• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.12
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• pp.2458-2467
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• 1994

This paper proposes a new design method for obtaining the impulse responses which satisfy the prescribed conditions designing for maximally flat FIR lowpass filters and highpass filters. The bandpass filters and band-reject filters have been directly derived from the addition and subtraction of impulse responses of a lowpass filter and a highpass filter. The two-dimensional maximally flat FIR lowpass filter, highpass filters, bandpass filters and band-reject filters with zero-phase have been designed by transforming the impulses of the one-dimensional filters designed in this research, which do not destroy lines and edges at the image signal processing.

• BMB Reports
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• v.41 no.12
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• pp.833-839
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• 2008

Angiogenesis in tumors is driven by multiple growth factors that activate receptor tyrosine kinases. An important driving force of angiogenesis in solid tumors is signaling through vascular endothelial growth factor (VEGF) and its receptors (VEGFRs). Angiogenesis inhibitors that target this signaling pathway are now in widespread use for the treatment of cancer. However, when used alone, inhibitors of VEGF/VEGFR signaling do not destroy all blood vessels in tumors and do not slow the growth of most human cancers. VEGF/VEGFR signaling inhibitors are, therefore, used in combination with chemotherapeutic agents or radiation therapy. Additional targets for inhibiting angiogenesis would be useful for more efficacious treatment of cancer. One promising target is the signaling pathway of hepatocyte growth factor (HGF) and its receptor (HGFR, also known as c-Met), which plays important roles in angiogenesis and tumor growth. Inhibitors of this signaling pathway have been shown to inhibit angiogenesis in multiple in vitro and in vivo models. The HGF/c-Met signaling pathway is now recognized as a promising target in cancer by inhibiting angiogenesis, tumor growth, invasion, and metastasis.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.17 no.2
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• pp.30-37
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• 2008

An object transport system is driven by a conveyor belt system or a magnetic levitation system. It is an indispensable device in many fields and especially it is very important in the factory automation. However, the conventional transport system can damage precision optical components by the contact force and destroy the inner structure of semiconductor by the magnetic field. The new transport system for transporting without damage is required. The ultrasonic transport system is a device that transports objects on the elastic body using ultrasonic wave. In this paper, an object transport system using the ultrasonic wave is developed for transporting precision elements without damage. Traveling waves are generated by the ultrasonic wave generator fixed in both ends of the beam. The traveling wave of the ultrasonic transport system is theoretically analyzed. Transport direction of the object is examined according to phase difference and frequency. The theoretical results are verified by experiments.

• Proceedings of the Materials Research Society of Korea Conference
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• 2009.05a
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• pp.7.1-7.1
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• 2009

The use of Duplex stainless steel as a thermo-implant categorizes into two clinical applications: hyperthermia and thermal ablation or destruction. The goal of hyperthermia is to destroy the heat-sensitive abnormal cells and minimize normal cell death maintaining heat between $42^{\circ}C$ and $46^{\circ}C$. Thermal ablation takes place when the local tissue temperature increases greater than $46^{\circ}C$. This elevated temperature denatures protein irreversibly resulting cellular death. The author introduced several thermo-implants such as thermo-rod, thermo-stent, thermo-coil and thermoacupuncture-needle. Those thermo-implants are made of duplex stainless steel which can produce regulated heat by itself within an induction magnetic field. Thermal ablation characteristics of the thermo-rod on tumor hyperthermia depend on configurations of the thermo-rods and the magnitude of the induction magnetic strength. The exothermic properties of the thermo-implants can be characterized using the calorimetric test and the heat affected zone(HAZ) analyses in vitro. Thermal radiation studies using thermo-coils and thermo-stents show the capability of the occlusion of animal blood vessels and inhibiting the proliferation of the abnormal smooth muscle cell growth and inflammatory cell reactions maintaining the heat between $42^{\circ}C$ and $46^{\circ}C$ minimizing a normal cell death in the study on external iliac artery of the New Zealand White (NZW) rabbit. Thermal stimulation study using thermo-acupuncture needles suggests the potential applications of the automated acupunctural therapies.

