• Journal of Periodontal and Implant Science
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• v.45 no.1
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• pp.14-22
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• 2015

Purpose: The purpose of this study was to compare serum amyloid A (SAA) protein levels with high-sensitive C-reactive protein (hs-CRP) levels as markers of systemic inflammation in patients with chronic periodontitis. The association of serum titers of antibodies to periodontal microbiota and SAA/hs-CRP levels in periodontitis patients was also studied. Methods: A total of 110 individuals were included in this study. Patients were assessed for levels of hs-CRP and SAA. Nonfasting blood samples were collected from participants at the time of clinical examination. The diagnosis of adipose tissue disorders was made according to previously defined criteria. To determine SAA levels, a sandwich enzyme-linked immunosorbent assay was utilized. Paper points were transferred to a sterile tube to obtain a pool of samples for polymerase chain reaction processing and the identification of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Tannerella forsythia. The serum level of IgG1 and IgG2 antibodies to P. gingivalis, A. actinomycetemcomitans, and T. forsythia was also determined. Results: SAA and hs-CRP levels were higher in periodontitis patients than in controls (P<0.05). In bivariate analysis, high levels of hs-CRP (>3 mg/L) and SAA (>10 mg/L) were significantly associated with chronic periodontitis (P=0.004). The Spearman correlation analysis between acute-phase proteins showed that SAA positively correlated with hs-CRP (r=0.218, P=0.02). In the adjusted model, chronic periodontitis was associated with high levels of SAA (odds ratio [OR], 5.5; 95% confidence interval [CI], 1.6-18.2; P=0.005) and elevated hs-CRP levels (OR, 6.1, 95% CI, 1.6-23.6; P=0.008). Increased levels of serum IgG2 antibodies to P. gingivalis were associated with high levels of SAA (OR, 3.6; 95% CI, 1.4-8.5; P=0.005) and high concentrations of hs-CRP (OR, 4.3; 95% CI, 1.9-9.8; P<0.001). Conclusions: SAA and hs-CRP concentrations in patients with chronic periodontitis are comparably elevated. High serum titers of antibodies to P. gingivalis and the presence of periodontal disease are independently related to high SAA and hs-CRP levels.

• Journal of Radiation Protection and Research
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• v.42 no.3
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• pp.146-153
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• 2017

Background: Acute radiation syndrome (ARS) primarily refers to damage to the hematopoietic system, myeloid system, and gastrointestinal (GI) system caused by radiation exposure. Such damage progresses to become life-threatening. In particular, as the syndrome develops very rapidly-within several hours from radiation exposure-prompt and accurate diagnosis and treatment are needed, as is further research into appropriate diagnostic and treatment modalities. Materials and Methods: Minipigs, which display human-like properties, underwent whole-body irradiation at 2 or 4 Gy (doses causing hematopoietic ARS) or at higher doses of 7 or 12 Gy. Changes in the blood cells and clinical symptoms were analyzed and we performed a necropsy when the animals succumbed to ARS. Results and Discussion: The minipig irradiated with 2 Gy showed a decrease in white blood cells, including neutrophils, lymphocytes, and platelets in the early stages. However, the blood cell counts gradually increased and returned to normal values. The minipig irradiated with 4 Gy succumbed due to hematopoietic ARS. In contrast, the minipigs irradiated with 7 or 12 Gy exhibited clinical symptoms of combined GI damage and hematopoietic syndrome. Moreover, a characteristic pattern of platelet changes was observed in the 7 and 12 Gy irradiated minipigs. Conclusion: The changes in the platelet count caused by radiation exposure observed in minipigs, which are hematologically and pathohistologically similar to humans, suggest that they can be used as a novel diagnostic criterion.

• The Transactions of the Korean Institute of Power Electronics
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• v.25 no.5
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• pp.376-384
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• 2020

An energy storage system is composed of lithium-ion batteries in modern applications. Batteries are regarded as storage devices for renewable and residual energy. The failure of batteries can cause the performance reduction and explosion of battery systems. High maintenance cost is essential when dealing with the problem of battery safety. Therefore an accurate health diagnosis is required to ensure the high reliability of battery systems. A battery pack is a combination of single cells in series and parallel connections. A battery pack has to consider various factors to assess battery health. Battery health involves conventional factors and additional factors, such as cell-to-cell imbalance. For large applications, state-of-health (SOH) can be inaccurate because of the lack of factors that indicate the state of the battery pack. In this study, six characterization factors are proposed for improving the SOH estimation of battery packs. The six proposed characterization factors can be regarded as health indicators (HIs). The six HIs are applied to the principal component analysis (PCA) algorithm. To reflect information regarding capacity, voltage, and temperature, the PCA algorithm extracts new degradation factors by using the six HIs. The new degradation factors are applied to a multiple regression model. Results show the advancement and improvement of SOH estimation.

