• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.22 no.4
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• pp.350-357
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• 2019

Purpose: This study aimed to evaluate a possible association between the anti-tissue transglutaminase antibody (anti-tTG) titer and stage of duodenal mucosal damage and assess a possible cut-off value of anti-tTG at which celiac disease (CD) may be diagnosed in children in conjunction with clinical judgment. Methods: This observational study was conducted at a gastroenterology clinic in a tertiary hospital from April 2012 to May 2013. Seventy children between 6-months and 18-years-old with suspected CD underwent celiac serology and duodenal biopsy. Statistical analyses were done using SPSS 16. Diagnostic test values were determined for comparing the anti-tTG titer with duodenal biopsy. An analysis of variance and Tukey-Kramer tests were performed for comparing the means between groups. A receiver operating characteristics curve was plotted to determine various cut-off values of anti-tTG. Results: The mean antibody titer increased with severity of Marsh staging (p<0.001). An immunoglobulin (Ig) A-tTG value at 115 AU/mL had 76% sensitivity and 100% specificity with a 100% positive predictive value (PPV) and 17% negative predictive value (NPV) for diagnosis of CD (p<0.001, 95% confidence interval [CI], 0.75-1). Conclusion: There is an association between the anti-tTG titer and stage of duodenal mucosal injury in children with CD. An anti-tTG value of 115 AU/mL (6.4 times the upper normal limit) had 76% sensitivity, 100% specificity, with a 100% PPV, and 17% NPV for diagnosing CD (95% CI, 0.75-1). This cut-off may be used in combination with clinical judgment to diagnose CD.

• Sleep Medicine and Psychophysiology
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• v.28 no.1
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• pp.18-26
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• 2021

Sleep is essential to brain function and mental health. Insomnia and obstructive sleep apnea (OSA) are the two most common sleep disorders, and are major public health concerns. Proton magnetic resonance spectroscopy (¹H-MRS) is a non-invasive method of quantifying neurometabolite concentrations. Therefore, ¹H-MRS studies on individuals with sleep disorders may enhance our understanding of the pathophysiology of these disorders. In this article, we reviewed ¹H-MRS studies in insomnia and OSA that reported changes in neurometabolite concentrations. Previous studies have consistently reported insomnia-related reductions in γ-aminobutyric acid (GABA) levels in the frontal and occipital regions, which suggest that changes in GABA are important to the etiology of insomnia. These results may support the hyperarousal theory that insomnia is associated with increased cognitive and physiological arousal. In addition, the severity of insomnia was associated with low glutamate and glutamine levels. Previous studies of OSA have consistently reported reduced N-acetylaspartate (NAA) levels in the frontal, parieto-occipital, and temporal regions. In addition, OSA was associated with increased myo-inositol levels. These results may provide evidence that intermittent hypoxia induced by OSA may result in neuronal damage in the brain, which can be related to neurocognitive dysfunction in patients with OSA. The current review summarizes findings related to neurochemical changes in insomnia and OSA. Future well-designed studies using ¹H-MRS have the potential to enhance our understanding of the pathophysiology of sleep disorders including insomnia and OSA.

• The Korea Journal of Herbology
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• v.37 no.4
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• pp.1-8
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• 2022

Objectives : Dioscorea batas Decaisne (DB) has been known to be good for the digestive system on Eastern Asia. However, the protective effect of DB on acute pancreatitis (AP) has not been studied. In this study, we tried to investigate the protective effect of DB water extract on caerulein-induced AP. Methods : To measure the protective effect of DB on AP, Mice were injected with cholecystokinin analogue caerulein (50 ㎍/kg) hourly for 6 times. DB water extract (200 or 400 mg/kg) or saline (control group) was administered orally 1 h before the first injection of caerulein. The mice were sacrificed at 6 h after the last injection of caerulein. The pancreas tissues and serum samples were immediately taken for further analysis. Results : Administration of DB water extract showed the inhibitory effect on the increase of pancreas weight/body weight ratio, pancreatic histological damage. And the rise of serum lipase level was significantly reduced in DB water extract treatment group during AP in mice. However administration of DB water extract did not show significant reduction in serum amylase level. Also, mRNA levels of pro-inflammatory cytokines Interleukin (IL)-6 and Tumor necrosis factor (TNF)-𝛼 but not IL-1𝛽 were inhibited by administration of DB water extract. Conclusions : Taken together, we found that administration of DB water extract ameliorates the severity of caerulein-induced AP, which suggests the potential to be an effective treatment on AP.

