• Biomolecules & Therapeutics
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• 제29권1호
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• pp.98-103
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• 2021

The demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Intensive investigation on the culture broth of Streptomyces sp. SCO-736, a marine bacterium from the Antarctica coast, has led to the isolation of a new natural product named antaroide (1). The chemical structure was established through the interpretation of MS, UV, and NMR spectroscopic data. Antaroide is a nine-membered macrolide with lactone and lactam moieties. To investigate its applicability in skin whitening cosmetics, its anti-melanogenic activity in B16F10 murine melanoma cells was examined. As a result, antaroide displayed strong inhibitory activities against melanin synthesis and also attenuated the dendrite formation induced by the α-melanocyte stimulating hormone (α-MSH). Antaroide suppressed the mRNA expression of the melanogenic enzymes such as tyrosinase, TRP-1 and TRP-2. This suggests that it may serve as a transcriptional regulator of melanogenesis. Collectively, the discovery of this novel natural nine-membered macrolide and its anti-melanogenic activity could give new insights for the development of skin whitening agents.

• 동서간호학연구지
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• 제15권1호
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• pp.54-62
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• 2009

Purpose: The purpose of this study was to examine the effects of relaxation therapy to reduce anxiety level among spinal anesthesia surgery patients. Methods: The study employed a quasi-experimental pre-and-posttest design with nonequivalent control group. The experimental group was provided with the 15-min muscle relaxation therapy on the day before the surgery and an hour before the spinal anesthesia. Data were collected from 44 patients (22 in experimental and 22 in control group) who were planned to have spinal anesthesia surgery from an orthopedic surgery department at a general hospital in Seoul from January 13 to March 21, 2006. Results: The experimental group reported lower level of state anxiety after the surgery (23.18 vs. 33.64) than did control group but was not statistically significant. There were no significant differences in blood pressure or pulse rate between experimental and control groups after surgery. Conclusions: The further research should be conducted to polish the muscle relaxation therapy for various types of patients and to create more comfortable environment setting for application of the therapy. The muscle relaxation therapy may be a convenient and useful nursing intervention to reduce anxiety among spinal anesthesia surgery patients if more studies prove its effectiveness.

• 한국입자에어로졸학회지
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• 제20권1호
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• pp.13-24
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• 2024

The concentrations of polycyclic aromatic hydrocarbons (PAHs) and elemental carbon (EC) in particulate matter, typical primary aerosols have decreased in Seoul between 2003 and 2018 (80% for PAHs and 85% for EC). The yearly mean benzo[a]pyrene (BaP) concentration has been lower than 1 ng/m3 since 2010-2011, the target value set by the European Union (EU) and China. A series of policies related to solid fuel and vehicle in South Korea and China should be effective in the reduction of the ambient PAHs and EC concentrations. But the emission data of PAHs and EC at both countries did not support that hypothesis. Possible causes are uncertainties in the emission inventories of primary carbonaceous aerosols in South Korea and China, although there may be a minor effect of the emissions from North Korea on the concentrations in Seoul. Thus the further policy directions against PAHs and EC such as improvements of emissions inventories and measurements, intensive regulation of non-road mobile sources and control of PAHs derivatives are discussed.

• Journal of Yeungnam Medical Science
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• 제41권2호
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• pp.96-102
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• 2024

Background: The aim of this study was to compare the early outcomes of octogenarians undergoing minimally invasive right anterior mini-thoracotomy aortic valve replacement (RAT-AVR) with those undergoing transcatheter aortic valve implantation (TAVI) for aortic valve disease. Methods: In this single-center retrospective study, data were collected from octogenarians before and after RAT-AVR and TAVI between January 2021 and July 2022. Short-term outcomes, including the length of hospital stay, in-hospital mortality, all-cause mortality, and other major postoperative complications, were compared and analyzed. Results: There were no significant differences in in-hospital mortality, stroke, acute kidney dysfunction requiring renal replacement therapy, length of intensive care unit stay, or length of hospital stay. However, the TAVI group had a higher incidence of permanent pacemaker insertion (10% vs. 0%, p=0.54) and paravalvular leaks (75% vs. 0%, p<0.001). Conclusion: In the present study on octogenarians, both TAVI and RAT-AVR showed comparable short-term results. Although both procedures were considered safe and effective in the selected group, RAT-AVR had a lower incidence of complete atrioventricular block and paravalvular regurgitation.

