• 동의신경정신과학회지
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• 제26권2호
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• pp.191-200
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• 2015

Objectives: We performed this study to certify the objectivity and significance of the Core Assessment Instrument Based on Chiljeong as a diagnostic measure in insomnia patients. Methods: We collected self-report questionnaires from inpatient and outpatient targets that had symptoms of insomnia. Descriptive statistics, Independent t-test, One-way repeated measure ANOVA and Pearson Correlation analysis were used for data analysis. Results: Bi and Kyeong emotion scores were higher but the Hui emotion score was lower for insomnia patients. Regarding the relationship between ISI score and the Core Assessment Instrument Based on Chiljeong, the more severe the insomnia, the higher the Sa and Kyeong emotion scores were, whereas the Hui emotion score was lower. Patients that were male, married, old, and had higher education showed a stronger correlation between Gyeong and ISI scores. Conclusions: Using the Core Assessment Instrument Based on Chiljeong for insomnia is thought to be helpful in both the diagnostic and clinical aspects of insomnia.

• 한국산림과학회지
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• 제94권5호통권162호
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• pp.307-312
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• 2005

This study aimed to develop an agroforestry technology through the participation of local people. The study was conducted in the Makiling Forest Reserve (MFR) of the University of the Philippines Los Banos (UPLB). Diagnosis and Design (D&D) methodology was employed to plan and implement effective research and development projects. Diagnostic interview and direct field observation were conducted to identify the significance of the land-use system and to understand how the system works. As a result of the diagnostic interview and direct field observation in San Vicente, old coconut-based land-use system is shifting to mahogany-based agroforestry system. One of the reasons is due to the very complicated socio-economic and silvicultural factors including lower price of coconut farm products, industry development, lack of labor force, and pest and diseases. Change in land use brought about by the shifting to mahogany-based farming system is slow. Also, mahogany trees are observed to be not well-maintained. However, mahogany based land use system gives farmers' a bigger income as well as environmental benefit. Farmer's cooperation and local forestry policy for CDM were proposed to encourage people's self-restoration effort.

• 대한핵의학회지
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• 제13권1_2호
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• pp.31-36
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• 1979

The TRH stimulation test was known as a highly diagnostic method in hypothalamopituitary disorders. To evaluate the location and the extension of the lesion, we estimated TSH response to TRH test in 27 patients. Correlation between volume of sella and TSH response was also studied. The results obtained were as follows: 1. In Sheehan's syndrome, TSH response after TRH test were not observed in all of 12 patients. 2. All 2 acromegaly patients showed normal TSH response. 3. In 4 cases of chromophobe adenoma, 2 cases showed no TSH response. In 2 responded cases, one patient whose tumor mass extended to suprasella region was hypothyroid state. 4. In craniopharyingioma 3 cases, the tumor which extended to intrasella showed hypothyroid and no TSH response. 5. Correlation between volume of sella and TSH response were valuable in 2 cases, but no diagnostic significance. 6. In diabetes inspidus, TSH response were all absent. 7. In primary amenorrhea, TSH response observed in 1 case, which conformed with isolated FSH deficiency.

• 사상체질의학회지
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• 제35권3호
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• pp.12-28
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• 2023

Introduction This study reports case series of Soyangin patients with coldness in hands and feet using Sasang constitutional medicine approach. This study suggests a value of using constitutional medicine indicators as both prognostic and diagnostic tools. Methods Among patients who visited an outpatient clinic, 7 patients were selected based on the criteria. These selected patients were exclusively treated with herbal medicine and monitored every 2 to 4 weeks retrospectively. Results The average treatment period was 8 weeks. Patients with a favorable pattern showed the improvement within 8 weeks, while those with an unfavorable pattern required more time. Discussion This study confirms the significance of Sasang constitutional medicine approach in Soyangin exterior cold syndrome with coldness in hands and feet. It also validates the current coldness in hands and feet as meaningful diagnostic indicator of Soyangin exterior cold syndrome. Furthermore, it highlights the value of original symptoms as prognostic tools.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7575-7581
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• 2014

MicroRNAs (miRNAs) play an essential role in the development and progression of nasopharyngeal carcinomas (NPC). Despite advances in the field of cancer molecular biology and biomarker discovery, the development of clinically validated biomarkers for primary NPC has remained elusive. In this study, we investigated the expression and clinical significance of miRNAs as novel primary NPC diagnostic biomarkers. We used an array containing 2, 500 miRNAs to identify 22 significant miRNAs, and these candidate miRNAs were validated using 67 fresh NPC and 25 normal control tissues via quantitative real-time PCR (qRT-PCR). Expression and correlation analyses were performed with various statistical approaches, in addition to logistic regression and receiver operating characteristic curve analyses to evaluate diagnostic efficacy. qRT-PCR revealed five differentially expressed miRNAs (miR-93-5p, miR-135b-5p, miR-205-5p and miR-183-5p) in NPC tissue samples relative to control samples (p<0.05), with miR-135b-5p and miR-205-5p being of significant diagnostic value (p<0.01). Moreover, comparison of NPC patient clinicopathologic data revealed a negative correlation between miR-93-5p and miR-183-5p expression levels and lymph node status (p<0.05). These findings display an altered expression of many miRNAs in NPC tissues, thus providing information pertinent to pathophysiological and diagnostic research. Ultimately, miR-135b-5p and miR-205-5p may be implicated as novel NPC candidate biomarkers, while miR-93-5p, miR-650 and miR-183-5p may find application as relevant clinical pathology and diagnostic candidate biomarkers.