• Journal of the Korea Society for Simulation
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• v.27 no.3
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• pp.109-116
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• 2018

In order to destroy the hard target, it is essential to develop a penetration warhead with high penetration performance. To design a penetration warhead, this paper discusses the effect of nose shape factors such that nose shape, nose length, nose tip diameter, on the penetration performance of the penetrator. AUTODYN-2D has been used to conduct the computational analysis. The experimental result of Forrestal, and a simulation result have been compared to verify the reliability of computational analysis. Computational results show that the nose length have more influence on the penetration performance than the nose shape. Furthermore, simulation results show that the penetration performance can be improved by increasing the nose tip diameter to a specific value, when the nose length of the penetrator is uniform.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.28 no.4
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• pp.1009-1019
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• 2018

Bitcoin is the first application utilizing the blockchain, but it has limitations in terms of scalability. The concept of Lightning Network was recently introduced to address the scalability problem of Bitcoin. In this paper, we found that the real-world Bitcoin Lightning Network shows the scale-free property. Therefore, the Bitcoin Lightning Network can be vulnerable to the intentional attacks targeting some specific nodes in the network while it is still robust to the random node failures. We experimentally analyze the robustness of the Bitcoin's Lightning Network via the simulation of network attack model. Our simulation results demonstrate that the real-world Lightning Network is vulnerable to target attacks that destroy a few nodes with high degree.

• Journal of the Korea Institute of Military Science and Technology
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• v.18 no.4
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• pp.350-357
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• 2015

Many countries have been developing and operating an underwater surveillance system in order to protect their oceanic environment from infiltrating hostile marine forces which intend to lay mines, conduct reconnaissance and destroy friendly ships anchored at the harbor. One of the most efficient methods to detect unidentified submarine approaching harbor is sensing variation of magnetism of target by magnetic sensors. This measurement system has an advantage of high possibility of detection and low probability of false alarm, compared to acoustic sensors, although it has relatively decreased detection range. The contents of this paper mainly cover the analysis of possible effectiveness of magnetic sensors. First of all, environmental characteristics of surveillance area and magnetic information of simulated targets has been analyzed. Subsequently, a signal processing method of separating target from geomagnetic field and methods of estimating target location has been proposed.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2011.10a
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• pp.705-707
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• 2011

Smart devices have the characteristics of duality of fire and the property of double-sided swords. They also both conveniency and the weakness at a time due to the structure of the devices. Although there have not been a big threat with the smart devices, but they have potential enough to destroy the network society. This is because of the fact that the devices mainly depend on the applications and the applications can abuse the devices' critical hardware sections such as camera, file system, etc.. In this contribution, we analyze the issues and the problems of the weakness of smart devices and discuss a method to solve the issues.

• Journal of Pharmacopuncture
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• v.14 no.1
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• pp.61-69
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• 2011

Objectives : Elastic fibers are found in the skin, lungs, arteries, veins and other structures. Elastases destroy the elastic fibers and cause the emphysema and pulmonary hypertension. Oxidative stress is needed for these pathologic changes. Accordingly, present study was designed to investigate the effect of Yukmigeehwang-hwan extracts (YHE) on elastase activity and anti-oxidative effects of YHE. Methods : The inhibitory effects on elastase and DPPH and NO free radical scavenging activities of YHE were measured. Results : The elastase activity was significantly inhibited by YHE. YHE significantly scavenged DPPH and NO free radicals as well. Conclusion : YHE showed the elastase-inhibiting effects and anti-oxidative activities in vitro. These results suggest that YHE may have potential roles in the treatment of pulmonary emphysema and pulmonary hypertension.

• Journal of Microbiology and Biotechnology
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• v.17 no.5
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• pp.847-852
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• 2007

This study investigated an efficient method for the extraction of astaxanthin from the red yeast Xanthophyllomyces dendrorhous. The extraction process comprised three steps: 1) cultivating the yeast; 2) treating the yeast culture suspension with microwaves to destroy the cell walls and microbodies; and 3) drying the yeast and extracting the astaxanthin pigment using ethanol, methanol, acetone, or a mixture of the three as the extraction solvent. Ultimately, various treatment tests were performed to determine the conditions for optimal pigment extraction, and the total carotenoid and astaxanthin contents were quantified. A frequency of 2,450 MHz, an output of 500 watts, and irradiation time of 60 s were the most optimum conditions for yeast cell wall destruction. Furthermore, optimal pigment extraction occurred when using a cell density of 10g/l at $30^{\circ}C$ over 24 h, with a 10% volume of ethanol.