• Title/Summary/Keyword: differential distribution

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Stromal Modulation and its Role in the Diagnosis of Papillary Patterned Thyroid Lesions

  • Daoud, Sahar Aly;Esmail, Reham Shehab El Nemr;Hareedy, Amal Ahmed;Khalil, Abdullah
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.8
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    • pp.3307-3312
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    • 2015
  • The papillary patterned lesion of thyroid may be challenging with many diagnostic pitfalls. Tumor stroma plays an important part in the determination of the tumor phenotype. CD34 is thought to be involved in the modulation of cell adhesion and signal transduction as CD34(+) fibrocytes are potent antigen-presenting cells. Smooth muscle actin (SMA) positivity could be diagnostic for fibroblast activation during tumorigenesis. We aimed to examine the expression of CD34 and alphaSMA in the stroma of papillary thyroid hyperplasia, papillary thyroid carcinoma and papillary tumors of uncertain malignant potential in order to elucidate their possible differential distribution and roles. A total number of 54 cases with papillary thyroid lesions were studied by routine H&E staining, CD34 and ASMA immunostaining. ASMA was not expressed in benign papillary hyperplastic lesions while it was expressed in papillary carcinoma, indicating that tumors have modulated stroma. Although the stroma was not well developed in papillary lesions with equivocal features of uncertain potentiality, CD34 was notable in such cases with higher incidence in malignant cases. So ASMA as well as CD34 could predict neoplastic behavior, pointing to the importance of the stromal role. Differences between groups suggest that the presence of CD34 + stromal cells is an early event in carcinogensis and is associated with neoplasia, however ASMA+ cells are more likely to be associated with malignant behavior and metastatic potential adding additional tools to the light microscopic picture helping in diagnosis of problematic cases with H&E.

Comparative Analysis and Evaluation of Dietary Intake between with and without Hypertension Using 2001 Korea National Health and Nutrition Examination Survey (KNHANES) (2001년도 국민건강영양조사 자료를 이용한 고혈압 유무에 따른 식생활 비교 및 평가)

  • Park, Jung-Hyun;Moon, Hyun-Kyung
    • Journal of Nutrition and Health
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    • v.40 no.4
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    • pp.347-361
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    • 2007
  • The purpose of this study was to analyze and evaluate dietary intake between with and without hypertension. Study subjects were more than 30 years old adults (n = 3,806) who participated in the 2001 Korea National Health and Nutrition Examination Survey. People who have 'self-recognition about hypertension' and 'having diet for hypertension' were excluded. Using the WHO standard, subjects were divided into the hypertensive group (SBP> 140, DBP> 90) and the normal group (SBP< 140, DBP< 90). The Body Mass Index (BMI) and the Waist-Hip Ratio (WHR) of a hypertensive group were higher than those of a normal group (p < 0.01). The distribution of the subjects for smoking, alcohol consumption, exercise, stress, preference of salty food were not significantly different between a normal group and a hypertensive group (p>0.05). Dietary intakes were investigated by the 24-hour recall method. When food and dish intakes analyzed by sociodemographic factors, normal group consumed more fruits than those of a hypertensive group. Statistical significant were shown at female group, residences in metropolitan area and having elementary school education (p<0.05). Hypertensive group consumed more alcoholic beverages than those of a normal group at 'age 39-39', 'aged 50-64', 'high economic status', 'low economic status' and 'residences in metropolitan' (p<0.05) The amount of intakes for fat, potassium, thiamin, vitamin C and alcohol were significantly different between the normal group and the hypertensive group (p<0.05). The highest score of the Dietary diversity score (DDS) was 4 in both normal group and hypertensive group. Normal group showed high Nutrition Density (ND) of vitamin C and hypertensive group showed high ND of sodium. In summary, these results showed that significant difference for people with hypertension were intakes of fruits, alcohol, thiamin, vitamin C. And these results differed by sociodemographic groups. Therefore, the differential approach in each group is demanded for prevention and control of the hypertension.