• Journal of Trauma and Injury
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• v.35 no.1
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• pp.19-24
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• 2022

Purpose: The current study aimed to report the perioperative complications of the modified Stoppa approach for the treatment of pelvic bone fractures. Methods: We analyzed 48 consecutive operations in 45 patients who were treated with internal fixation using the modified Stoppa approach between March 2016 and July 2018. This included three revision operations. The mean age of the patients was 54.5 years, and the patients included 35 male patients and 10 female patients. All fractures occurred as a consequence of high-energy trauma and 70.3% had associated injuries at the time of the fracture. The mean Injury Severity Score was 9.03±5.60. The perioperative complications found during and immediately after surgery were recorded and were classified into three categories: vascular injuries, nerve injuries, and other complications. Results: Overall, 14 perioperative complications (29.2%) in 14 cases were identified. The most common complications were nerve injuries, which occurred in seven cases, all involving the obturator nerve. Uncontrollable vascular injuries occurred in six cases, which required additional incisions and support of vascular surgeons or postoperative interventions. Additionally, one case of peritoneal tearing occurred, which required help from an abdominal surgeon. Conclusions: While the modified Stoppa approach seems to be a viable method to treat pelvic fractures, significant perioperative complications may occur, suggesting that surgeons should pay careful attention to minimize the damage to other structures and that appropriate support from other surgical departments is paramount.

• Wind and Structures
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• v.34 no.2
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• pp.173-183
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• 2022

The galloping of iced conductors has long been a severe threat to the safety of overhead transmission lines. Compared with normal transmission lines, the ultra-high-voltage (UHV) transmission lines are more prone to galloping, and the damage caused is more severe. To control the galloping of UHV lines, it is necessary to conduct a comprehensive analysis of galloping characteristics. In this paper, a large-span 1000-kV UHV transmission line in China is taken as a practical example where an 8-bundled conductor with D-shaped icing is adopted. Galerkin method is employed for the time history calculation. For the wind attack angle range of 0°~180°, the galloping amplitudes in vertical, horizontal, and torsional directions are calculated. Furthermore, the vibration frequencies and galloping shapes are analyzed for the most severe conditions. The results show that the wind at 0°~10° attack angles can induce large torsional displacement, and this range of attack angles is also most likely to occur in reality. The galloping with largest amplitudes in all three directions occurs at the attack angle of 170° where the incoming flow is at the non-iced side, due to the strong aerodynamic instability. In addition, with wind speed increasing, galloping modes with higher frequencies appear and make the galloping shape more complex, indicating strong nonlinear behavior. Based on the galloping amplitudes of three directions, the full range of wind attack angles are divided into five galloping regions of different severity levels. The results obtained can promote the understanding of galloping and provide a reference for the anti-galloping design of UHV transmission lines.

• Journal of Environmental Science International
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• v.32 no.1
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• pp.67-76
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• 2023

Under constant environmental pollution, the incidence of Atopic Dermatitis (AD) caused by air pollutants and allergens has increased. AD is an allergy inflammatory skin disease characterized by pruritus, eczema, and skin dryness. In herbal medicine, Anemarrhena asphodeloides (Anemarrhenae Rhizoma; AR) has been utilized to treat Alzheimer's disease, osteoporosis, hypertension, and inflammation. The purpose of study evaluated the effect of AR in a mouse model of 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions. After acclimatization for 5 days, the mice (6-week-old, male Balb/c) were divided into five groups (n=6/group): NC (normal control), DNCB (control), Dex (5 mg·kg-1, p.o.), AR100 (100 mg·kg-1, p.o.), and AR300 (300 mg·kg-1, p.o.). On days 1 and 3, 1% DNCB was applied to the skin and ears. After 4 days, 0.5% DNCB was applied once every 2 days for 2 weeks. Then, skin and ears eczema area and severity index (EASI); skin nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) levels; and plasma immunoglobulin E (IgE) levels were examined. The AR groups showed lower EASI, skin and ear thickness, mast cell count, and IgE levels than the control groups. Moreover, AR reduced iNOS, COX-2, and PGE2 levels. Therefore, AR possesses anti-inflammatory properties and can improve skin damage, indicating its therapeutic potential against AD.

