• 제목/요약/키워드: design methodologies

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A Short Review on the Application of Combining Molecular Docking and Molecular Dynamics Simulations in Field of Drug Discovery

  • Kothandan, Gugan;Ganapathy, Jagadeesan
    • Journal of Integrative Natural Science
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    • v.7 no.2
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    • pp.75-78
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    • 2014
  • Computer-aided drug design uses computational chemistry to discover, enhance, or study drugs and related biologically active molecules. It is now proved to be effective in reducing costs and speeding up drug discovery. In this short review, we discussed on the importance of combining molecular docking and molecular dynamics simulation methodologies. We also reviewed the importance of protein flexibility, refinement of docked complexes using molecular dynamics and the use of free energy calculations for the calculation of accurate binding energies has been reviewed.

Preliminary Design Program Development for Aircraft Gas Turbine Combustors : Part 1 - Combustor Sizing (항공용 가스터빈 연소기 기본 설계 프로그램 개발 : Part 1 - 연소기 크기 결정)

  • Kim, Daesik;Ryu, Gyong Won;Hwang, Ki Young;Min, Seong Ki
    • Journal of the Korean Society of Combustion
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    • v.18 no.3
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    • pp.54-60
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    • 2013
  • This paper shows a general development process for aircraft gas turbine combustors. As a first step for developing the preliminary combustor design program, several combustor sizing methodologies using reference area concepts are reviewed. There are three ways to determine the reference area; 1) combustion efficiency approach, 2) pressure loss approach, 3) velocity assumption approach. The current study shows the comparisons of the calculated results of combustor reference values from the pressure loss and velocity assumption approaches. Further works are required to add iterative steps in the program using more reasonable values of pressure loss and velocities, and to evaluate the sizing results using data for actual combustor performance and sizes.

Development of an Air-conditioning Fan for a Van (승합차량용 공조 팬의 개발)

  • 김재원;정윤영
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.1 no.1
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    • pp.1-14
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    • 2000
  • This paper is concerningon the development of cross-flow fan (CFF) for vehicles. CFF is widely usedhome-appliance products. This work mainly Intends developing CFF only for an automobile. In order to do that, new design involving blade shapes is proposed with enough performance for the operation. Spacially three steeps are proceeded for blade design. injection conditions for manufacturing, and capacity test for fluid mechanics. The present methodologies are to find optimal design for the blades and conditions for the injection process. This project has continued since last two years and finally succeeded.

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Quality Improvement by enhancing Informal Requirements with Design Thinking Methods

  • Kim, Janghwan;Kim, R. Young Chul
    • International journal of advanced smart convergence
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    • v.10 no.2
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    • pp.130-137
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    • 2021
  • In the current software project, it is still very difficult to extract and define clear requirements in the requirement engineering. Informal requirements documents based on natural language can be interpreted in different meanings depending on the degree of understanding or maturity level of the requirements analyst. Also, Furthermore, as the project progresses, requirements continue to change from the customer. This change in requirements is a catastrophic failure from a management perspective in software projects. In the situation of frequent requirements changes, a current issue of requirements engineering area is how to make clear requirements with unclear and ambigousrequirements. To solve this problem, we propose to extract and redefine clear requirements by incorporating Design Thinking methodologies into requirements engineering. We expect to have higher possibilities to improve software quality by redefining requirements that are ambiously and unclearly defined.

Review of the reinforcement sizing in the strength design of reinforced concrete slabs

  • Gil-Martina, Luisa Maria;Hernandez-Montes, Enrique
    • Computers and Concrete
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    • v.27 no.3
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    • pp.211-223
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    • 2021
  • This paper presents a review of the two widespread approaches which deal with the ultimate strength design of RC slabs subjected to bending moments and torsion: The Field of Moments Method (FoMM) and the Sandwich method (SM). Special attention is paid to the ultimate strain distribution implicitly assumed when using each one of the methodologies, in particular, the yielding of the steel reinforcement. This work analyzes the initial assumption regarding ultimate strain distribution in the SM. Furthermore, this work studies the resisting moments field on which the Wood-Armer method is based, and it finds some inconsistencies. Several examples have been developed.

Development of Problem-Based Learning in an English-Mediated College Science Course: Design-Based Research on Four Semesters Instruction

  • LAHAYE, Rob;LEE, Sang-eun
    • Educational Technology International
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    • v.19 no.2
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    • pp.229-254
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    • 2018
  • Universities in Korea have driven universities' new attempts to adopt more learner-centered and active learning in English. Problem-based Learning (PBL) is one of the well-known constructive teaching and learning methodologies in higher education. Our research goal was to design and develop the optimal PBL practices for a college physics course taught in English to promote learning and course satisfaction. For four semesters, we have tried and adjusted PBL components, and looked at the trend of the exam scores and group work achievement in each semester. We found that the number of problems and the duration of problem solving are the critical factors that influence the effect of PBL in a college physics course taught in English by going through iterative implementation. The iterative process of applying, designing, and constructing PBL to physics classes was meaningful not only in that we have found the optimal PBL model for learning a college physics course, but also in that we have been reflecting on the continuous interaction with learners during the course.

