• 한국임상수의학회지
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• 제27권4호
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• pp.421-426
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• 2010

In view of free from bluetongue (BT) in the domestic cattle population in Korea, the key of quarantine testing for BT virus (BTV) infection is detection of cattle previously exposed to the virus. The objective of this study was to estimate the probability of detecting a cattle infected with BTV using a stochastic modeling analysis of existing quarantine testing data. Three testing scenarios were considered in this study: serological testing of all animals in all imported lots (scenario 1), serological testing of a sample of cattle from all imported lots (scenario 2), and serological testing of 50% of imported lots (scenario 3). In scenario 2 and 3, it was assumed that cattle were sampled (sample size) within each lot to detect 5% of the cattle in each lot with a 95% confidence, taking into account diagnostic sensitivity of the ELISA (enzyme-linked immunosorbent assay). The model output was the total number of BTV-infected cattle and the prevalence of BTV infection in imported cattle from the US, Australia, Canada and Japan. Compared to the scenario 1, the probability of detecting a BTV-infected cattle was estimated to be 19% and 1.6% in scenario 2 and 3, respectively. Furthermore, the analyses showed a 95% confidence that BTV prevalence was less or equal to $9.7{\times}10^{-4}$ (median = $1.5{\times}10^{-5}$), indicating that, for the scenario 2 and 3 with serological testing for a sample of cattle, the risk of introducing an exotic strain of BTV into Korea through the importation of live cattle would not be acceptable.

• 대한안전경영과학회지
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• 제16권4호
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• pp.427-431
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• 2014

The purpose of this study is to monitor the current adverse reactions in administering CT contrast agents at general hospitals and also to suggest the practical guidelines to minimize the risk and to show the successful patient management. At four Dajeon city general hospitals, the contrast agents were administered in 646,828 cases and the overall prevalence of adverse reactions was 4,110 cases from January 2010 to December 2013. However, we excluded the two hospitals' 3,658 cases because the patients' data was inadequate. Consequently, the case surveys on the rest of 452 cases have been studied and submitted. After comparing the patients with a control group, we evaluated that the key factors of the adverse reactions were the gender and age difference of the patients, the examination period, the examination method, the quantity and administrating speed of the contrast agents. Even though the four general hospitals have their own management systems on adverse reactions, but their systems were not satisfying. To improve the quality of the management systems and to investigate further cases, some hospital administration procedures on the subject should be systemized and general hospitals should follow the recommended procedures. Moreover, the existing three-year-term evaluation should not only judge the adverse reaction management but also conclude some details on the sub criteria of the evaluation. The details on the sub criteria include the contrast agent characters, the quantity and administrating speed of the drug, the incidents' occurred time, an anamnesis; a case history, the medical history of the patients and the reaction occurring body parts, and the examination title. The details of the medical examiners are also added to the sub criteria.

• 한국철도학회논문집
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• 제20권2호
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• pp.210-222
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• 2017

철도의 분기기 시스템은 철도에서 가장 중요한 시스템 중 하나로서, 차량의 진로를 설정한다. 분기기 시스템은 철도에서 가장 취약한 시스템 중 하나이며, 건전성을 유지하기 위해서 지속적인 관리가 필요하다. 분기기 진단 시스템은 분기기의 열화 상태를 자동적으로 측정할 수 있다. 분기기 시스템을 진단하기 위해서, 기존의 분기기 점검절차와 분기기에서 나타나는 물리적 특성을 규명하였다. 도출된 측정항목을 이용하여, 적절한 센서들을 선정하고, 영업노선에 설치하여, 데이터를 수집하였다. 본 논문에서는 분기기와 같이 열악한 환경에서 센서의 강건성과 데이터 획득에 대한 잡음 간섭 여부를 판단하였다.

