• Korean Journal of Veterinary Service
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• v.44 no.4
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• pp.195-207
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• 2021

Species A rotaviruses (RVAs) replicate and assemble their immature particles within electron dense compartments known as viroplasms, where lipid droplets (LDs) interact with the viroplasm and facilitate viral replication. Despite the importance of LD formation in the life cycle of RVAs, the upstream molecules modulating LD formation remain unclear. This study aimed to find out the role of sterol regulatory element-binding proteins (SREBPs) in reprogramming of LD formation after RVA infection. Here, we demonstrate that RVA infection reprograms the sterol regulatory element-binding proteins (SREBPs)-dependent lipogenic pathways in virus-infected cells, and that both SREBP-1 and -2 transactivated genes, which are involved in fatty acid and cholesterol biosynthesis, are essential for LD formation. Our results showed that pharmacological inhibition of SREBPs using AM580 and betulin and inhibition of their downstream cholesterol biosynthesis (simvastatin for HMG-CoA reductase) and fatty acid enzymes (TOFA) negatively modulated the intracellular triacylglycerides and cholesterol levels and their resulting LD and viroplasm formations. Interestingly, pharmacological inhibition of SREBPs significantly reduced RVA protein synthesis, genome replication and progeny production. This study identified SREBPs-mediated lipogenic reprogramming in RVA-infected host cells, which facilitates virus replication through LD formation and its interaction with viroplasms, suggesting that SREBPs can be a potential target for the development of efficient and affordable therapeutics against RVA infection.

• Journal of the Earthquake Engineering Society of Korea
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• v.21 no.1
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• pp.69-76
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• 2017

Seismic analyses of a pile under a large rigid basement foundation embedded in the homogeneous soil layer were performed practically by a response displacement method assuming a sinusoidal wave form. However, it is hard to take into account the characteristics of a large mat foundation and a heterogeneous soil layer with the response displacement method. The response displacement method is relevant to the 2D problems for longitudinal structures such as tunnel, underground cave structure, etc., but might not be relevant with isolated foundations for building structures. In this study, seismic pile analysis by a pseudo 3D finite element method was carried out to compare numerical results with results of the response displacement method considering 3D characteristics of a foundation-soil system which is important for the building foundation analyses. Study results show that seismic analyses results of a response displacement method are similar to those of a pseudo 3D numerical method for stiff and dense soil layers, but they are too conservative for a soft soil layer inducing large soil pressures on the foundation wall and large pile displacements due to ignored foundation rigidity and resistance.

• Computers and Concrete
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• v.21 no.5
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• pp.539-546
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• 2018

Making a transverse opening in concrete beams in order to accommodate utility services through the member instead of below or above of that, sometimes may be necessary. It is obvious that inclusions of an opening in a beam decreases its flexural and shear strengths. Fabricated steel bars are usually used to increase the capacity of the opening section, but details of reinforcements around the opening are dense and complex resulting in laborious pouring and setup process. The goal of this study was to investigate the possibility of using steel fibers in concrete mixture instead of complex reinforcement detailing order to strengthen opening section. Nonlinear finite element method was employed to investigate the behavior of steel fiber reinforced concrete beams. The numerical models were validated by comparison with experimental measurements tested by other investigators and then used to study the influence of fiber length, fiber aspect ratio and fiber content on the shear performance of SFRC slender beams with opening. Finally, it was concluded that the predicted shear strength enhancement is considerably influenced by use of steel fibers in concrete mixture but the effect of fiber length and fiber aspect ratio wasn't significant.

• Geomechanics and Engineering
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• v.33 no.2
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• pp.195-202
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• 2023

In this study, the ground settlement in backside of retaining wall and the behavior of the retaining wall were analyzed according to the method of groundwater drawdown due to excavation by using two-dimensional(2D) finite element analysis. Numerical analysis was performed by applying 1) fixed groundwater level, 2) constant groundwater drawdown, and 3) transient groundwater drawdown. In addition, the behavior of the retaining wall according to the initial groundwater level, ground conditions, and surcharge pressure in backside of retaining wall was evaluated. Based on the numerical analysis results, it was confirmed that when the groundwater level is at 0.1H from the ground surface (H: Excavation soil height), the wall displacement and ground settlement are not affected by the method of groundwater drawdown, regardless of soil conditions (dense or loose) and surcharge pressure. On the other hand, when the groundwater level is at 0.5H from the ground surface, the method of groundwater drawdown was found to have a significant effect on wall displacement and ground settlement. In this case, the difference in ground settlement presents by up to 4 times depending on the method of groundwater drawdown, and the surcharge load could increase the ground settlement by up to 1.5 times.

