• Molecules and Cells
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• v.45 no.5
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• pp.343-352
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• 2022

The advent of the assay for transposase-accessible chromatin using sequencing (ATAC-seq) has shown great potential as a leading method for analyzing the genome-wide profiling of chromatin accessibility. A comprehensive reference to the ATAC-seq dataset for disease progression is important for understanding the regulatory specificity caused by genetic or epigenetic changes. In this study, we present a genome-wide chromatin accessibility profile of 44 liver samples spanning the full histological spectrum of nonalcoholic fatty liver disease (NAFLD). We analyzed the ATAC-seq signal enrichment, fragment size distribution, and correlation coefficients according to the histological severity of NAFLD (healthy control vs steatosis vs fibrotic nonalcoholic steatohepatitis), demonstrating the high quality of the dataset. Consequently, 112,303 merged regions (genomic regions containing one or multiple overlapping peak regions) were identified. Additionally, we found differentially accessible regions (DARs) and performed transcription factor binding motif enrichment analysis and de novo motif analysis to determine new biomarker candidates. These data revealed the gene-regulatory interactions and noncoding factors that can affect NAFLD progression. In summary, our study provides a valuable resource for the human epigenome by applying an advanced approach to facilitate diagnosis and treatment by understanding the non-coding genome of NAFLD.

• The Journal of Asian Finance, Economics and Business
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• v.10 no.2
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• pp.257-265
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• 2023

This paper investigates the determinants of credit accessibility and the effect of credit on the income of farm households borrowing from Vietnam Bank for Agriculture and Rural Development, Giong Rieng District Branch, Kien Giang Province. Based on the primary data of 200 farming households who are the customer of the bank, the study applied the Probit regression model to examine determinant factors of credit accessibility of farm households and employed the Propensity score matching method to investigate the impact of credit on households' income. The findings of the Probit regression shown that three independent variables that significantly influence the access to credit of households are household size, income source, and farm size. Besides that, the Propensity score matching method results showed a difference of 23.799 million VND/year between the income of borrowing households and that of non-borrowing households at the significance level of 1%. The difference in the imcome from the interval and central matching methods are VND 24.700 million VND/year and VND 24.633 million VND/year, respectively. Given empirical findings suggetsted that several recommendations to increase the credit accessibility of farm households, thereby creating favorable conditions for improving their income.

• Journal of Preventive Medicine and Public Health
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• v.12 no.1
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• pp.99-106
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• 1979

Accessibility to medical facilities and personnels has been known as one of important determinants of medical care utilization. This study attempted to identify the effects of medical accessibility in terms of geographical distance and occupational opportunity to the medical utilizations. Two-year-experiences of Yonsei University Health Insurance Cooperatives were used as the sources of data. Out patient utilization patterns of 713 members sampled from 4,352 members of Health Insurance Cooperatives were analyzed in order to identify the effects of medical accessibilities. Findings: 1 Average clinic visit rate of Yonsei Health Insurance is 1.66 per person per year. 2. The utilization rates of geographically more accessible group were 33% higher than that of less accessible group. 3. No marked difference in clinic visit rate were observed between medical and non-medical personnel and their family members. 4. Clinic visit rates among occupationally accessible group were slightly higher than those of less accessible. The utilization rate was more sensitively changed by the insurance policy changes in occupationally accessible group.

• Asia-Pacific Journal of Business
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• v.11 no.1
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• pp.1-16
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• 2020

Purpose - The purpose of this research is to investigate the determinants of bakery revisit intention. This research selects Paris Baguette as the research context because the market share of Paris Baguette was the highest in Korean bakery market. Design/methodology/approach -This research employed revisit intention as the dependent variable, while this research chooses six attributes to account for revisit intention. Six attributes are price fairness, taste, product variety, accessibility, display, and membership. This research uses survey as the main instrument. For the data collection, online survey using Google survey form was implemented. The survey participants are domestic consumers of Paris Baguette. The number of observation is 245. For the data analysis, this study used frequency analysis, correlation matrix, exploratory factor analysis, reliability analysis, and multiple regression model. There are four control variables, which contains age, gender, visiting frequency, and monthly income. Findings - The results shows that price fairness, taste, product diversity, and accessibility are significant attributes with the positive effect. Among the significant attributes, taste presented the highest magnitude to explain the revisit intention. However, membership and display appeared as non-significant attributes to account for bakery revisit intention. Research implications or Originality - This study provides the bakery managers with the information to design their service and product. This study also contributes to the literature by understanding the consumer behavior more in the domain of bakery service.

• Journal of Distribution Science
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• v.21 no.2
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• pp.119-129
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• 2023

Purpose: This study intended to examine the effects of the characteristics of platforms for purchasing airline tickets on perceived ease of use, usefulness, and e-loyalty, applying the technology acceptance model. Research design, data and methodology: A research model was established based on previous studies, and data were collected from consumers with experience in the airline ticket purchasing platform. 175 valid samples were used and analyzed using SEM. Results: Characteristics of the ticket purchase platform were classified into sub-factors of accessibility, functionality and information reliability through theoretical consideration. The established hypotheses for the research were partially accepted. Conclusions: First, functionality and information reliability were found to have significant positive effects on perceived ease of use, while accessibility did not have such effect. Second, accessibility did not affect the perceived usefulness, and both functionality and information reliability had a significant positive effect on perceived usefulness. Third, it was found that the perceived ease of use had a positive effect on perceived usefulness. Finally, it was found that perceived ease of use did not affect e-loyalty of the ticket purchasing platform, only perceived usefulness affected e-loyalty. This study had important academic and practical implications in the context of air ticket distribution.

