• KSBB Journal
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• v.18 no.5
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• pp.352-355
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• 2003

${\beta}$-(1,6)-Branched ${\beta}$-(1,3)-D-glucans are known to enhance the immune system in human body, and in most cases have higher molecular weights over 1 MDa. In order to enhance the efficacy of glucans by decreasing their molecular weights, sonication, acid treatment, and enzymatic hydrolysis were tested and compared in this work. Treatment of sonication was effective to decrease the molecular weight to the extent of several dozens of kilo-daltons, but have a risk to disorder the triple helical structure of the glucans. Acid treatment was also an effective method to degrade polysaccharides, but ${\beta}$-(1,6)-branched of the glucan molecules was found to be also hydrolyzed. Treatment of ${\beta}$-(1,3)-glucanase was an effective method to decrease the molecular weight in mild conditions, but could not hydrolyse the highly ${\beta}$-(1,6)-branched ${\beta}$-(1,3)-glucans efficiently.

• Journal of Nutrition and Health
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• v.46 no.5
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• pp.410-417
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• 2013

Caloric restriction is recognized as one of the best treatment options for obesity, and is associated with changes in body composition. The purpose of this study was to determine the influence of age in caloric restriction in overweight and obese women. In this caloric restriction study, nutrient intake of 61 women was evaluated using food records written by subjects for three days. Body composition and metabolic risk factors were assessed before and after caloric restriction. Blood levels of lipids, glucose, leptin, and adiponectin were measured. Visceral fat and subcutaneous fat were evaluated using bioimpedance analysis. General linear models (GLM) identified the independent effects of age after co-varying baseline weight and difference of energy intake. Weight, fat mass, visceral fat, subcutaneous fat, and blood pressure showed a significant decrease by caloric restriction of 452 kcal/day. The percent changes in weight, visceral fat, and subcutaneous fat were -4.5%, -12.0%, and -8.2%, respectively, after caloric restriction. The percent changes of weight, visceral fat, and subcutaneous fat showed an independent association with age co-varying baseline weight and difference of energy intake. Decreased change in percent of leptin by caloric restriction also showed an association with age. Changes in body composition and leptin by caloric restriction showed an independent association with age. This may indicate greater difficulty in achievement of change of body composition as well as greater obesity-related metabolic risk with aging. Therefore, caloric restriction considering age should be recommended for effective dietary treatment in overweight or obese women.

• Journal of the Korean Society of Food Culture
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• v.26 no.6
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• pp.727-733
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• 2011

This study was performed to examine the relationship between the body mass index (BMI), the body fat, and the serum lipids of post-menopausal women in rural areas. The subjects were 510 women aged 50 and over. As a result of this study, we found a trend of decreasing BMI as age increased, but body fat increased. In addition, there was a significant decreasing of the lean body mass than an increasing of the body mass index according to increasing age. Therefore, this study confirmed that a main cause of rural women being classified as obese is a decrease in lean body mass, rather than an increase in of body fat. Of all subjects, 36.3% ($18.5{\leq}BMI$ < 23) of all subjects were classified as having normal BMI, whereas only 21.4% were classified as having normal body fat. Out of 190 subjects who were body fat 30% and over, 38 subjects were classified as obese ($BMI{\geq}25$) and 113 subjects were classified as overweight ($23{\leq}BMI$ < 25). The percentile of those with a BMI of $25kg/m^2$ was 70, and they had 30.82% body fat. HDL cholesterol showed a negative correlation with anthropometric factors (height, weight, body mass index, waist circumference, waist hip ratio, body fat), and total cholesterol, LDL cholesterol, and triglycerides showed a positive correlation. Especially, total cholesterol, LDL cholesterol, and hip circumference showed significant correlations. Because of differences in the body fat and lean body mass by age group, it seems difficult to assess obesity via BMI only. The elderly especially should have a higher significance placed on body fat or abdominal fat than only BMI.

