• Proceedings of the KOR-BRONCHOESO Conference
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• 1979.05a
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• pp.7.1-7
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• 1979

This paper was attempted to analyze 31 cases of fiberoptic bronchoscopy during the period of 8 months from October 1978 till February 1979 in the Chung-Ang University Hospital. The results were as follows; 1) Among 31 cases. 20 cases were male, 11 cases female. Sex ratio was 2 : 1. 2) In age distribution, 22 cases (70.1%) were in 4th-7th decade, and the other age groups showed relatively even distribution. 3) The chief complaints were hemoptysis (11 cases, 35.5%), coughing (9 cases, 29.0%), chest pain (6 cases, 19.4%), dyspnea (3 cases, 9.7%) and others (2cases, 6.5%). 4) In Gram staining of bronchial secretion, Gram (-) diplococci were in 12 cases (38.7%), Gram (+) cocci 10 cases (32.3%), Gram (+) rods 6 cases (19.4%)and Gram (-) rods 3 cases (9.7%). In culture of bronchial secretion, no growth were in 17 cases (54.8%). Neisseria group 6 cases (19.4%), Proteus and Klebsiella group 1 case (3.2%) and mixed group 3 cases (9.7%). In histopathological study, 11 cases (35.5%) revealed chronic bronchitis, 9 cases (29.0%) bronchogenic carcinoma, 3 cases (9.7%) chronic granulomatous disease and 2 cases (6.5%) no specific findings. In 6 cases biopsy specimens were too small to be examined histopathologically. 5) In diagnosis by bronchoscopic appearance and by laboratory examination of bronchoscopically removed specimens, 9 cases(29.0%) were primary carcinoma of bronchus, 6 cases (19.4%) chronic bronchitis, 4 cases (12.9%) pneumonia in the order of freguency

• Journal of the Society of Cosmetic Scientists of Korea
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• v.40 no.3
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• pp.279-287
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• 2014

Estrogen deficiency results in a reduction of skin quality and function in postmenopausal women. Over the past decade, many studies have supported that estrogen provides anti-aging effects as a result of the ability of estrogen to prevent skin collagen decline, restore skin elasticity, and increase skin hydration in postmenopausal women skin. Due to their structural similarity with estrogen, isoflavones have been called phytoestrogens. Photoprotective effects of isoflavones are well established while their estrogenic-like activities are not fully understood in human skin. In this study, we investigated whether daidzein, an effective isoflavone, has phytoestrogenic activity and induces transcriptional change of extracellular matrix components in dermal fibroblasts. We examined the luciferase activity of daidzein and ${\beta}$-estradiol using transiently transfected NIH3T3-ERE cells. The estrogenic receptor-dependent transcriptional activity was increased in a dose-dependent manner when treated with daidzein, with a maximum of 2.5-fold induction at $10{\mu}g/mL$ of daidzein compared with non-treated control. In addition, daidzein significantly in creased the expressions of collagen type I, collagen type IV, elastin, and fibrillin-1 in human dermal fibroblasts. By comparing with the effects of ${\beta}$-estradiol through out all the experiments, we confirmed that daidzein had estrogenic activity and function in fibroblasts. These results suggest that daidzein-based application, having both photoprotective and phytoestrogenic effects, may be a powerful approach for skin anti-aging of postmenopausal women.

• Journal of Life Science
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• v.27 no.4
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• pp.482-499
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• 2017

Allergic diseases have increased over the past several decade worldwide including developing countries. Allergic inflammatory responses are caused by Th (T helper)2 immune responses, triggered by allergen ingestion by antigen presenting cells such as dendritic cells (DCs). Intestinal microorganisms control the metabolism and physiological functions of the host, contribute to early immune system maturation during the early life, and homeostasis and epithelial integrity during life. Bifidobacteria have strain-specific immunostimulatory properties in the Th1/Th2 balance, inhibit TSLP (thymic stromal lymphopoietin) and IgE expression, and promote Flg (Filaggrin) and FoxP3 (Treg) expression to alleviate allergies. In addition, unmethylated CpG motif ODN (oligodeoxynucleotides) is recognized by TLR (toll-like receptors)9 of B cells and plasmacytoid dendritic cells (pDCs) to induce innate and adaptive immune responses, while the butyrate produced by Clostridium butyricum activates the GPR (G-protein coupled receptors)109a signaling pathway to induce the expression of anti-inflammatory gene of pDCs, and directly stimulates the proliferation of thymically derived regulatory T (tTreg) cells through the activation of GPR43 or inhibits the activity of HADC (histone deacetylase) to differentiate naive $CD4^+$ T cells into pTreg cells through the histone H3 acetylation of Foxp3 gene intronic enhancer.

