• 대한한방소아과학회지
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• 제19권1호
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• pp.35-52
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• 2005

Objectives : Conclusion : The purpose of this study is to examine effect that KDKEJ used to atopic dermatitis disease patient get in atopy eruption control experimentally. Methods : We analyzed the expression of IgE, IL-6, II-4, IL-5 and IL-13's level in serum, and $IFN-{\gamma}'$ production by KDKEJ extract. We also analyzed KDKEJ extract get to NC/Nga mine's skin establishment analyzes neck-back skin after biopsy, and H&E method measured about epidermis and dermis part in comparison with control group. Results : In this research KDKEJ extract as treatment result to a NC/Nga mice, IgE and IL-6 content in serum decreased remarkably than control group. And decreased than result control group which measure II-4, IL-5 and IL-13's level in serum and $IFN-{\gamma}'$ production secreted in Th1 cell displayed increase by KDKEJ extract. IL-4 and $IFN-{\gamma}'$ gene revelation amount displayed marked decrease than control group in result that observe effect that get in skin of a NC/Nga mice's skin establishment analyzes neck-back skin after biposy, and dye by H&E method decreased about epidermis and inflammation of dermis part remarkable than control group. Conclusions : These results suggest that Th1 cell and Th2 cell observe to be shifted by secretion amount of IL-4 and $IFN-{\gamma}$ by KDKEJ extract could know that KDKEJ extract can use usefully in allergy autoimmune disease.

• 한방안이비인후피부과학회지
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• 제24권3호
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• pp.1-16
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• 2011

Objective : In the theory of Korean medicine, Scrophulariae Radix (SR) can clear away heat and cool the blood, nourish yin and promote the production of the body fluids, relieve toxin and benefit the throat. The present study was carried out to investigate effects of SR on allergic contact dermatitis (ACD) induced by 2,4-dinitrochlorobenzene (DNCB) in mice. Methods : In this experiment, effects of SR on clinical aspects on the skin, histopathological changes such as spongiosis, mast cell distribution, immune cell infiltration in tissue, spleen / body ratio and production levels of serum cytokines were investigated in vivo. In addition, effects on cell viability and release of b-hexosaminidase and histamine were also investigated in vitro. Results : SR treatment diminished erythema, desquamation and keratosis which were induced by repeated painting of DNCB. Spongiosis and edema were diminished by painting of SR in histopathological observation, infiltrations of mast cell and monocytes were also decreased in SR group. In addition, spleen / body ratio was lowered compared to ADC control group. Production level of IFN-${\gamma}$ in serum was decreased, but level of IL-4 did not affected by SR. Finally, more than 400 ${\mu}g/ml$ of SR treatment groups showed decreased cell viabilities in RBL-2H3 cells. Treatment with over 200 ${\mu}g/ml$ of SR decreased b-hexosaminidase release, and treatment with over 400 ${\mu}g/ml$ decreased histamine release in vitro. Conclusion : these data suggest that SR can decrease symptoms of ACD, then SR is useful to treat patient with ACD.

• 동의생리병리학회지
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• 제20권1호
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• pp.58-64
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• 2006

The purpose of this study is to examine closely effect that YKS used to atopic dermatitis disease patient get in atopy eruption control experimentally. We analyzed the expression of IgE, IL-6, IL-4, IL-5 and IL-13's level in serum, and IFN-${\gamma}'$ production by YKS extract. We also analyzed YKS extract get to NC/Nga mice's skin establishment analyzes neck-back skin after biopsy, and H&E method measured about epidermis and dermis part in comparison with control group. In this research YKS extract as treatment result to a NC/Nga mice, IgE and IL-6 content in serum decreased remarkably than control group. And decreased than result control group which measure IL-4, IL-5, IL-13's level in serum, and IFN-${\gamma}'$ production secreted in Th1 cell displayed increase by YKS extract. IL-4 and IFN-${\gamma}'s$ gene revelation amount displayed marked decrease than control group in result that observe effect that get in skin of a NC/Nga mice. Also, In culture supernatant which cultivate for 14 day after separate skin cell, IL-13 and IL-6 production decreased than control group. YKS extract get to NC/Nga mice's skin establishment analyzes neck-back skin after biopsy, and dye by H&E method decreased about epidermis and inflammation of dermis part remarkably than control group. These results suggest that Th1 cell and Th2 cell observe to be shifted by secretion amount of IL-4 and IFN-$\gamma$ by YKS extract could know that YKS extract can use usefully in allergy autoimmune disease.

