• Journal of Acupuncture Research
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• v.31 no.2
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• pp.75-85
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• 2014

Objectives : We investigated whether bee venom(BV) inhibit cell growth through enhancement of death receptor expressions in the human cervix cancer C33A cells. Methods : BV($1{\sim}5{\mu}g/ml$) inhibited the growth of cervix cancer C33A cells by the induction of apoptotic cell death in a dose dependent manner. Results : Consistent with apoptotic cell death, expression of Fas, death receptor(DR) 3, 4, 5 and 6 was increased concentration dependently in the cells. Moreover, Fas, DR3 and DR6 revealed more sensitivity to BV. Thus, We reconfirmed whether they actually play a critical role in anti-proliferation of cervix cancer C33A cells. Consecutively, expression of DR downstream pro-apoptotic proteins including caspase-8, -3, -9 was upregulated and Bax was concomitantly overwhelmed the expression of Bcl-2. NF-${\kappa}B$ were also inhibited by treatment with BV in C33A cells. Conclusions : These results suggest that BV could exert anti-tumor effect through induction of apoptotic cell death in human cervix cancer C33A cells via enhancement of death receptor expression, and that BV could be a promising agent for preventing and treating cervix cancer.

• Journal of Korean Academy of Nursing
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• v.36 no.1
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• pp.74-83
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• 2006

Purpose: The purpose of this study was to develop an evaluation instrument integrated and interdisciplinary death education for the human service areas such as nursing, social welfare, and education and to test the reliability and validity of it. Method: The subjects used to verify the instrument's reliability and validity were 407 students who were enrolled in the departments of nursing, social welfare, and education in universities located in Seoul, Pusan, Daegu, and Daejeon. The data was collected from April to May, 2005, and was analyzed by SPSS/WIN 12. Result: A factor analysis was conducted. Items with over a .40 factor loading and over a 1.0 eigen value were selected. Nine identified factors were learning about death, role of professionals, personal attitudes, hospice care, ethics and legal issues, death and dying, spiritual aspect of' death, transcultural aspect of death, and multidisciplinary theory of death. The instrument consisted of 44 items and the reliability was a cronbach's of .953 Conclusion: Based on the study results, the content scale developed in this study was identified as a tool with a high degree of reliability and validity.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.11 no.2
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• pp.213-219
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• 2004

Purpose: This study was done for the purpose of comparing death orientation scores of nurses before and after a hospice training program. Method: The participants were 56 nurses who completed the hospice training program at C university in Kwang Ju city. The data were gathered from October 2001 to December 2002 by questionnaire. The data were analyzed by using frequency, paired t-test, ANOVA and Pearson's correlation coefficients. Results: The mean scores for death orientation before and after hospice training were mid range scores of 57.2 and 57.0 respectively and this difference was not significant. The death orientation score before hospice training was significantly different according to the 'work place (F=3.16, p=.033)' of nurses but after the hospice training there was no significant difference for any of the general characteristics. The death orientation scores before and after hospice training showed no correlation with the religiosity score either. Conclusion: Considering the mid range scores and the lack of significant difference after the intervention, this study shows that there is a need to analyze the content of hospice education programs and the need to change death orientation. This is especially true when the participants are professional hospice nurses who are being prepared to give care to people who are dying. In order to develop more appropriate programs there is a need to examine the process by which nurses come to view death more positively.

• Journal of Korean Academy of Nursing
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• v.42 no.5
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• pp.680-688
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• 2012

Purpose: The purposes of this study were to explore the effects of family cohesion and subjective happiness on death anxiety of Korean elders and to identify other factors contributing to death anxiety. Methods: The participants were 280 elders who lived in P metropolitan city. Data were collected between November 5, 2011 and January 12, 2012 using the Short Portable Mental Status Questionnaire (SPMSQ), Family Cohesion Evaluation Scale, Subjective Happiness Scale, and Fear of Death Scale (FODS). Data were analyzed using the SPSS/WIN 19.0 program. Results: Family cohesion, marital status, religious activity, perceived health status, and subjective happiness were included in the factors affecting death anxiety of Korean elders. These variables explained 50.1% of death anxiety. Conclusion: The results of the study indicate that these variables should be considered in developing nursing intervention programs to decrease death anxiety and increase family cohesion and subjective happiness for life integration in Korean elders.

• Korean Parent-Child Health Journal
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• v.19 no.1
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• pp.33-44
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• 2016

Purpose: The purpose of this study is to identify the factors influencing the death attitude of nursing students. Methods: A survey was administered to 350 nursing students in two university located in D city, Korea. data were collected for 40 days from August 1 to September 10, 2015 by using self-report questionnaires. Collected data were treated with the IBM (SPSS) Program 21.0 program for frequency and percentage, mean and standard deviation, ANOVA, $Scheff\acute{e}$, Pearson's correlation coefficient, and multiple regression analysis. Results: As for mean points in the subareas of death attitude, the nursing students scored a mean of $5.4{\pm}0.8$ in neutral acceptance, $4.1{\pm}1.1$ in fear of death, $3.5{\pm}1.2$ in approach acceptance, $2.9{\pm}1.3$ in death avoidance, and $2.8{\pm}1.4$ in escape acceptance. The factors influencing the death attitude of nursing students was most influenced by self esteem, social support, spiritual wellbeing, and life satisfaction. Conclusion: The importance of this study is that the influencing factors such as self esteem, social support, spiritual wellbeing, and life satisfaction were identified. These influencing factors should be considered the program development for nursing students to improve the positive attitude of death.

