• Parasites, Hosts and Diseases
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• v.51 no.1
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• pp.61-68
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• 2013

Entamoeba histolytica, which causes amoebic colitis and occasionally liver abscess in humans, is able to induce host cell death. However, signaling mechanisms of colon cell death induced by E. histolytica are not fully elucidated. In this study, we investigated the signaling role of NOX in cell death of HT29 colonic epithelial cells induced by E. histolytica. Incubation of HT29 cells with amoebic trophozoites resulted in DNA fragmentation that is a hallmark of apoptotic cell death. In addition, E. histolytica generate intracellular reactive oxygen species (ROS) in a contact-dependent manner. Inhibition of intracellular ROS level with treatment with DPI, an inhibitor of NADPH oxidases (NOXs), decreased Entamoebainduced ROS generation and cell death in HT29 cells. However, pan-caspase inhibitor did not affect E. histolytica-induced HT29 cell death. In HT29 cells, catalytic subunit NOX1 and regulatory subunit Rac1 for NOX1 activation were highly expressed. We next investigated whether NADPH oxidase 1 (NOX1)-derived ROS is closely associated with HT29 cell death induced by E. histolytica. Suppression of Rac1 by siRNA significantly inhibited Entamoeba-induced cell death. Moreover, knockdown of NOX1 by siRNA, effectively inhibited E. histolytica-triggered DNA fragmentation in HT29 cells. These results suggest that NOX1-derived ROS is required for apoptotic cell death in HT29 colon epithelial cells induced by E. histolytica.

• Journal of the Korea Convergence Society
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• v.9 no.11
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• pp.433-441
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• 2018

The purpose of this study is to understand the effect of psychosocial support, death preparedness, and ego integrity on death anxiety in old people. The participant of this study were the elderly who attended welfare centers, worked in their workplaces, or lived at their home in Seoul regions, from whom this study had collected their data from February to May 2017. A total of 350 questionnaires were distributed and 329 copies of them were used for its final analysis using SPSS 24.0 and AMOS 20.0 statistical programs. According to the results of this study, psychosocial support had no statistically significant effect on death anxiety, whereas death preparedness and ego integrity had statistically significant effects on death anxiety. Based upon these research results, this study suggested that it is necessary to develop death education and counseling programs as policy supports and practical methods for helping old people to accept their death positively, reintegrate their ego, and perform their successful aging.

• Korean journal of communication and information
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• v.68
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• pp.65-86
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• 2014

Photography is frequently associated with the death because it seems to remind us of our own mortality by representing the dead people. The indexical character of photography reinforces this association. Photography is used in many ceremonial activities and medias to represent death. Five types of death photography can be differentiated: funeral portrait, post-mortem photography, conflict and disaster photography, death penalty photography, anatomic and forensic photography. These death photographies serve for four individual and social purposes: mourning and remembrance, resistance and struggle, rule and domination, disclosure and accusation.

• BMB Reports
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• v.41 no.1
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• pp.1-10
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• 2008

Surgery, Chung-Ang Unviersity College of Medicine, Yong-San Hospital, Seoul, Korea Apoptosis is considered to be a programmed and controlled mode of cell death, whereas necrosis has long been described as uncontrolled and accidental cell death resulting from extremely harsh conditions. In the following review, we will discuss the features and physiological meanings as well as recent advances in the elucidation of the signaling pathways of both apoptotic cell death and programmed necrotic cell death.

• The Journal of Korean Academic Society of Nursing Education
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• v.16 no.1
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• pp.72-82
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• 2010

Purpose: The purpose of this study is to understand the meaning of dignified dying expressed by undergraduate nursing students. Method: Data were collected by in-depth interviews with fifteen nursing students. Conventional qualitative content analysis was used to analyze the data. Result: There were six major themes and eleven sub-categories from the analysis. Six major themes include death with no artificial life support, obedient death as a human nature, death with family members, meaningful death, no self destructive death, and sympathized death receiving from health care providers. Conclusion: The result of this study suggests that the nursing curriculum related to dignified dying can be developed and may affect the teaching and learning settings to improve end-of-life care performance among undergraduate nursing students, as well as, students in human service areas and health care providers.

