• Journal of Microbiology and Biotechnology
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• v.28 no.4
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• pp.527-533
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• 2018

This study compared the radioprotective effects of high-molecular-weight poly-gamma-glutamate (${\gamma}-PGA$, average molecular mass 3,000 kDa) and a reduced form of glutathione (GSH, a known radioprotector) on calf thymus DNA damage. The radiation-induced DNA damage was measured on the basis of the decreased fluorescence intensity after binding the DNA with ethidium bromide. All the experiments used $^{60}Co$ gamma radiation at 1,252 Gy, representing 50% DNA damage. When increasing the concentration of ${\gamma}-PGA$ from 0.33 to $1.65{\mu}M$, the DNA protection from radiation-induced damage also increased, with a maximum of 87% protection. Meanwhile, the maximal DNA protection when increasing the concentration of GSH was only 70%. Therefore, ${\gamma}-PGA$ exhibited significant radioprotective effects against gamma irradiation.

• Korean Journal of Plant Resources
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• v.27 no.6
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• pp.714-719
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• 2014

This study investigated DNA damage protection and anti-inflammatory activity of different solvent fractions from Aruncus dioicus var. kamtschaticus (A. dioicus) aerial parts water extract. As for DNA damage protection, distilled water ($H_2O$) fraction displayed the most powerful protection for DNA damage at a concentration of 1 mg/ml. As for anti-inflammatory activity, dichloromethane ($CH_2Cl_2$) fraction exhibited the highest NO inhibition activity, ranging from 61% to 19% ($10-40{\mu}g/ml$). Furthermore, the levels of pro-inflammatory cytokines mRNA expressions and intracellular reactive oxygen species (ROS) were employed to verify the anti-inflammatory activity of the $CH_2Cl_2$ fraction on further researches. It could be concluded that A. dioicus had a significantly effect of DNA damage protection and anti-inflammatory activity which also as an essential edible vegetable and medicinal species.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.05a
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• pp.475-478
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• 2012

Cyberspace is becoming increasingly important. Incidentally, there exist possibilities of the industrial secrets leaked, cyber attacks, privacy protection problems. In addition, there are growing concern of cyber war between nations. Thus potential hazards in cyberspace and the extent of damage are getting bigger. Therefore, a systematic understanding of cyber damage and damage scale is very important and damage estimation method should be developed to establish solid cyber protection system. In this study, current and potential damage types are understood and damage scales are surveyed based on the analysis of existing studies and try to develop a reasonable methods to estimate economic effects of cyber protection.

• Journal of Power System Engineering
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• v.19 no.2
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• pp.5-14
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• 2015

This investigation presents reviews of many research results on lightning damage to wind turbines and lightning protection strategies from IEC Standard, Europe, USA, Japan and Korea. There have been few studies on lightning protection of wind turbines in Korea, while various investigations have been performed in the other countries. It is necessary to apply some good lightning protection strategies of IEC Standard and the other countries to Korea. Those are as follows: The guideline for lightning protection of wind turbines should be established based on IEC Standards. It needs to be carried out both development of software and experimental studies for understanding the types of lightning damage to wind turbines and compiling the database. In order to minimize the lightning damage to wind turbines, it is a key factor for wind farm owners and researchers to provide the information about the damage cases and wind farm operation technique.

• Computers and Concrete
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• v.20 no.5
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• pp.521-527
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• 2017

This paper proposes using the multi-type sensor vibration measurements, such as from a relative displacement sensors and a traditional accelerometer for the damage detection of shear connectors in composite bridge under moving loads. Hilbert-Huang Transform (HHT) spectra of these responses will be fused with a data fusion approach i.e., Dempster-Shafer method, to detect the damage of shear connectors. Experimental studies on a composite bridge model in the laboratory are conducted to demonstrate the effectiveness and performance of using the proposed approach in detecting the damage of shear connectors in composite bridges. Both undamaged and damaged scenarios are considered. The detection results with the data fusion of multi-type sensor measurements show a more reliable and robust performance and accuracy, avoiding the false identifications.

