• 대한가정학회지
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• 제42권12호
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• pp.161-174
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• 2004

The primary objective of this study was to employ Darden's store patronage model in order to investigate the role that shopping orientation and store attributes play in store patronage. The study sample consisted of 340 female university students residing in Seoul. The data was analyzed by using path analysis and factor analysis. The recreational shopping orientation played a greater role in influencing the importance of store attributes than did the convenience shopping orientation. Recreational shoppers want a variety of brands and convenience shoppers can be attracted by a convenient location and availability of parking. Six important store attributes(variety of products and price level, proximity, variety of trendy brands, store decor, sales promotion, sales personnel) have a differential influence on store patronage. Shopping orientation was a direct predictor of patronage behavior and mediated the relationship between shopping orientation and store attribute importance. The finding indicated that both the recreational shopping orientation and convenience shopping orientation can be used effectively to position store patronage in such a way as to provide a strong means for shoppers to satisfy their needs. The findings of this study demonstrated that South Korean female shoppers with different shopping orientation have different store attribute preference and store patronage. The results provide a basis for building a successful strategy to attract shoppers and generate sales. The study focused on a specific product category, i.e., women's apparel. To meet the needs of female apparel shoppers, further research is needed to learn more about the distinctive characteristics of Korean consumers that could be applied to a variety of jobs, ages and living areas.

• 대한한의학방제학회지
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• 제11권1호
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• pp.1-18
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• 2003

Science of prescriptions is an important part in the education of Korean Oriental Medicine. In spite of that, there is less agreement on measures for improving the education quality of science of prescriptions. Science of prescriptions can be classified into generalities and particulars. This study sought to present contents that must be incorporated into Introduction to Science of Prescriptions to enhance the quality of education by examining both teaching materials being used in colleges of traditional Chinese medicine and those of Korean oriental medicine and the Introduction part of books related with science of prescriptions. And when this study was carried out, training Korean oriental medicine practitioners and researchers and educators of science of prescriptions was taken into account. It is judged that Introduction to Science of Prescriptions needs to be divided into seven chapters and that each chapter requires containing opinions of ancient doctors and references to lay the basis of learning and revised and practical contents in addition to traditional ones. Chapter One Introduction (Conception, History, Disciplinery, Study, How to Learn, Range of Study, How to Study, Academic Activities) Chapter Two Prescriptions and Selection of Treatment Based on the Differential Diagnosis Chapter Three Prescriptions and Therapeutic Methods (Eight Therapeutic Methods, Sixty Four Therapeutic Methods etc.) Chapter Four Classification of Prescriptions Chapter Five Designing and Modification of Prescriptions (Compatibility, Designing, Modification) Chapter Six Preparation Forms of the Prescriptions (Origin, Charicteristics) Chapter Seven Methods of Decocting and Taking Korean Oriental Herbal Medicines Appendix Tables of Apothecaries' Measures and Weights in Current and Ancient Times

• 통상정보연구
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• 제3권2호
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• pp.215-233
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• 2001

국제주의 질서나 지역주의 및 쌍무주의 질서가 일응 무역자유화를 지향하는 점에서 양자는 일치하면서도 후자가 역내 자유주의와 역외 보호주의라는 양면성을 가지므로 갈등과 모순이 있을 수 밖에 없다. 그러나 차선 이론이나 GATT나 WTO의 현실인정의 예외 규정으로 보완내지 공존관계에 있음이 현실이고 나아가 지역주의와 쌍무주의가 국제주의의 실험장이 될 수도 있다. 우리나라의 통상현안과 관련하여 볼 때 WTO출범에도 불구하고 이처럼 국제주의질서와는 별개로 지역주의 및 쌍무주의 질서가 현실적으로 공존함으로써 우리의 어려운 통상환경의요인으로 작용하고 있으므로 대국적인 통상정책으로 이에의 적절한 대응이 요구된다. 요컨데 우리경제가 OECD에 가입했고 선진경제대열에 진입하고 있음을 감안할 때 범세계적 시각에서 통상관련제도를 국제주의 질서의 측면에서 최대한 개편 보강하여 통상협력 하는 한편, 지역주의나 쌍무주의 측면에서도 권역별로 충화된 수단의 최적 Mix를 도출함으로서 조화로운 통상관계를 정립시켜 나가야 할 것이다.

