• Steel and Composite Structures
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• v.39 no.5
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• pp.493-509
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• 2021

There is not enough mixed finite element method (MFEM) model developed for static and dynamic analysis of functionally graded material (FGM) beams in the literature. The main purpose of this study is to develop a reliable and efficient computational modeling using an efficient functional in MFEM for free vibration and static analysis of FGM composite beams subject to high order shear deformation effects. The modeling of material properties was performed using mixture rule and Mori-Tanaka scheme which are more realistic determination techniques. This method based on the assumption that a two phase composite material consisting of matrix reinforced by spherical particles, randomly distributed in the beam. To explain the displacement components of the shear deformation effects, it was accepted that the shear deformation effects change sinusoidal. Partial differential field equations were obtained with the help of variational methods and then these equations were transformed into a novel functional for FGM beams with the help of Gateaux differential derivative operator. Thanks to the Gateaux differential method, the compatibility of the field equations was checked, and the field equations and boundary conditions were reflected to the function. A MFEM model was developed with a total of 10 degrees of freedom to apply the obtained functional. In the numerical applications section, free vibration and flexure problems solutions of FGM composite beams were compared with those predicted by other theories to show the effects of shear deformation, thickness changing and boundary conditions.

• Bulletin of the Korean Chemical Society
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• v.29 no.2
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• pp.363-371
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• 2008

As a computational method for the discovery of the effective agonists for PPARd, we address the usefulness of molecular dynamics free energy (MDFE) simulation with explicit solvent in terms of the accuracy and the computing cost. For this purpose, we establish an efficient computational protocol of thermodynamic integration (TI) that is superior to free energy perturbation (FEP) method in parallel computing environment. Using this protocol, the relative binding affinities of GW501516 and its derivatives for PPARd are calculated. The accuracy of our protocol was evaluated in two steps. First, we devise a thermodynamic cycle to calculate the absolute and relative hydration free energies of test molecules. This allows a self-consistent check for the accuracy of the calculation protocol. Second, the calculated relative binding affinities of the selected ligands are compared with experimental IC50 values. The average deviation of the calculated binding free energies from the experimental results amounts at the most to 1 kcal/mol. The computational efficiency of current protocol is also assessed by comparing its execution times with those of the sequential version of the TI protocol. The results show that the calculation can be accelerated by 4 times when compared to the sequential run. Based on the calculations with the parallel computational protocol, a new potential agonist of GW501516 derivative is proposed.

• Journal of Ship and Ocean Technology
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• v.6 no.1
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• pp.34-53
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• 2002

Numerical solution of the forward-speed radiation problem for a half-immersed cylinder advancing in regular waves is presented by making use of the improved Green integral equation in the frequency domain. The B-spline higher order panel method is employed stance the potential and its derivative are unknown at the same time. The present numerical solution of the improved Green integral equation by the B-spline higher order Kelvin panel method is shown to be free of irregular frequencies which are present in the Green integral equation using the forward-speed Kelvin-type Green function.

• Environmental Analysis Health and Toxicology
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• v.5 no.1_2
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• pp.45-50
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• 1990

In order to investigate the phototoxicity of five phenothiazine derivatives and one thioxanthen derivative were examined by using in vitro method based on growth inhibition of Candida albicans and red blood cell hemolysis. Effects of the test compounds on RBCs were monitored with a spectrophotometer and a drug PI in the Candida albicans was calculated on the basis of the lowest concentration giving a yeast-free zone. All phenothiazines phototoxic in the red blood cell hemolysis method were positive in the yeast test except promethazine. It was also observed that toxic photo-products were formed by perphenazine and chlorpromazine in the red blood cell hemolysis.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.5 no.3
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• pp.204-211
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• 1993

Boundary element method is applied to simulate nonlinear water waves using Green's identity formula in a numerical wave flume. A system of linear equations is formulated from the governing equation and free surface boundary conditions in order to calculate velocity potential and water surface elevation at each nodal point. The velocity square terms are included in the dynamic free surface boundary condition. The free surface is treated as a moving boundary. the vertical variation of velocity potential being considered in calculating the time derivative of the velocity potential at the free surface. The present method is applied to simulate solitary wave and Stokes 2nd order wave, and shows excellent agreements with their theoretical values.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2001.10a
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• pp.202-206
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• 2001

A three dimensional incompressible Navier-Stokes code based on the third derivative upwind is employed to simulate the flow around the underwater vehicle advancing on the calm water. Computations are carried out in the range of Froude numbers 0.4 to 0.7. The wave resistance, lift, moment and the pressure distribution on the body are calculated. Computations are performed in a rectangular grid system based on the Marker & Cell method. For validation, computation results are compared with existing experimental results.