• Journal of the Korean Data and Information Science Society
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• v.26 no.4
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• pp.1007-1015
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• 2015

The purpose of this study was to explore the prevalence of hypertension in Haiti and to describe regional characteristics, and thus to speculate Haitian specific regional risk factors. This is a descriptive and comparative study. Subjects were 145 male/female Haitians, who aged between 30 and 59 and have lived in rural areas, had their hypertension indicators being screened. Data were analyzed with descriptive statistics, t-test and ANOVA. More than four fifth of the subjects (82.8%) showed pre-hypertensive or moderate to severe hypertensive condition. 65.5% of the total had abnormal pulse pressure ($PP{\geq}50$) and 13.8% of the sample showed tachycardia (Heart $Rate{\geq}100$). Female Haitian tended to have higher diastolic blood pressure and faster heart rate than male Haitian. The residents who lived in Part 5-1 area with less accessibility to drinking water tended to have higher systolic and diastolic pressure. Hydration status of Haitians was highly considered as an affecting factor on the distribution of hypertension as evidenced by different level of accessibility to drinking water.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.9
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• pp.4593-4601
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• 2013

The purpose of this study is to analyze neighborhood's land use and transit accessibility affecting residents' commuting trips through a case study of Seoul. The main data source used for this research is 2010 Household Travel Survey data from which 34,071 observations were selected as the final sample. Then a statistic analysis was carried out by applying random intercept logit model. Analysis shows that a high level of residential density, land use mix in neighborhood results in more use of subway for commuting. And higher access to subway station leads to more use of subway. Therefore, a high dense and mixed use development as well as a high accessibility to transit station can contribute to activating the use of public transportation for commuting. Finally, the walking range of subway station affecting transit mode for commuting is estimated at between 432 to 525m.

• Korea Journal of Hospital Management
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• v.27 no.1
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• pp.1-10
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• 2022

Background: This study aims to empirically compare and evaluate the current status of medical accessibility and health inequality between people with disabilities and without. We calculated the ACSC hospitalization rate, which is a medical accessibility index, for hypertension, a major risk factor for cardiovascular disease that accounts for more than 20% of deaths among people with disabilities using the 2016 National Health Insurance Big Data. Methods: The subjects of the study were a total of 601,520, including 64,018 people with disabilities and 537,501 people without. Logistic regression was performed to analyze the differences in hypertension hospitalization rates adjusted for demographic and sociological characteristics and disease characteristics using SAS 9.4 program. Results: Before adjusting for the characteristics, the hypertension hospitalization rate of people with disabilities was 1.55%, and the people without disabilities were 0.49%. After adjusting, it was found that people with disabilities were 2.11 times higher than people without disabilities, and it was statistically significant. Conclusion: The preventable hospitalization rate of people with disabilities is higher than that of people without, suggesting that the disabled have problems with access to medical care and health inequality. Therefore, the government's policy improvement is required to close the medical gap for the disabled.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.15 no.4
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• pp.1-11
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• 2016

The purpose of this study is to analyze the effect of public transit accessibility on the Carsharing use demand. By utilizing the rental historical DB of Greencar which is operated in Suwon city and public transit GIS DB, the use demand models for Carsharing by rental offices are built and analyzed in accordance with public transit accessibility. The result indicates 73% of walking as a majority, 3% cycling, and 20% using buses and urban railways to access Carsharing rental offices. The goodness of fit of Carsharing use models reflecting accessibility to buses and railways is verified as 0.818 which proves that public transit accessibility is a significant variable. Therefore, it is verified that installing Carsharing rental offices where public transit transfer is convenient can possibly increase the use demand. Especially, while accessibility to buses is verified as a significant variable out of other public transit means, the accessibility to urban railways is verified as not significant. This suggests that a variety of complementary policies such as transfer discount policy and one-way transfer return policy are necessary in between urban railways and Carsharing in order to promote mutual use demand in accordance with the other public transit means. This study result is yet the basic research on Carsharing, however it is expected to contribute to improvement of transfer demand in between different public transit means.

• Journal of Cadastre & Land InformatiX
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• v.49 no.2
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• pp.135-149
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• 2019

This article analyzed economic effects of changes in spatial accessibility on regional touruism expenditure structure resulting from highway investments on Gangwon province, Korea. The Seemingly Unrelated Regress(SUR) model is applied to analyze the structure of change in tourism expenditure of Gangwon Province, and the competition and complementary relationship of tourist demand were analyzed among 18 counties in Gangwon by Dendrinos-Sonis method. The spatial accessibility has a significant effect on the increase in amount of tourist expenditure, but by 1% increase in the accessibility resulted in a reduction of length of stay -0.18% and travel costs -0.34% by respectively. The most powerful variable for improving the on-site economy is the tourist service establishment, which increases one unit, the amount of tourist expenditure increased by 3.6%. Moreover, the competition and supplemental relationship of tourism demands in Gangwon was decided by the conditions under which traffic flow with passing occurred, such as inland or ocean-typed travel attractions, adjacent or remote regions to the highway. The limitations of this study were not able to use raw data of tourism expenditures before and after the opening the highway due to the restriction of priority data, and further research on the appropriate level of spatial accessibility for the regional economy is needed.