• 제목/요약/키워드: dietary life related factor

검색결과 68건 처리시간 0.025초

Enzyme-processed Korean Red Ginseng extracts protects against skin damage induced by UVB irradiation in hairless mice

  • Hwang, Eunson;Sun, Zheng-Wang;Lee, Taek Hwan;Shin, Heon-Sub;Park, Sang-Yong;Lee, Don-Gil;Cho, Byung-Goo;Sohn, Hyunjoo;Kwon, Oh Wook;Kim, Sun Yeou;Yi, Tae Hoo
    • Journal of Ginseng Research
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    • 제37권4호
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    • pp.425-434
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    • 2013
  • UV irradiation is the main factor contributing to skin damages that are associated with an excessive production of matrix-degrading metalloproteinase (MMP)-1 and a deficient expression of collagens. To date, red ginseng has been revealed to possess many biomedical effects, such as anti-aging, anti-oxidation, and anti-inflammatory. In this study, we prepared the Korean Red Ginseng extracts treated with enzyme (KRGE) and investigated the effects of dietary KRGE on the formation of wrinkles generated by UVB irradiation in hairless mice. It was found that KRGE inhibited the UVB-induced formation of wrinkles, epidermal thickness, and skin dryness in hairless mice. Further results also showed that KRGE attenuated UVB-induced MMP-${\beta}$1 level, while accelerated procollagen type I, transforming growth factor-${\beta}$1 secretion. Interestingly, the expression of profilaggrin and filaggrin in both the epidermis and dermis were decreased due to UVB exposure and reversed by KRGE. The KRGE 0.06% was prior to KRGE 0.24%. In view of these results, which indicated that KRGE protected skin from UVB-induced photodamages, which may not only mediated by regulating of MMP-1 and procollagen type I, but also by increasing the production of profilaggrin and filaggrin. In conclusion, our results suggest that KRGE may be a promising agent for the treatment of skin photodamages. The challenge of KRGE will be expected as cosmeceuticals and nutraceuticals in order to intervene in aging-related degenerative skin changes.

한국인 다소비 채소의 에탄올 추출물이 LPS 처리된 대식세포에서 NO, TNF-${\alpha}$와 MCP-1 분비에 미치는 영향 (Effects of Ethanol Extracts from Commonly Consumed Vegetables by Koreans on NO, TNF-${\alpha}$ and MCP-1 Production in LPS-stimulated RAW 264.7 Macrophages)

  • 안은미;강현주;박영희;김영;강민숙
    • 동아시아식생활학회지
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    • 제24권6호
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    • pp.776-784
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    • 2014
  • Korean dishes, Hansik are characterized by healthful vegetable intake. The purpose of this study was to evaluate the inhibitory effect of commonly consumed vegetables by Koreans on obesity/metabolic disease-related inflammation. Through statistical analysis of the KNHANES database ($1^{st}$ 1998, $5^{th}$ 2010, 2011) and a literature review, we selected vegetables for study. Among the vegetables, main or sub ingredients of Kimchi were excluded. Samples were prepared using only edible portions and freeze-dried. After grinding, samples were extracted with ethanol, evaporated and finally lyophilized. The cytotoxicity of samples was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, at various concentrations that do not affect cell viability. Raw 264.7 macrophages were treated with lipopolysaccharide (LPS) and 11 kinds of samples or positive control (troglitazone) dissolved in dimethyl sulfoxide (DMSO). After 24 hours, nitric oxide (NO), tumor necrosis factor ${\alpha}$ (TNF-${\alpha}$) and monocyte chemoattractant protein-1 (MCP-1) production were determined. Excepts for young pumpkin and bracken, nine samples effectively reduced NO production compared with control treated with LPS and DMSO. NO levels of five samples (bean sprouts, leeks, eggplant, mugwort, and pumpkin) were similar to that of the positive control. These five samples showed significantly decreased TNF-${\alpha}$ or MCP-1 compared to the control group. Our results suggest that consumption of commonly consumed vegetables contributes to partial prevention of obesity and related metabolic syndrome through reduction of NO, TNF-${\alpha}$, and MCP-1 production.