• Journal of Korean Academy of Nursing
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• v.35 no.5
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• pp.829-841
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• 2005

Purpose: The purpose of this study was to analyze death attitudes of students majoring In the human service area, such as nursing science, education, and social welfare. Method: The Q-methodology which provides a method of analyzing the subjectivity of each item was used, The 38 selected Q-statements from each of 42 subjects were classified into a shape of normal distribution using a 9 point scale. The collected data was analyzed using a QUANL PC program. Result: Four types of death attitudes for research subjects in nursing, education, and social welfare areas were identified. Type I is fatalistic admission, Type II is pursuit of existential life, Type III is uncertainty of life after death, and Type IV is separation-connection between life and death. Conclusion: The results of the study indicate that different approaches of death educational programs are recommended based on the four types of death attitudes.

• The Journal of Korean Medicine
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• v.30 no.4
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• pp.142-161
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• 2009

Objectives: There are many unknowns surrounding Jeong-Jo's death. To better understand Jeong-Jo's death, we closely inspected his medical records from the 20 days before his death in The Annals of the Chosun Dynasty (朝鮮王朝實錄) and Seungjeongwon Ilgi (承政院日記), Understanding medical treatment before death, we can correctly trace the cause of Jeong-Jo's death. Methods: According to The Annals of the Chosun Dynasty (朝鮮王朝實錄) and Seungjeongwon Ilgi (承政院日記), we examined his medical records between June 14 and June 28 of 1800, as to the change in chief complaint, cold and heat, thirst, syndrome differentiation, the opinions of Jeong-Jo, and the opinions of doctors, The original work, The Annals of the Chosun Dynasty and Seungjeongwon Ilgi were provided by NIKH (The National Institute of Korean History). The Korean translation of The Annals of the Chosun Dynasty was also provided by NIKH. Seungjeongwon Ilgi (original work written in Chinese characters) was directly translated into Korean by the study author. Results: 1. Jeong-Jo's is likely to have died of septicemia caused by an abscess on his back. 2. The cause of Jeong-Jo's death could be stroke due to hypertension, mental stress, and 'Wha (火) disease' Conclusions: The dominant view that Jeong-Jo was murdered by poison is not likely.

• Journal of Acupuncture Research
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• v.31 no.1
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• pp.121-130
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• 2014

Objectives : I investigated whether bee venom inhibit cell growth through enhancement of death receptor expressions in the human lung cancer cells, NCI-H460. Methods : Bee venom(1-5 ${\mu}g/ml$) inhibited the growth of NCI-H460 lung cancer cells by the induction of apoptotic cell death in a dose dependent manner. Results : Consistent with apoptotic cell death, expression of TNF-R1, TNF-R2, FAS, death receptors(DR) 3, 4, 5 and 6 was increased in the cells. Expression of DR downstream pro-apoptotic proteins including Caspase-8, -3, -9 was upregulated and Bax was concomitantly overwhelmed the expression of Bcl-2. NF-kB were inhibited by treatment with bee venom in NCI-H460 cells through TNF response change led by TNF-R1 and TNF-R2. Conclusions : These results suggest that bee venom should exert anti-tumor effect through induction of apoptotic cell death in NCI-H460 human lung cancer cells via enhancement of death receptor expression, and that bee venom could be a promising agent for preventing and treating lung cancer.

• Journal of Acupuncture Research
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• v.30 no.1
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• pp.57-70
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• 2013

This study was to investigated the effects of the bee venom on inhibition of cell growth via upregulation of death receptor expression in the A549 human lung cancer cells. Bee venom(1-5 ${\mu}g$/ml) inhibited the growth of A549 lung cancer cells by the induction of apoptotic cell death in a dose dependent manner. Consistent with apoptotic cell death, expression of TNFR1, Fas, death receptors(DR) 3, 4 and 6 was increased in the cells. Expression of DR downstream pro-apoptotic proteins including caspase-3, -9 and Bax was concomitantly increased, but the expression of Bcl-2, NF-${\kappa}B$ were inhibited by treatment with bee venom in A549 cells. Moreover, deletion of DR3, DR4 by small interfering RNA significantly reversed bee venom-induced cell growth inhibitory effect, whereas Apo3L strengthened anti-proliferative effect of bee venom through enhancement of DR3 expression. These results suggest that bee venom should exert anti-tumor effect through induction of apoptotic cell death in lung cancer cells via enhancement of death receptor expression, and that bee venom could be a promising agent for preventing and treating lung cancer.

• Journal of Korea Game Society
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• v.16 no.1
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• pp.33-42
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• 2016

The Purpose of this study is to analyze the mechanism of permanent death and playing aspects in Rogue-like games. The death in digital game is not only punishment of failure, but reward for player's growth. However the mechanism of permanent death which does not allow to resurrect is critical penalty for players and causes play-cycle with high anxiety. In the mechanism of permanent death, players do critical play to evade the death. But when they replay the game they modify their unethical choices to build alternative game world. Through the mechanism of permanent death which demands critical and alternative play, it could be possible to find the way to design games with serious choice.