• Journal of Yeungnam Medical Science
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• v.34 no.2
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• pp.174-181
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• 2017

Ferroptosis is a newly recognized type of cell death that results from iron-dependent lipid peroxidation and is different from other types of cell death, such as apoptosis, necrosis, and autophagic cell death. This type of cell death is characterized by mitochondrial shrinkage with an increased mitochondrial membrane density and outer mitochondrial membrane rupture. Ferroptosis can be induced by a loss of activity of system $X_c{^-}$ and the inhibition of glutathione peroxidase 4, followed by the accumulation of lipid reactive oxygen species (ROS). In addition, inactivation of the mevalonate and transsulfuration pathways is involved in the induction of ferroptosis. Moreover, nicotinamide adenine dinucleotide phosphate oxidase and p53 promote ferroptosis by increasing ROS production, while heat shock protein beta-1 and nuclear factor erythroid 2-related factor 2 inhibit ferroptosis by reducing iron uptake. This article outlines the molecular mechanisms and signaling pathways of ferroptosis regulation, and explains the roles of ferroptosis in human disease.

• 한국전자현미경학회:학술대회논문집
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• 2005.05a
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• pp.113-115
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• 2005

• Asian Oncology Nursing
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• v.10 no.2
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• pp.156-162
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• 2010

Purpose: The purposes of this study was to compare the meaning in life and death attitude between the participants and nonparticipants of the well-dying education program. Methods: This study adopted the descriptive comparative design. Data were collected by interviewing 85 participants and 94 non-participants of well-dying education. The instruments used for this study were a self-report questionnaire. Results: There were significant differences in age, gender, marital status, health status, and volunteer experience. The program participants showed higher scores in the death attitude than non-participants. There were significant correlations between meaning in life and death attitude in participant group. Death attitude was significantly associated with meaning in life in participant group with 6.0% variance. Conclusion: Based on the results, well-dying education program was effective to prepare good death with more comprehensive vision. Therefore, this program should be served for patient with life-threatening illness by nurse and this is the expended role of oncology and hospice palliative nurses.

• Korean Journal of Hospice Care
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• v.6 no.2
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• pp.19-34
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• 2006

The purpose of this study was to confirm the influence of nursing student's values on attitudes toward death of them. The subjects for this study was based 356 students of high school in Gwang Ju. The data were analyzed by using descriptive statistics, reliability, factor analysis, t-test, one -way ANOVA, scheffe, Pearson's correlation coefficient and Stepwise Multiple Regression. The results obtained were as follows : 1. The mean score for values was 24.31 The mean score for attitudes of death was 34.02 2. There was significant differences of attitudes of death according to religion, socioeconomic state, existence of parent, grades, smoking, alcohol intaking 3. There was a positive correlation that is values and attitudes toward death of nursing student. 4. There was a significant predictors influencing attitudes toward death of nursing students were values and alcohol intaking and these predictors accounted for 18.2% of attitudes toward death of them.

• SUVANNABHUMI
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• v.14 no.1
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• pp.229-246
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• 2022

Gabriel García Márquez's short story "The Handsomest Drowned Man in the World" ["El ahogado más hermoso del mundo," 1968] and the novel Chronicle of a Death Foretold [Crónica de una muerte anunciada, 1981] and Merlinda Bobis's novel Fish-Hair Woman (2012) and short story "O Beautiful Co-Spirit" (2021) feature unusual scenarios of death: the arrival of a drowned man's corpse at an island; the inaction of the community to stop the foretold death of a supposedly-innocent man; a woman with long hair that can fetch dead bodies at the bottom of the village river; and a Filipino Catholic and a Malaysian Muslim working together to prepare an Italian Catholic's corpse for a funeral. These narratives demand critical attention as all deaths make the community's existence meaningful as they alter its social reality. Looking into the works of the aforementioned Colombian writer and Filipino writer and unveiling how death affects the community, this paper relies on Jean-Luc Nancy's theory on death and inoperative community.