• 한국콘텐츠학회논문지
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• 제18권6호
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• pp.102-112
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• 2018

본 연구는 우리나라 에너지 절감 기술 개발이 절실히 요구되어지고 있으며 에너지 효율성 개선을 통해 환경부하를 최소화하여 경제적 원/부자재 절감으로 이어질 수 있도록 지역 중소기업의 핵심 신기술을 배경으로 외관디자인개발을 진행하고 기술에 대하여 특허 범위를 확대 강화하고 디자인권리를 확보함으로써 경쟁사의 침해를 피해 강소기업 설장의 발판이 되는 개발연구이다. 유형의 제품과 무형의 기술을 통합한 기술-디자인융합을 통해 기업에 대한 진단 분석을 진행하고 핵심기술에 대한 분석 평가를 진행하여 권리범위를 진단하고 디자인개발을 통해 신기술에 대한 권리범위와 디자인권리를 확대 및 권리침해를 예방하고 디자인 개발 이후 기업의 기술성장에 대한 분석에 그 목적이 있다. 기술-디자인융합을 통해 핵심기술에 대한 권리범위를 넓히고 기업의 제품을 디자인 개발하여 기업의 가치를 높이고 기업 핵심기술과 디자인에 대한 개발로 권리를 강화하고 역량기업으로 성장할 수 있도록 진행하고자 한다.

• BMB Reports
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• 제40권1호
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• pp.15-21
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• 2007

Breast cancer is the most common malignancy among women, and mutations in the BRCA1 gene produce increased susceptibility to these malignancies in certain families. In this study, the forward 1-13 exons of breast cancer associated gene BRCA1 were cloned from breast cancer cell line ZR-75-30 by RT-PCR method. Sequence analysis showed that nine BRCA1 splice forms were isolated and characterized, compared with wild-type BRCA1 gene, five splice forms of which were novel. These splice isoforms were produced from the molecular mechanism of 5' and 3' alternative splicing. All these splice forms deleting exon 11b and the locations of alternative splicing were focused on two parts:one was exons 2 and 3, and the other was exons 9 and 10. These splice forms accorded with GT-AG rule. Most these BRCA1 splice variants still kept the original reading frame. Western blot analysis indicated that some BRCA1 splice variants were expressed in ZR-75-30 cell line at the protein level. In addition, we confirmed the presence of these new transcripts of BRCA1 gene in MDA-MB-435S, K562, Hela, HLA, HIC, H9, Jurkat and human fetus samples by RT-PCR analysis. These results suggested that breast cancer associated gene BRCA1 may have unexpectedly a large number of splice variants. We hypothesized that alternative splicing of BRCA1 possibly plays a major role in the tumorigenesis of breast and/or ovarian cancer. Thus, the identification of cancer-specific splice forms will provide a novel source for the discovery of diagnostic or prognostic biomarkers and tumor antigens suitable as targets for therapeutic intervention.

• 식물분류학회지
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• 제40권1호
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• pp.27-42
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• 2010

본 연구는 한국산 쑥속 23분류군에 대하여 두상화서의 세부 형질을 조사하여 분류학적 중요도를 파악하고자 하였다. 쑥속의 속내 분류에 있어서 전통적인 아속의 구분형질인 중앙화의 임성 여부에 의해 중앙화가 불임성인 Dracunculus아속과 중앙화가 임성인 Artemisia아속으로 구분되었다. Artemisia아속 내에서 절을 구분하는 형질로 알려진 화탁의 털 유무는 화탁에 털이 밀생하거나, 성기게 나는 Absinthium절과 화탁에 털이 없는 Abrotanum절, Artemisia절과 구분되었다. 그러나 Abrotanum절의 큰비쑥(A. fukudo), 더위지기(A. sacrorum)와 Artemisia절의 외잎쑥(A. viridissima)에서 성기게 털이 있는 화탁이 관찰됨으로, 절의 식별형질로서 인정되는 무모성 화탁의 가치는 재검토되어야 할 것으로 판단되었다. 이외에 관찰된 형질 중 두상화서의 전체 형태와 크기, 주두정단의 특징, 포편의 털, 중앙화와 주변화 화관의 형태 등은 종의 식별로서 가치가 있는 것으로 판단된다.

• IMMUNE NETWORK
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• 제14권3호
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• pp.138-148
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• 2014

MicroRNAs (miRNAs) are endogenous small RNA molecules best known for their function in post-transcriptional gene regulation. Immunologically, miRNA regulates the differentiation and function of immune cells and its malfunction contributes to the development of various autoimmune diseases including systemic lupus erythematosus (SLE). Over the last decade, accumulating researches provide evidence for the connection between dysregulated miRNA network and autoimmunity. Interruption of miRNA biogenesis machinery contributes to the abnormal T and B cell development and particularly a reduced suppressive function of regulatory T cells, leading to systemic autoimmune diseases. Additionally, multiple factors under autoimmune conditions interfere with miRNA generation via key miRNA processing enzymes, thus further skewing the miRNA expression profile. Indeed, several independent miRNA profiling studies reported significant differences between SLE patients and healthy controls. Despite the lack of a consistent expression pattern on individual dysregulated miRNAs in SLE among these studies, the aberrant expression of distinct groups of miRNAs causes overlapping functional outcomes including perturbed type I interferon signalling cascade, DNA hypomethylation and hyperactivation of T and B cells. The impact of specific miRNA-mediated regulation on function of major immune cells in lupus is also discussed. Although research on the clinical application of miRNAs is still immature, through an integrated approach with advances in next generation sequencing, novel tools in bioinformatics database analysis and new in vitro and in vivo models for functional evaluation, the diagnostic and therapeutic potentials of miRNAs may bring to fruition in the future.

