields. Diffuse derivative technique copes with difficulty due to complexity of derivative computation of meshfree approximation. Collocation method with diffuse derivative accelerates computing speed for numerical solution. By solving inclusion and composite material problems, the robustness and effectiveness of the method are verified.

• Journal of Korean Society on Water Environment
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• v.21 no.6
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• pp.617-623
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• 2005

Forestry and agricultural land uses constitute 85% of Korea and these land uses are typically mixed in many watersheds. Biological Oxygen Demand (BOD) concentration is a primary factor for managing water qualities of the water resources in Korea. BOD loadings from diffuse sources, however, not well monitored yet. This study aims to assess BOD loadings from diffuse sources and their affecting factors to conserve quality of water resources. Event Mean Concentration (EMC) of BOD was calculated based on the monitoring data of forty rainfall events at four agricultural-forestry watersheds. Exceedence cumulative probability of BOD EMCs were plotted to show agricultural activities in a watershed impacts on the magnitude of EMCs. Prediction equation for each rainfall event was proposed to estimate BOD EMCs: $EMC_{BOD}(mg/L)=EXP(0.413+0.0000001157{\times}$(discharged runoff volume in $m^3$)+0.018${\times}$(ratio of agricultural land use to total watershed area).

• Journal of Korean Society on Water Environment
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• v.22 no.6
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• pp.1031-1037
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• 2006

In order to improve water quality of the Juam Lake, a constructed wetland was implemented and operated for 2 years with the effluent of sewage treatment plant and diffuse pollutant discharged from agricultural area. During the summer season, average removal efficiencies for BOD and SS were 15.8% and 39.4%, respectively. Due to the mixed effect of vegetation, soil microbes and sediments, the higher nutrient removal efficiencies were obtained: average T-N and T-P removal efficiencies were 64.2% and 71.7%, respectively. The concentration of sediment was increased initially, and maintained constant throughout monitoring period. The highest nitrogen and phosphorus uptake were observed in Phragmites japonica. The nitrogen uptake was estimated as 0.235 DW mg/g while phosphorus uptake was estimated as 2.059 DW mg/g.

• Journal of Chest Surgery
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• v.28 no.2
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• pp.162-165
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• 1995

To evaluate the impact of open lung biopsy on diagnosis and treatment of diffuse infiltrative lung disease, we conducted a retrospective review of 28 patients who underwent this procedure at the Kyoungpook National University Hospital from 1986 to 1993. There were 19 men and 9 women; average age was 50.9 years. During open lung biopsy, The region of the lobe was radiographically and grossly identified and was examined by a biopsy. The biopsy yielded a specific diagnosis in 27 [96.4 % patients and changes in therapy in 24[85.7% patients. Complications developed in three[10.8% patients, directly related to the biopsy procedure in 2. One patient died[3.6% due to underlying disease. We conclude that open lung biopsy can be accomplished safely in the patient with diffuse infiltrative lung disease and it is an important tool in decision-making process and therapy.

• Archives of Craniofacial Surgery
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• v.21 no.5
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• pp.305-308
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• 2020

Madelung's disease (MD) otherwise known as Launois-Bensaude syndrome, multiple symmetrical lipomatosis, or benign symmetric lipomatosis, is a rare disease characterized by abnormal diffuse lipomatosis in proximal upper limbs and neck. Here, we report a rare case of MD. A 66-year-old man presented with massive growth of soft tissues in the cervico-occipital region of more than 2 years duration. Physical examination showed diffuse enlargement of the anterior neck (Madelung's collar) and three huge humps at the posterior neck. Under a diagnosis of MD, lipectomy via a single anterior transverse incision and liposuction were performed. This rare case report may be helpful for assessing patients with abnormal diffuse lipomatosis in the neck and proximal upper limbs.

• Advances in pediatric surgery
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• v.9 no.2
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• pp.121-124
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• 2003

Diffuse cavernous hemangioma of the rectosigmoid is a rare lesion usually presented in children and young adult, often with life threatening hemorrhage. The clinical diagnosis is difficult and often delayed because of lack of awareness of the clinical features. We report a case of diffuse cavernous hemangioma of the rectosigmoid in a 12 year old boy who had undergone suture ligation under the impression of hemorrhoid at his age 3. Sphincter saving coloanal pull through procedure were applied as the surgical treatment. Sclerotherapy was needed with recurrent rectal bleeding 6 months after the pull through operation. The patient is well at 12 months follow-up.

• Journal of Chest Surgery
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• v.33 no.9
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• pp.748-751
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• 2000

The diffuse form of supravalvar aortic stenosis represents a surgical challenge when the ascending aorta, aortic arch, proximal descending thoracic aorta and arch arteries are involved. It can be treated by a variety of surgical approaches. We report a case of severe diffuse supravalvar aortic stenosis combined with an aortic valve anomaly and occlusion of the right coronary artery ostium in a 14-year-old boy with Williams syndrome. We enlarged the aortic root(Nick's procedure), ascending aorta, aortic arch, proximal descending thoracic aorta, and innominate artery with patches and replaced aortic valve with 19 mm St. Jude valve. Deep hypothermic circulatory arrest and retrograde cerebral perfusion were used during repair of the arch and arch artery.