• Journal of Pharmaceutical Investigation
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• v.36 no.6
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• pp.355-361
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• 2006

Intraarticular corticosteroid injections for therapy of rheumatic arthritis are administered with the aim of optimal local anti-inflammatory effect at the injection site. Since the side effects of corticosteroidal drug, dexamethasone(DEX), administered at hish dose limited the therapeutic efficacy, there was a need to design a new drug delivery system for controlled release of dexamethasone. As a prodrug for continuous therapeutic efficacy, dexamethasone-21-palmitate(DEX-PAL) was prepared via esterification of palmitoyl chloride and dexamethasone. DEX-PAL was identified by NMR and MASS analysis. DEX-PAL or DEX was entrapped in lipid nanosphere which could be prepared by using a self emulsification-solvent evaporation method. Physicochemical characteristics such as mean particle diameter, zeta potential and drug loading efficiency of the lipid nanospheres were investigated with variation of either the kind of lipid or the lipid composition. The lipid nanospheres had a mean diameter $83{\sim}95$ nm and DEX-PAL loading efficiency of up to 95%. The drug loading efficiency increased with the increase of aliphatic chain length attached to the phospholipid. The incorporation of cationic lipid was very efficient for both reducing particle size of lipid nanospheres and enhancing drug loading efficiency. The lipid nanospheres containing DEX-PAL may be a promising novel drug carrier for the controlled release of the poorly water-soluble drugs.

• Particle and aerosol research
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• v.15 no.4
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• pp.139-148
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• 2019

This study was performed for the application of a high-speed centrifugal cyclone to shale gas mining process. This device uses the centrifugal force to control particles similar to typical cyclones, and the disk located inside the cyclone is forced to rotate using a motor. The pressure difference occurred during the rotating of disk. Hence, inflow rate was generated without a blower fan. In addition, flow rate increased with elevating rpm of motor. The installing the disk in multiple stages on the inner rotor increased the instantaneous disk outlet flow. Hence, the control efficiency of oil particle increased from 1.05% to 31.2%. By modifying the structure of the disk so that the air flow to the opposite direction of the cyclone, the control efficiency of oil particles increased to 81.5%. By increasing the capacity of the motor and the size of the disk, the flow rate was increased to 2.5 ㎥/min because the rpm of motor and pressure difference increased. As rpm of motor increased, the cut-off diameter (d_pc) became smaller. Unlike the Lapple's equation, d_pc was inversely proportional to the effective number of rotations (N_e). The control efficiency was maintained even if the concentration of oil particles increased, for this reason, the higher the oil concentration, the more particles were accumulated and controlled.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.23 no.6
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• pp.761-768
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• 1999

This paper is studied to find the optimum condition of double-inlet Sirocco fan installed in an indoor PAC for low noise operation by the Taguchi method. The goal of this study is to obtain the best combination of each control factor which results in a desired flowrate of Sirocco fan with minimum variability. In this study, the parameter design of the Taguchi method is adopted for robust design by the dynamic characteristic analysis using orthogonal arrays and S/N ratios. The flowrate measurements are conducted by using a multiple-nozzle-type fan tester according to the orthogonal array L9($3^4$). The results of this study can be summarized as follows ; (i) The optimum condition of control factor is a set of where A is an inner to outer diameter ratio($D_1/D_2$), B is a width to outer diameter ratio($L/D_2$), C is a blade attachment angle(${\theta}$) and D is a number of blade(Z), (ii) The flowrate under the optimum condition satisfies the equation $y=0.0384{\cdot}M$ where M is a signal factor, namely number of revolution. The flowrate performance improves about 7.3% more largely as compared with the current condition, which results in about 35RPM reduction of number of revolution for the target flowrate $18.5m^3/min$, and (iii) The sensitivity analysis shows that the major factors in contribution to flowrate performance are A, B, and D ; the percentage contributions of each control factor are 44.01%(Z), 26.77%($D_1/D_2$) and 20.42%($L/D_2$).

