• 한국식품영양학회지
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• 제33권4호
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• pp.363-371
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• 2020

This study was designed to evaluate the improvement in exercise endurance by Hovenia dulcis fruit hot water extract (HDWE) for the potential application as a functional food material. The effect was based on the evaluation of the forced-swimming capacity and changes in biochemical parameters in mice. Six-week-old mice were classified into four groups based on a randomized block design: the negative control group, the HDWE 50 mg/kg body weight group, the HDWE 200 mg/kg body weight group, and the 1-octacosanol 50 mg/kg body weight group (n=8 mice per group). The swimming exercise time in the HDWE-50 group was increased at 545±43 sec compared to the control group at 263±28 sec. The HDWE-200 fatigue indicators, lactate acid and ammonia content, decreased to 4.99±0.33 mg/mL and 0.63±0.05 mg/mL, respectively. In addition, the content of glycogen in the liver and muscle tended to increase in the group administered HDWE but was not significant. Likewise, the LDH and glucose contents were increased compared to the control group. The muscle damage indicators ALT (52.7±2.6 U/L) and AST (42.5±5.2 U/L) tended to decrease compared to the control group (76.4±10.2 U/L).

• 한국잠사곤충학회지
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• 제29권2호
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• pp.31-37
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• 1987

Cd를 농도별로 뽕잎에 분무하여 5령 기잠부터 급상한 후 잠업량 기관 및 조직의 건물중량과 이들의 Cd 및 Zn함량을 분석하였고 또한 이들의 누에 생리에 미치는 영향을 비교한 바, 다음과 같은 결과를 얻었다. 1. 상엽에 Cd를 분무처리한 후의 Cd 잔유량은 처리량의 약 50% 정도였다. 잠업량은 무처리구보다 Cd처리구가 적었으며 암수별로 보면 무처리구는 암컷이 많은데 비해 Cd처리구는 암컷이 적었다. 2. 전부 및 중부사선의 중량은 Cd 100ppm처리구에서 암컷은 모두 14% 감소했고 숫컷의 전부사선은 95 감소하였으나 후부사선은 감소하지 않았다. 3. Cd 100ppm처리상엽의 급여로 건물중량에 가벼워진 것은 견사선, 지방체, 후장 등이며 무거워진 것은 중상과 말피기관이었다. 누에 전체 건물중량은 암수 모두 Cd 100ppm처리로 가벼워지고 그 비율은 암컷에서 크게 나타났다. 4. 각 기관조직에서 Cd함량은 무처리구에서는 검출되지 않았으나 Cd처리구에서는 중상>후상>말피기관>두부순이며 지방체와 견사선에서는 적게 축적되었다. 5. Cd축적량은 암수별로 보면 중상에는 숫컷이 많아Td나 그외의 견사선, 지방체, 말피기관, 두부, 기관, 피층조직 등에서는 암컷에서 축적이 많았다. 6. 누에 전체 Zn함량은 무처리구가 60ppm 이하인데 비해 Cd 100ppm처리구에서는 80ppm 이상이였다. 그리고 Cd처리구에서의 Zn함량이 증가된 부위는 견사선, 말피기관 및 중상 등이였고 지방체에서는 감소하였다. 7. Cd처리구의 견사선에서는 Cd는 암컷에서, Zn은 숫컷에서 많이 축적되었다.

• Korean Journal of Acupuncture
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• 제20권1호
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• pp.31-38
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• 2003

Effects of Haenggan($LR_2$) and Chungwan ($CV_{12}$) acupuncture on plasma lipid composition were investigated in rat fed high fat diet. Body weight gain showed a tendency to decrease in acupuncture groups and in acupuncture groups, chungwan acupuncture groups showed a lower values than haenggan acupuncture group. Concentrations of plasma triglyceride, free fatty acids showed a decrease in the acupuncture groups. Concentration of plasma lipoprotein showed a tendency to decrease in acupuncture groups, however in the control group and haenggan group, the values showed no significantly different. Plasma glucose concentration showed a low values than control group, in acupuncture groups, the values showed no significantly different. In plasma cholesterol concentration, total cholesterol and LDL-cholesterol showed a tendency to decrease in acupuncture groups, however the values of LDL-cholesterol showed no significantly different in the control group and haenggan group. HDL-cholesterol concentration showed no significantly different in all treatment groups.