• 한국식품영양학회지
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• 제18권4호
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• pp.380-384
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• 2005

2004년 10월부터 2005년 9월까지 대전 선골한의원에 아토피를 주 증상으로 내원한 환자 총 36명을 대상으로 증상에 따라 1개월에서 12개월 동안 복용하도록 한 후 몇 가지 일반상황 및 한방 추출물 복용 전후의 아토피 증상 호전도 등을 조사하였다. 환자 중 남녀의 성비는 61.11:38.89이었으며, 연령별 분포는 20세 이하가 18명으로 전체 환자수의 $50\%$를 차지하는 것으로 나타나 성인기, 노인기보다는 유년 및 청년기에 아토피 환자가 더 많은 것을 알 수 있었다. 아토피 증상이 호발하는 부위로는 다리와 사타구니가 $25.88\%$로 가장 많았으며, 그 다음이 팔과 목, 얼굴로 각각 $22.35\%,\;16.47\%,\;14.12\%$였고, 겨드랑이가 $2.35\%$로 가장 낮았으며 아토피가 나타나는 부위 중 한 개 혹은 두 개 이상의 부위를 가지고 있는 환자수를 조사한 결과 $50\%$이상의 환자가 3가지 이상의 아토피 호발 부위를 가진것으로 나타났다. 아토피 환자에게 한방 추출액을 복용시킨 결과 복용 전 환자들은 $72.22\%$가 중증도의 홍박과 $63.8\%$가 경도의 부종과 $44.44\%$의 경도 찰상을 보유하고 복용후 홍반과 부종, 찰상이 각각 경도 ($55.56\%$), 경도($52.78\%$), 없음($83.33\%$)으로 복용전보다 호전된 것을 알 수 있었다.

• 한국임상약학회지
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• 제33권3호
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• pp.178-185
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• 2023

Objective: Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disease. Both tralokinumab and dupilumab have been recommended in the European Guideline for the treatment of adult patients with severe AD. In Korea, dupilumab has been approved for patients with moderate to severe AD, and reimbursed for those with severe AD. Since there is no clinical trial directly comparing tralokinumab and dupilumab, we conducted indirect comparison to assess the clinical usefulness in patients with AD. Methods: We selected clinical trials for indirect comparison through a systematic literature review. Individual patient data were available for the tralokinumab clinical trial, and aggregated data were available for the dupilumab clinical trial. Therefore, we employed the Matching-Adjusted Indirect Comparison (MAIC) method. The treatment efficacy was assessed based on whether patients achieved a 75% reduction on the Eczema Area and Severity Index (EASI 75) after drug administration. Results: The difference in the proportion of patients achieving EASI 75 between tralokinumab and dupilumab was 4.7% (95% CI: -7.9 to 17.3). Considering the non-inferiority margin for the EASI 75 achievement rate is -10%, tralokinumab is deemed non-inferior to dupilumab as the lower bound of the CI for the difference in the EASI 75 achievement rate between tralokinumab and dupilumab was within -10%. Conclusion: We conducted a MAIC analysis comparing tralokinumab and dupilumab based on EASI 75 achievement. The findings of this study show that tralokinumab is non-inferior to dupilumab and can be implemented in Korean clinical settings with a therapeutic position comparable to dupilumab.

• 사상체질의학회지
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• 제33권3호
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• pp.161-170
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• 2021

Introduction Hand eczema is dermatitis that occurs on the hand and fingers. In this case, the patient had chronic hand eczema that had relapsed for 3 years, worsened for 6 months, and did not improve even with standard dermatological treatment. We report significant improvement of the patient with chronic hand eczema, diagnosed with Soeunmin Greater Yin Symptomatology based on Sasang Constitutional Medicine. Methods We prescribed herbal medicine, Sibimigwanjung-tang(十二味寬中湯), and the western medications were continued throughout the treatment period. To evaluate the treatment progression, we observed objective and subjective symptoms and took pictures of the patient's hands. Results At the first time of the outpatient visit, the patient complained of pain, oozing, scaling and severe itching even though she had taken dermatological medication for over 6 months. After 8 weeks of Korean medicine treatment, most symptoms showed improvement, and after about 47 weeks of treatment, the symptoms maintained 90% improvement even after stopping western medications and herbal medications. Conclusion The patient in this case showed a significant improvement of chronic hand eczema and the improvements have been maintained even stopping western medications and herbal medications during follow-up for 15 weeks. In addition, the patient showed improvement and maintenance of general conditions as well as skin-related symptoms. In this case, we can concern the effect of the Sasang Constitutional Medicine focused on treating the patient's general pathology as well as the patient's chief complaint at chronic hand eczema not responding to standard dermatological treatment.