• Journal of Korean Clinical Health Science
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• v.7 no.2
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• pp.1337-1344
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• 2019

Purpose. This study was the analyze the refractive status of presbyopia in Korea. Methods. The subjects was from November 2018 to October 2019, two hundred thirty four subjects( 117 male subjects, 117 female subjects; from 40-year old to 88-year old ) were performed in refraction test using the Auto-Refraction(Speed -K model, Japan). The myopia, hyperopia, astigmatism, and anisometropia were defined as spherical equivalent(SE)≤-0.50 diopters, SE ≥+1.00 D, cylinder error ≥0.75 D and SE difference≥1.00 D between binocular eyes, respectively. Results. The refractive status by spherical equivalent among all subjects was myopia 61.43%, astigmatism 86.86%, emmetropia 19.18%, anisometropia 12.07%, and hyperopia 18.54. The prevalence of myopia and astigmatism were much more common in male. However, The hyperopia and astigmatism were much more common in female. The prevalence of spherical equivalent was much common from -0.50 diopter to -5.00 diopter. On the other hand, the prevalence of astigmatism and myopia was much more than hyperopia in all subjects. There was a statistical significance between OD and OS of the female and male in the spherical equivalent power(p<.000). However, there was not statical significant between female and male of OD and OS in the spherical equivalent power(p<.070). On the other hand, The prevalence of againest axis in astigmatism was more common in all subjects. In ADD power for the near vision correction, the female was much more diopter than male. Conclusions. These results suggested that the analysis of the refractive status on the presbyopia in Korea can give the useful diagnosis data for the correction of visual acuity at near distance.

• Annals of Clinical Neurophysiology
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• v.7 no.2
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• pp.65-74
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• 2005

Charcot-Marie-Tooth (CMT) disease was described by Charcot and Marie in France and, independently, by Tooth in England in 1886. CMT is the most common form of inherited motor and sensory neuropathy, and is a genetically heterogeneous disorder of the peripheral nervous system. Therefore, many genes have been identified as CMT-causative genes. Traditionally, subclassification of CMT have been divided into autosomal dominant inherited demyelinating (CMT1) and axonal (CMT2) neuropathies, X-linked neuropathy (CMTX), and autosomal recessive inherited neuropathy (CMT4). Recently, intermediate type (CMT-Int) with NCVs between CMT1 and CMT2 is considered as a CMT type. There are several related peripheral neuropathies, such as $D{\acute{e}}j{\acute{e}}rine$-Sottas neuropathy (DSN), congenital hypomyelination (CH), hereditary neuropathy with liability to pressure palsies (HNPP) and giant axonal neuropathy (GAN). Great advances have been made in understanding the molecular basis of CMT, and 17 distinct genetic causes of CMT have been identified. The number of newly discovered mutations and identified genetic loci is rapidly increasing, and this expanding list has proved challenging for physicians trying to keep up with the field. Identifying the genetic cause of inherited neuropathies is often important to determine at risk family members as well as diagnose the patient. In addition, the encouraging studies have been published on rational potential therapies for the CMT1A. Now, we develop a model of how the various genes may interact in the pathogenesis of CMT disorder.

• Journal of the Korean Society of Marine Environment & Safety
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• v.23 no.2
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• pp.153-160
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• 2017

It may be reasonable to consider density per unit area over time rather than analyze traffic volume, which is simply the traffic volume per unit of time, in assessing the maritime traffic congestion of a certain area. This study contributes to the standardization of maritime traffic congestion assessment methods for the maritime traffic safety diagnosis institute while seeking a new method to minimize evaluation error due to converted traffic volume per ship tonnage level. To solve this problem, a method to evaluate maritime traffic congestion by comparing the area occupied by a vessel with the area of its route using vessel identification data from the Automatic Identification System (AIS) has been proposed. In this new model, it is possible to use actual data due to the development of information and communication technology, reducing conversion error while allowing for the evaluation of maritime traffic congestion by route.

