• Title/Summary/Keyword: detection technique

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Effective Harmony Search-Based Optimization of Cost-Sensitive Boosting for Improving the Performance of Cross-Project Defect Prediction (교차 프로젝트 결함 예측 성능 향상을 위한 효과적인 하모니 검색 기반 비용 민감 부스팅 최적화)

  • Ryu, Duksan;Baik, Jongmoon
    • KIPS Transactions on Software and Data Engineering
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    • v.7 no.3
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    • pp.77-90
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    • 2018
  • Software Defect Prediction (SDP) is a field of study that identifies defective modules. With insufficient local data, a company can exploit Cross-Project Defect Prediction (CPDP), a way to build a classifier using dataset collected from other companies. Most machine learning algorithms for SDP have used more than one parameter that significantly affects prediction performance depending on different values. The objective of this study is to propose a parameter selection technique to enhance the performance of CPDP. Using a Harmony Search algorithm (HS), our approach tunes parameters of cost-sensitive boosting, a method to tackle class imbalance causing the difficulty of prediction. According to distributional characteristics, parameter ranges and constraint rules between parameters are defined and applied to HS. The proposed approach is compared with three CPDP methods and a Within-Project Defect Prediction (WPDP) method over fifteen target projects. The experimental results indicate that the proposed model outperforms the other CPDP methods in the context of class imbalance. Unlike the previous researches showing high probability of false alarm or low probability of detection, our approach provides acceptable high PD and low PF while providing high overall performance. It also provides similar performance compared with WPDP.

Application of Computer-Aided Diagnosis a using Texture Feature Analysis Algorithm in Breast US images (유방 초음파영상에서 질감특성분석 알고리즘을 이용한 컴퓨터보조진단의 적용)

  • Lee, Jin-Soo;Kim, Changsoo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.1
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    • pp.507-515
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    • 2015
  • This paper suggests 6 cases of TFA parameters algorithm(Mean, VA, RS, SKEW, UN, EN) to search for the detection of recognition rates regarding breast disease using CAD on ultrasound images. Of the patients who visited a university hospital in Busan city from August 2013 to January 2014, 90 cases of breast ultrasound images based on the findings in breast US and pathology were selected. $50{\times}50$ pixel size ROI was selected from the breast US images. After pre-processing histogram equalization of the acquired test images(negative, benign, malignancy), we calculated results of TFA algorithm using MATLAB. As a result, in the TFA parameters suggested, the disease recognition rates for negative and malignancy was as high as 100%, and negative and benign was approximately 83~96% for the Mean, SKEW, UN, and EN. Therefore, there is the possibility of auto diagnosis as a pre-processing step for a screening test on breast disease. A additional study of the suggested algorithm and the responsibility and reproducibility for various clinical cases will determine the practical CAD and it might be possible to apply this technique to range of ultrasound images.

Analysis of $^1H$ Magnetic Resonance Spectroscopy Pattern in Invasive Ductal Carcinoma of Breast (유방 침윤성 관상피암에서 수소핵 자기공명분광상의 특성 분석)

  • Cho, Jae-Hwan;Park, Cheol-Soo;Lee, Sun-Yeob;Kim, Bo-Hui
    • Progress in Medical Physics
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    • v.21 no.1
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    • pp.22-28
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    • 2010
  • To evaluate the potential value of $^1H$ Magnetic resonance spectroscopy (MRS) for detecting and characterizing invasive ductal carcinoma of breast. We conducted $^1H$ Magnetic resonance spectroscopy (MRS), using a 3.0T MR scanner, on 40 patients who were histologically diagnosed to have invasive ductal carcinoma (IDC); tumor areas of the patients were designated as experimental samples, and non-tumor areas as control samples. The peak at 3.2 ppm is characteristically intense and observed in 34 cases of the total 40 invasive ductal carcinoma (sensitivity 86.2%; specificity 100%; positive predictive value 100%; negative predictive value 60%). In constrast peak at 1.3 ppm is characteristically intense and observed in normal breast (sensitivity 86.2%; specificity 100%; positive predictive value 100%; negative predictive value 60%). The study shows that $^1H$ MRS can effectively discriminate invasive ductal carcinoma from normal breast in most cases. It also demonstrates the feasibility of localized in vivo $^1H$ MRS technique as a new diagnostic modality in the detection of breast tumor.

