• Journal of Pharmaceutical Investigation
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• v.40 no.1
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• pp.1-7
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• 2010

K-$BEtest^{(R)}$ is a well known program for bioequivalence test using a $2{\times}2$ design. Lee et al.(1998) and Park et al.(1999) suggested a $3{\times}3$ and $3{\times}2$ design, and also discussed their benefits. We developed a computer program, called BioEquiv, which can analyze some complex experimental designs such as, $3{\times}3$ design and $3{\times}2$ design including a standard $2{\times}2$ design. This program is a user-friendly one and overcomes the disadvantages of K-$BEtest^{(R)}$. The detailed statistical formula and structure of BioEquiv are presented with some examples. The comparison between K-$BEtest^{(R)}$ and BioEquiv are given with actual data analysis. BioEquiv is able to present a table of ANOVA test over some complex experimental designs. Moreover K-$BEtest^{(R)}$ and BioEquiv draw the same result when data consists of $2{\times}2$ design.

• Proceedings of the KIEE Conference
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• 2005.07a
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• pp.632-634
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• 2005

Korea takes part in overseas business by use of accumulated advanced technology through construction of the worlds first 765kV double circuit transmission system designed with pure local technology. 'Development Study on the Power System Network Analysis in Myanmar' was received in the year 2001 and was completed in the year 2002. The following project,'Feasibility Study and Basic Designs for the 500kV Transmission System in Myanmar' has been in progress since January, 2004. With regards to this project the master plan for the Myanmar long term power system was submitted in January 2005, and now the basic designs for the 500kV transmission system construction are in progress. Technical data for the design of the transmission line is calculated using a very complex numerical formula that is almost impossible to be completed by hand. So the transmission technical calculation system was developed to calculate and support Myanmar technical data for the design of transmission line with respect to factors such as wind prossure load, tower design data conductor design data and insulator design data on the basis of weather conditions for the Myamar transmission line design area of the Myanmar 500kV trans- mission line construction basic design.

• Journal of Industrial Technology
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• v.22 no.B
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• pp.219-230
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• 2002

The sliding stability of monolithic vertical caisson of composite breakwaters is quantitatively analyzed by using a reliability model, FMA of Level II, in order to study the variation of sliding failure of caisson due to the occurrence of extreme waves exceeded deepwater design wave. The reliability index and several parameters in the wave pressure formula are inter- related to find out the effects of extreme wave exceeded design wave on the sliding failure of vertical monolithic caisson. The sliding failure of caisson seems to be largely increased as the heights and periods of extreme waves exceeded design wave increase, also depends directly on the water depth in front of the composite breakwaters. From the numerical simulations carried out with several kinds of extreme waves exceeded design wave which are assumed to be occurred during the service periods of breakwater, it is found that the effects of the wave height on the sliding failure of caisson may be more dominant than those of wave periods and angles of wave incidence.

• The Mathematical Education
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• v.51 no.1
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• pp.47-61
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• 2012

Students can infer mathematical principles in a very natural way by connecting mutual relations between mathematical fields. These process can be revealed by taking tasks that can derive mathematical connections. The task of this study is to make expression and design it and derive mathematical principles from the design. This study classifies the mathematical field of expression for design and analyzes mathematical thinking process by connecting mathematical fields. To complete this study, 40 gifted students from 5 to 8 grade were divided into two classes and given 4 hours of instruction. This study analyzes their personal worksheets and e-mail interview. The students make expressions using a functional formula, remainder and figure. While investing mathematical principles, they generalized design by mathematical guesses, generalized principles by inference and accurized concept and design rules. This study proposes the class that can give the chance to infer mathematical principles by connecting mathematical fields by designing.

• Journal of the Society of Naval Architects of Korea
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• v.29 no.4
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• pp.18-26
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• 1992

This paper describes a design model for conceptual design of ship. Existing design models have some problems. For example, operating environment of batch versions can not reflect design procedure of real world truely and reliability of results are not high because means of performance estimation are based only on empirical formula. To improve these problems of existing design models, a new design model has been developed. The new model consists of interactive environment with databases of main engine and existing ship data. To develop user-oriented system, graphic user interface(GUI) is adapted.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.5A
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• pp.289-297
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• 2012

This study proposes an experimental formula that can estimate the applied tensile stress of a bonded PSC by measuring a longitudinal stress wave velocity of tendon. To develop practical formula, the various bonded PSC specimens are constructed with different levels of prestresses. For all the bonded PSC specimens, the longitudinal impact-echo tests are repeated with various experimental conditions. Considering a few influence factors such as temperature, length and the number of strands, the application of the law of similarity results in a nondemensional experimental formula that could estimate existing tensile stress on tendon by measuring its longitudinal stress wave velocity. Next, a feasibility study of proposed approach has been conducted for a real reactor building containment. The estimated stress levels of two vertical tendons embedded in the nuclear plant are close to their design values.