• Hwankyungkyoyuk
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• v.19 no.1 s.29
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• pp.30-42
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• 2006

The Ministry of Environment supports environmental education mainly in two ways ; one is by supporting schools engaged in environment conservation model school and the other is by extending grants for experiential environmental education programs. This research aims to evaluate the current status of grant for experiential environmental education programs while proposing possible improvement for constructive and continuing development of the support measures. Grant for experiential environmental education programs is divided into two areas of grant for schools and grant for community-based civil organizations. The diagnosis and evaluation were conducted in terms of 7 areas, such as time, facilities, programs, manpower (professional expertise), operation, administrative and financial support mechanism and others. Research process involved the review of previous studies in 2001 and 2003, comparison of the grant program with other grants in and out of Korea for environment education, and the following areas considered when identifying improvement options: i) Overall review of objectives and operations, ii) expansion supports programs oriented problem solving as well as those focused ecological sensitivity, iii) change from expendable, one-time program to productive, continuous program, iv) link to social changes and issues, v) principles for operation and evaluation, vi) criteria and methods for program selection and evaluation, and vii) improving operation system. Based on review and the overall evaluation on the experiential environmental education program grant, the recommendation for improving operation system were provided, which included stages of passive improvement, active improvement and building infrastructure for environment education, and building capacity of the members related in the initiatives.

• Journal of Korean Society of Archives and Records Management
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• v.11 no.1
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• pp.47-66
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• 2011

An exclusive monopoly on public sector information has been faced with dramatic changes. The movement of Government 2.0, which is described as meeting of Web 2.0 technologies and public services, provides a new paradigm for public information services, and spreads rapidly into many western countries. However, due to the absence of domestic Government 2.0 cases, our academic discussion on Government 2.0 ends up in the introduction of oversea cases and in a theoretical diagnosis. In the context, this study focuses on the first two cases of Government 2.0 in South Korea; Gwacheon Parliament's 'Local Parliament 2.0' and Seoul Metropolitan Office of Education's 'Seoul Education 2.0' along with theoretical debates on concepts of public sector information and Government 2.0. The case study reveals the role of Freedom of Information Center not only as a think tank, but also a policy coordinator for implementing Government 2.0 movements. As a conclusion, the study presents elements for public sector information services and proposes a planning model of Government 2.0.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.14 no.1
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• pp.1-14
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• 2010

Backgrounds : Bojungikgitang is one of the most common herbal prescriptions in Oriental Medicine, and it is highly recommended prescription for Nogwonsang syndrome. The Author developed Nogwonsang questionnaire for quantitative evaluation. Nogwonsang questionnaire is consisted of causes that induce fatigue, symptoms that directly associated with fatigue, and secondary symptoms that is induced from fatigue. Purposes : This study aims to verify whether the Bojungikgitang Questionnaire has causality and meaningful path structure by path analysis. Methods : 242 patients from 12 OMD clinics participated in this study. The patients executed a question investigation in the object. Factor analysis was conducted for extraction of factor and abridgment of items. Path analysis was conducted to verify path structure. SPSS 15.0 for Windows and AMOS 7.0 were used for statistical analysis. Results : Overwork factor explains fatigue factor. Coefficient is 0.771. Fatigue factor explains digesting and cold factor. Individually coefficient is 0.632 and 0.465. Model fit is $X^2=61.395$(df=51), GFI=0.960, AGFI=0.939, NFI= 0.924, CFI=0.986, RMSEA=0.029. Path structure is proved to be significant. Conclusions : Further research is needed Gold standard of Nogwonsang. Establishment of Gold standard leads and the collection of data and the research which are objective are possible. Connection of the clinical indexes which are objective on the paperweight outside and leads and the development of the diagnosis tool which is fixed quantity is demanded.

• Journal of the Korea institute for structural maintenance and inspection
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• v.15 no.1
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• pp.120-128
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• 2011

Recently, safety diagnosis of the existing structures has been emerged as important issue. In particular, systematical and precise safety diagnostics for steel structures for power substation, have been required. Steel structures for power substation are under the periodical impact loads from operations of gas insulated switchgear. These loading condition accelerates damage and aging of structure. The objective of this research is to evaluate damage of structure under periodical impact loads. To evaluate the integrity of structures as organizing mathematical models including the dynamic characteristics of structures, Frequency Domain Decomposition method was choiced and an algorism was proposed. For verifying this methods and algorism, a mathematical model is composed of the development of a variety of reverse analysis and a signal processing technology reflecting physical damage of structures. A series of analysis and test results indicatge that proposed method has a confidence for applying a filed test. Therefore, it is expected to be able to take advantage of system identification to detect damage for the maintenance and management of steel structures under periodical impact loads such as power substation.