• Molecules and Cells
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• v.43 no.2
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• pp.160-167
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• 2020

Runt-related transcription factor 2 (RUNX2) is a key transcription factor for bone formation and osteoblast differentiation. Various signaling pathways and mechanisms that regulate the expression and transcriptional activity of RUNX2 have been thoroughly investigated since the involvement of RUNX2 was first reported in bone formation. As the regulation of Runx2 expression by extracellular signals has recently been reviewed, this review focuses on the regulation of post-translational RUNX2 activity. Transcriptional activity of RUNX2 is regulated at the post-translational level by various enzymes including kinases, acetyl transferases, deacetylases, ubiquitin E3 ligases, and prolyl isomerases. We describe a sequential and linear causality between post-translational modifications of RUNX2 by these enzymes. RUNX2 is one of the most important osteogenic transcription factors; however, it is not a suitable drug target. Here, we suggest enzymes that directly regulate the stability and/or transcriptional activity of RUNX2 at a post-translational level as effective drug targets for treating bone diseases.

• Journal of Oral Medicine and Pain
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• v.44 no.3
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• pp.118-122
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• 2019

Paraneoplastic pemphigus (PNP) is a rare and often fatal autoimmune blistering disease accompanied by both benign and malignant neoplasms. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by PNP patients. Oral ulcers are initial lesions in various autoimmune diseases like pemphigus, bullous pemphigoid, erythema multiforme, graft-versus-host, lichen planus, it does not improved despite of high-dose steroid therapy. We report a-35-year-old female who presented oral ulceration, lip crust and skin lesions. By doing several examinations, such as enzyme-linked immunosorbent assay, incisional biopsy with indirect immunofluorescence, she was diagnosed PNP with non-Hodgkin's lymphoma on pancreas.

• Journal of Korean Dental Hygiene Science
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• v.4 no.2
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• pp.67-75
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• 2021

Background: Workers' oral health problems result in work disruption, including absenteeism or early leave, which reduces work efficiency. This study was conducted to investigate the subjective oral health status and oral problems of workers,and to identify the factors disrupting workflow due to oral problems. Methods: A self-report questionnaire was administered to 300 industrial workers in a metropolitan area. A total of 284 individuals were finally analyzed, after excluding the data of 16 workers who had missing responses among the recovered questionnaires. Results: Subjective oral health status was average in 44.4%, healthy in 32.0%, and unhealthy in 16.9% of the study population. Subjective oral health problems were the highest in the order of food impaction(28.9%), cavity(26.8%), tooth sensitivity (22.9%), and calculus(21.1%). However, sudden and unexplained tooth pain (12.0%), gum swelling and tooth mobility (10.2%), and wisdom tooth pain (4.9%) were relatively low. The average monthly income (p<.05) and subjective oral health status (p<.01) were statistically significant factors interrupting workflow. Conclusion: To minimize workers' oral health problems and work disruption due to oral diseases, it is necessary to promote workers' oral health and oral disease prevention programs within the workplace.

• Journal of Korean society of Dental Hygiene
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• v.24 no.2
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• pp.91-98
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• 2024

Objectives: This case study aimed to evaluate changes in periodontal pathogens and systemic disease indicators following the adjunctive use of probiotics for periodontal treatment. Methods: Two adults, a 64-year-old male and 71-year-old female, were selected with ethical approval and underwent comprehensive oral and systemic health assessments before and after probiotic intake with periodontal debridement. Results: There was a significant reduction in the periodontal pathogens, particularly Porphyromonas gingivalis and Treponema forsythia, and no adverse systemic indicators were observed. Moreover, a trend toward improved lipid profiles was noted, suggesting a potential positive impact on systemic health. Conclusions: This study shows the potential role of probiotics in enhancing oral health and preventing systemic diseases, thus highlighting the need for further research and clinical trials.

