Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.323.2-323.2
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- 2002
Differential involovement of JNK in apicidin-induced apoptosis.
- Kim, Ji-Ae (Lab of Biochemistry & Mol. Boilogy, College of Pharmacy, Department of Genetic Engineering College of Life sci. & Tech. Sungkyungkwan University.) ;
- Cho, Eun-jung (College of Medicine, Konyang University) ;
- Lee, Hoi-Young (College of Medicine, Konyang University) ;
- Hong , Sung-Youl (College of Medicine, Konyang University) ;
- Lee, Hyang-Woo (College of Medicine, Konyang University) ;
- Han, Jeung-Whan (College of Medicine, Konyang University)
- Published : 2002.10.01
Abstract
We previously reported that apicidin induces apoptosis through selective induction of Fas/Fas ligand. resulting in the release of cytochrome C from mitochondria to the cytosol and subsequent activation of caspase-9 and \ulcorner However. we observed that apicidin did not induce the apoptosis in a specific cell line. such as HeLa. which was characterized by nuclear DNA fragmentation. On the basis of these facts, we tested whether JNK activation is involved in cell death induced by apicidin. (omitted)
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