• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.323.2-323.2
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• 2002

We previously reported that apicidin induces apoptosis through selective induction of Fas/Fas ligand. resulting in the release of cytochrome C from mitochondria to the cytosol and subsequent activation of caspase-9 and \ulcorner However. we observed that apicidin did not induce the apoptosis in a specific cell line. such as HeLa. which was characterized by nuclear DNA fragmentation. On the basis of these facts, we tested whether JNK activation is involved in cell death induced by apicidin. (omitted)

• Advances in nano research
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• 제13권6호
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• pp.545-559
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• 2022

This paper studies the buckling response of nonuniform functionally graded micro-sized tubes according to the high-order tube theory (HOTT) and classical beam theory (CBT) in addition to nonlocal strain gradient theory. The microtube is made of axially functionally graded material (AFGM). Both inner and outer tube radiuses are changed along the tube length; the microtube is the truncated conical type of tube. The nonlinear partial differential (PD) the formulations are obtained on the basis of the energy conservation method. Then, the linear and nonlinear results are computed via a powerful numerical approach. Finally, the impact of various parameters on the stability of axially functionally graded (AFG) microtube regarding the buckling analysis is discussed.

• Computers and Concrete
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• 제30권4호
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• pp.243-256
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• 2022

The static analysis of spinning functionally graded (FG) nanotube on the basis of the nonlocal strain gradient theory (NSGT) is presented. The high-order beam theory is employed for mathematical modeling of the tube structures according to the Sinusoidal shear deformation beam theory. The energy conservation principle is operated to generate the equations. The centrifugal force is assumed along the tube length due to the rotating of the tube, moreover, the nanotube is made of functionally graded material (FGM) composed of ceramic and metal phases along the tube radius direction. The generalized differential quadratic method (GDQM) is utilized to solve the formulations. Finally, the numerical results are discussed in detail to examine the impact of different relevant parameters on the bending the buckling behavior of the rotating nanotube.

• Steel and Composite Structures
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• 제43권1호
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• pp.129-137
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• 2022

Dynamic response of a laminated porous concrete beam reinforced by nanoparticles subjected to harmonic transverse dynamic load is investigated considering structural damping. The effective nanocomposite properties are evaluated on the basis of Mori-Tanaka model. The concrete beam is modeled by the sinusoidal shear deformation theory (SSDT). Utilizing nonlinear strains-deflection, energy relations and Hamilton's principal, the governing final equations of the concrete laminated beam are calculated. Utilizing differential quadrature method (DQM) as well as Newmark method, the dynamic displacement of the concrete laminated beam is discussed. The influences of porosity parameter, nanoparticles volume percent, agglomeration of nanoparticles, boundary condition, geometrical parameters of the concrete beam and harmonic transverse dynamic load are studied on the dynamic displacement of the laminated structure. Results indicated that enhancing the nanoparticles volume percent leads to decrease in the dynamic displacement about 63%. In addition, with considering porosity of the concrete, the dynamic displacement enhances about 2.8 time.

• Advances in nano research
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• 제12권3호
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• pp.281-290
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• 2022

In the current research, the thermal buckling characteristics of the bi-directional functionally graded nano-scale tapered beam on the basis of a couple of nonlocal Eringen and classical beam theories are scrutinized. The nonlocal governing equation and associated nonlocal boundary conditions are constructed using the conservation energy principle, and the resulting equations are solved using the generalized differential quadrature method (GDQM). The mechanical characteristics of the produced material are altered along both the beam length and thickness direction, indicating that it is a two-dimensional functionally graded material (2D-FGM). It is thought that the nanostructures are defective because to the presence of porosity voids. Finally, the obtained results are used to design small-scale sensors and make an excellent panorama of developing the production of nanostructures.

