• The KIPS Transactions:PartD
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• v.10D no.1
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• pp.133-142
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• 2003

The major challenge for post-genomic study is to identify structural similarity and relationships of proteins. SCOP (Structural Classification of Proteins) is a typical database for this purpose, providing a derailed description of the structural and functional relationships of the proteins whose three-dimensional structures have been determined. Unfortunately, since the SCOP data is only available as a plain text format, it is cumbersome and error-prone to develop tools and resources to utilize the data more effectively. To meet these researchers to utilize the data more effectively. To meet these requirements, we have developed an XML representation for the SCOP site, users of the tool, named, SCOPBrowser, for effective search of SCOP database. In addition to the information available from the SCOP site, users of the tool can obtain various information such as viewing the tree hierarchy of structure classification of proteins, searching into whole protein domains, showing XML contents of a specific domain, and some useful statistics about protein structures.

• Journal of Biomedical Engineering Research
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• v.25 no.1
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• pp.77-82
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• 2004

The purpose of this study is to establish a reference for image acquisition for completion of a standard brain for diverse Korean population, and to develop a management system that saves and manage database of the acquired brain image and personal information of those who were tested. 3D MP-RAGE technique, which has excellent SNR and CNR and reduces the times for image acquisition, was selected for anatomical Image acquisition, and parameter values were obtained for the optimal image acquisition. The database management system was devised to obtain not only anatomical image data but also subjects' basic demographic factors, medical history, handedness inventory state-trait anxiety inventory, A-type personality inventory, self-assessment depression inventory questionnaires of Sasang Constitution Mini-Mental State Examination, intelligence test, and personality test via a survey questionnaire and to save and manage the results of the tests. In addition, this system was designed to have functions of saving, inserting, deleting, searching, and Printing of image da a and personal information of subjects, and to have accessibility to them as well as automatic connection setup with ODBC. This newly developed system may have major contribution to the completion of a standard brain of diverse Korean population in that it can save and manage their image date and personal information.

• Journal of Korean Society of Environmental Engineers
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• v.28 no.10
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• pp.1082-1089
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• 2006

This study describes a methodology to develop a environmental and geographical information system for managing a national scale which is supports the environmental fate modeling. This system was developed via the integration of environmental and geographical information database(DB) and the DB usage software. For the sound environmental management, the DB were constructed by extracting the geometrical figures-such as points, polylines, and/or polygons-based on the geographical information previously developed in Korea. Then it was connected with the environmental information. Based on the Visual Basic Complier, the software can be a useful tool for visualizing the DB, for searching the environmental & geographical information, and supporting the environmental fate modeling.

• Journal of Ginseng Research
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• v.37 no.2
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• pp.227-247
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• 2013

MicroRNAs (miRNAs) are a class of recently discovered non-coding small RNA molecules, on average approximately 21 nucleotides in length, which underlie numerous important biological roles in gene regulation in various organisms. The miRNA database (release 18) has 18,226 miRNAs, which have been deposited from different species. Although miRNAs have been identified and validated in many plant species, no studies have been reported on discovering miRNAs in Panax ginseng Meyer, which is a traditionally known medicinal plant in oriental medicine, also known as Korean ginseng. It has triterpene ginseng saponins called ginsenosides, which are responsible for its various pharmacological activities. Predicting conserved miRNAs by homology-based analysis with available expressed sequence tag (EST) sequences can be powerful, if the species lacks whole genome sequence information. In this study by using the EST based computational approach, 69 conserved miRNAs belonging to 44 miRNA families were identified in Korean ginseng. The digital gene expression patterns of predicted conserved miRNAs were analyzed by deep sequencing using small RNA sequences of flower buds, leaves, and lateral roots. We have found that many of the identified miRNAs showed tissue specific expressions. Using the insilico method, 346 potential targets were identified for the predicted 69 conserved miRNAs by searching the ginseng EST database, and the predicted targets were mainly involved in secondary metabolic processes, responses to biotic and abiotic stress, and transcription regulator activities, as well as a variety of other metabolic processes.

• Journal of KIISE:Databases
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• v.33 no.2
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• pp.224-238
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• 2006

As XML became the standard of data exchange in the internet, the needs for effective query processing for XML data in streaming environment is increasing. Applying the existing database technique which processes data with the unit of tuple to the streaming XML data causes the out-of-memory problem due to limited memory volume. Likewise the cost for searching query path and accessing specific data may be remarkably increased because of special structure of XML. In a word it is unreasonable to apply the existing database system to the streaming environment that processes query for partial data, not the whole one. Thus, it should be able to search partial streaming data that rapidly satisfies join predicate through using low-capacity memory, based on a store technique suitable to streaming XML data. In this thesis, in order to study the store technique for low-capacity memory, the PCDATA and the CDATA-related parts, which can be used as predicate on join query, were fetched and saved. In addition, in an attempt to compare rapid join predicates, the range window of streaming XML data was set with the object of selectively joining windows that satisfies the query, based on Cardinality * and + among the structure information of DTD.

• The Journal of Korean Obstetrics and Gynecology
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• v.33 no.1
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• pp.1-18
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• 2020

Objectives: This review is aimed at assessing the efficacy and effectiveness of oriental medicine for the prevention of Ovarian Hyperstimulation Syndrome (OHSS) through literature research and overview. Methods: Database searching was conducted to identify relevant randomized controlled trials (RCTs) on oriental medicine for the prevention of Ovarian Hyperstimulation Syndrome. Studies were searched from Journal of Korean Obstetrics and Gynecology, Korean studies Information Service System, Korean Medical Database, China National Knowledge Infrastructure, Cochrane library, PubMed and EmBase up to 7^th November, 2019. Results: Ten RCTs were finally selected. Eight studies intervened with oral Chinese herb medicine, one is intervened with Chinese medicine enema and the other with acupuncture. Eight studies concluded that intervention with oriental medicine significantly decreased OHSS incidence. Five studies showed significantly higher pregnancy rate in the intervention groups. Two studies reported higher ovulation rate and other two studies showed more maturated eggs than the control groups. Four studies showed opposite results in serum Estradiol level. Vascular Endothelial Growth Factor level was significantly lower in the intervention groups in two studies. Conclusions: From ten studies, oriental medicine reduced OHSS incidence rate and showed preventable effectiveness. Further strictly designed studies and acupuncture intervened studies are needed to establish evidences.