• 기본간호학회지
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• 제9권3호
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• pp.349-359
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• 2002

Purpose: The purpose of this study was two-fold : to describe the level of recognition of nosocomial respiratory infections by ICU nurses and to compare self evaluation and objective evaluation of nosocomial respiratory infection control practices by ICU nurses. Method: Data were collected from 78 nurses in intensive care units in one university affiliated hospital in Kyung Ki Province. Data were collected from March 4 to March 18, 2002. The recognition and self evaluation data were collected through a self report questionnaire and an objective evaluation which was done by observing the actual behavior of the nurses. Result: The results of this study showed that there was a significant positive relationship between recognition scores and self evaluation scores. However, there was no significant relationship between level of recognition and objective evaluation, nor between self evaluation and objective evaluation of infection control Practices by ICU nurses. Conclusion: ICU nurses In this study gave higher scores on self evaluation of their practice than were shown in the observation evaluation of actual practice. Moreover, in the objective evaluation the nurses had the lowest score on the item, 'washing hands before taking care of patients'. The results indicate that it is necessary to develop a standardized practice manual on nosocomial respiratory infection control in the ICU. Also, it is necessary to have a program to transfer knowledge into actual practice.

• 한국연안방재학회지
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• 제4권1호
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• pp.7-19
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• 2017

In this study, waves and currents observed by acoustic AWAC, VECTOR and Aquadopp Profiler in Anmok coastal waters were analysed to account for the variability of wave and current and to understand the mechanism of sediment transport generated by wave-induced current in the surf-zone. The monthly variation of wave and residual currents were analysed and processed with long-term observed AWAC data at station W1, located at the water depth of about 18m measured during from February 2015 to September 2016. Wave-induced currents were also analysed with intensive field measurements such as wave, current, suspended sediment, and bathymetry data observed at the surf-zone during in winter and summer. The statistical result of wave data shows that high waves coming from NNE and NE in winter (DEC-FEB) are dominant due to strong winds from NE. But in the other season waves coming from NE and ENE are prevalent due to the seasonal winds from E and SE. The residual currents with southeastern direction parallel to the shoreline are dominant throughout a year except in winter showing in opposite direction. The speed of ebb-dominant southeastern residual currents decreasing from surface to the bottom is strong in summer and fall but weak in winter and spring. By analysing wave-induced current, we found that cross-shore current were generated by swell waves mainly in winter with incoming wave direction about $45^{\circ}$ normal to the shoreline. Depending on the direction of incoming waves, longshore currents in the surf-zone were separated to southeastern and northwestern flows in winter and summer respectively. The variation of observed currents near crescentic bars in the surf-zone shows different direction of longshore and cross-shore currents depending on incoming waves implying to the reason of beach erosion generating the beach cusp and sandbar migration during high waves at Anmok.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제18권6호
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• pp.1692-1705
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• 2024

In this paper, we present a method that integrates a Grammar Transducer as an external language model to enhance the accuracy of the pre-trained Korean End-to-end (E2E) Automatic Speech Recognition (ASR) model. The E2E ASR model utilizes the Connectionist Temporal Classification (CTC) loss function to derive hypothesis sentences from input audio. However, this method reveals a limitation inherent in the CTC approach, as it fails to capture language information from transcript data directly. To overcome this limitation, we propose a fusion approach that combines a clause-level n-gram language model, transformed into a Weighted Finite-State Transducer (WFST), with the E2E ASR model. This approach enhances the model's accuracy and allows for domain adaptation using just additional text data, avoiding the need for further intensive training of the extensive pre-trained ASR model. This is particularly advantageous for Korean, characterized as a low-resource language, which confronts a significant challenge due to limited resources of speech data and available ASR models. Initially, we validate the efficacy of training the n-gram model at the clause-level by contrasting its inference accuracy with that of the E2E ASR model when merged with language models trained on smaller lexical units. We then demonstrate that our approach achieves enhanced domain adaptation accuracy compared to Shallow Fusion, a previously devised method for merging an external language model with an E2E ASR model without necessitating additional training.

