• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.383-387
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• 2005

One of the most important issues in post-genome era is identifying functions of genes and understanding the interaction among them. Such interactions from complex biochemical pathways, which are very useful to understand the organism system. We present an integrated biochemical pathway database system with a set of software tools for reconstruction, visualization, and simulation of the pathways from the database. The novel features of the presented system include: (a) automatic integration of the heterogeneous biochemical pathway databases, (b) gene ontology for high quality of database in the integration and query (c) various biochemical simulations on the pathway database, (d) dynamic pathway reconstruction for the gene list or sequence data, (e) graphical tools which enable users to view the reconstructed pathways in a dynamic form, (f) importing/exporting SBML documents, a data exchange standard for systems biology.

• Journal of the Korean Society for Precision Engineering
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• v.15 no.2
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• pp.107-113
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• 1998

Grinding operation has difficulty in satisfying the qualitative knowledge based on the skilful expert as well as the quantitative data for all user. Design of grinding database based on the frame-based model is more effective method for utilizing the empirical and qualitative knowledge. In this paper. basic strategy to develop the grinding database by taking frame-based model, which is strongly dependent upon experience and intuition, is described. Grinding database based on the frame based model for designing the interaction and inference among the slots is accomplised by the object-oriented paradigm system.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.13
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• pp.5325-5330
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• 2014

Background: Chronic myelocytic leukemia is a disease that threatens both adults and children. Great progress has been achieved in treatment but protein-protein interaction networks underlining chronic myelocytic leukemia are less known. Objective: To develop a protein-protein interaction network for chronic myelocytic leukemia based on gene expression and to predict biological pathways underlying molecular complexes in the network. Materials and Methods: Genes involved in chronic myelocytic leukemia were selected from OMIM database. Literature mining was performed by Agilent Literature Search plugin and a protein-protein interaction network of chronic myelocytic leukemia was established by Cytoscape. The molecular complexes in the network were detected by Clusterviz plugin and pathway enrichment of molecular complexes were performed by DAVID online. Results and Discussion: There are seventy-nine chronic myelocytic leukemia genes in the Mendelian Inheritance In Man Database. The protein-protein interaction network of chronic myelocytic leukemia contained 638 nodes, 1830 edges and perhaps 5 molecular complexes. Among them, complex 1 is involved in pathways that are related to cytokine secretion, cytokine-receptor binding, cytokine receptor signaling, while complex 3 is related to biological behavior of tumors which can provide the bioinformatic foundation for further understanding the mechanisms of chronic myelocytic leukemia.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.23 no.60
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• pp.73-81
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• 2000

The testing processes for VLSI finished devices are considerably complex because they require different types of ATE to be linked together. Due to the interaction effect between two or more linked ATEs, it is difficult to trace down the cause of the unexpected longer ATE setup time and random yields, which frequently occur in the VLSI circuit-testing laboratory. The goal of this paper is to develop and demonstrate the methodology designed to eliminate the possible interaction factors that might affect the random yields and/or unexpected longer setup time as well as increase the productivity. The statistical method such as design of experiment or multivariate analysis cannot be applied to the final testing floor here directly due to the environmental constraints. Expanded product data information (PDI) is constructed by combining product data information and ATE control information. An architecture utilizing expanded PDI is designed, which enables the engineer to conduct statistical approach investigation and reduce the setup time, as well as increase yield.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2561-2567
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• 2015