• Herbal Formula Science
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• v.27 no.3
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• pp.189-197
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• 2019

Objectives : The purpose of this study was to confirm whether Codonopsis Radix(CR) could be used in the same way for expected indications or diseases of adaptation instead of Ginseng Radix(GR), which acts as a principal herb in Sagunja-tang. Methods : The Traditional Chinese Medicine Systems pharmacology(TCMSP), a database for the study of systems biology related to Chinese medicine, screened potential active compounds in each quartet. By searching for all the proteins that each compound provides, the target of Sagunja-tang with GR(GRST) and the target of Sagunja-tang with CR(CRST) were compared using the network analysis method, and the top ranked target of each serving was selected. Results : Through TCMSP, a Chinese medicine database, the potential effective ingredients of GRST or CRST screened, and the target proteins related to these substances were found to be the most affected by Glycyrrhizae Radix et Rhizome, an herbal medicine mixed in Sagunja-tang, and the target diseases were the same. And the same were found for the target protein, gene and target diseases of GRST and CRST. Conclusions : The prescription with similar composition is likely to have similar network pharmacology analysis results, and the analysis result may be controlled by the herbal medicines which are assumed to be the main function. Therefore, rich and reproducible basic studies is more important because network pharmacological studies can be dominated by data that has been done a lot of previous studies.

• Journal of Korean Medicine Rehabilitation
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• v.31 no.4
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• pp.75-86
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• 2021

Objectives This study aimed to analyze the research trends in clinical studies on the traditional Korean medicine used for cancer treatment between 2011 and 2020. Methods We searched 7 Korean web databases (Research Information Sharing Service [RISS], Oriental Medicine Advanced Searching Integrated System [OASIS], Koreanstudies Information Service System [KISS], Korean Medical database [KMBASE], DBpia, Korea Institute of Science and Technology Information [KISTI], and KoreaMed) and classified collected papers dated between 2011 and 2020 by the year of publication, publication journal, study design, type of cancer affecting the patients, interventions used, evaluation system used, and combination with conventional medicine. Results A total of 167 papers were collected. More than 10 papers were published annually. The papers were mainly published in the Journal of Korean Traditional Oncology (28.7%). The predominant type of the study was case study (67.7%). The main type of cancer was breast cancer, affecting 262 patients. Most of the studies reported using multiple traditional Korean medicine treatments (55.1%). Eighty-nine studies reported using clinical laboratory tests for evaluation. Most of the patients took conventional medicine simultaneously (608 patients). Conclusions Research related to Korean medicine for cancer patients is at a rudimentary level. Therefore, for further clarity, high evidence-based researches, including randomized controlled trials and cohort studies, should be conducted.

• Korean Journal of Acupuncture
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• v.38 no.3
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• pp.122-132
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• 2021

Objectives : This systematic review aims to assess the effectiveness of thread embedding therapy on animal model for rheumatoid arthritis. Methods : Search was conducted in the Cochrane library, MEDLINE (PubMed), EMBASE, the Chinese National Knowledge Infrastructure, Wan-Fang Database, Technology Journal Database, the Korean Studies Information Service System, the Oriental Medicine Advanced Searching Integrated System, the Research Information Sharing Service, the National Digital Science Library, the Korean Traditional Knowledge Portal and the Korea Citation Index. Data were extracted concerning animal model, intervention and rheumatoid arthritis indicator by two independent reviewers. Reporting quality was also evaluated by the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines 2.0. Results : One thousand thirty six studies were primarily selected. After screening, 10 studies met the inclusion criteria. 1 study was published 2005, 1 study was published 2010, 1 study was published 2012, 1 study was published 2015, 2 studies were published 2016, 3 studies were published 2017, 1 study was published 2018. The most frequently used acupoints were ST36 and BL23, and were used with an average frequency of 11.8 days. All of these thread embedding therapy studies were effective on behavioral, morphological, immunohistological and hematological indicators to treat of rheumatoid arthritis model. Conclusions : These results demonstrated the effectiveness of thread embedding therapy and suggested the putative mechanism. However, considering the small number of included studies, low reporting quality and differences in study design, further studies with rigorous designs and high reporting quality need to be conducted.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.7 no.1
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• pp.265-276
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• 2017

Korean petroglyphs have been found over a lot of ruins through nation-wide regions including Daegok-ri Bangudae and Cheonjeon-ri in Ulsan. In this paper, we present an information system for Korean petroglyph ruins named KPetro which supports the dedicated camera application and the timeline service. The system provides the services for searching and updating information in various ways over the primary database constructed with the data on petroglyph ruins, which are collected by the Bangudae Petroglyph Institute. In addition, through the camera application developed for the system, users can easily add photos to the appropriate petroglyph ruin according to the GPS information of the location where those photos are taken. Also, the system provides the timeline service showing the photos for a specific petroglyph ruins in order of shooting time. To support both mobile and desktop environments, KPetro provides its functions in a web browser using the HTML5 standard technology and the JavaScript language, enabling the system to be adaptable to various user devices and extendable for its functionalities.