• Journal of Veterinary Science
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• 제22권4호
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• pp.50.1-50.10
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• 2021

Background: Bovine papillomatosis is a type of proliferative tumor disease of skin and mucosae caused by bovine papillomavirus (BPV). As a transboundary and emerging disease in cattle, it poses a potential threat to the dairy industry. Objectives: The aim of this study is to detect and clarify the genetic diversity of BPV circulating in dairy cows in Xinjiang, China. Methods: 122 papilloma skin lesions from 8 intensive dairy farms located in different regions of Xinjiang, China were detected by polymerase chain reaction. The genetic evolution relationships of various types of BPVs were analyzed by examining this phylogenetic tree. Results: Ten genotypes of BPV (BPV1, BPV2, BPV3, BPV6, BPV7, BPV8, BPV10, BPV11, BPV13, and BPV14) were detected and identified in dairy cows. These were the first reported detections of BPV13 and BPV14 in Xinjiang, Mixed infections were detected, and there were geographical differences in the distribution of the BPV genotypes. Notably, the BPV infection rate among young cattle (< 1-year-old) developed from the same supply of frozen sperm was higher than that of the other young cows naturally raised under the same environmental conditions. Conclusions: Genotyping based on the L1 gene of BPV showed that BPVs circulating in Xinjiang China displayed substantial genetic diversity. This study provided valuable data at the molecular epidemiology level, which is conducive to developing deep insights into the genetic diversity and pathogenic characteristics of BPVs in dairy cows.

• 대한의용생체공학회:의공학회지
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• 제21권3호
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• pp.255-260
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• 2000

본 연구는 중환자실, 응급실, 수술실등 병실내에서 환자를 구속하지 않고. 무선으로 환자의 활력징후 신호등을 관찰할 수 있는 생체신호 무선 전송장치를 설계 제작하는데 목적을 두었다. 본 무선 환자감시장치는 활력징후 신호 수집기, 무선 송수신 장치 및 활력징후 관찰기로 구성된다. 활력징후 신호 수집부는 생체신호를 증폭하기 위한 아날로그신호 증폭기와 디지털데이터 변환을 위한 단일 칩 마이크로 컨트롤러로 구성된다. 전송신호의 품질을 확보하고 신호처리 및 구성이 간단하여 저 비용으로 구성할 수 있는 주파수편이변조(FSK) 방법을 사용하였고 디지털신호는 UHF 대역의 미약 무선주파수에 의하여 송수신되었다. 활력징후 신호 관찰기는 무선 수신기에 의해 디지털 데이터를 복조하고 활력징후 신호를 상시 모니터링하기 위한 액정모니터(LCD) 및 신호를 기록하기 위한 감열기록장치(thermal Printer)로 설계 제작되었다.

• 대한기계학회논문집A
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• 제20권8호
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• pp.2555-2560
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• 1996

Inspecting the dimensional accuracy of a car-body in assembly line is a very important process to assure high productivity. Now there exist two common inspecting methods in practice. One is to measure a sampled car-body with three dimensional measuring machine, and the other is to measure car-body with three dimensional measuring machine, and the other is to measure car-body in assembly line using many sensors fixed to a large jig frame. The formal method takes too long to inspect a sampled car-body of a same sort, and cannot therefore give an useful error trend for the whole production. On the other hand, the latter lacks flexibility and is very cost-intensive. By using industrial robots and sensors, an in-line Car-Body Measuring(CBM) system which ensured high flexiblity and sufficient accuracy was developed. This CBM cell operates in real production line and measures the check points by the non-contact type using camera and laser displacement sensor(LDS). This system can handle about 15 Measuring points within a cycle time of 40 seconds. A process computer controls whole process such as data acquisition file handling and data analysis. Robot arms changes in length due to ambient temperature fluctuation affecting the measuring accuracy. To compensate this error, a robot arm calibration process was developed.