• Honam Mathematical Journal
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• v.44 no.4
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• pp.572-593
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• 2022

Crime committed by civilians and criminals using legal and illegal firearms and conversion of legal firearms into illegal ones has become a common practice around the world. As a result, policies to control civilian gun ownership have been debated in several countries. The issue arose because the linkages between firearm-related mortality, weapon accessibility, and violent crime data can imply diverse options for addressing criminality. In this paper, we have projected a mathematical model in terms of the Caputo fractional derivative to address the issues viz. input of legal guns, crime committed by legal and illegal guns, and strict government policies to monitor the license of legal guns, strict action against violent crime. The boundedness, existence and uniqueness of solutions and the stability of points of equilibrium are examined. It is observed that violent crime increases with the increase of crime committed by illegal guns, crime committed by legal guns and, decreases with the increase of legal guns, the deterrent effect of civilian gun ownership, and action of law against crime. Further, legal guns increase with the increase of the limitation of trade of illegal guns and decrease with the increase of conversion of legal guns into illegal guns and increase of the growth rate of illegal guns. Again, as crime is committed by legal guns also, the policy of illegal gun control does not assure a crime-free society. Weak gun control can lead to a society with less crime. Theoretical aspects are numerically verified in the present work.

• The Journal of Korea Robotics Society
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• v.15 no.1
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• pp.77-89
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• 2020

This paper proposes a simple and intuitive model-free torque-tracking control for rotary electro-hydraulic actuators. The undesirable natural-velocity-feedback effect is discussed by introducing mechanical impedance into the electro-hydraulic actuation system. The proposed model-free torque control comprises inner- and outer-loop control to achieve two control objectives. Inner-loop control reduces the mechanical impedance passively and optimally. To improve the tracking accuracy, a certain form of proportional-integral-derivative control is applied to the outer loop. The robustness of the proposed closed-loop system against external disturbances is demonstrated by transforming the two-loop control structure into a disturbance observer form. The proposed method is validated on a single joint electro-hydraulic actuator.

• Journal of radiological science and technology
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• v.10 no.1
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• pp.85-90
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• 1987

Preliminary studies on the measurement of the free thyroxine in the serum with Amerlex $FT_{4}$ RIA kit were investigated using a tracer as $^{125}I-T_{4}$ derivative which is not almostly bound to thyroxine binding globulin, etc. The results are followed: 1. Linearity was tested on standards at various concentrations, and reproducibility and accuracy was excellent. 2. The antibody specificity is also excellent, and standard calibration curve of total $T_{4}$ was similar that of adding the TBG inhibitor. 3. Each value of $T_{4}$ in serum (the normal group, the hypothyroidism patients the pregnant women and the TBG dificiency patients) was not significant. As mentioned above, this method is more simple and rapid, compared to the other method.

• Structural Engineering and Mechanics
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• v.88 no.5
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• pp.439-449
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• 2023

Non-linear vibration characteristics of functionally graded CNT-reinforced composite (FG-CNTRC) cylindrical shell panel on elastic foundation have not been sufficiently examined. In this situation, this study aims at the profound numerical investigation of the non-linear vibration response of FG-CNTRC cylindrical panels on Winkler-Pasternak foundation by introducing an accurate and effective 2-D meshfree-based non-linear numerical method. The large-amplitude free vibration problem is formulated according to the first-order shear deformation theory (FSDT) with the von Karman non-linearity, and it is approximated by Laplace interpolation functions in 2-D natural element method (NEM) and a non-linear partial derivative operator H_NL. The complex and painstaking numerical derivation on the curved surface and the crucial shear locking are overcome by adopting the geometry transformation and the MITC3+ shell elements. The derived nonlinear modal equations are iteratively solved by introducing a three-step iterative solving technique which is combined with Lanczos transformation and Jacobi iteration. The developed non-linear numerical method is estimated through the benchmark test, and the effects of foundation stiffness, CNT volume fraction and functionally graded pattern, panel dimensions and boundary condition on the non-linear vibration of FG-CNTRC cylindrical panels on elastic foundation are parametrically investigated.