Robust Design Methodology for Optimizing Perceived QoS of VoIP (인터넷 전화의 사용자 관점 품질 최적화를 위한 강건 설계 기법 연구)

  • Yoon, Hyoup-Sang;Choi, Soo-Hyun;Kim, Seong-Joon
    • IE interfaces
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    • v.22 no.1
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    • pp.95-103
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    • 2009
  • During the past few years, design of experiments (DOE) has been gaining acceptance in the telecommunications research community as a mean for designing and analyzing experiments economically and efficiently. In addition, the need for introducing a systematic robust design methodology (i.e., one of the most popular DOE methodologies) to network simulations has been increasing. In this paper, we present an architecture of voice over IP (VoIP) application and the E-Model for calculating the perceived quality of service (QoS). Then, we apply the Taguchi robust design methodology to optimize the perceived QoS of VoIP application, and describe the detailed step-by-step procedures. We have used ns-2 simulator to collect experimental data in which the SN ratio, a robustness measure, is analyzed to determine an optimal design condition. The analysis shows that "initial delay time in playout buffer" is a major control factor for ensuring robust behaviors of the perceived QoS of VoIP. Finally, we verify the proposed optimal design condition using a confirmation experiment.

Psychoanalytic approach and unconscious human desires in art and design - A focus on its application to contemporary space design - (정신분석학과 조형에서의 무의식 욕구 분석 - 현대 공간디자인에의 적용을 중심으로 -)

  • Lee Jeongmin;Hong Euitaek
    • Korean Institute of Interior Design Journal
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    • v.14 no.2 s.49
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    • pp.83-94
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    • 2005
  • 20th century was the age of Modernism which was based on rational side of human mind. However, with the fall of Modernism, also came the fall of rationalism's dictatorship. Now, we see the pursuit and quest of irrational thinking as a new possibility of human expression which actually was already begun by Dada and Surrealism in early 20th century. It was facilitated by re-evaluation of Freud's psychoanalytic theory at the end of 20th century. This paper researches psychoanalytic approach applied to the analyses of unconscious human desires in art and design, especially its application to contemporary space design. These designs represent, without making any ethical evaluation, the fact that those unconscious desires are part of inborn human nature and the fact that 21st century is heading toward open society which embraces diverse values and possibilities. By analyzing irrational tendencies in contemporary space designs, this paper aims at proving the meaning and value for one of new directions in 21st century space design. First chapter is an introduction. Second chapter studies Freud's psychoanalytic theory. Third chapter examines the psychoanalytic methodologies with which unconscious desires are expressed in art and design. Fourth chapter classifies the types of subconscious desires expressed in contemporary space designs and analyzes their case studies. Fifth chapter is the conclusion.

SIZE OPTIMIATION OF AN ENGINE ROOM MEMBER FOR CRASHWORTHINESS USING RESPONSE SURFACE METHOD

  • Oh, S.;Ye, B.W.;Sin, H.C.
    • International Journal of Automotive Technology
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    • v.8 no.1
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    • pp.93-102
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    • 2007
  • The frontal crash optimization of an engine room member using the response surface method was studied. The engine room member is composed of the front side member and the sub-frame. The thicknesses of the panels on the front side member and the sub-frame were selected as the design variables. The purpose of the optimization was to reduce the weight of the structure, under the constraint that the objective quantity of crash energy is absorbed. The response surface method was used to approximate the crash behavior in mathematical form for optimization procedure. To research the effect of the regression method, two different methodologies were used in constructing the response surface model, the least square method and the moving least square method. The optimum with the two methods was verified by the simulation result. The precision of the surrogate model affected the optimal design. The moving least square method showed better approximation than the least square method. In addition to the deterministic optimization, the reliability-based design optimization using the response surface method was executed to examine the effect of uncertainties in design variables. The requirement for reliability made the optimal structure be heavier than the result of the deterministic optimization. Compared with the deterministic optimum, the optimal design using the reliability-based design optimization showed higher crash energy absorption and little probability of failure in achieving the objective.

A Study on the Residents' Participation Design according to the Remodeling right before Moving in Apartments (거주자들의 참여 디자인 방법에 관한 연구 - 공동주택 입주시점의 개조행위를 통한 -)

  • 오인욱;조명은
    • Korean Institute of Interior Design Journal
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    • no.39
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    • pp.62-71
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    • 2003
  • This research alms to understand the residents' actual conditions and reasons for remodeling in order to search for the desirable participation design methods, under the assumption that the remodeling of apartments by their current residents is a problem. The subjects of this research are residents of mixed-used apartments supplied via the fitting form housing supply methods recently. The results are shown below. First, the reasons for remodeling by the current residents we expansion of Interior space and change in interior atmosphere. Positive participation of the residents in the design decision is high and this remodeling problem is easily solved. Second, based on the Habraken's SAR theory, supports units and variable units were separated and in each process rational and systematic design methodologies according to the role and responsibility of the residents were observed. Third, considering the great level of remodeling right before moving in, there is a need for the variable housing supply methods of residents to easily participate in the design, construction, and supply of the apartments. Through the participation of the residents In the apartment design process will not only solve the problem of repeated apartment remodeling, but also accommodate the various needs of the residents.