노인의 건강신념과 건강관행에 관한 연구 (A Study on Health Belief and Health Behaviors of the Elderly)

  • 왕명자;차남현
    • 동서간호학연구지
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    • 제8권1호
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    • pp.103-112
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    • 2003
  • This paper focused on providing the groundwork for the development of proper nursing interventions to enhance the quality of life for the elderly by identifying the factors that may affect their health beliefs and behaviors. A survey was conducted on a group of people aged between 60 and 86 years residing in S and K cities from January to March of 2003, who agreed to participate in the research. Data was collected using instruments measuring health beliefs and health behaviors, and was analyzed by using SPSS. The results of this study are as follow. 1) Those in the group were aged between60 and 86 years, and the average age was 66.94 years old. Most of them were living together with their spouses. From the survey, 83.5% replied "above average" on the question regarding their current health condition, whereas, 46.0% mentioned that they had some sort of diseases. 2) Overall average score of the health belief was 516.05, with a mean $3.71{\pm}4.07$. This indicates that the studied group held a high level of health belief, which affects their attitude and intention to lead a healthy life by placing the present life under control in harmony with nature. 3) Overall average score of the health behaviors was 392.24 with a mean $2.82{\pm}.52$. For health purposes, the behaviors that the elderly people were taking were mostly static ones requiring a low level of activity. The analysis showed that they generally were involved in self-trained, individualized health care. Thus, the elderly place a higher priority on regular dietary behaviors than on physical activity. 4) The correlation between health belief, a cognitive aspect on health, and health behaviors, a behavioral aspect showed a very high linear relationship (r=.520, p<.000). Consequently, it is found that those who have higher cognitive health belief are involved in higher level of behavioral health practice. These findings concluded that the Korean elderly have good health beliefs, well controlling their minds and being harmonious with nature. Health behaviors that they are engaged in are mostly static, requiring low level activity, while they place higher priority on regular dietary habits and conducting self-trained individualized health care. Important factor affecting their health beliefs and health behaviors was found to be their health practice. Since higher health belief is highly related with good health behaviors, development of health activity programs is in need as a means for an efficient health improvement, where motivating environment may be established to enhance the health belief of the elderly and to satisfy individual values.

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HMR 무인매장 서비스 품질 분류에 관한 연구 (Classification of Service Quality for HMR unmanned store business)

  • 이종원
    • 서비스연구
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    • 제13권2호
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    • pp.41-61
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    • 2023
  • 제4차 산업혁명 시대의 보편적 삶의 형태는 비대면이라는 키워드로 요약될 수 있을 것이다. 특히 소비 활동 측면에서도 점차 대면 접촉이 최소화되는 시스템으로 변화하고 있으며, 오프라인 매장에서는 키오스크(kiosk)와 로봇 등을 통한 비접촉 서비스로의 전환이 빠르게 이어지고 있다. 사회 구조 역시 시간의 흐름에 따라 변화되고 있으며 특히 1인 가구 증가와 고령화는 식생활과 연관된 외식산업의 변화에도 영향을 미치고 있다. 가정 내에서 직접 조리하는 노동이 줄어들고, 대체할 수 있는 식품의 이용이 증가하고 있음에 따라 가정간편식 (HMR: Home Meal Replacement)시장이 큰 규모로 성장하였다. 시장의 규모가 커지며 상품을 제공하는 비즈니스의 형태도 다양해졌다. 기술의 발전, 비대면 문화 그리고 기업의 경영 효율성이 맞물리며 최근 무인매장이 확산되고 있는 추세이다. 본 연구에서는 차츰 경쟁이 심화되는 HMR 무인매장의 서비스 품질 속성을 분류하여 고객만족을 기반으로 한 서비스 경영 관리 측면의 시사점을 제공하고자 Kano model을 활용한 서비스 품질 분류 및 Timko의 고객만족계수를 산출하였다. 분석결과 '상품(메뉴) 다양성' 등이 매력적 품질로 분류되었으며, '매장 내부/외부 청결성' 등이 일원적 품질로 분류되었다. 또한 '셀프 계산 과정의 편리성'은 당연적 품질, '매장 내 통행의 편리성' 무관심 품질로 분류되었다. 나아가 만족계수가 가장 높은 요소는 '상품(메뉴)다양성'으로, 불만족계수가 가장 높은 요소는 '셀프 계산과정의 편리성'으로 나타났다. 본 연구의 결과를 통해 HMR 무인매장의 서비스 품질 관리에 있어 우선순위를 도출하고, 이를 통해 관련 비즈니스에서의 전략적 시사점을 제공하고자 한다.