The Effect of HEMM on Microstructure and Mechanical Properties of Ti-Nb Alloy for Implant Biomedical Materials (생체의학 임플란트재료로서 Ti-Nb계 합금의 조직과 기계적 성질에 미치는 HEMM의 영향)

  • Woo, Kee-Do;Choi, Gab-Song;Lee, Hyun-Bum;Kim, In-Yong;Zhang, Deliang
    • Korean Journal of Materials Research
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    • v.17 no.11
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    • pp.587-592
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    • 2007
  • Al-42wt%Nb powder was prepared by high-energy mechanical milling(HEMM). The particle size, phase transformation and microstructure of the as-milled powder were investigated by particle size distribution (PSD) analyzer, scanning electron microscopy (SEM), X-ray diffractometery (XRD), transmission electron microscopy (TEM)and differential thermal analysis (DTA). The milled powders were heated to a sintering temperature at 1000C with under vaccum with vaccum tube furnace. Microstructural examination of sintered Ti-42wt%Nb alloy using 4h-milled powder showed Ti-rich phases (${\alpha}$-Ti) which are fine and homogeneously distributed in the matrix (Nb-rich phase: ${\beta}$-Ti). The sintered Ti-42wt%Nb alloy with milled powder showed higher hardness. The microstructure of the as quenched specimens fabricated by sintering using mixed and milled powder almost are same, but the hardness of as quenched specimen fabricated by using mixed powder increased due to solution hardening of Nb in Ti matrix. The aging effect of these specimens on microstructural change and hardening is not prominent.

Taebaek Mountainous Region as a Natural Unit (자연 지역으로서의 태백 산지)

  • Kee, Keun-Doh
    • Journal of the Korean association of regional geographers
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    • v.8 no.4
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    • pp.468-479
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    • 2002
  • This study attempts to characterize Taebaek mountainous region as a natural unit, relating to morphoclimatic milieu and landform development patterns of the mountains of each lithologic type. In the case of granitic mountains of Nothern parts of this region, the slopes presents more or less steep or irregular profile because of abundant microforms of exposed bedrocks and blocks. The development of such landscape is essentially due to differential weathering, associated with difference of joint density. In the case of gneissic mountains, the slopes are well regularized straight steep ones, due not only to generalized superficial weathering but also to massmovement of weathered materials. In the Middle parts of this region, especially in Taegwallyong area, with frequent alternations both of freezing-thawing and of snow accumulation-melting, the roles played by cryo-nival processes proved to be important in weathering of granite as well as in morpho-pedogenesis. In this area, weathered mantle, developed by cryogenic activity under humid condition of nival environment, covered almost all over the slopes. Although Southern parts of this region consist of limestone, on the mountainous volume, distribution of Karst forms are limited while predominate none karst forms such as cockpit type peaks, V-shaped type valleys dissecting steep slopes covered with thin deposits in thickness containing rock debris.

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Physicochemical Characteristics of Starches in Rice Cultivars of Diverse Amylose Contents

  • Yoon, Mi-Ra;Chun, A-Reum;Oh, Sea-Kwan;Hong, Ha-Cheol;Choi, Im-Soo;Lee, Jeong-Heui;Cho, Young-Chan;Kim, Yeon-Gyu
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.57 no.3
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    • pp.226-232
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    • 2012
  • Through the sampling four rice cultivars with differing amylose contents, the relationship between the structural and gelatinization properties of endosperm starches was analyzed. These rice varieties exhibited different chain length distribution ratio within the amylopectin cluster as well as varing amylose levels. The proportion of amylopectin short chains of in Goami cutlivars was higher than the other varieties, whereas the Goami 2 which shows amylose extender mutant properties in the endosperm showed the highest proportion of long chains. In X-ray diffraction analysis of rice starches, the Goami 2 variety displayed a B-type pattern whereas the other varieties were all A-type. Among the cultivars with high and normal rice starch levels, those with the higher amylose contents showed distinctly lower swelling. Goami 2 rice was found to have the highest onset and peak gelatinization temperature from the differential scanning calorimetry results. The four rice cultivars under analysis also showed different rates of hydrolysis by amyloglucosidase. These findings suggest that the composition and chemical structure of the starch content is a major determinant of both the gelatinization and functional properties of rice.