• 한국환경과학회지
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• 제7권2호
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• pp.223-232
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• 1998

득량만의 조석주기에 따른 성층특성을 연구하기 위하여 우선 30여개 관측점에서 관측된 수온, 염분, 밀도, 해류, 열수지, 바람, 밀도류 자료를 조사하였다. 이 관측자료를 토대로 성층현상을 규명할 수 있는 해석적 모델을 개발하였으며 이 해석적모델을 이용하여 얻어진 연구결과에 따르면, 득량만의 성층을 이루는 요인은 조석, 태양열, 밀도,류인 것으로 나타났으며, 성층을 파과할 수 있는 조석에너지의 혼합에너지의 에너지 기여율 $\varepsilon$ 은 약 0.020 - 0.021정도 되는 것으로 나타났다.

• 식물분류학회지
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• 제35권1호
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• pp.25-46
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• 2005

한국산 Platanthera(제비난초속)를 외부형태학적 특징, 특히 꽃의 구조를 바탕으로 검토하였다. Platanthera와 순판 기부 양쪽의 돌출 부분 유무로 구분하던 Tulotis는 그 형질이 뚜렷하지 않아 Platanthera로 통합하는 견해를 지지하였다. 분류학적 처리에서, 현재까지 우리나라 대부분의 문헌에서 P. metabifolia라고 기재한 제비난초는 P. chlorantha의 오동정임이 확인되었으며, 아울러 P. neglecta(하늘산제비란)는 P. mandarinorum(산제비란)과 별개의 종으로 처리하는 것이 타당한 것으로 나타났다. 한국산 제비난초속 식물을 P. chlorantha(제비난초), P. mandarinorum(산제비란), P. neglecta(하늘산제비란), P. hologlottis(흰제비란), P. japonica(갈매기난초), P. ophrydioides(구름제비란), P. ussuriensis(제비잠자리란), P. fuscescens(나도잠자리란)의 8종으로 정리하였으며, 동시에 한국산 제비난초속의 검색표를 작성하였고 이들의 분류학적 문제점을 논의하였다.

• 대한한방소아과학회지
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• 제35권4호
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• pp.112-124
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• 2021

Objectives The aim of this study is to examine the effects of Pediatric Tuina Massage (PTM) as a treatment of Chlidren's Epilepsy (CE) and to seek guidance for future follow-up studies and the use of Pediatric Tuina Massage (PTM) in clinical setting. Methods The articles were obtained from the China National Knowledge Infrastructure (CNKI) from 2000 to 2021 by key words 'epilepsy', '癲癎', '癲癎病', 'infantile spasm', '婴幼儿痉挛', '小儿发作', '婴幼儿痉挛' and '推拿', '按摩', 'Tuina', 'Chuna', 'massage' in cross combination way. Results Seven articles were selected and analyzed by authors, years published, characteristics, diagnostic criteria, treatment methods and contents, treatment periods, evaluation criteria and research results. Also, stability and side effects were reviewed, and the qualities of the randomized controlled trials (RCT) were evaluated according to Risks of Bias 2 (RoB 2). All studies using Pediatric Tuina Massage (PTM) treatment have achieved effective therapeutic results for treating Children's epilepsy (CE). Conclusion Pediatric Tuina Massage (PTM) is economical, safe without side effects and non-invasive, but still produce a good effect. Also, it is a good treatment option for children who feels anxious of ordinary Korean Medical treatment such as acupuncture, moxa, herbal medicine, which also results in good compliance with the treatment. In addition, it is possible to enhance therapeutic effect by combining it with pharmacological therapies in treating children's epilepsy (CE). Therefore, Pediatric Tuina Massage (PTM) provides an essential clinical basis in guiding further studies for the treatment of CE.