전라도에 거주하는 여자노인의 당화혈색소 수준에 따른 건강위험인자의 비교분석 - 생화학적 요인, 식습관 및 영양상태 - (The Comparative Analysis of Health Risk Factor according to HbA1c Level of Elderly Women Dwelling in Jeonla Province - Blood Health Status, Food Habit and Nutrient Intake -)

  • 오세인;곽충실;이미숙
    • 한국식품영양학회지
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    • 제29권3호
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    • pp.392-403
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    • 2016
  • The purpose of this study was to investigate the relations between HbA1c level and health risk factor. For analysis, 330 elderly women aged 65 years and over were recruited in Jeonla province, Korea. The subjects were classified into two groups according to their HbA1c level; the diabetic group (HbA1c level${\geq}6.5%$, n=68, 20.6%) and control group (HbA1c level<6.5%, n=262, 79.4%). Demographic characteristics were collected, as well as information on physical measurements, blood tests for biochemical indicators, a health status and health-related life style, dietary behavior, favorite food groups, consumption frequency of food groups and nutrient intake. Educational level of the diabetic group was significantly lower than that of the control group. The height of the diabetic group was shorter, and percentage fat of the diabetic group was higher than those of the control group. In the diabetic group, the higher concentrations of creatinine and activity of alkaline phosphatase were found to be significantly unfavorable factors. Therefore, the diabetic group was assumed to be at risk of decreased liver and renal function. The self-rated health level of the diabetic group has a declining tendency, while the medicine intake was significantly higher than that of the control group, but there are no significant differences in visiting frequency of hospital and community health center. The distribution of physical activity showed a significant difference between the groups. Although there are no significant differences in nutrient intake, the diabetic group had relatively inferior nutrient intake of diet, especially vitamin C, as contrasted with the control group. In conclusion, the weight control and increasing physical activity may be effective in the prevention of the diabetes and continuous education and intervention by specialized nutritionists will be needed for diabetic patients. These results could be useful to plan effective strategies to increase the health-life expectancy and the prevention of the diabetes of Korean elderly people living in rural areas.

인터넷 사용자의 온라인 식품 구매 실태 조사 (A Survey on Food Purchasing of Internet Users via On-line Shopping)

  • 남세현;심기현
    • 한국식품조리과학회지
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    • 제29권4호
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    • pp.367-376
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    • 2013
  • The objectives of this study are to provide the food market of internet shopping malls with effective marketing data, to provide basic data for the development of related fields of the study, and ultimately to increase the satisfaction of food consumers of internet shopping malls. To achieve the object of this research, a cluster analysis of the research subjects was carried out based on the following 5 factors of food purchasing attribute that had been deduced by a factor analysis by the types of food purchasers: quality characteristics, informativity, convenience, price and diversity. According to the result of the cluster analysis, the research subjects were classified into the 2 clusters of diversity and informativity. The deduced 2 clusters, together with age and occupation among general characteristics, were used as independent variables to find out food purchasing behaviors and satisfaction at internet shopping malls. The results are as follows: Regarding the frequency of food purchasing experiences at internet shopping malls according to occupation, the highest frequency was shown by those involved in service, sales and self-employed businesses; whereas regarding the frequency according to age, those in their 30s and 40s showed the highest frequency. The total amount of money spent on food purchasing for 1 year at internet shopping malls was shown to increase as age increased. The frequency of the purchasing experiences of agricultural products and fish products was shown to be higher as age increased. However, overall purchase satisfaction was highest among those in their 30s, while lowest among those in their 40s. Regarding satisfaction by the types of food purchased via internet shopping malls, satisfaction was relatively higher with common foods and functional foods, while lower with fish products. Taken together, it was concluded that purchasing behaviors at internet food shopping malls, such as the frequency of purchasing experiences and purchase amount, varied depending on age rather than purchasing attribute. Accordingly, in order to vitalize internet food shopping malls, it would be necessary to provide customized food shopping information for individual age groups.