• Information Systems Review
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• v.13 no.2
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• pp.55-72
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• 2011

As the complexity of business environment increases rapidly the use advanced information technology start to affect not only the business processes of individual companies but also the fundamental nature of business and industrial ecosystem. The changes observed at the level of business and industrial ecosystem encompasses a broad range of transformation. This unit of analysis is not sufficiently dealt with by existing information systems research. This research attempted to analyze the changes in business ecosystem caused by digital transformation using a relatively new approach called ecosystem mapping. We developed and suggested an ecosystem mapping methodology step by step and applied the methodology to film industry. The film industry is chosen because it is an industry very sensitive to the changes in technology and has gone through massive transformation during the last three decade by way of using modem information technology.

• Korean Security Journal
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• no.15
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• pp.199-219
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• 2008

This study analyzed the contents of the 225 papers included in Korea Security Science Association during the decade -from 1997 to 2007. This study was classified the study method qualitative. First, characteristic of researchers(distinction of sex, distinction of academic degree, regional distribution, one's position and regional distribution, participants per paper). Second, study trends classified by fields of study(where receiving research expenses support or not, change of study subject). Third, study trends classified by methods of study(study method by year, study method by study subject, statistical analysis by year) were subdivided. Analysis shows that there are some shortcomings on the research of Korea Security Science Association as compared with other fields. However, it shows advanced trends for example participation in different study field, evenly distributed regional study participation, variety trial of analysis method. Then again, the distinction of sex, one's position, too much emphasis on independence research, vulnerability about support of research expenses, emphasis on study fields and study trends wandering from industrial circles are getting deeper In study methods, generalized research form such as document study and phenomenon technical case study is limited so deduction of kernel result is not thoroughgoing enough as well as it shows the trend that limits to duplicate and generalized proposal technic.

• Journal of Korea Water Resources Association
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• v.53 no.6
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• pp.437-450
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• 2020

This study presents a probabilistic distributed hydrological model for Ephemeral catchment, where zero flow often occurs due to the influence of distinct climate characteristics in South Korea. The gridded hydrological model is developed by combining the Sacramento Soil Moisture Accounting Model (SAC-SMA) runoff model with a routing model. In addition, an error model is employed to represent a probabilistic hydrologic model. To be specific, the hydrologic model is coupled with a censoring error model to properly represent the features of ephemeral catchments. The performance of the censoring error model is evaluated by comparing it with the Gaussian error model, which has been utilized in a probabilistic model. We first address the necessity to consider ephemeral catchments through a review of the extensive research conducted over the recent decade. Then, the Yongdam Dam catchment is selected for our study area to confirm the usefulness of the hydrologic model developed in this study. Our results indicate that the use of the censored error model provides more reliable results, although the two models considered in this study perform reliable results. In addition, the Gaussian model delivers many negative flow values, suggesting that it occasionally offers unrealistic estimations in hydrologic modeling. In an in-depth analysis, we find that the efficiency of the censored error model may increase as the frequency of zero flow increases. Finally, we discuss the importance of utilizing the censored error model when the hydrologic model is applied for ephemeral catchments in South Korea.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38B no.5
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• pp.385-393
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• 2013

In the past decade, a paradigm shift from machine-centered to human-centered and from technology-driven to user-driven has been witnessed. Consequently, Social search is getting more social and Social Network Service (SNS) is a popular Web service to connect and/or find friends, and the tendency of users interests often affects his/her who have similar interests. If we can track users' preferences in certain boundaries in terms of Web search and/or knowledge sharing, we can find more relevant information for users. In this paper, we propose a novel Topic Sensitive_Social Relationship Rank (TS_SRR) algorithm. We propose enhanced Web searching idea by finding similar and credible users in a Social Network incorporating social information in Web search. The Social Relation Rank between users are Social Relation Value, that is, for a different topics, a different subset of the above attributes is used to measure the Social Relation Rank. We observe that a user has a certain common interest with his/her credible friends in a Social Network, then focus on the problem of identifying users who have similar interests and high credibility, and sharing their search experiences. Thus, the proposed algorithm can make social search improve one step forward.