Adenosine $^{99m}Tc-MIBI$ Scintigraphy in the Diagnosis of Coronary Artery Disease: Comparison with Exercise $^{99m}Tc-MIBI$ Scintigraphy (관상동맥 질환에서의 Adenosine 부하 $^{99m}Tc-MIBI$ 심근 스캔의 진단적 가치 : 운동 부하 $^{99m}Tc-MIBI$ 심근 스캔과의 비교)

  • Kang, Seung-Wan;Woo, Eon-Jo;Chae, Sung-Chull;Jun, Jae-Eun;Park, Wee-Hyun;Chung, Byung-Cheon;Choi, Chung-Il;Lee, Jae-Tae;Lee, Kyu-Bo
    • The Korean Journal of Nuclear Medicine
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    • v.26 no.1
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    • pp.72-81
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    • 1992
  • Pharmacologic coronary vasodilation in conjunction with myocardial scintigraphy has become an accepted alternative to dynamic exercise testing for the diagnosis of coronary artery disease. Although dipyridamole has traditionally been used for this purpose, it causes frequent side effect, which at times can be life-threatening. Moreover, dipyridamole dose not elicit maximal coronary vasodilation in a substantial number of patients receiving the usual i.v. dose. Adenosine is an endogenously produced compound that has significant effects as a coronary vasodilator and rapid onset action and extremely short half-life (< 10 seconds). The diagnostic accuracy and safety profile of adenosine $^{99m}Tc-MIBI$ myocardial scintigraphy were evaluated and comparison with exercise $^{99m}Tc-MIBI$ was performed. Twenty-eight subjects underwent $^{99m}Tc-MIBI$ imaging after adenosine infusion and exercise $^{99m}Tc-MIBI$ imaging. Adenosine was infused intravenously at a dose of 0.14mg/kg/body weight per minute for 6 min and MIBI was injected at 3 minute. Adenosine caused an incerease in heart rate ($64{\pm}12$ at baseline versus $74{\pm}16$ beats/min at peak effect, p<0.001), a mild decrease in systolic and diastolic blood pressure and a slightly increase in PR interval(p; NS). Side effects were reported in 92% of patients and were mostly mild in nature and promptly resolved within 1 or 2 minutes of termination of adenosine infusion. Facial flushing (53%), chest pain (36%), mild dyspnea (39%), headache (21%), throat discomfort (21%) were frequent symptoms. ST segment depression (> 1 mm) and second degree AV block in electrocardiography occured in 11% of the patients, respectively. The overall sensitivity and specificity for individual coronary stenoses in 16 patients underwent coronary angiography were 88% and 95%, respectively. The agreement ratio of segmental perfusion between adenosine and exercise images was 92% (Kappa index=0.82). In conclusion, $^{99m}Tc-MIBI$ myocardial perfusion scintigraphy with intravenous adenosine is a feasible, safe and highly accurate noninvasive technique for the detection of coronary artery disease and results are at least comparable with those of exercise $^{99m}Tc-MIBI$ scintigraphy.

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Application of Micro-BLISA in Serodiagnosis of Fascioliasis in Cattle (간질증의 효소면역학적 진단)

  • Lee, Jae-Gu;Baek, Byeong-Geol;Lee, Sang-Bok
    • Parasites, Hosts and Diseases
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    • v.23 no.1
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    • pp.95-101
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    • 1985
  • Fascioliasis in cattle is one of the most common and very serious trematode diseases in Korea. In the present study, the enzyme linked immunosorbent assay (ELISA) was applied in the diagnosis of fascioliasis using antigen of Fasciela hepatica, perokidase of conjugate anti-cattle Is G and orthophenylenediamine as a substrate by micro-method technique of Volley et at. (1976b) and MacLaren (1978) with a slight modification. Results obtained from the present study are as follows. 1. In assay for optimal dilution of stock antigen, the antigen (protein contents; 0. Bmgymz) was diluted from 1150 to 1/600 with carbonate buffer (pH 9.6), and then absorbance values were measured with 1/100 diluted sera. The regression equations between the OD values of ELISA and dilution of antigen were log Y: -0.181-0.00127X in infected sera, and log Y: -0.578-0. 000879X in normal sera. The significantly higher (p<0.05) OD value was observed in the former. 2. In assay for optimal dilution of sera, the sera were diluted from 1125 to 1/400 with in PBSJ Tween 20 (pH 7.4), and absorbance values were measured with 1/200 diluted antigen. The regression equation between the OD values of ELISA and dilution of sera were log Y: -0.1540-0.0007238X in infected sera and log Y: -0.4834-0.00116X in normal sera. The former was higher than the latter (p<0.05). 3. In the 27 cases of negative intradermal test, OD values of the ELISA are $0.447{\pm}0.144$, the 95% confidence interval (Mean+2 H SD) of the values was 0.735, and there was no case over the values. Therefore, the sensitivity of the antigen to diagnose fascioliasis was 100% in the negative case. The OD value 0.7 which is designed as a criterion (detection level of positive one) is useful for the performance of the ELISA in fascioliasis. 4. According to the OD value of criterion in the regression equations, the optimal dilutions of stock antigen and serum were 1/250 and 1/100, respectively. 5. In the 58 cases of fascioliasis from which the adult could be found in the bile ducts, the OD value was $0.846{\pm}0.224$. The 75% (44 cattle) among them had higher value with compared to the criterion, and the 60% (20 cattle) of the cases of proliferative cholangitis of 33 cattle which had been infected previousely with Fasciola sp. is higher than the criterion. 6. Prevalence of fascioliasis was 43.4% in the application of the ELISA to 272 cattle which were reared in Jeonbug district.