• Journal of Microbiology
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• 제43권2호
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• pp.133-143
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• 2005

Shigellosis is a global human health problem. Four species of Shigella i.e. S. dysenteriae, S. flexneri, S. boydii and S. sonnei are able to cause the disease. These species are subdivided into serotypes on the basis of O-specific polysaccharide of the LPS. Shigella dysenteriae type 1 produces severe disease and may be associated with life-threatening complications. The symptoms of shigellosis include diarrhoea and/or dysentery with frequent mucoid bloody stools, abdominal cramps and tenesmus. Shigella spp. cause dysentery by invading the colonic mucosa. Shigella bacteria multiply within colonic epithelial cells, cause cell death and spread laterally to infect and kill adjacent epithelial cells, causing mucosal ulceration, inflammation and bleeding. Transmission usually occurs via contaminated food and water or through person-to-person contact. Laboratory diagnosis is made by culturing the stool samples using selective/differential agar media. Shigella spp. are highly fragile organism and considerable care must be exercised in collecting faecal specimens, transporting them to the laboratories and in using appropriate media for isolation. Antimicrobial agents are the mainstay of therapy of all cases of shigellosis. Due to the global emergence of drug resistance, the choice of antimicrobial agents for treating shigellosis is limited. Although single dose of norfloxacin and ciprofloxacin has been shown to be effective, they are currently less effective against S. dysenteriae type 1 infection. Newer quinolones, cephalosporin derivatives, and azithromycin are the drug of choice. However, fluoroquinolone-resistant S. dysenteriae type 1 infection have been reported. Currently, no vaccines against Shigella infection exist. Both live and subunit parenteral vaccine candidates are under development. Because immunity to Shigella is serotype-specific, the priority is to develop vaccine against S. dysenteriae type 1 and S. flexneri type 2a. Shigella species are important pathogens responsible for diarrhoeal diseases and dysentery occurring all over the world. The morbidity and mortality due to shigellosis are especially high among children in developing countries. A recent review of literature (KotIoff et al.,1999) concluded that, of the estimated 165 million cases of Shigella diarrhoea that occur annually, $99\%$ occur in developing countries, and in developing countries $69\%$ of episodes occur in children under five years of age. Moreover, of the ca.1.1 million deaths attributed to Shigella infections in developing countries, $60\%$ of deaths occur in the under-five age group. Travellers from developed to developing regions and soldiers serving under field conditions are also at an increased risk to develop shigellosis.

• Journal of Pharmaceutical Investigation
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• 제38권1호
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• pp.23-29
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• 2008

Red ginseng is made of white ginseng through the steaming and drying procedure. In this process, the amounts of toxic elements of ginseng are decreased and those of effective components, ginsenosides are increased. In order to identify the components alteration of white ginseng by processing time, we applied HPLC-based metabolomics approach combined with the principal component analysis (PCA) multivariate analysis. White ginsengs were steamed at 0, 1, 2, 4, 8 and 16 h, respectively and followed by drying process at moderate temperature. Then the steamed ginsengs and the commercial red ginsengs were analyzed by HPLC. On the basis of HPLC results, PCA multivariate analysis was applied for evaluating the quality of red ginseng, which showed the processed ginsengs are grouped by processed time because less polar ginsenosides were increased in proportion as the steaming time was increased. The purchased red ginsengs were distributed in the range of $0{\sim}1$ hour steaming time. This pilot experiment suggests that HPLC-based metabolomics approach is able to allow the quality of herbal medicines to be controlled with a simple and economic method.

• The Korean Journal of Physiology and Pharmacology
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• 제7권3호
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• pp.125-130
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• 2003

The aim of this study was to provide a basis for studying the molecular mechanism of pharmacological action of chlorhexidine digluconate. Fluorescence polarization of n-(9-anthroyloxy)stearic acid was used to examine the effect of chlorhexidine digluconate on differential rotational mobility of different positions of the number of membrane bilayer phospholipid carbon atoms. The six membrane components differed with respect to 2, 3, 6, 9, 12, and 16-(9-anthroyloxy)stearic acid (2-AS, 3-AS, 6-AS, 9-AS, 12-AS and 16-AP) probes, indicating different membrane fluidity. Chlorhexidine digluconate increased the rate of rotational mobility of hydrocarbon interior of the cultured Porphyromonas gingivalis outer membranes (OPG) in a dose-dependent manner, but decreased the mobility of surface region (membrane interface) of the OPG. Disordering or ordering effects of chlorhexidine digluconate on membrane lipids may be responsible for some, but not all of its bacteriostatic and bactericidal actions.

• 한국축산식품학회지
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• 제30권6호
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• pp.923-929
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• 2010