브로콜리 유래 sulforaphane에 의한 NAG-1과 p21 유전자의 발현 조절 (Up-Regulation of NAG-1 and p21 Genes by Sulforaphane)

  • 정병걸;김순영;이건주;김종식
    • 생명과학회지
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    • 제22권3호
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    • pp.360-365
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    • 2012
  • 본 연구에서는 대장암 세포주 모델에서 브로콜리 유래 sulforaphane에 의한 항 성장 활성과 항암 단백질 NAG-1과 p21의 발현 및 발현 조절에 대해서 연구하였다. 그 결과, 처리한 sulforaphane의 농도가 증가됨에 따라 세포사멸이 증가되었고, 세포 생존율은 감소하였다. 또한, sulforaphane에 의한 항암 단백질 NAG-1과 p21의 발현증가를 농도별, 시간대별로 확인한 결과, 두 단백질 모두 sulforaphane 농도와 처리시간 의존적으로 발현이 증가됨을 확인하였다. Sulforaphane에 의한 NAG-1과 p21의 발현의 p53 의존성을 연구한 결과, p21의 발현은 p53에 의존적 이지만 NAG-1의 발현은 p53에 비 의존적인 것으로 생각된다. 또한, sulforaphane이 dietary histone deacetylase inhibitor로서 NAG-1의 발현을 증가시킬 가능성은 매우 미미한 것으로 생각된다. 전사조절인자인 ATF3의 발현을 sulforaphane을 시간대 별로 처리한 후 확인한 결과, 2시간째부터 발현이 증가되어 NAG-1의 발현 보다 먼저 증가됨을 확인하였다. 이러한 연구 결과는 sulforaphane의 항암 기능을 이해하는 새로운 기전을 제시해 줄 것으로 기대된다.

Butyrate and taurine exert a mitigating effect on the inflamed distal intestine of European sea bass fed with a high percentage of soybean meal

  • Rimoldi, Simona;Finzi, Giovanna;Ceccotti, Chiara;Girardello, Rossana;Grimaldi, Annalisa;Ascione, Chiara;Terova, Genciana
    • Fisheries and Aquatic Sciences
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    • 제19권10호
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    • pp.40.1-40.14
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    • 2016
  • Background: Due to the paucity of oceanic resources utilized in the preparation of diets for cultured fish, commercial feed producers have been trying to replace fishmeal (FM) using alternative protein sources such as vegetable protein meals (VMs). One of the main drawbacks of using VMs in fish feed is related to the presence of a variety of anti-nutritional factors, which could trigger an inflammation process in the distal intestine. This reduces the capacity of the enterocytes to absorb nutrients leading to reduced fish growth performances. Methods: We evaluated the mitigating effects of butyrate and taurine used as feed additives on the morphological abnormalities caused by a soybean meal (SBM)-based diet in the distal intestine of sea bass (Dicentrarchus labrax). We used three experimental diets, containing the same low percentage of FM and high percentage of SBM; two diets were supplemented with either 0.2% sodium butyrate or taurine. Histological changes in the intestine of fish were determined by light and transmission electron microscopy. Infiltration of $CD45^+$ leucocytes in the lamina propria and in the submucosa was assessed by immunohistochemistry. We also quantified by One-Step Taqman$^{(R)}$ real-time RT-PCR the messenger RNA (mRNA) abundance of a panel of genes involved in the intestinal mucosa inflammatory response such as $TNF{\alpha}$ (tumor necrosis factor alpha) and interleukins: IL-8, IL-$1{\beta}$, IL-10, and IL-6. Results: Fish that received for 2 months the diet with 30% soy protein (16.7% SBM and 12.8% full-fat soy) developed an inflammation in the distal intestine, as confirmed by histological and immunohistochemistry data. The expression of target genes in the intestine was deeply influenced by the type of fish diet. Fish fed with taurine-supplemented diet displayed the lowest number of mRNA copies of IL-$1{\beta}$, IL-8, and IL-10 genes in comparison to fish fed with control or butyrate-supplemented diets. Dietary butyrate caused an upregulation of the $TNF{\alpha}$ gene transcription. Among the quantified interleukins, IL-6 was the only one to be not influenced by the diet. Conclusions: Histological and gene expression data suggest that butyrate and taurine could have a role in normalizing the intestinal abnormalities caused by the SBM, but the underling mechanisms of action seem different.