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A Study on the IT R&D Emerging Technology Detection through Knowledge Map: Focus on Access Network Field (지식맵을 활용한 IT R&D 유망영역 탐색: 가입자망 분야를 중심으로)

  • Lee, Woo-Hyoung;Jung, Ji-Bum;Lee, Seong-Hwi
    • Information Systems Review
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    • v.10 no.2
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    • pp.1-19
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    • 2008
  • The purpose of this research is to schematize and suggest the new trends of study and changing aspects of science and technology hidden in a bibliographical phenomenon of documentation to researchers and policy-makers all through the Knowledge Map. The field of study to be analyzed in this research is the Access Network field. The reason why this field has been selected as the main target of study is that the Access Network field is economically important and characterized by its wide sphere where a variety of fields are interconnected. In addition, it is important to measure the applied as well as fundamental aspects of technology by using bibliographical method and technique. Knowledge Map successfully visualizes the inter-relations of the keywords and sub-fields of Access Network. The importance of visualizing methods in the convincing presentation of results has not been sufficiently understood in the past. Knowledge Map opens a new opportunity for cartography of science and information visualization. The Knowledge Map results have produced a great deal more than statistical artifact. We aimed to exploit the visualization effect of the Knowledge Maps to the aid of searchers in Access Network domain, and the results are quite encourging.

Quantitative Analysis of Contents of Vegetable Oils in Sesame Oils by NIRS (근적외선분광광도법을 이용한 참기름중 이종식용유지 정량법에 관한 연구)

  • Kim, Jae-Kwan;Kim, Jong-Chan;Ko, Hoan-Uck;Lee, Jung-Bock;Kim, Young-Sug;Park, Yong-Bae;Lee, Myung-Jin;Kim, Myung-Gil;Kim, Kyung-A;Park, Eun-Mi
    • Journal of Food Hygiene and Safety
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    • v.22 no.4
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    • pp.257-267
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    • 2007
  • The possibility of rapid non-destructive qualitative and quantitative analysis of vegetable oils such as perilla, com, soybean and rapaseed oils in sesame oils was evaluated. A calibration equation calculated by MPLS(Modified Partial Least Squares) regression technique was developed and coefficients of determination for perilla oil, com oil, soybean oil and rapaseed oil contents were 0.9992, 0.9694, 0.9795 and 0.9790 respectively. According to the data obtained from validation study, $R^2$ of contents of perilla, com, soybean, rapaseed oils were 0.997, 0.848, 0.957 and 0.968, and SEP of content of them 0.747, 5.069, 3.063 and 3.000 by MPLS respectively. The results indicate that the NIRS procedure can potentially be used as a non-destructive analysis method for the rapid and simple measurement of sesame oil mixed with other vegetable oils. The detection limits of the NIRS for perilla oil, com oil, soybean oil and rapaseed oil were presumed as 2%, $15{\sim}20%,\;15{\sim}20%$ and 10%, respectively.

Detection and distribution of iridoviruses in five freshwater ornamental fish species (담수관상어 5종에서의 iridoviruses 검출과 분포 분석)