• Journal of Radiation Protection and Research
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• v.38 no.3
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• pp.157-165
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• 2013

To determine the factors affecting the external radiation dose rates of patients undergoing PET-MRI examinations and to assess the trends of these differences, we measured the changes in the dose rates of $^{18}F$-FDG during a set period of time for each body region. Consistent with theoretical predictions, the dose rate decreased over time in patients undergoing PET-MRI examinations. Furthermore, immediately after the $^{18}F$-FDG injection, the dose rate in the chest region was the highest, followed by the abdominal region, the head region, and the foot region. The dose rate decreased drastically as time passed, by 2.47-fold, from $339.23{\pm}74.70mSv\;h^{-1}$ ($6.73{\pm}5.79$ min) at the time point immediately after the $^{18}F$-FDG injection to $102.71{\pm}26.17mSv\;h^{-1}$ ($136.11{\pm}25.64$ min) after the examination. In the foot region, there were no significant changes over time, from $32.05{\pm}20.23mSv\;h^{-1}$ ($6.73{\pm}5.79$ min) at the time point immediately after the $^{18}F$-FDG injection, to $23.89{\pm}9.14mSv\;h^{-1}$ ($136.11{\pm}25.64$ min) after the examination. The dose rate is dependent on the individual characteristics of the patient, and differed depending on the body region and time point. However, the dose rates were higher in patients who had a lower body weight, shorter stature, fewer urinations, lower fluid intake, and history of diabetes mellitus. To decrease radiation exposure, it is difficult or impossible to change factors inherent to the patient, such as sex, age, height, body weight, obesity, and history of diabetes mellitus. However, factors which can be changed, such as the $^{18}F$-FDG dose, fasting time, fluid intake, number of urinations, and contrast agent dose can be controlled to minimize the external radiation exposure of the patient.

• Journal of Animal Science and Technology
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• v.47 no.2
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• pp.195-204
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• 2005

The current study was conducted to investigate the effects of dietary conjugated linoleic acid(CLA) on growth performance and body fat metabolism in broiler chickens. A total of 48 male birds aged 3 days were randomly allotted into three dietary groups; CORN(com oil 1.5%), CLA I (com oil 0.75 %+ CLA 0.75 %) and CLA II(CLA 1.5%) groups. After feeding commercial diet ad libitum for 3 weeks, eight selected birds on the basis of body weight were housed, two birds in a cage, and continuously given ad libitum corresponding experimental diet for another 2 weeks. As a result, dietary addition of CLA did not influence on body weight, gain and feed conversion rote. The relative weights of the liver and deposited fats(abdominal and thigh fat' pads) were not also affected by the dietary treatments. Serum glucose, triglyceride and cholesterol levels markedly( P < 0.05) decreased in CLA II compared with those in CORN group. However, serum nonesterified fatty acid(NEFA) was not altered by dietary CLA. Serum leptin level was tended to be decreased by dietary CLA without statistical difference. The diet supplemented with CLA caused a significant(P< 0.05) decrease in hepatic total lipid and NEFA without changing triglyceride level. Also, feeding dietary CLA at the level of 1.5% reduced leptin mRNA expression in the liver and abdominal fats compared with feeding com oil, In conclusion, our results suggest that dietary 1.5% CLA may affect, at least in part, lipid metabolism in the liver of broiler chickens.

• Journal of Aquaculture
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• v.6 no.3
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• pp.199-211
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• 1993

In order to elucidate the effect of dietary n-3 highly unsaturated fatty acids (n-3HUFA) on the changes of body weight and chemical compositions in the Korean rockfish during starvation, the fish were not fed for 9 weeks after fed different levels $(0\~1.5\%)$ of n-3 HUFA for 10 weeks. The higher level of n-3HUF A was contained in the diets, the slower body weight loss was resulted (P< 0.05). The decreasing rates of the body nutrients of the fish were significantly higher in the fish fed n-3HUF A deficient diets than those of the fish fed n-3 HUF A sufficient diets. Protein and lipid contents of the whole body were decreased with starvation whereas moisture content was increased. Decrease of lipid was mainly due to the decrease of nonpolar lipid. Amounts of polar lipid in the whole body were almost constant throughout the starvation, meaning not being affected by dietary n-3HUF A levels. Percentage of 22: 6n-3 was increased in the polar lipid fraction, but monoenic acids (16:1, 18:1), n-3 series (18:3, 18 4, 20:4) and n-6 series (20:2, 22:4, 22:5) were decreased with starvation. Fatty acid compositions of nonpolar lipid were not changed with starvation. These results suggest that all fatty acids of nonpolar lipid are equally utilized for energy during starvation.