• 동의신경정신과학회지
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• 제15권1호
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• pp.27-41
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• 2004

This study was performed to evaluate the effects of Jowiseungchungtang and fluoxetine in the chronic mild stress(CMS) model of depression in rats. Chronic exposure to mild unpredictable stress was found to depress the consumption of sucrose solution in rats for 5 weeks. These CMS-treated rats were stratified into Jowiseungchungtang group, fluoxetine group and vehicle group. And control rats were also stratified into other CMS-treated group. The change of the consumption of sucrose solution was measured, and open field test were performed to investigate the anti-depression effect of Jowiseungchungtang and fluoxetine. The results were as follows : 1. The consumption of sucrose solution was significantly reversed in Jowiseungchungtang-treated group at 7 week, but there was no significant change in other groups. 2. CMS schedule decreased body weight. Jowiseungchungtang group and fluoxetine group showed significant decrease of body weight after 6 weeks. 3. In open field test, Jowiseungchungtang group and fluoxetine group showed no significant change of exploratory activity.

• Clinical and Experimental Reproductive Medicine
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• 제39권4호
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• pp.144-152
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• 2012

Objective: Concerns are growing about the decrease in male reproductive health. Caffeine is one of the popular nutrients that has been implicated as a risk factor for infertility. In the present study, we examined whether in utero and lactational exposure to caffeine affects the reproductive function of the offspring of rats. Methods: Pregnant rats received caffeine via drinking water during gestation (26 and 45 mg/kg) and lactation (25 and 35 mg/kg). Body and reproductive organ weight, seminiferous tubule diameter, germinal epithelium height, sperm parameters, fertility rate, number of implantations, and testosterone level of the offspring were assessed from birth to adulthood. Results: Significant dose-related decreases were observed in the body and reproductive organ weight, seminiferous tubule diameter, and germinal epithelium height of the offspring. Sperm density had declined significantly in offspring of the low-dose and high-dose groups, by 8.81% and 19.97%, respectively, by postnatal day 150. The number of viable fetuses had decreased significantly in females mated with male offspring of the high-dose group at postnatal days 60, 90, 120, and 150. There were also significant reductions in testosterone levels of high-dose group offspring from birth to postnatal day 150. Conclusion: It is concluded that maternal caffeine consumption impairs gonadal development and has long-term adverse effects on the reproductive efficiency of male offspring rats.

• 약학회지
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• 제7권1호
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• pp.18-25
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• 1963

We have studied on the effects of Panax Ginseng on the carbohydrate metabolism of rat. Ginseng does not so much effect on the body weight of the nutrition diet groups, but effects much on the carbohydrate deficient diet groups; it remarkably inhibited the decrease of body weight. Liver glycogen, both in the nutrition and carbohycdrate deficient diet groups, is higher than that of the control. Particularly, the increase of the glycogen is eminent is the nutrition diet-ginseng administered group. In the nutrition diet group, the blood sugar level of ginseng-adminstered rats is the higher, while, in the carbohydrate deficient diet groups, the blood sugar level of ginseng-administered rats is decreased compared with that of control. the oxidation rate of glucose by rat liver slice indicates that only in the carbohydrate deficient diet groups, from the 6th to 15th hour, the oxidation rate of glucose in ginseng-administered group is increased, compared with that of the control. But there is no statistical significance between them. It is thought that Panax Ginseng would effect more on the enzyme system involved in gluconeogenesis and glycogenesis rather than that of carbohydrate oxidation.