• Journal of Korean Society of Forest Science
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• v.94 no.6
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• pp.453-461
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• 2005

Structural characteristics and successional trends of actual forest vegetation in Youngil soil erosion control district, South Korea, were studied and described by the phytosociological investigations and diameter measurement. And also the incremental growth pattern of the major trees for erosion control analyzed using increment core. Sixty-eight releves were sampled with $100m^2$ plots. Two main vegetation types (Lespedeza bicolor-Miscanthus sinensis-type and Alnus firma-Styrax japonica-type) have been distinguished and typified nine vegetation units. Constancy classes diagram showed that the higher species (${\geq}IV$) have only 2.6% and that most species occurred were rare and had low abundances. The successional trends of the actual forest vegetation would be mostly changed as Quercus serrata forest. Annual diameter growth was 3.0~3.4 mm in case of conifer (Pinus rigida and Pinus thunbergii), and the broad-leaved trees (Alnus firma, Robinia pseudo-acacia, and Alnus hirsuta) showed 4.3~4.9 mm. The incremental growth patterns showed to be decreased rapidly since twenty to twenty-five years regardless of the species of trees.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.11
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• pp.7745-7753
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• 2015

Gas springs of the television is to control the piston speed when operating under along stroke(200~300 mm, television elevation)is possible. User by this principle is capable of elevation adjustment. First carried out a flow analysis of the piston. A piston speed adjustment technique for precise pipe type cross-section was examined. The piston structure for flow rate control and elevation action is proposed. This study is the development of a gas spring of more than 50 inch television with a large television stand. Hollow piston rod for optimal control(the outer diameter 19.9 mm, the inner diameter 13.9 mm) was injected into the nitrogen gas(0.3 mm/s) in. As a result, the flow rate the pressure drop of the piston rod as the increase was increased without any change of the external force. As a result, control of the displacement via the gas spring is possible.

• Journal of Bio-Environment Control
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• v.10 no.1
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• pp.55-60
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• 2001

To investigate the effect of red light (R) and far-red light(FR) on controlling the growth of tomato transplants, height, length of 1st internode, and stem diameter of plant were measured every 12 days during 24 days of light treatment. At the end of experiment, fresh and dry weights of roots and shoots were measured. Generally, it was shown that the height of plant was suppressed by the treatment of FR. However, the effect of light-treatment time (10 or 20 min) on plant height was not significant. Stem diameter of the plant treated with R was greater than that of the plant treated with FR or the control. Dry weight ratio of shoot to root of the plant treated with R was smaller that of the plant treated with FR. R was more effective than the control, which was more effective than FR, in making the transplant compact.

• Journal of Embryo Transfer
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• v.32 no.3
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• pp.111-122
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• 2017

The objective of this experiment was to explore the effects of Roscovitine (Rosco) prior to in vitro maturation (IVM) of immature pig oocyte. Brilliant cresyl blue test has been used to select the good quality of oocyte. Specifically, the effects of Rosco exposure on nuclear and cytoplasmic maturation, diameter, intracellular glutathione (GSH) and reactive oxygen species (ROS), and embryonic development after parthenogenetic activation (PA) and somatic cell nuclear transfer (SCNT), and gene expression levels in SCNT embryos have been measured. Cumulus oocyte complexes (COCs) have been exposed in $75{\mu}M$ of Rosco for 22 and 44 h. The COCs that were matured in the IVM for 44 h without Rosco used as control group. Diameter of matured porcine oocytes 44 h culture with Rosco was significantly lower than 22 h culture with Rosco and control groups. GSH was higher in control group than 22 h and 44 h with Rosco but reduction of ROS in 22 h than 44 h with Rosco. In PA, exposure with Rosco 44 h oocytes group has been significantly lower than 22 h and control group in rates of maturation, cleavage and blastocyst formation. Similarly, in SCNT embryos rates of maturation, cleavage and formation of blastocyst have been also significantly lower in 44 h Rosco treated group than other two groups. SCNT embryos treated with Rosco 22 h showed greater expression levels of POU5F1, DPPA2 and NDP52Il mRNA compared with other two groups. Our results demonstrate that Rosco treatment with 22 h prior to IVM improves the development competence of porcine oocyte.

• Journal of Ecology and Environment
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• v.47 no.4
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• pp.241-249
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• 2023