• Journal of Korean Medicine for Obesity Research
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• v.24 no.1
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• pp.102-110
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• 2024

This study reports the clinical effects of Korean medicine treatments, herbal medicine, modified fasting, and space spinal conduction exercise and manipulation (SSCEM) on adolescent obesity patient. A 16-year-old male with a body mass index (BMI) 35.5 kg/m² was diagnosed with class III obesity. We prescribed herbal medicine and modified fasting alternately three times over a period of five months. Additionally, Korean medicine treatments and SSCEM were performed during the treatment period. After treatment, there was a decrease in body weight by 19.86%, from 115.8 kg to 92.8 kg, BMI from 35.5 kg/m² to 28.6 kg/m², and body fat mass from 38.1 kg to 17.0 kg. The results of this study showed that Korean medicine treatments, herbal medicine, modified fasting, and SSCEM could be useful in influencing changes in body composition among obese adolescents.

• Advances in Traditional Medicine
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• v.5 no.1
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• pp.62-68
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• 2005

Doxorubicin is a powerful anticancer antibiotic extensively used in the treatment of several types of cancers. Long-term administration of this drug results in cumulative dose related cardiotoxicity due to enhanced production of free radicals leading to oxidative stress. Our earlier investigations have demonstrated significant antioxidant, anti-inflammatory and antitumour properties of Ganoderma lucidum extracts. We extended our investigations to evaluate the protective effect of Ganoderma lucidum extract against doxorubicin-induced cardiotoxicity. Administration of 3 doses of doxorubicin, 6 mg/kg body weights, i.p. per each dose, alternative days, showed dear signs of cardiotoxicity in rats. The drug enhanced serum creatine kinase (CK) activity and lipid peroxidation in tissue drastically. The drug also induced significant decrease in GSH level and activities of CAT, SOD and GPx. Administration of methanolic extract of G.lucidum (500 and 1,000 mg/kg body weight) significantly increased the level of GSH and activities of CAT, SOD and GPx. Activity of CK was significantly lowered in a dose dependent manner. The treatment also caused significant decrease in lipid peroxidation (MDA). The results thus indicated that methanolic extract of G.lucidum prevented oxidative stress caused by doxorubicin administration and the increase in serum CK activity and lipid peroxidation in the tissue. The experimental findings suggest the therapeutic potential of G.lucidum as adjuvant in cancer chemotherapy.

• Korean Journal of Veterinary Research
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• v.18 no.1
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• pp.1-7
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• 1978

In order to detect the clinical effect of combelen which is used for sedation of domestic animals, 10 heads of clinically healthy Korean native goats were used in this study. They were divided into two groups; one is dose level of 1ml per 10 kg of body weight with 1% combelen and the other is dose level of 3 ml. Clinical observations and changes in blood components after administration of combelen were made. 1. There was no adverse effect due to combelen, but sedative effect was insufficient. 2. During sedative period the changes in heart rate and respiratory rate showed noticeable change, and body temperature was slightly decreased. 3. In ECG recordings, except for slight changes in T wave, significant change was not observed. 4. Erythrocytes, leukocytes, hemoglobin concentration and packed cell volume showed tendency to decrease during the period of sedation. 5. SGOT activity showed a remarkable increase and BUN showed a great decrease 24 hours after administration in the group of 3ml/10kg. Blood glucose level increased during the period of sedation in both groups.

• The Korea Journal of Herbology
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• v.38 no.5
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• pp.31-37
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• 2023

Objective : This study was conducted to investigate the muscle-improving and therapeutic effects of Boehmeria platanifolia (BP) in a mouse model of dexamethasone-induced muscle atrophy. Methods : Muscle atrophy was induced in C57BL/6 mice by intraperitoneal administration of dexamethasone for 12 days. BP extract was administered orally at doses of 100 mg/kg and 200 mg/kg for 19 days, starting 7 days before the intraperitoneal administration of dexamethasone. Mice were weighed during the experimental period, and muscle strength and muscle weight were measured at the end of the experiment. The gastrocnemius (GASTROC) muscles of mice were isolated and the cross-sectional area (CSA) of the muscle fibers was measured after H&E staining. Results : Dexamethasone-induced muscle atrophy mice had a decrease in body weight compared to normal mice, and BP-administrated mice did not show significant change in body weight compared with a control group. Muscle strength in mice with induced muscle atrophy was reduced compared to normal and significantly increased with BP administration and positive control. In addition, the weight of the quadriceps (QUAD) muscle and fiber size of the GASTROC muscle, which was reduced in sarcopenia-induced mice, was increased by BP. Conclusion : BP extract increased muscle strength, muscle weight, and muscle fiber size in dexamethasone-induced muscle atrophy mice. This suggests that the efficacy of BP extracts in improving muscle strength and preventing and treating sarcopenia may be beneficial for the development of potential therapeutic or functional products.