• Journal of Korea Water Resources Association
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• v.57 no.4
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• pp.249-261
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• 2024

Climate change has intensified the severity of extreme floods, presenting substantial challenges to dam management and operation. Traditionally, flood control strategies for dam operations have been based on theoretical scenarios, such as designed floods, without taking into account downstream conditions. However, in practice, managing floods involves operating dams based on climate forecasts. This strategy encounters challenges due to the limited predictability of climate forecasts, which in turn leads to uncertainty in decisionmaking among dam managers. This study proposes a flood control approach for dam operations that involves gradually increasing the outflow, considering the operational constraints and potential downstream damage, based on inflow data. The effectiveness of this method was assessed through simulation, employing both a designed flood and data from the most significant historical flood. The dam operation strategy for flood control presented in this study provides a framework for dam operators, facilitating consistent decisionmaking in flood management by integrating realistic dam operational conditions.

• IMMUNE NETWORK
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• v.22 no.6
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• pp.48.1-48.13
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• 2022

With the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, which are randomly mutated, the dominant strains in regions are changing globally. The development of preclinical animal models is imperative to validate vaccines and therapeutics against SARS-CoV-2 variants. The objective of this study was to develop a non-human primate (NHP) model for SARS-CoV-2 Delta variant infection. Cynomolgus macaques infected with Delta variants showed infectious viruses and viral RNA in the upper (nasal and throat) and lower respiratory (lung) tracts during the acute phase of infection. After 3 days of infection, lesions consistent with diffuse alveolar damage were observed in the lungs. For cellular immune responses, all macaques displayed transient lymphopenia and neutrophilia in the early stages of infection. SARS-CoV-2 Delta variant spike protein-specific IgM, IgG, and IgA levels were significantly increased in the plasma of these animals 14 days after infection. This new NHP Delta variant infection model can be used for comparative analysis of the difference in severity between SARS-CoV-2 variants of concern and may be useful in the efficacy evaluation of vaccines and universal therapeutic drugs for mutations.

• Journal of the Korean Society of Safety
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• v.39 no.1
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• pp.62-69
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• 2024

Ensuring swift on-site access to fire engines is crucial in preserving the golden time and minimizing damage. However, various mobility constraints in alleyways hinder the timely entry of fire engines to the fire scene, significantly impairing their initial response capabilities. Therefore, this study analyzed the significant mobility constraints of fire engines, focusing on Seoul, which has many old town areas. By leveraging survey responses from firefighting experts and actual observations, this study quantitatively assessed the frequency and severity of mobility constraint factors affecting the disaster responses of fire engines. Survey results revealed a consistent set of top five factors regarding the frequency and disturbance level, including illegally parked cars, narrow paths, motorcycles, poles, and awnings/banners. A comparison with actual road-view images showed notable consistency between the survey and observational results regarding the appearance frequency of mobility constraint factors in vulnerable areas in Seoul. Furthermore, the study emphasized the importance of tailored management strategies for each mobility constraint factor, considering its characteristics, such as dynamic or static. The findings of this study can serve as foundational data for creating more detailed fire safety maps and advancing technologies that monitor the mobility of fire engines through efficient vision-based inference using CCTVs in the future.

• Structural Engineering and Mechanics
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• v.89 no.6
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• pp.617-626
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• 2024

The study investigated the behavior of plain and fibered Ultra-High Performance Concrete (UHPC) beams under varying loading conditions using integrated analysis of the flexure and acoustic emission tests. The loading rate of testing is -0.25 -2 mm/min. It is observed that on increasing loading rate, flexural strength increases, and toughness decreases. The acoustic emission testing revealed that higher loading rates accelerate crack propagation. Fiber effect and matrix cracking are identified as significant contributors to the release of acoustic emission energy, with fiber rupture/failure and matrix cracking showing rate-dependent behavior. Crack classification analysis indicated that the rise angle (RA) value decreased under quasi-static loading. The average frequency (AF) value increased with the loading rate, but this trend reversed under rate-dependent conditions. K-means analysis identified distinct clusters of crack types with unique frequency and duration characteristics at different loading rates. Furthermore, the historic index and signal strength decreased with increasing loading rate after peak capacity, while the severity index increased in the post-peak zone, indicating more severe damage. The sudden rise in the historic index and cumulative signal strength indicates the possibility of several occurrences, such as the emergence of a significant crack, shifts in cracking modes, abrupt failure, or notable fiber debonding/pull-out. Moreover, there is a distinct rise in the number of AE knees corresponding to the increase in loading rate. The crack mapping from acoustic emission testing aligned with observed failure patterns, validating its use in structural health monitoring.