• Geomechanics and Engineering
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• v.9 no.4
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• pp.531-545
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• 2015

Two fundamental issues exist in the damage theory of geo-material based on the concept of thermodynamics: existence or nonexistence of the dissipation potential, and whether the dissipation potential could be decoupled into a damage potential and a plastic one or not. Thermodynamics theory of elastoplastic damage assumes the existence of dissipation potential, but the presence of dissipation potential is conditional. Based on the dissipation inequality in accord with the second law of thermodynamics, the sufficient and necessary conditions are given for the existence of the dissipation potential separately in total and incremental forms firstly, and proved strictly in theory. With taking advantage of the basic mechanical properties of geo-materials, the nonexistence of the dissipative potential is verified. The sufficient and necessary conditions are also given and proved for the decoupling of the dissipation potential of geo-materials in total and incremental forms. Similarly, the non-decoupling of the dissipation potential has also been proved, which indicates the dissipation potential of geo-materials in total or incremental forms could not be decoupled into a dissipative potential for plasticity and that for damage respectively. The research results for the fundamental issues in the thermodynamics theory of damage will help establish and improve the theoretic basis of elastoplastic damage constitutive model for geo-materials.

• Geomechanics and Engineering
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• v.9 no.5
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• pp.569-583
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• 2015

Two fundamental issues exist in the damage theory of geo-material based on the concept of thermodynamics: existence or nonexistence of the dissipation potential, and whether the dissipation potential could be decoupled into a damage potential and a plastic one or not. Thermodynamics theory of elastoplastic damage assumes the existence of dissipation potential, but the presence of dissipation potential is conditional. Based on the dissipation inequality in accord with the second law of thermodynamics, the sufficient and necessary conditions are given for the existence of the dissipation potential separately in total and incremental forms firstly, and proved strictly in theory. With taking advantage of the basic mechanical properties of geo-materials, the nonexistence of the dissipative potential is verified. The sufficient and necessary conditions are also given and proved for the decoupling of the dissipation potential of geo-materials in total and incremental forms. Similarly, the non-decoupling of the dissipation potential has also been proved, which indicates the dissipation potential of geo-materials in total or incremental forms could not be decoupled into a dissipative potential for plasticity and that for damage respectively. The research results for the fundamental issues in the thermodynamics theory of damage will help establish and improve the theoretic basis of elastoplastic damage constitutive model for geo-materials.

• Preventive Nutrition and Food Science
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• v.17 no.2
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• pp.116-121
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• 2012

Water extract from Pinus densiflora (WPD) was investigated for its antioxidant activity and its ability to provide protection from DNA damage. A series of antioxidant assays, including a 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging assay, a reducing power assay, a metal-chelating assay, a superoxide radical scavenging assay, and a nitrite scavenging ability, as well as a DNA damage protection assay were performed. Total phenolic content was found to be 211.32 mg Tan/g WPD. The extract scavenged 50% DPPH free radical at a concentration of 21.35 ${\mu}g/mL$. At that same concentration, the reducing power ability of WPD was higher than that of ${\alpha}$-tocopherol. The extract chelated 68.9% ferrous ion at the concentration of 4 mg/mL. WPD showed better nitrite scavenging effect at the lower pH. Meanwhile, WPD exhibited a strong capability for DNA damage protection at 1 mg/mL concentration. Taken together, these data suggest water extract from Pinus densiflora could be used as a suitable natural antioxidant.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6535-6539
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• 2015

This study was designed to assess, whether a new chemotherapeutic microtubule inhibitor, Epothilone B (EpoB, Patupilone), can induce DNA damage in normal ovarian cells (MM14.Ov), and to evaluate if such damage could be repaired. The changes were compared with the effect of paclitaxel (PTX) commonly employed in the clinic. The alkaline comet assay technique and TUNEL assay were used. The kinetics of DNA damage formation and the level of apoptotic cells were determined after treatment with IC50 concentrations of EpoB and PTX. It was observed that PTX generated significantly higher apoptotic and genotoxic changes than EpoB. The peak was observed after 48 h of treatment when the DNA damage had a maximal level. The DNA damage induced by both tested drugs was almost completely repaired. As EpoB in normal cells causes less damage to DNA it might be a promising anticancer drug with potential for the treatment of ovarian tumors.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.23 no.7
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• pp.14-19
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• 2009

This paper presents statistics on lightning-caused damage to humans, structures, and electrical and electronic equipment. To reduce the number and amount of casualties and damage caused by lightning strikes, the statistical analysis of lightning-related damage reports is important in establishing lightning protection measures. The statistics of lightning death, injury and damage in Korea from 2000 to 2007 were primarily derived from mass media As a result, the annual average of lightning-caused deaths in Korea is about 5. Most lightning casualties involve people who work outdoors such as farmers and recreationists. Data on lightning-caused injuries to humans and damage to structures in this paper may be underestimated since the available data from mass media are incomplete. The actual lightning-caused casualties and damage in Korea may be greater than those presented in this paper.