울산지역 노인의 생활습관에 따른 항산화 영양소 섭취실태 및 혈액내 항산화 영양 상태 비교 (The Effects of Smoking, Drinking and Exercise on Autioxidant Vitamin Intakes and Plasma Antioxidant Status in Elderly People Living in Ulsan)

  • 김미정;김옥현;김정희
    • 대한지역사회영양학회지
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    • 제7권4호
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    • pp.527-538
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    • 2002
  • Body antioxidant status is an important factor in the prevention of many chronic diseases caused by oxidative stress, especially in the elderly and is affected by health-related habits, such as smoking, drinking and regular physical activity. The aim of this study was to investigate the relationship between these health-related habits and plasma antioxidant status in the elderly. Plasma antioxidant status was examined by determining plasma levels of antioxidant vitamins (vitamin C, A, E, $\beta$ -carotene), total antioxidant status (TAS) and thiobarbituric acid-reactive substance (TBARS) . The subjects included 225 elderly persons aged over 60 yews (63 males, 162 females) living in the Ulsan area. They were interviewed to collect data on their general characteristics and health behaviors such as smoking, exercise and alcohol consumption by means of questionnaires. Their dietary intakes were obtained by means of semi-quantitative food frequency questionnaires (FFQ) The study population was divided into two or three groups according to their smoking, drinking, and exercise status. The ratio of smoker, drinker and exerciser was 16.7%, 31.0% and 44.2% respectively. The dietary antioxidant vitamin intakes were not significantly different among groups of smoking and drinking status, but tended to be higher in non-smokers and non-drinkers than in smokers and drinkers. Plasma vitamin C and $\beta$ -carotene levels were significantly higher in non-smokers, but Plasma vitamin A and TBARS levels were significantly lower in non-smokers than in smokers. Plasma TAS was not significantly different among the smoking groups, but showed a tendency to decrease with an increase in the number of packyear. Plasma vitamin C and $\beta$ -carotene levels of the non-drinkers were higher than those of drinkers and past-drinkers, but plasma vitamin A, C, E, TAS and TBARS showed no difference among the groups of drinker. All vitamin intakes of the exercisers were slightly higher than those of the non-exercisers, but vitamin C intake was significantly higher in female exercisers than in non-exercisers. Plasma $\beta$ -carotene levels were significantly higher in male exercisers and plasma vitamin A, C, E, TAS and TBARS levels tended to be higher in exercisers than in non-exercisers. These results suggested that change to non-smoker, modulation of alcohol consumption and regular exercise could enhance antioxidant defences against reactive oxygen species and might increase the likelihood of a healthier life span.

Extract of Curcuma zedoaria R. prevents atherosclerosis in apolipoprotein E-deficient mice

  • Kim, Ki Mo;Lee, Joo Young;Jeon, Byeong Hwa;Quan, Khong Trong;Na, MinKyun;Nam, Kung-Woo;Chae, Sungwook
    • Nutrition Research and Practice
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    • 제15권3호
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    • pp.319-328
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    • 2021
  • BACKGROUND/OBJECTIVES: Curcuma zedoaria R. (Zingiberaceae) has been used to treat headache, fever, and hypertension-related symptoms in Asian countries, including Korea, China, and Japan. We investigated whether dietary intake of a C. zedoaria extract (CzE) affected atherosclerosis in vivo. MATERIALS/METHODS: Apolipoprotein E-deficient (ApoE-/-) mice (n = 32) were fed a normal diet (ND), a high-cholesterol diet (HCD), an HCD containing CzE (100 mg/kg/day), or an HCD containing simvastatin (10 mg/kg/day) for 12 weeks. The anti-atherosclerotic effects were evaluated by observing changes in fatty streak lesions, immunohistochemical analysis, ex vivo fluorescence imaging, lipid profiles, and western blot analysis. RESULTS: The CzE-fed group showed a 41.6% reduction of atherosclerosis. Furthermore, CzE significantly reduced the levels of serum triglyceride, high-density lipoprotein, the chemokine (C-X3-C-motif ) ligand 1, the adhesion molecules vascular cell adhesion molecule-1, intracellular adhesion molecule-1, and E-selectin; down-regulation of tumor necrosis factor-α, interleukin-6, high mobility group box-1, and cathepsin levels in the aortic sinuses and aortas of ApoE-/- mice were also observed. CONCLUSIONS: The results suggest that the inclusion of a water extract of C. zedoaria in a HCD is closely correlated with reducing the risk of vascular inflammatory diseases in an ApoE mouse model.