• Journal of Korean society of Dental Hygiene
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• v.2 no.1
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• pp.115-129
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• 2002

The purpose of this study was to examine the actual dental hygiene status of workers in cement industry in an effort to serve as a basis for enhancing their dental hygiene. The subjects in this study were 420 laborers from the cities of Curi, Donghae and Samcheok who handled cement. As a result of conducting a survey, the following findings were given : l. The workers investigated found their working environment satisfactory, getting a mean score of 323. They also expressed a high job satisfaction with a mean score of 333. 2. They didn't have a big interest in oral health. By age group, those who were aged between 36 and 40, or who cared less about health management, showed a higher interest in oral health. Besides, the laborers who kept smoking for a longer period, or who drunk more, expressed greater interest. 3. The toothbrushing method was considered most important for periodontal health, by 45.0% of the workers, and the next most crucial one was regular dental examination, followed by refraining from smoking and staying away from sweet food in the order named. 4. Concerning daily mean toothbrushing frequency, 455% brushed their teeth three times a day on the average. More than half them didn't pay enough attention to toothbrushing. 5. Regarding scaling, the large number of the workers, 42.4%, had no experience to get their teeth scaled, 37.6%, the greatest percentage, didn't have their teeth scaled because it seemed to make their teeth painful or cold. 6. As fororal health education experience, 67.6%, the great number of them, had no experience to receive dental health education. The above-mentioned findings suggest that the cement-related workers generally neglected dental health management. They should be encouraged to correct their wrong oral health knowledge or habit to make their oral cavity more healthy. To make it happen, it's required to provide oral health education and promote organized dental health projects.

• Journal of Korean society of Dental Hygiene
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• v.18 no.3
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• pp.269-280
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• 2018

Objectives: The purpose of this study was to investigate the change in the posture of dental hygiene students and clinical dental hygienists when implementing dental scaling before and after posture correction training using the rapid upper limb assessment (RULA) method and 3D motion analysis. Methods: Thirty-two healthy volunteers performed dental scaling to remove artificial calculus on dental manikin. The movement and angle of the joints were verified by RULA and 3D motion analysis during the procedure. The subjects were also photographed for 1 minute during the procedure for 10 minutes while the calculus was removed. After the removal of the calculus, the subject and the instructor checked the video together. Posture correction training was conducted by the instructor so that the subject could perform the calculus removal operation in the correct posture. Artificial calculus of the adjacent teeth was then removed for the same period of time, and the change in posture was reviewed. Results: The total score of the posture change using RULA was $5.72{\pm}0.58$ before training and $4.31{\pm}0.10$ after training, showing a significant decrease after training (p<0.001), and upper arm, lower arm, wrist position, neck and waist position showed significant decrease after training. The three-dimensional motion analysis showed significant differences according to the criteria measured at all measurement sites except the left shoulder (p<0.05) Conclusions: It was confirmed through RULA and 3D motion analysis that postural correction training using calculus removal images was effective, and that correct postural education is essential to preventing musculoskeletal diseases caused by removal of calculus.

• Journal of Periodontal and Implant Science
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• v.46 no.6
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• pp.405-414
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• 2016

Purpose: This study aimed to evaluate the effects of a policy change to expand Korean National Health Insurance (KNHI) benefit coverage to include scaling on access to dental care at the national level. Methods: A nationally representative sample of 12,794 adults aged 20 to 64 years from Korea National Health and Nutritional Examination Survey (2010-2014) was analyzed. To examine the effect of the policy on the outcomes of interest (unmet dental care needs and preventive dental care utilization in the past year), an estimates-based probit model was used, incorporating marginal effects with a complex sampling structure. The effect of the policy on individuals depending on their income and education level was also assessed. Results: Adjusting for potential covariates, the probability of having unmet needs for dental care decreased by 6.1% and preventative dental care utilization increased by 14% in the post-policy period compared to those in the pre-policy period (2010, 2012). High income and higher education levels were associated with fewer unmet dental care needs and more preventive dental visits. Conclusions: The expansion of coverage to include scaling demonstrated to have a significant association with decreasing unmet dental care needs and increasing preventive dental care utilization. However, the policy disproportionately benefited certain groups, in contrast with the objective of the policy to benefit all participants in the KNHI system.