Seasonal Changes of Water Properties and Current in the Northernmost Gulf of Aqaba, Red Sea

  • Manasrah, Riyad;Zibdah, Mohammad;Al-Ougaily, Firas;Yusuf, Najim;Al-Najjar, Tariq
    • Ocean Science Journal
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    • v.42 no.2
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    • pp.103-116
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    • 2007
  • Seasonal changes of tide signal(s), temperature, salinity and current were studied during the years 2004-2005 in the northernmost Gulf of Aqaba, which is under developmental activities, to obtain scientific bases for best management and sustainability. Spectrum analysis revealed permanent signals of tide measurements during all seasons, which represented semidiurnal and diurnal barotropic tides. The other signal periods of 8.13, 6.10-6.32, 4.16 and 1.02-1.05 h were not detected in all seasons, which were related to shallow water compound and overtides of principle solar and lunar constituent and to seiches generated in the Red Sea and the Gulf of Aqaba. Spatial and temporal distribution of temperature, salinity and density showed significant differences between months in the coastal and offshore region and no significant differences among the coastal sites, between the surface and bottom waters and between coastal and offshore waters. Therefore, the temporal and spatial variation of water properties in the northernmost Gulf of Aqaba behave similarly compared to other parts. The coastal current below 12 m depth was weak $(3-6\;cms^{-1})$ and fluctuated from east-northeastward to west-southwestward (parallel to the shoreline), which may be related to the effect of bottom topography and/or current density due to differential cooling between eastern and western parts in the study area, and wind-induced upwelling and downwelling in the eastern and western side, respectively. The prevailing northerly winds and stratification conditions during summer were the main causes of the southward current at 6 and 12 m depths with average speed of 28 and $12cms^{-1}$ respectively.

Morphologic and Genetic Identification of Diphyllobothrium nihonkaiense in Korea

  • Jeon, Hyeong-Kyu;Kim, Kyu-Heon;Huh, Sun;Chai, Jong-Yil;Min, Duk-Young;Rim, Han-Jong;Eom, Kee-Seon S.
    • Parasites, Hosts and Diseases
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    • v.47 no.4
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    • pp.369-375
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    • 2009
  • Diphyllobothrium nihonkaiense was first described by Yamane in 1986 but the taxonomical features have been obscure due to lack of critical morphologic criteria in its larval and adult stages. In Korea, this tapeworm had long been known as Diphyllobothrium latum. In this study, we observed 62 specimens collected from Korean residents and analyzed them by morphological features and nucleotide sequences of mitochondrial cox1 gene as well as the ITS1 region. Adult tapeworms were examined after carmine or trichrome stain. Longitudinal sections of the gravid proglottids showed an obtuse angle of about 150 degree between the cirrus sac and seminal vesicle. This angle is known as a major differential point compared with that of D. latum. Nucleotide sequence differences between D. latum and the specimens from Koreans represented 17.3% in mitochondrial DNA cox1 gene. Sequence divergence of ITS1 among 4 Korean isolates was 0.3% and similarity was 99.7% with D. nihonkaiense and D. klebanovskii. All of the Korean specimens analyzed in this study were identified as being D. nihonkaiense (n = 62). We propose its Korean name as "Dong-hae-gin-chon-chung" which means 'long tapeworm of the East Sea' for this newly analyzed diphyllobothriid tapeworm in Korea.

