• Childhood Kidney Diseases
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• v.27 no.1
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• pp.11-18
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• 2023

Remarkable advances in genetic diagnosis expanded our knowledge about inherited tubulopathies and other genetic kidney diseases. This review suggests a simple categorization of inherited tubular disease, clarifies the concept of autosomal dominant tubulointerstitial kidney disease (ADTKD), and introduces novel therapies developed for tubulopathies. Facing patients with suspicious tubular disorders, clinicians should first evaluate the status of volume and acid-base. This step helps the clinicians to localize the affected segment and to confirm genetic diagnosis. ADTKD is a recently characterized disease entity involving tubules. The known causative genes are UMOD, MUC1, REN, and HNF1β. Still, only half of ADTKD patients show mutations for these four identified genes. Whole exome sequencing is a suitable diagnostic tool for tubulopathies, especially for ADTKD. Genetic approaches to treat tubulopathies have progressed recently. Despite the practical obstacles, novel therapies targeting inherited tubulopathies are currently in development.

• Journal of Korean Medical classics
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• v.36 no.4
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• pp.41-54
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• 2023

Objectives : To examine Korean Medical treatment of abnormal uterine bleeding in classical texts, along with their clinical applicability. Methods : The Benglou chapters in the Donguibogam, Fuqingzhunuke, Xuezhenglun were examined in terms of diagnostic pattern and treatment. Benglou chapters of other medical texts were referenced as well. Basic Korean Medical knowledge of abnormal uterine bleeding and its clinical application were studied. Results : As abnormal uterine bleeding is generally caused by internal damage or deficiency from excessive labor, sexual activity, food, emotional stress, specific causes for each individual should be considered when approaching each case. Conclusions : Korean Medical treatment allows for a tailored approach to each pathology according to age and duration of illness, and has strength in dealing with various situations such as emergency situations, excessive bleeding, blood stagnation. As such, application of Korean Medicine in abnormal uterine bleeding is highly appropriate.

• International Journal of Advanced Culture Technology
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• v.12 no.2
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• pp.90-97
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• 2024

Shoulder impingement syndrome (SIS) is a common musculoskeletal condition characterized by pain and functional limitation due to the impingement of subacromial structures. This comprehensive review elucidates the complex nature of SIS, covering its pathophysiology, diagnostic methodologies, treatment options, and preventive measures. Through an exhaustive examination of current literature and clinical practices, the review highlights the importance of a multifaceted approach to SIS management. Physical therapy plays a pivotal role, focusing on exercises to strengthen shoulder musculature, enhance scapular stability, and improve range of motion. The review also discusses the strategic use of medications such as NSAIDs and corticosteroid injections, emphasizing their effectiveness in pain and inflammation management. Additionally, it advocates for structured rehabilitation programs post-treatment to restore function and prevent recurrence, recommending preventive strategies like ergonomic adjustments, targeted exercises, and proper technique training. This paper underscores the need for personalized and evidence-based treatment strategies, integrating physical therapy and pharmacological management when necessary.

• Korean Journal of Radiology
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• v.21 no.8
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• pp.955-966
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• 2020

Ultrasound (US) is an attractive diagnostic approach to identify both common and uncommon nipple pathologies, such as duct ectasia, nipple abscess, nipple leiomyoma, nipple adenoma, fibroepithelial polyp, ductal carcinoma in situ (restricted to nipple), invasive carcinoma, and Paget's disease. US is the reliable first-line imaging technique to assess nipple pathologies. It is useful to identify and characterize nipple lesions. Additionally, we have presented the mammography and MRI outcomes correlated with histopathologic features for the relevant cases.

• Journal of Trauma and Injury
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• v.37 no.3
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• pp.171-181
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• 2024

Renal injuries commonly occur in association with blunt trauma, especially in the setting of motor vehicle accidents. Contrast-enhanced computed tomography is considered the gold-standard imaging modality to assess patients for renal injuries in the setting of blunt and penetrating trauma, and to help classify injuries based on the American Association for the Surgery of Trauma injury scoring scale. The management of renal trauma has evolved in the past several decades, with a notable shift towards a more conservative, nonoperative approach. Advancements in imaging and interventional radiological techniques have enabled diagnostic angiography with angiographic catheter-directed embolization to become a viable option, making it possible to avoid surgical interventions that pose an increased risk of nephrectomy. This review describes the current management of renal trauma, with an emphasis on renal artery embolization techniques.

• The Korean Journal of Medicine
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• v.99 no.4
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• pp.206-209
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• 2024

Narrow QRS tachycardia is a common clinical condition characterized by a heart rate exceeding 100 beats per minute and a QRS complex duration of less than 120 ms. This article provides an overview of the diagnostic approach to narrow QRS tachycardia, focusing on the differentiation between various supraventricular tachycardias, such as atrioventricular nodal reentrant tachycardia (AVNRT), atrioventricular reentrant tachycardia (AVRT), atrial tachycardia (AT), and sinus tachycardia. The discussion includes an analysis of the presenting symptoms, electrocardiographic (ECG) findings, and the use of vagal maneuvers and pharmacological agents in diagnosis.