• Herbal Formula Science
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• v.28 no.4
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• pp.429-441
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• 2020

Objectives : Systemic sclerosis(SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs and vasculopathy. The purpose of this study was to investigate the trend in the research on SSc using herbal medicine. Methods : We searched for papers which had both systemic sclerosis and herbal medicine from Pubmed, KCI and NDSL. After searching papers, we classified according to the study design and analyzed selected studies. Results : 18 studies were searched. The types and numbers of study were as follows: 11 were in vitro or in vivo studies using herbal medicine or active components, and 7 were clinical research including case reports. 1. Herbal medicines include the therapeutic effects of "tonifying qi(補氣)" or "active blood(活血)" improved systemic sclerosis in vivo and in vitro studies. 2. Active components isolated from Herbal Medicine such as Astragalus membranaceus(黃芪), Zhizi(梔子), Salvia miltiorrhiza(丹蔘) have anti-fibrotic effects. 3. Clinical trials showed that herbal medicine can improve the symptom of systemic sclerosis including skin fibrosis, Raynaud's phenomenon, pain and gastric dysmotility. Conclusions : This study showed that herbal medicine can be effective for treating SSc. However, further studies are needed to develop novel medicine for SSc.

• Journal of the Korean Society of Hazard Mitigation
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• v.7 no.4
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• pp.67-74
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• 2007

Rational method has been widely used to calculate peak runoff drainage design or small watershed because of simplicity and convenience. Runoff coefficient(C) is the most important parameter in the rational method which varies according to rainfall intensity, return period, rainfall duration time and soil characteristics. In practice, constant which is value of C in rational formula has been used from the table, originally based on ASCE. These table value does not consider the upper conditions of the depending factors, hence peak runoff calculation could be in correct. Therefore to calculate C in this paper we have devised an improved formula, considering relationship with rainfall duration, return period and CN of NRCS method. This formula is considered to be more reliable and helpful to the hydrologists and engineers to predict correct peak runoff.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6181-6185
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• 2012

Background: The aim of the study was to evaluate the available breast nomograms (MSKCC, Stanford, Tenon) to predict non-sentinel lymph node metastasis (NSLNM) and to determine variables for NSLNM in SLN positive breast cancer patients in our population. Materials and Methods: We retrospectively reviewed 170 patients who underwent completion axillary lymph node dissection between Jul 2008 and Aug 2010 in our hospital. We validated three nomograms (MSKCC, Stanford, Tenon). The likelihood of having positive NSLNM based on various factors was evaluated by use of univariate analysis. Stepwise multivariate analysis was applied to estimate a predictive model for NSLNM. Four factors were found to contribute significantly to the logistic regression model, allowing design of a new formula to predict non-sentinel lymph node metastasis. The AUCs of the ROCs were used to describe the performance of the diagnostic value of MSKCC, Stanford, Tenon nomograms and our new nomogram. Results: After stepwise multiple logistic regression analysis, multifocality, proportion of positive SLN to total SLN, LVI, SLN extracapsular extention were found to be statistically significant. AUC results were MSKCC: 0.713/Tenon: 0.671/Stanford: 0.534/DEU: 0.814. Conclusions: The MSKCC nomogram proved to be a good discriminator of NSLN metastasis in SLN positive BC patients for our population. Stanford and Tenon nomograms were not as predictive of NSLN metastasis. Our newly created formula was the best prediction tool for discriminate of NSLN metastasis in SLN positive BC patients for our population. We recommend that nomograms be validated before use in specific populations, and more than one validated nomogram may be used together while consulting patients.

• Journal of the Korean GEO-environmental Society
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• v.11 no.10
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• pp.5-13
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• 2010

Low slump mortar grouting is widely used in reinforcement of structural foundation and ground improvement in soft ground, and has advantage which construction is possible in insufficient space. However it has been not yet studied sufficiently to estimate the effect of ground improvement in design step and to prove the estimating method. So the method must be developed in order to use the low slump mortar grouting method in various cases. In this study, the field tests were performed in the reclaimed soils to measure the effect of ground improvement. Then it was compared with what was calculated by the existing formula that was formerly suggested. The results show that the value from the formula was similar with the value from the field tests. Also it was proved that the formula was available to estimate the effect of ground improvement in the loose granular soils.