Equity of Access to Health Services under National Health Insurance System in Korea (의료서비스에 대한 접근성의 형평 분석)

  • 장동민;문옥륜
    • Health Policy and Management
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    • v.6 no.1
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    • pp.110-143
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    • 1996
  • The purpose of this study is to assess the extent of inequality in health outcomes and the distribution of health services according to health need under National Health Insurance System in Korea. For the empirical analysis, data were collected through an interview survey during one month of October, 1994. Interview were conducted with a total of 10, 875 of the employees and the self-employed selected through cluster, systematic sampling. The major findings of this research are as follows: 1. The analysis of the differentials in morbidity rates by socio-economic group showed that health inequality in the pro-higher groups existed in all self-reported morbidity indicators. 2. The findings of the conventional use measures showed that the lower socio-economic groups had more ambulatory and inpatient services than the higher groups. In contrast to the level of the medical care utilization, however, the higher socio-economic groups were more likely to use the high-quality source of care in terms of their treatment place compared to the lower groups. 3. By using the need-based use measures, the results were different from each use-disability ration indicator. Using the use-disability ration measured by physician visits per 100 restricted-activity days in the population, it was found that there was no evidence favoring the higher socio-economic groups. In contrast, the use-disability ration based on physician visits per a chronic patient in one year displayed that there was remarkable relative difference by income group as well as the evidence of the pro-higher income groups. 4. The results of logistic regression analysis and two-stage estimation method indicated that although the utilization is significantly affected by type and duration of insurance coverage, the use or nonuse of service and the volume of physician care consumed is determined by health need and demographic characteristics rater than economic status. In sum, these findings suggest that physician service is equitably distributed according to health need under national health insurance system in Korea. As there were some evidences of inequality including the differential in physician visits of chronic patients by income group, however, the government should strengthen the activities to guarantee the equity of health services utilization.

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Geological Structural Lines and Hamdeok-Pyoseon Graben in Jeju Island (제주도의 지질구조선과 함덕-표선 지구대)

  • Booh Seong-An;Jeong Gyo-Cheol;Kim Hye-Bin;Kim Kyeong-Su;Woo Myoung-Ha;Lee Byoung-Ho
    • The Journal of Engineering Geology
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    • v.15 no.4 s.42
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    • pp.475-486
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    • 2005
  • According to the inference results of formation process of the tectonic lineament, totally four events of subsidence including two events after upheaval of granite body and two events after sedimentation of unconsolidated sedimentary layer formed the macroscopic tensional lineament. The subsidence was occurred by tensional stress oriented ENE-WSW direction and compressional stress oriented NNW-SSE direction. The deeper distribution of tuff and unconsolidated sedimentary layer as much as 70-140m and that of granite as much as 50-500m at Hamdeok and Shinheung than those of the eastern and the western area around Hamdeok and Shinheong is due to the Hamdeok-Pyoseon Graben by three events of differential subsidence from Hamdeok to Pyoseon including Shinheung.

Some Physicochemical Properties of Large and Small Starch Granules of Barley (보리 전분의 대.소입자에 관한 연구)

  • Kang, Mi-Young
    • Korean Journal of Food Science and Technology
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    • v.21 no.1
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    • pp.52-57
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    • 1989
  • Large and small starch granules were isolated and characterized from kernels of Hiproly barley. Average size of large granules were $28-30{\mu}m$ and that of small granules were $6{\mu}m$. The small granules consist of 95% of total starch granules. Large granules contained more amylose than small granules. Distribution of isoamylase-debranched starch components, X-ray diffraction patterns, gelatinization characteristics by differential scanning calorimetry, and starch-granule susceptibility to acid were investigated. Large granules contained more long B chains of amylopectin and had the lower ratios of Fr. III to Fr. II , which represent one of the structural characteristics of amylopectin, than those of small granules. Small granules had higher conclusion temperature and smaller heat of gelatinization than those of large granules by D.S.C.. Both granules had A-type pattern of X-ray diffractopgrams, but hydrolysis of granules with acid showed different A-type patterns between large and small granules.

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