Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.323.1-323.1
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- 2002
Proteome Analysis of Apicidin- Treated Human Cervix Cancer Cells
- Shim , Won-Jo (Lab of Biochemistry ＆ Mol. Boilogy, College of Pharmacy, Department of Genetic Engineering College of Life sci. ＆ Tech. Sungkyungkwan University.) ;
- Cho, Eun-jung (College of Medicine, Konyang University) ;
- Lee, Hoi-Young (College of Medicine, Konyang University) ;
- Hong , Sung-Youl (College of Medicine, Konyang University) ;
- Han, Jeung-Whan (College of Medicine, Konyang University) ;
- Lee, Hyang-Woo (College of Medicine, Konyang University)
- Published : 2002.10.01
Abstract
Apicidin ［cyclo(N-O-methyl-l -tryptophanyl-L -isoleucinyl-D-pipecolinyl-L-2-amino-8-oxodecano y)］. a histone deacetylase inhibitor. has been shown to cause growth arrest and morphological change of cancer cells. resulting from the alternation of protein expression. such as p21WAF1/Cip1 and gelsolin. However. proteome of altered by apicidin are poorly studied. In this study. we used a functional proteornics approach to identify the proteome altered by apicidin in Hela cells at 24hr post-treatment. (omitted)
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