• Journal of Advanced Research in Ocean Engineering
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• v.3 no.4
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• pp.158-164
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• 2017

A pipeline is one of the most important structures for the transportation of fluids such as oil, natural gas, and wastewater. The uplift behavior of pipelines caused by earthquakes and buoyancy is one of the reasons for the failure of pipelines. The objective of this study is to examine the peak uplift resistance using parametric studies with numerical modeling of PLAXIS 3D Tunnel. The effects of burial depth and pipe diameter on the uplift resistance of loose and dense sand were first examined. Subsequently, the effects of the length of geogrid layers and the number of geogrid layers were examined to prevent uplift behavior.

• Journal of Korea Foundry Society
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• v.21 no.5
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• pp.286-289
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• 2001

The glass formation behavior was investigated in the melt spun Zr-Ti-Cu-Ni-X (X=B, P and Si) ribbons. The magnitude of supercooled liquid region of Zr-Ti-Cu-Ni alloy increased with an addition of alloying element. The glass transition temperature and the crystallization temperature increased and the magnitude of supercooled liquid region decreased with increasing the content of alloying elements. The largest supercooled liquid region was observed in the Si containing alloy. This is believed to be due to the dense atom packing with the optimum atomic size ratio of constituent elements.

• Journal of the Optical Society of Korea
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• v.18 no.4
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• pp.406-413
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• 2014

An optical true-time delay beam-forming system using a tunable dispersion compensating module (DCM) for dense-wavelength division modulation (DWDM) and a multiwavelength fiber ring laser for a phased array antenna is proposed. The multiwavelength fiber ring laser has one output that includes four wavelengths; and four outputs that include only single-wavelength. The advantage of such a multiwavelength fiber ring laser is that it minimizes the number of devices in the phased array antenna system. The time delays according to wavelengths, which are assigned for each antenna element, are obtained from the tunable DCM. The tunable DCM based on a temperature adjustable Fabry-Perot etalon is used. As an experimental result, a DCM could be used to obtain the change of the beam angle by adjusting the dispersion value of the DCM at the fixed lasing wavelengths of the fiber ring laser in the proposed optical true-time delay.

• Economic and Environmental Geology
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• v.30 no.2
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• pp.117-122
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• 1997

Soils collected from pusan metropolitan city were analysed for Cu, Pb, Zn, Cd, Mn to determine their dispersion patterns, mode of occurrences and to investigate the pollution level of heavy metals by urbanization. Element couples of Zn-Cu and Pb-Cd showed good correlation respectively and pollution sources of Zn-Cu, and Pb-Cd were similar. Pb was highly enhanced in dense traffic areas. Soil chemistry around mineralized areas originating from basic host rocks are characterized by high content of Pb, Zn, Cu, Cd, Mn and As.

• Proceedings of the KIEE Conference
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• 1999.07e
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• pp.2044-2046
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• 1999

In this paper, the propagation of corona streamer was simulated using finite element method(FEM) combined with Flux-Corrected Transport(FCT) algorithm. To obtain more effective grid distribution, the adaptive mesh generation scheme was also employed. The employed adaptive scheme can refine the mesh where needed. In addition, it is possible to coarsen the unnecessarily dense mesh. Two models were analyzed with proposed method. And the results are shown.

• Proceedings of the Optical Society of Korea Conference
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• 2003.02a
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• pp.156-157
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• 2003

The wavelength converter is considered to be a key element of future dense WDM optical networks. It enables wavelength reuse and resolves contention problem. Moreover, the tunability of the wavelength converter enhance the flexibility of network systems by facilitating reconfigurable dynamic wavelength routing. In order to achieve optically tunable wavelength conversion, we recently proposed and experimentally demonstrated wavelength conversion and tuning based on cascaded sum and difference frequency generation in a Ti：PPLN channel waveguide. (omitted)