• 대한세포병리학회지
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• 제19권2호
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• pp.111-118
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• 2008

Background : Cervicovaginal cytology is a screening test of uterine cervical cancer. The sensitivity of cervicovaginal cytology is less than 50%, but studies of cytologic/histologic correlation are limited. We analyzed the diagnostic accuracy of cervicovaginal cytology in the detection of the squamous epithelial lesions of the uterine cervix and investigate the cause of diagnostic discordance. Materials and Methods : We collected a total of 481 sets of cervicovaginal cytology and biopsies over 5 years. The cytologic diagnoses were categorized based on The Bethesda System and the histologic diagnoses were classified as negative, flat condyloma, cervical intraepithelial neoplasia (CIN) I, CIN II, CIN III, or squamous cell carcinoma. Cytohistologic discrepancies were reviewed. Results: The concordance rate between the cytological and the histological diagnosis was 79.0%. The sensitivity and specificity of cervicovaginal cytology were 80.6% and 92.6%, respectively. Its positive predictive value and negative predictive value were 93.7% and 77.7%, respectively. The false negative rate was 19.4%. Among 54 false negative cytology cases, they were confirmed by histology as 50 flat condylomas, 2 CIN I, 1 CIN III, and 1 squamous cell carcinoma. The causes of false negative cytology were sampling errors in 75.6% and interpretation errors in 24.4%. The false positive rate was 7.4%. Among 15 false positive cytology cases, they were confirmed by histology as 12 atypical squamous cells of undetermined significance (ASCUS) and 3 low grade squamous intraepithelial lesions (LSIL). The cause of error was interpretation error in all cases. The overall diagnostic accuracy of cervicovaginal cytology was 85.7%. Conclusions : Cervicovaginal cytology shows high overall diagnostic accuracy and is a useful primary screen of uterine cervical cancer.

• 대한영상의학회지
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• 제82권6호
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• pp.1545-1555
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• 2021

목적 동료평가를 시행하여 원격판독 불일치의 정도와 불일치 판독의 임상적 의의를 세부전공분야와 촬영장비별로 평가하고자 하였다. 대상과 방법 한 국내 원격판독 의료기관에서 2018년과 2019년에 시행한 동료평가를 대상으로 세부전공분야와 촬영장비별로 판독 불일치를 분석하였다. 동료평가 점수를 적격 진단과 부적격 진단으로 분류하였고, 판독 불일치는 임상적 의의에 따라 무의한 불일치와 유의한 불일치로 분류하였다. 카이제곱 검증으로 통계를 시행하였다. 결과 총 1312건의 동료평가 중 부적격 진단은 117건(8.9%)이고, 총 462건의 진단 불일치 중 유의한 불일치는 104건(21.6%)이었다. 세부전공분야에서 부적격 진단율은 근골격(21.4%)이 가장 높았고(각각 p < 0.05), 복부(7.3%)는 신경두경부(1.3%)에 비해 높았다(p < 0.05). 유의한 불일치는 흉부(32.7%)가 복부(17.1%)와 근골격(19.5%)에 비해 높았다(각각 p < 0.05). 촬영장비에서 부적격 진단은 MR (16.2%)이 일반촬영(7.8%)에 비해 높았고(p < 0.05), 유의한 불일치는 차이가 없었다. 결론 동료평가를 통해서 원격판독의 부적격 진단과 임상적 유의한 불일치의 정도, 세부전공분야와 촬영장비에 따른 차이를 알 수 있었다.

• 동의생리병리학회지
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• 제16권5호
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• pp.873-880
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• 2002

We study on the significance and application of the whole body form diagnosis. The results were as follows; The general form diagnosis is the method to observe the individual physiology and pathology. The phase of thinking, the current and activity of KI, the pattern of general form diagnosis have organic relations with the symptoms. The general form diagnosis is made up the principle of the imaging phase, therefore it must make synthetic union the differentiation of syndromes. The general form diagnosis of NAE GYEONG shows the typical phases and it is divided with the sight of YIN YANG and Five-Element. The general form diagnosis of SEOP GAE is practiced the theory of constitution's demonstration before the understanding of symptoms. Then JANG NAM tried the type of constitution's demonstration. The general form diagnosis of DONG MU becomes the diagnostic root of constitution's demonstration in four type constitution theory.

• 대한세포병리학회지
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• 제4권2호
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• pp.93-99
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• 1993

The cytologic detection of endometrial carcinoma in Papanicolaou(Pap) smear according to histologic type, grade and stage was studied in 49 patients. The smears of patients who had histologically confirmed were retrospectively evaluated by the Bethesda System. The cytologic diagnosis of endometrial carcinoma was made in 61% (39/49) of patients, atypical glandular cells of undetermined significance (AGCUS) in 16% (8/49) and within normal limits in 23% (11/49). The positive rate for AGCUS and carcinoma was correlated to the histologic type, grade and stage. The cytologic grade revealed a good correlation with histologic grade, too. In conclusion, the presence of cancer cells in Pap smear suggests the tumor in high grade and high stage. Additionally, cytologic detection of AGCUS or carcinoma needs a further diagnostic evaluation. The Pap smear is a valuable method to screen for endometrial carcinoma.

• 대한핵의학회지
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• 제19권2호
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• pp.57-63
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• 1985

To evaluate the clinical significance of lung ventilation scan using $^{99m}Tc-DTPA$ in patient with bronchiectasis, we compared the involovement area of bronchogram and lung ventilation scan according to lobar and segmental distribution. There were no correlation between impairment of pulmonary function test and the number of bronchiectatic lobe and segment(p>0.5). Lung ventilation scan showed 66.7% of sensivity, 100% of specificity, ana 91.7% of accuracy according to lobar distribution, and 51.9% of sensivity, 96.9% of specificity, and 88.9% of accuracy according to segmental distribution. These results suggest that lung ventilation scan can be used as diagnostic tool in patient with bronchiectasis in whom bronchogram is not tolerable.