• Journal of Dental Anesthesia and Pain Medicine
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• v.19 no.4
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• pp.217-226
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• 2019

Background: We aimed to assess the dose needed to achieve the propofol effect-site concentration using target-controlled infusion in intellectually disabled patients and to detail the most effective method for achieving a safe level of consciousness without hemodynamic changes as well as detail any resulting adverse effects. Methods: We performed a retrospective review of sedation service records of 138 intellectually disabled patients (51, mental retardation; 36, autism; 30, brain lesion, 12 genetic diseases, 9 dementia) aged over 15 years and weighing over 30 kg. These patients had received propofol via target-controlled infusion in the special care dental clinic of Seoul National University Dental Hospital from May 2008 to September 2018 for restorative treatment (112), minor surgery (13), prosthodontics (7), periodontics treatment (5), and implant (1). Results: For all groups, the duration of dental treatments was $43{\pm}18$ minutes, total sedation time was $73{\pm}23$ minutes, and total BIS values was $57{\pm}12$. The propofol maintenance dosage values for each group were: mental retardation, $3{\pm}0.5(2-4){\mu}g/ml$; autism, $3.1{\pm}0.7(2-5){\mu}g/ml;$; brain lesion, $2.8{\pm}0.7(1.5-5){\mu}g/ml;$; genetic disease, $2.9{\pm}0.9(1-4){\mu}g/ml;$ and dementia $2.3{\pm}0.7(1-3.4){\mu}g/ml;$. Conclusions: The dementia group needed a lower dosage to reach a safe, effective propofol effect-site concentration than the other groups. Since there were no complications, deep sedation is a great alternative to general anesthesia for dental treatment of intellectually disabled patients.

• Journal of Korean society of Dental Hygiene
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• v.22 no.6
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• pp.477-483
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• 2022

Objectives: The purpose of this study was to provide basic data that would inform the direction of oral rehabilitation and how to expand of the role of dental hygienists in Japan. Methods: A systematic literature review was conducted on the role of dental hygienists in the field of oral rehabilitation in Japan. Results: Japan has been making academic and practical developments in the field of oral rehabilitation for over 30 years, and has been gradually implementing a fee support policy since the 1990s. In addition, Japan has been operating a dental hygienist system specializing in oral rehabilitation since 2006. The related work was being carried out with the dental hygienist's expertise in the field of rehabilitation medical treatment secured. Dental hygienists work full-time at long-term care facilities for the elderly in addition to conducting oral care activities under the local comprehensive care system, in the areas of convalescence and acute rehabilitation, as well as in the field of visiting rehabilitation. It can be seen that, in the field of nursing care, they are specialized in oral care tasks for the elderly. Conclusions: In the future, a policy and related fee system should be gradually prepared to expand the role of dental hygienists in the field of oral rehabilitation that can contribute to improving oral health linked to systemic diseases.

• Journal of Korean society of Dental Hygiene
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• v.9 no.4
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• pp.593-605
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• 2009

Objectives : In an aging society, as the necessity of the elderly oral health care was increased, the oral health dimensions was a lot more visible important to a community public health service for the quality of life improvement. In oral health care of the elderly, the periodic scaling treatment was required to manage periodontal tissue care. Methods : So, the 319 elderly people were selected by a random sampling method, those who are visitors of 5 public health centers in the South Jeolla Province. based on the findings of personal interview questionnaires and oral health states from these elderly subjects, we made a comparative analysis of oral health states of the elderly scaling program subjects. Results : 1. Among the participants, 52.4% of the elderly benefited from scaling care project otherwise 47.6%, the subjects with periodontal diseases were 78.4%, whereas 21.6% of the ones who don't. 2. In regard to perceptions of oral cavity abnormal symptoms, findings revealed that the teeth smart sensation with something cold was 'yes' 62.7%, 'No' 37.3%, gingival bleeding was 'yes' 61.4%, 'No' 38.6%, oral odor(halitosis) was 'yes' 63.3%, 'No' 36.7%, and dried mouth was 'yes' 63.3%, 'No' 36.7%. 3. The study data showed 73.2% of periodontal disease subjects, and 24.6% of no periodontal diseases responded that they have hyperesthesia and 67.6% of periodontal diseases, 39.1% no periodontal diseases responded that they have gingival bleeding. 4. In comparison of the presence of periodontal disease with scaling service program state, it is show that the elderly scaling service program was significant statistically in Elderly's periodontal disease prevention. according to analysis, 52.4% of the subjects with and 34.8% of no periodontal diseases received the Elderly scaling service program(p<0.05). Conclusions : Therefore, oral health care of the elderly, a community public health service the periodic scaling treatment was required to manage periodontal tissue care.