Background: This study analyzed the drought responses of five forest tree species grown in Korean peninsula, Korean fir Abies koreana (Ak), eastern white pine Pinus strobus (Ps), keyaki Zelkova serrata (Zs), tulip tree Liriodendron tulipifera (Lt), and Japanese elm Ulmus japonica (Uj). Physiological (chlorophyll, root collar diameter [RCD]) and biochemical responses (non-structural carbohydrates, proline, lipid peroxidase and abscisic acid [ABA]) of the plants grown under mild (MD) and severe drought (SD) were compared. Results: In this study, three soil moisture regimes: control (100% precipitation), MD (60% reduction in precipitation) and SD (20% reduction in precipitation) were applied. Soil moisture content showed high water content in control site compared to MD and SD. A decline in RCD was found for Korean fir, keyaki, and tulip plants, with eastern white pine and Japanese elm showing no significant decline to the prolonged drought exposure (both MD and SD). Total chlorophyll showed a significant decline in Korean fir and tulip, with the sugar levels indicating a significant increase in Korean fir and keyaki species under SD compared to control plants. Non-significant decline in sugar level was noted for eastern white pine and Japanese elm. High accumulation of ABA, malondealdehyde and proline was noted in Korean fir, tulip, and keyaki under SD compared to control. Signs of tree mortality was only observed in Korean fir under MD (38%) and SD (43%). Conclusions: The observed findings indicate the drought responses of five tree species. The majority of the morpho-physiological (especially mortality) and biochemical variables assessed in our study indicate superior long-term drought resistance of Ps and Uj compared to the highly sensitive Ak, and moderately sensitive Lt and Zs. The results provided will help species selection for afforestation programs and establishment of sustainable forests, especially of drought-tolerant species, under increased frequency and intensity of spring and summer droughts.

• Korean Journal of Optics and Photonics
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• v.32 no.2
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• pp.49-54
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• 2021

In this paper, we design and construct the equipment to manufacture large-diameter optical fiber end caps, which are the core parts of high-power fiber lasers, and we fabricate large-diameter optical fiber end caps using the home-made equipment. This equipment consists of a CO2 laser as a fusion-splice heat source, a precision stage assembly for transferring the position of a large-diameter optical fiber and an end cap, and a vision system used for alignment when the fusion splice is interlocked with the stage assembly. The output of the laser source is interlocked with the stage assembly to control the output, and the equipment is manufactured to align the polarization axis of the large-diameter polarization-maintaining optical fiber with the vision system. Optical fiber end caps were manufactured by laser fusion splicing of a large-diameter polarization-maintaining optical fiber with a clad diameter of 400 ㎛ and an end cap of 10×5×2 ㎣ (W×D×H) using home-made equipment. Signal-light insertion loss, polarization extinction ratio, and beam quality M2 of the fabricated large-diameter optical fiber end caps were measured to be 0.6%, 16.7 dB, and 1.21, respectively.

• The Korean Journal of Nuclear Medicine
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• v.37 no.6
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• pp.393-401
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• 2003

Objective: Pullulan derivatives (PD) can be used to make self-assembled hydrogel nanoparticles which are responsive to ionic strength. The aim of this study is to evaluate the potential of PD as a retaining carrier of radioisotope inside tumors. Materials and Methods: Four types of PD were evaluated which included pullulan acetate (PA), succinylated PA (SPA), PA-DTPA and SPA-DTPA conjugates. They were radiolabeled with Tc-99m. Labelling efficiencies were determined at 30 min, 1, 2, 4 and 12 hours after radiolabeling. CT-25 colon cancer cells were subcutaneously injected into Balb/c mice. After 2 weeks of subcutaneous injection, Tc-99m-labelled PD (Tc-99m-PD) were injected into the tumors. Whole body images of mice were obtained at 30 min, 1, 2, and 12 hr after intratumoral injection. All twenty mice were grouped into four groups by largest diameter; control A (largest diameter = 5 mm, n = 5), control B (largest diameter = 10 mm, n = 5), pullulan A (largest diameter = 5 mm, n = 5), pllulan B (largest diameter = 10 mm, n = 5). Dynamic images were obtained for 1 hour after intratumoral injection. Static images were obtained at 1 hr, 2 hr, 3 hr and 4 hr after intratumoral injection with Tc-99m pertechnetate and Tc-99m-PA. Target-to-background ratios and retention rates were calculated. Results: Labeling efficiencies of PA, SPA, PA-DTPA and SPA-DTPA were $94.5{\pm}5.9%,\;97.8{\pm}3.5%\;94.2{\pm}3.8%,\;and\;92.5{\pm}6.2%$, respectively (p>0.05). Percent retention rates (%RR) of PA and PA-DTPA were significantly higher than those of control, however, those of SP-DTPA and SPA became similar to control at 4 and 12 hr, respectively. %RR of pullulan A and pullulan B at 1, 4 and 8 hr is significantly higher than that of control (p < 0.05). However, %RR between pullulan A and pullulan B were similar. Conclusion: The lonic strength dependent PD-nanoparticles are retained in the tumor. No difference of %RR according to tumor size was noted. Therapeutic application of PD labelled with beta- or alpha- emitting radionuclides can be expected.