• 대한한방소아과학회지
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• 제20권3호
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• pp.161-169
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• 2006

Objectives : Patients who visit oriental medical hospital for growth treatment are increasing. So we aimed to classify the tendency of the patients. Methods : We studied 231 patients who visited Oriental medical hospital for growth treatment from January 2004 to August 2005. We classified sex ratio, height percentile, symptom form of the Oriental medicine, age ratio and developed complication of patients. We used X-ray, endoscope for nasal cavity, blood sample, the Standard Growth Table made by the Korean Association of Pediatrics, 1998. Results : The results which were classified as follows; boys were 50.2 percentile, girls were 49.8 percentile. The classification according to age stage resulted as follows; infant stage 1.3 percentile, preschool age 13.4%, school age 28.6%, rapid growth stage 22.9 percentile, puberty 33.8 percentile. The classification according to height percentile resulted as follows; 3 percentile or under 12.1%, 25 percentile or under 48.9%, 50 percentile or under 25.6%, 75 percentile or under 10.8%, 75 percentile excess 2.6%. The classification according to disease resulted as follows; paranasal sinusitis 12.1 percentile, allergic rhinitis 10 percentile, atopic dermatitis 5.6 percentile, nocturia 3 percentile, convulsion or tic disorder 2.2 percentile, precocious puberty 1.3 percentile, Tuner syndrome 0.9 percentile, developmental disability 0.4 percentile. Conclusions : Sex ratio of children patients who visited Orienatal medical hospital were nearly the same. 13.4% of hospital visit children patients were taller than average. Most of the male children patients were school ages while the female were in puberty. 35.5% of them have developed complication as follows; paranasal sinusitis, allergic rhinitis, atopic dermatitis, nocturia, convulsion or tic disorder, precocious puberty, Tuner syndrome and developmental disability.

• Clinical and Experimental Pediatrics
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• 제59권8호
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• pp.319-327
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• 2016

Allergic diseases such as asthma, allergic rhinitis, atopic dermatitis, and food allergy, are most common chronic, noncommunicable diseases in childhood. In the past few decades, the prevalence has increased abruptly worldwide. There are 2 possible explanations for the rising prevalence of allergic diseases worldwide, that an increased disease-awareness of physician, patient, or caregivers, and an abrupt exposure to unknown hazards. Unfortunately, the underlying mechanisms remain largely unknown. Despite the continuing efforts worldwide, the etiologies and rising prevalence remain unclear. Thus, it is important to identify and control risk factors in the susceptible individual for the best prevention and management. Genetic susceptibility or environments may be a potential background for the development of allergic disease, however they alone cannot explain the rising prevalence worldwide. There is growing evidence that epigenetic change depends on the gene, environment, and their interactions, may induce a long-lasting altered gene expression and the consequent development of allergic diseases. In epigenetic mechanisms, environmental tobacco smoke (ETS) exposure during critical period (i.e., during pregnancy and early life) are considered as a potential cause of the development of childhood allergic diseases. However, the causal relationship is still unclear. This review aimed to highlight the impact of ETS exposure during the perinatal period on the development of childhood allergic diseases and to propose a future research direction.

• 한국임상수의학회지
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• 제32권3호
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• pp.259-262
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• 2015

아토피성 피부염 장기 치료중인 개가 식욕부진을 동반한 갑작스러운 호흡기 증상으로 내원하였다. 영상학적 진단 및 기관지 세척액의 세포검사 결과 곰팡이성 폐렴으로 진단되었다. 관찰된 곰팡이는 분자적 동정 및 계통분석학적 분석 결과 Candida catenulata로 확인되었다. 3주간의 경구 itraconazole 치료 후 환자는 회복되었다. 이 증례는 개에서 C. catenulata 감염의 첫 예이다.

• 한방안이비인후피부과학회지
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• 제9권1호
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• pp.166-172
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• 1996

The alopecia is classified to Alopecia areata, Telogen effluvium, Anagen effluvium and Androgenetic alopecia. The exact cause of alopecia is not known, but a inherent and immunologic anc psychosomatic and endocrinic factors are suspected. We analysed clinical study in 77 patients, who had visited to the Dept. of Dermatology, Hospital of Oriental Medicine, Kyung Hee University to treat alopecia from June, 1994 to March, 1995. The results were summarized as follows; 1. In the series of 77 patients, $52\%\;were\;male\;and\;48\%$ were female. The peak incidence of age group was 20 to 29 ($55\%$). 2. The peak incidence of age group at on set was 20 to 29 ($49\%$). 3. The most frequent feature was insomnia ($25\%$). Frequent appeared signs and symptoms in descending order were head itching, head scale, fatigue and dizziness. 4. The personal history of patient were seborrheic dermatitis ($17\%$), atopic dermatitis, disorder of thyroid gland and acne in descending order. 5. The patients with family history occupied $25\%$. 6. Shineung Yangjin Dan was most used in treatments as $36\%$.