• Advances in concrete construction
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• 제15권1호
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• pp.47-61
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• 2023

This paper examines the dynamic response of rotating nanodevices under the external harmonic load. The spinning nanosystem is made of nanoscale tubes that rotate around the central nanomotor and is mathematically modeled via high-order beam theory as well as nonclassical nonlocal theory for the size impact. According to the Hamilton principle, the dynamic motion equations are derived, then the time-dependent results are obtained using the Newmark Beta technique along with the generalized differential quadratic method. The presented results are discussed dynamic deflection, resonant frequency, and natural frequency in response to the different applicable parameters, which help develop and produce nanoelectromechanical systems (NEMS) for various applications.

• Steel and Composite Structures
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• 제46권1호
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• pp.143-152
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• 2023

In this paper, static and dynamic bending of nanocomposite micro beam armed with CNTs considering agglomeration effect is studied. The structural damping is considered by Kelvin-Voigt model. The agglomeration effects are assumed using Mori-Tanaka model. The micro beam is modeled by third order shear deformation theory (TSDT). The motion equations are derived by principle of Hamilton's and energy method assuming size effects on the basis of Eringen theory. Using differential quadrature method (DQM) and Newmark method, the static and dynamic deflections of the structure are obtained. The effects of agglomeration and CNTs volume percent, damping of structure, nonlocal parameter, length and thickness of micro-beam are presented on the static and dynamic deflections of the nanocomposite structure. Results show that with increasing CNTs volume percent, the static and dynamic deflections are decreased. In addition, enhancing the nonlocal parameter yields to higher static and dynamic deflections.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2022년도 추계학술대회
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• pp.168-169
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• 2022

In this study, we investigates the auto-berthing problem for the underactuated surface vessel in the presence of constraints of dynamic uncertainties, finite time, transmission load, and environmental disturbance. A novel control scheme is proposed by fusing the finite time control technology and the event-triggered input algorithm. In the algorithm, differential homeomorphism coordinate the transformation is used to solve the problem of underactuation. Then, we apply the finite time technology and event triggered to save the time of the berthing vessel and relieve transmission burden between the controller and the vessel respectively. Moreover, a radial basis function network is used to approximate unknown nonlinear functions, and minimum learning parameters are introduced to lessen the computational complexity. A sufficient effort has been made to verify the stability of the closed-loop system based on the Lyapunov stability theory. Finally, simulation results display the effectiveness of the proposed scheme.

• Advances in nano research
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• 제15권3호
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• pp.203-213
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• 2023

The possibility of energy harvesting as well as vibration of a three-layered beam consisting of two piezoelectric layers and one core layer made of nonpiezoelectric material is investigated using nonlocal strain gradient theory. The three-layered nanobeam is resting on an elastic foundation. Hamilton's principle is used to derive governing equations and associated boundary conditions. The generalized differential quadrature method (GDQM) was used to discretize the equations, and the Newmark beta method was used to solve them. The size-dependency of the elastic foundation is considered using two-phase elasticity. The equations, as well as the solution procedure, are validated utilizing some compassion studies. This work can be a basis for future studies on energy harvesting of small scales.

• Steel and Composite Structures
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• 제49권3호
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• pp.349-359
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• 2023

Dynamic response and economic of a laminated porous concrete beam reinforced by nanoparticles subjected to harmonic transverse dynamic load is investigated considering structural damping. The effective nanocomposite properties are evaluated on the basis of Mori-Tanaka model. The concrete beam is modeled by the sinusoidal shear deformation theory (SSDT). Utilizing nonlinear strains-deflection, energy relations and Hamilton's principal, the governing final equations of the concrete laminated beam are calculated. Utilizing differential quadrature method (DQM) as well as Newmark method, the dynamic displacement of the concrete laminated beam is discussed. The influences of porosity parameter, nanoparticles volume percent, agglomeration of nanoparticles, boundary condition, geometrical parameters of the concrete beam and harmonic transverse dynamic load are studied on the dynamic displacement of the laminated structure. Results indicated that enhancing the nanoparticles volume percent leads to decrease in the dynamic displacement about 63%. In addition, with considering porosity of the concrete, the dynamic displacement enhances about 2.8 time.