• Asian-Australasian Journal of Animal Sciences
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• 제11권1호
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• pp.55-59
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• 1998

To study the effect of induced hypothyroidism on fertility status of male Black Bengal goats, 10 adult healthy mature males were divided into control and treated groups. Hypothyroidism was induced successfully by injecting thiourea subcutaneously initially for 15 days at the rate of 100 mg/kg body weight, followed by 66.7 mg/kg body weight for the subse quent 15 days. This resulted in a decrease (p < 0.01) in plasma tri-iodothyronine, thyroxine and testosterone levels, with increasing duration of thiourea treatment. It also adversely affected semen quality, ejaculate volume, sperm concentration, motility and viability. Live percentage declined to 75% for treated and control remained at 90%. Artificial insemination fo female goats with semen of thiourea-treated goats, resulted in failure of conception. However, females inseminated with semen of male goats of control group showed 100% conception. These observations indicate that, thyroid hormones play a key role in maintaining the normal reproductive processes of male goats.

• 동의생리병리학회지
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• 제25권5호
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• pp.870-875
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• 2011

Arthritis of the knee is the most common type of joint inflammatory disorder and it is associated with pain and inflammation of the joint capsule. The aim of present study was to investigate the endogenous effect of low intensity laser acupuncture on collagen-induced arthritis in rats. Forty Sprague-Dawley rats were randomly divided into normal group, arthritis group, low laser group with 10 rats in each group. Arthritis in rats was induced by subcutaneous injection of type II collagen combined with complete Freund's adjuvant. Here we investigated the effects of low intensity laser therapy in experimentally induced rat knee arthritis. To evaluate preventive and therapeutic effects of low intensity laser acupuncture on collagen-induced arthritis rats. In collagen induced arthritic rats, there was significant increase in rat paw volume and decrease in body weight increment, whereas low intensity laser therapy groups, showed significant reduction in paw volume and normal gain in body weight. The altered biochemical parameters(blood urea, serum creatinine, total proteins and acute phase proteins) in the arthritic rats were significantly brought back to near normal by the low intensity laser therapy. Therefore, low intensity laser acupuncture may be a useful treatment in the prevention and treatment of collagen-induced arthritis.

• 사상체질의학회지
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• 제28권2호
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• pp.163-175
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• 2016

Objectives It is important to care aftereffects of the tuberculosis such as cough and sputum especially for the old. The purpose of this study is to report a case which showed symptoms improvement after treatment with Hyungbangjihwang-tang.Methods To evaluate the results of this treatment, Decrease of cough and sputum was assessed by Visual Analogue Scale(VAS). The patient`s oral intake and body weight were measured.Results The patient who suffered with cough and sputum after tuberculosis developed high fever and pleural effusion of unknown origin. After treatment with western and oriental medicine, high fever and pleural effusion were subsided but cough and sputum got worse and body weight was decreased after high fever and pleural effusion. So we prescribed Hyungbangjihwang-tang and then the symptoms of the patient were improved.Conclusions This study suggests that using Sasang constitutuional medical treatment is effective for Soyangin patient with afftereffects of the tuberculosis such as cough and sputum.

• Journal of Nutrition and Health
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• 제29권7호
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• pp.713-720
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• 1996

To study the effect of caffeine intake levels on iron metabolism, the iron utilization, iron contents of serum, liver, spleen, kidney, hemoglobin and hematocrit were compared in rats of different sex fed various levels of caffeine (3.5 and 7.0mg/100g body weight) for three weeks. There were no significant caffeine induced differences in feed intake, body weight gain but feed intake of male rats were significantly lower than that of female rats. Hemoglobin, hematocrit and iron contents of the serum were not significantly different between caffeine free and caffeine groups or male and female rats. Iron contents of kidney were decreased by elevation of injected caffeine levels rather than those of liver and spleen. caffeine male groups showed more increased uine volume, urinary and fecal excretions of iron than caffeine free or caffeine female groups. Apparent digestibility and retention of iron were significantly decreased by increment of injected caffeine levels. Male rate rats were more susceptible to injected caffeine on iron excretion than female rats. Current findings suggest that excessive caffeine consumption can affect iron excretion via urine and feces thereby decrease the utilization of iron, and have more significant effect on male than female rats.