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer death worldwide. Our study aimed to reveal molecular mechanisms. Microarray data of GSE15471 (including 39 matching pairs of pancreatic tumor tissues and patient-matched normal tissues) was downloaded from Gene Expression Omnibus (GEO) database. We identified differentially expressed genes (DEGs) in PDAC tissues compared with normal tissues by limma package in R language. Then GO and KEGG pathway enrichment analyses were conducted with online DAVID. In addition, principal component analysis was performed and a protein-protein interaction network was constructed to study relationships between the DEGs through database STRING. A total of 532 DEGs were identified in the 38 PDAC tissues compared with 33 normal tissues. The results of principal component analysis of the top 20 DEGs could differentiate the PDAC tissues from normal tissues directly. In the PPI network, 8 of the 20 DEGs were all key genes of the collagen family. Additionally, FN1 (fibronectin 1) was also a hub node in the network. The genes of the collagen family as well as FN1 were significantly enriched in complement and coagulation cascades, ECM-receptor interaction and focal adhesion pathways. Our results suggest that genes of collagen family and FN1 may play an important role in PDAC progression. Meanwhile, these DEGs and enriched pathways, such as complement and coagulation cascades, ECM-receptor interaction and focal adhesion may be important molecular mechanisms involved in the development and progression of PDAC.

• Journal of The Korean Astronomical Society
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• v.40 no.4
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• pp.165-169
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• 2007

The numerical simulations associated with the interaction of High Velocity Clouds (HVC) with the Magnetized Galactic Interstellar Medium (ISM) are a powerful tool to describe the evolution of the interaction of these objects in our Galaxy. In this work we present a new project referred to as Theoretical Virtual i Observatories. It is oriented toward to perform numerical simulations in real time through a Web page. This is a powerful astrophysical computational tool that consists of an intuitive graphical user interface (GUI) and a database produced by numerical calculations. In this Website the user can make use of the existing numerical simulations from the database or run a new simulation introducing initial conditions such as temperatures, densities, velocities, and magnetic field intensities for both the ISM and HVC. The prototype is programmed using Linux, Apache, MySQL, and PHP (LAMP), based on the open source philosophy. All simulations were performed with the MHD code ZEUS-3D, which solves the ideal MHD equations by finite differences on a fixed Eulerian mesh. Finally, we present typical results that can be obtained with this tool.

• Proceedings of the Korea Database Society Conference
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• 2001.11a
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• pp.388-421
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• 2001

o Web sites are now at the core of business interaction. o Users are no longer content with static content. o Rich content has become a necessity. o Change is rapid. (omitted)

• Proceedings of the Korea Database Society Conference
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• 2001.06a
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• pp.183-192
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• 2001

eCRM은 인터넷 상의 고객의 행동을 파악, 가치있는 고객 세그먼트를 찾아내고, 이들에게 타겟 마케팅을 실시함으로써 기업의 수익성을 높이거나, 마케팅활동을 자동화함으로써 고객관리 프로세스의 효율성을 높이는 일련의 과정 (중략)

• Journal of the Korea Society of Computer and Information
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• v.28 no.7
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• pp.145-153
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• 2023

The aim of this study is to examine the relationship between self-regulated learning, NLR(non-learning-related) behavior, interaction and flow on satisfaction in database classes. To achieve this purpose, this study proposed a research model consisting of self-regulated learning, NLR behavior, interaction, flow and satisfaction. A survey was conducted to test the research hypotheses, and a total of 122 online questionnaires were obtained and used for the final statistical analysis. The main findings of the analysis are as follows: First, flow was consistently identified as a key determinant of satisfaction. Second, self-regulated learning was found to have a significant effect on flow. Third, NLR behavior and interaction were found to mediate the relationship between self-regulated learning and flow. This study provides insights into the role of NLR behavior and interaction in promoting flow and offers implications for understanding how to promote flow.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2000.04a
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• pp.766-769
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• 2000

In recent years, Internet/Intranet represents the next generation of computing environment. Therefore, it is necessary to integrate WWW((World Wide Web) over internet/intranet and DBMS(Database Management System) in proportion to the increase of various users' request and an amount of data variety. Also, also full variety of service over WWW need to accomplish rapidly modification of bug and make a betterment of system according to a feature of rapid change of information and an importance of interaction with users. The typical CGI method commonly used to connect with database has a disadvantage in time and resources in system due to frequent connection with database. Therefore, this paper provides the conceptual structure and implementation of information management system over WWW with applying a recent information technology called ASP(Active Server Pages) that controls and arranges client logic dynamically in server-side and introducing a concept of working group and folder to database design.