• Journal of Korean Orthopaedic Sports Medicine
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• v.1 no.2
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• pp.138-142
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• 2002

Purpose: To evaluate the results and prognosis of operative repair to acute rupture of achilles tend on associated sports injury. Materials and Methods: 21 cases were surgically treated and average follow-up period was 1 year and eight months. The forth decade was most common with $55\%$ and soccer was most common in sports with 5 cases. End-to-end suture of ruptured achilles tendon was performed, and paratendinous structure was wrapped sufficiently. Postoperatively. ankle was plantarflexed for 6 weeks with longleg cast. And then 2 weeks interval, short leg cast with equinous position was conversed to functional position. About 10 weeks after operation, ankle was recovered to right angle. Hooker scale was used to evaluate the results. Results: Compared to normal side, heel-floor distance of ruptures side was decreased 0.7 cm in average, and 0.8 cm was deceased after 20 times weight loaded dorsiflexion. Mid-calf circumference was deceased 0.3 cm, and active dorsiflexion and plantar flexion of ankle was decreased each 3 and 5degree. 16 cases showed ‘excellent’result and 5 cases showed ‘satisfactory’. There was no complication, such as re-rupture or infection at operation site. Conclusion: After end-to-end operative repair to achilles tendon, sufficient wrapping of paratendinous structure is efficient for healing and prevention of postoperative adhesion. And serial dorsiflex-ion cast change is considered to be a successful treatment for preventing residual equinus deformity.

• Journal of Korea Technology Innovation Society
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• v.14 no.3
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• pp.466-487
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• 2011

This study analyzed the effect of small and medium businesses' R&D intensity and patents on their price-earnings (P/E) ratios. Regression analysis was conducted on a sample of manufacturers listed on the Korean Securities Dealers Automated Quotations (KOSDAQ) for the past decade (2000~2009). The result is summarized as follows. First, a negative correlation was identified between companies' R&D intensity and their P/E ratios, but no significant relationship was found between their numbers of domestic patent applications and registrations and P/E ratios. Second, the analysis of the effect of the companies' R&D intensity on their P/E ratios resulted in a negative correlation of -1%. Third, the analysis of the effect of the companies' number of domestic patent applications and registrations on their P/E ratios showed that they did not have any significant relationship. Fourth, high-tech firms' R&D intensity had a negative correlation of -1% with their P/E ratios, but had a positive correlation of 1% with their numbers of domestic patent applications. Furthermore, the R&D intensity of middle-to-high and middle-to-low tech enterprises had a negative correlation of -1% with their P/E ratios, whereas their numbers of domestic patent applications and registrations had no significant relationship with their P/E ratios. The above results suggest that to produce successful outcomes from their R&D investment and patents, individual firms need strategies for technological innovation that relate to their technological level.

• Microbiology and Biotechnology Letters
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• v.39 no.3
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• pp.238-244
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• 2011

Biodiesel, mono-alkyl esters of long chain fatty acids, is one of the alternative fuels derived from renewable lipid feedstock, such as vegetable oils or animal fats. For decade, various lipases have been used for the production of biodiesel. However, the production of biodiesel by enzymatic catalyst has profound restriction in industry application due to high cost. To overcome these problems, many research groups have studied extensively on the selection of cheap oil sources, the screening of suitable lipases, and development of lipase immobilization methods. In this study, we produced biodiesel from plant oil using Proteus vulgaris lipase K80 expressed in Escherichia coli cells. The recombinant lipase K80 was not only expressed in high level but also had high specific lipase activity and high stability in various organic solvents. Lipase K80 could produce biodiesel from olive oil by 3-stepwise methanol feeding method. The immobilized lipase K80 also produced biodiesel using the same 3-stepwise method. The immobilized lipase could produce biodiesel efficiently from various plant oils and waste oils.