  • Jeong, Hyun-Do;Lyu, Ji-Hyo;Jeong, Joon-Bum;Kim, Ho-Yeoul;Jun, Lyu-Jin;Cho, Hye-Jin;Lee, June-Woo
    • Journal of fish pathology
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    • v.19 no.3
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    • pp.197-206
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    • 2006
  • The distribution of iridoviruses in five freshwater ornamental fishes, pearl gourami (Trichogaster leeri), dwarf gourami (Colisa lalia), silver gourami (Trichogaster microlepis), blue gourami (Trichogaster trichopterus sumatranus) and freshwater angelfish (Pterophyllum scalare), imported from Singapore was examined in 2004 and 2005. The presence of iridoviruses in 56 sample groups was determined using PCR technique and showed PCR positive in 11 sample groups. The proportion of fish infected by iridovirus was differed depending upon species; 31.8% (7/22) for pearl gourami, 18.2% (2/11) for dwarf gourami, 16.7% (1/6) for blue gourami, 9.1% (1/11) for silver gourami and 0% (0/6) for angelfish. In quantitative comparison of viral DNAs isolated from infected tissues, the DNA concentration of iridovirus in pearl gourami was higher than that in dwarf gourami. Although pearl gourami infected naturally by iridovirus showed 100% mortality in keeping experiment for 3 weeks, only 57% of those was positive in PCR. In the comparison of nucleotide sequences of the PstⅠ fragment known as the most variable genomic region, both iridoviruses isolated from pearl gourami and dwarf gourami showed identity more than 99% with infectious spleen and kidney necrosis virus (ISKNV) isolated from mandarinfish (Siniperca chuatsi).

Radiation Therapy of Nasopharyngeal Cancers (비인강암의 방사선치료성적)

  • Shin, Sei-One;Kim, Sung-Kyu;Kim, Myung-Se
    • Journal of Yeungnam Medical Science
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    • v.9 no.2
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    • pp.312-320
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    • 1992
  • Radiotherapeutically, nasopharyngeal cancer is an important disease in korea. Because of its blind anatomic location, early detection is relatively uncommon. Clinically, most of cases are locally advanced and nodal involvement are common. Recently better understanding of nature of the disease and improvement of radio-therapy technique permit better treatment results, including locoregional control and survival rate, and minimal normal tissue damages comparing with previously published data. We analyzed 31 patients of pathologically proven and previously untreated naso-pharyngeal carcinoma with different treatment techniques, retrospectively. Minimal and maximal follow up period of the survuor is 6 months and 68 months, respectively. Thirteen patients with squamous cell carcinoma are included in this analysis. The median age is 49 years(range from 20 to 64 years). Twenty two patients are stage III. Eleven patients are treated with radiotherapy alone and 20 are treated with comblined modalities treatment. The degree of responses after radiotherapy are categorized by 3-classes, i.e. complete response, partial response. In spite of simioarities of complete response rate and 1-year survival rate between two different treatment techniques, those patients with undifferentiated carcinoma appear to benefit from the adjuvant chemotherapy. In addition, systemic failure is more prominant in radiotherapy alone group than in combined modalities treatment group. These results suggest that adjuvant therapy in the radiotherapeutic management of nasopharyngeal cancers needs additional research according to histologic types and future extensive clinical trials.

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Prenatal Aneuploidy Detection in Uncultured Amniotic Fluid Interphase Cells by Fluorescence in situ Hybridization (FISH) (형광직접보합법을 이용한 미배양 양수세포에서 산전 이수배수체 확인)

  • Seol, Hye-Won;Ko, Hee-Jung;Song, Nam-Hee;Kim, Sook-Ryoung;Lee, Hwa-Jin;Oh, Sun-Kyung;Park, Joong-Shin;Jun, Jong-Kwan;Yoon, Bo-Hyun;Syn, Hee-Chul;Moon, Shin-Yong
    • Clinical and Experimental Reproductive Medicine
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    • v.30 no.3
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    • pp.223-231
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    • 2003
  • Objective: The aim of the present study was to evaluate the clinical efficiency of fluorescent in situ hybridization (FISH) in the prenatal diagnosis of chromosomal aneuploidy. Methods: We reviewed data of 268 cases to identify women undergoing genetic amniocentesis at cytogenetic laboratory, from January 2000 to December 2002. Amniotic fluid was submitted for both rapid FISH on uncultured interphase amniocytes using a commercially available DNA probe for chromosome 13, 18, 21, X, Y and standard karyotyping on cultured metaphase amniocytes. Results from FISH and full karyotype were compared. Results: There were 251 cases (84%) normal and 17 cases (16%) abnormal in FISH results. All 17 cases of trisomy 13, 18, 21 including two cases of mosaicism and sex chromosome aneuploidies which are detected by FISH were confirmed with conventional cytogenetics and there was no false positive result. Twenty two cases had karyotypically proven abnormalities that could not have been detected by the targeted FISH. Conclusion: Interphase FISH analysis of uncultured amniotic fluid cells has been shown to be an effective and reliable technique for rapid fetal aneuploidy screening during pregnancy as an adjunctive test to conventional cytogenetics.