• Microbiology and Biotechnology Letters
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• v.52 no.3
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• pp.221-232
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• 2024

Zoonotic diseases are rare but the transmission of disease to humans may cause serious illness. Nipah virus (NiV) is a bat-borne zoonotic pathogen, which can cause severe encephalitis and respiratory distress. The transmission of Nipah virus from bats to humans was first reported in Malaysia in 1998. Different strains of NiV show different epidemiological and clinical features. Few of the strains are highly lethal and can spread to the community resulting in a global threat. However, the availability of effective management or prophylactic measures are only limited. Thus, it is essential to contain such outbreaks by implementing proper infection control and surveillance measures. Many serological and molecular diagnostic techniques have been developed for diagnosis of this infection. This review mainly focuses on the epidemiology, transmission of Nipah virus, pathogenesis and management of NiV infection. The review also throws light on the immune response of NiV in humans and the role of One Health approach in prevention and control of NiV infection.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.32 no.3
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• pp.51-57
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• 2004

An intelligent performance diagnostic computer program of a gas turbine using the NN(Neural Network) was developed. Recently on-condition performance monitoring of major gas path components using the GPA(Gas Path Analysis) method has been performed in analyzing of engine faults. However because the types and severities of engine faults are various and complex, it is not easy that all fault conditions of the engine would be monitored only by the GPA approach Therefore in order to solve this problem, application of using the NNs for learning and diagnosis would be required. Among then, a BPN (Back Propagation Neural Network) with one hidden layer, which can use an updating learning rate, was proposed for diagnostics of PT6A-62 turboprop engine in this work.

• Imaging Science in Dentistry
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• v.43 no.3
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• pp.153-161
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• 2013

Purpose: To prevent low bone mineral density (BMD), that is, osteoporosis, in postmenopausal women, it is essential to diagnose osteoporosis more precisely. This study presented an automatic approach utilizing a histogram-based automatic clustering (HAC) algorithm with a support vector machine (SVM) to analyse dental panoramic radiographs (DPRs) and thus improve diagnostic accuracy by identifying postmenopausal women with low BMD or osteoporosis. Materials and Methods: We integrated our newly-proposed histogram-based automatic clustering (HAC) algorithm with our previously-designed computer-aided diagnosis system. The extracted moment-based features (mean, variance, skewness, and kurtosis) of the mandibular cortical width for the radial basis function (RBF) SVM classifier were employed. We also compared the diagnostic efficacy of the SVM model with the back propagation (BP) neural network model. In this study, DPRs and BMD measurements of 100 postmenopausal women patients (aged >50 years), with no previous record of osteoporosis, were randomly selected for inclusion. Results: The accuracy, sensitivity, and specificity of the BMD measurements using our HAC-SVM model to identify women with low BMD were 93.0% (88.0%-98.0%), 95.8% (91.9%-99.7%) and 86.6% (79.9%-93.3%), respectively, at the lumbar spine; and 89.0% (82.9%-95.1%), 96.0% (92.2%-99.8%) and 84.0% (76.8%-91.2%), respectively, at the femoral neck. Conclusion: Our experimental results predict that the proposed HAC-SVM model combination applied on DPRs could be useful to assist dentists in early diagnosis and help to reduce the morbidity and mortality associated with low BMD and osteoporosis.

• The Korean Journal of Nuclear Medicine
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• v.35 no.3
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• pp.117-124
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• 2001

Serum thyroglobulin measurement and I-131 whole-body scintigraphy (WBS) are well-established methods for the detection of recurrence in the follow-up of patients with thyroid carcinoma. However, inconsistent results are observed frequently, and these two methods are not always able to detect recurrence. In some patients, serum thyroglobulin level is elevated but the WBS is negative, because the recurrent tumor is too small and below the sensitivity of the diagnostic scan, or there is a dissociation between thyroglobulin synthesis and the iodine frapping mechanism. In such cases, various nuclear imaging methods including Tl-201 Tc-99m-sestamibi, and F-18-FDG PET can be used besides anatomical imaging methods. Among them, FDG PET localizes recurrent lesions in WBS-negative thyroid carcinoma with high accuracy. Several studies have suggested that empirical high-dose I-131 therapy resulted in a high rate of visualization in post-therapy scans with evidence of subsequent improvement. An important question is when to operate on patients with recurrent tumor. We believe that surgical removal is the best means of treatment for patients with localized persistent tumor, despite the high-dose I-131 therapy. with tumor in thyroid remnant, and with isolated recurrence in the lymph node, lung or bone. In addition, we recommend palliative resection of locally unresectable mass with subsequent treatment with high-dose I-131 therapy. Before I-131 therapy, the evaluation of sodium-iodide symporter expression in thyroid carcinoma can predict iodine uptake. Retinoic acid is known to induce redifferentiation, and to enhance I-131 uptake in thyroid carcinoma. Retinoic acid therapy may represent an alternative approach before high-dose I-131 therapy.