Colostral whey prepared from colostrum (pooled from first six post-partum milkings) was heated for 10 min at $100^{\circ}C$ Heated colostral whey was incubated with 1% enzymes (protein equivalent basis) for 15, 30, 60, 90, and 120 min at $50^{\circ}C$. Papain, pepsin, trypsin, and alcalase produced different degrees of hydrolysis (DH), 10.66%, 12.42%, 10.83%, and 25.31%, respectively, at an incubation time of 120 min. The SDS-PAGE reveals that significant amounts of bovine serum albumin (BSA), ${\beta}$-lactoglobulin (${\beta}$-LG), and ${\alpha}$-lactalbumin (${\alpha}$-LA) survived papain digestion. In contrast, pepsin completely removed BSA but not ${\beta}$-LG present in heated colostral whey. Alcalase completely eliminated BSA, ${\beta}$-LG, and ${\alpha}$-LA. This differential hydrolysis was confirmed by reversed-phase HPLC analysis. Using ion-exchange chromatography, fraction-1 (F-1) was obtained from alcalase hydrolysate at a NaCl gradient concentration of 0.25 M. Reversed-phase HPLC chromatograms of alcalase F-1 showed numerous small peaks, which probably indicate that a variety of new peptides were produced. Iron content of alcalase F-1 was 28.94 ppm, which was the highest among all enzyme fractions, whereas iron content of colostral whey was 36.56 ppm. Main amino acids contained in alcalase F-1 were Thr (15.45%), Glu (14.12%), and Ser (10.39%). Therefore, alcalase can be used to generate good iron-binding peptides in heated colostral whey, and the resulting iron-binding peptides could be suitable as a value-added food ingredient for food supplements.

• Reproductive and Developmental Biology
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• 제33권4호
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• pp.243-248
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• 2009

To examine the differential expression of proteins during the cycling (70~80% confluences) and G0/G1 (full confluences) phases in porcine fetal fibroblast cells, we used a global proteomics approach by 2-D gel electrophoresis (2-DE) and MALDI-TOF-MS. Cycling cell were harvested at approximately 70% to 80% confluent state while cells in G0/G1 phase were recovered after maintenance of a confluent state for 48 hr. Cellular proteins with isoelectric points ranging between 3.0~10.0, were analyzed by 2-DE with 2 replicates of each sample. A total of approximately 700 spots were detected by 2.D gels stained with Coomassie brilliant blue. On comparing the cell samples obtained from the cycling and G0/G1 phases, a total of 13 spots were identified as differentially expressed proteins, of which 8 spots were up-regulated in the cycling cell and 5 were up-regulated in the G0/G1 phase. Differentially expressed proteins included K3 keratin, similar to serine protease 23 precursor, protein disulfide-isomerase A3, microsomal protease ER-60, alpha-actinin-2, and heat-shock protein 90 beta. The identified proteins were grouped on the basis of their basic functions such as molecular binding, catabolic, cell growth, and transcription regulatory proteins. Our results show expression profiles of key proteins in porcine fetal fibroblast cells during different cell cycle status.

• Bulletin of the Korean Chemical Society
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• 제30권10호
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• pp.2253-2258
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• 2009

wet spun polyacrylonitrile (PAN) fiber precursors. The process variables chosen were treatment temperature, applied tension in stabilization process. The temperature profile of the stabilization was set on the basis of exothermic peaks of the differential scanning calorimetry (DSC) result. Both tensile strength and modulus increased with holding at onset temperatures of the exothermic peaks for extended duration, and with a higher heating rate up to the onset temperatures at a given applied tension among the experimental conditions. The increase in load monotonously increased the tensile modulus, on the other hand, the tensile strength was maximum at the load of 15 mg/filament (T15). The load 20 mg/ filament (T20) was considered to be exceeded to form oriented crystalline structure, possibly introducing more defects in the fiber than under load of T15. The sample CP3-T15 O5 H30 showed the best tensile properties among the samples experimented whose tensile properties are compatible with the commercialized grade of general purpose carbon fibers even at low carbonization temperature such as $800\;{^{\circ}C}$ (the carbonization temperature in the commercial process. 1300∼$1500\;{^{\circ}C}$).

• The International Journal of Costume Culture
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• 제2권2호
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• pp.60-70
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• 1999

The purposes of this study were to investigate preference and images of Korean traditional motifs, and to identify the relationship between them. The subjects consisted of 369 male and 356 female undergraduate students. The experimental materials used in this study were 48 stimuli and a questionnaire composed of 7-point semantic differential scales of 26 adjectives. Twelve motifs selected from 3 groups of Korean motifs were used as pattern design stimuli. Twelve repeated patterns were constructed from them to be applied on a CAD-simulated dress. The data were analyzed by ANOVA, Duncan's multiple range test, and regression. The major findings were as follows : 1. Category, composition type, and application object had a significant effect on the preference. Interpretation type has no significant effects on the preference independently, but it had interaction effects when combined with composition type, and category. Especially the composition type had a greater effect than the other variables on the preference. Cloud motif and its abstract and decorative type were found to be more related to the preference than the other category and interpretation type. On the basis of the analysis results, image charts and preference charts were developed. By combining information from the image chart and preference chart, motifs and images preferred by consumers may be selected and developed into new valuable designs. 2. The preference was affected mainly by 'quality'image followed by 'simplicity', 'interest', and 'modernity'image. The preference on pattern design was affected by 'quality', 'simplicity', 'interest', and 'interest', 'simplicity', and 'modernity'image in the order. The relationship between the preference and sensibility images has been represented by equations.