• Journal of Korean Neurosurgical Society
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• v.44 no.5
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• pp.308-313
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• 2008

Objective: The serum S100 protein has been known to reflect the severity of neuronal damage. The purpose of this study was to assess the prognostic value of the serum S100 protein by Elecsys S100 immunoassay in patients with subarachnoid hemorrhage (SAH) and intracerebral hemorrhage (ICH) and to establish reference value for this new method. Methods: Serum S100 protein value was measured at admission, day 3 and 7 after bleeding in 42 consecutive patients (SAH : 20, ICH : 22) and 74 healthy controls, prospectively. Admission Glasgow coma scale (GCS) score, Hunt & Hess grade and Fisher grade for SAH, presence of intraventricular hemorrhage, ICH volume, and outcome at discharge were evaluated. Degrees of serum S100 elevation and their effect on outcomes were compared between two groups. Results: Median S100 levels in SAH and ICH groups were elevated at admission (0.092 versus $0.283{\mu}g/L$) and at day 3 (0.110 versus $0.099{\mu}g/L$) compared to healthy controls ($0.05{\mu}g/L;$ p<0001). At day 7, however, these levels were normalized in both groups. Time course of S100 level in SAH patient was relatively steady at least during the first 3 days, whereas in ICH patient it showed abrupt S100 surge on admission and then decreased rapidly during the next 7 days, suggesting severe brain damage at the time of bleeding. In ICH patient, S100 level on admission correlated well with GCS score (r=-0.859; p=0.0001) and ICH volume (r=0.663; p=0.001). A baseline S100 level more than $0.199{\mu}g/L$ predicted poor outcome with 92% sensitivity and 90% specificity. Logistic regression analyses showed Ln (S100) on admission as the only independent predictor of poor outcome (odd ratio 36.1; 95% CI, 1.98 to 656.3) Conclusion: Brain damage in ICH patient seems to develop immediately after bleeding, whereas in SAH patients it seems to be sustained for few days. Degree of brain damage is more severe in ICH compared to SAH group based on the S100 level. S100 level is considered an independent predictor of poor outcome in patient with spontaneous ICH, but not in SAH. Further study with large population is required to confirm this result.

• Journal of Life Science
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• v.23 no.1
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• pp.31-37
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• 2013

The present study aimed to investigate effects of ethanol extracts from Hydropsyche kozhantschikovi on cell and DNA damage caused by oxidative stress. In a radical scavenging assay, compared with ascorbic acid used as a control, the level of DPPH (1,1-diphenyl-2-picrylhydrazyl) and that of hydroxyl radicals in H. kozhantschikovi extracts were 60.0% and 43.7%, respectively. The ferrous iron chelating level was 37.5% compared to the chelating value of EDTA (ethylenediaminetetraacetic acid) as a positive control at the same concentration. To verify inhibitory effects of oxidative cell damage induced by reactive oxygen species (ROS), the relative level of lipid peroxidation and the expression level of the p21 protein were compared in extracts-treated and untreated groups. Lipid peroxidation was completely inhibited in the extracts-treated group compared with the radical-only treated group. The level of p21 protein expression was restored to 92.2% of p21 protein expression in the control sample. In addition, DNA cleavage inhibition in the H. kozhantschikovi extracts was 74.1% compared with that of the control group, suggesting that H. kozhantschikovi extracts repress DNA cleavage induced by ROS. Moreover, the phosphorylation ratio of the H2AX protein was 16.7% in the radical-treated group, indicating that the ethanol extracts inhibited 83.3% of DNA damage. Our findings suggest that ethanol extracts from H. kozhantschikovi are effective not only in repressing the oxidation of free radicals and highly toxic hydroxyl radicals, but also in decreasing cell and DNA damage caused by oxidative stress.

• Environmental and Resource Economics Review
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• v.30 no.3
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• pp.365-393
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• 2021

Using the Choice Experiment Method, this paper identified whether subsidy to the household around landfil in Seoul metropolitan area is being provided corresponding to the scale of the environmental damage. Since 2001, the subsidy program has been operating for nearly 20 years to compensate for various environmental damage (foul odor, noise, air pollution, water pollution, etc.) from landfill site in the metropolitan area, but it is not clear on what ground the subsidy is allocated. This paper estimated the marginal WTP by attribute (odor, noise, air pollution, and water pollution) based on mixed logit model and compared them with current subsidy level per household in each town. As a result of the comparison, it was found that the subsidy for each town was not allocated in proportion to the amount of the marginal WTP for each household in the corresponding town. In addition, this paper constructs a level-by-level scenario for environmental improvement attributes and compares economic benefits and current subsidy levels. As a result, the current subsidy level is insufficient compared to the level at which environmental damage is completely eliminated, but excessive subsidy is allocated compared to partial improvement levels.

• Journal of Conservation Science
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• v.30 no.4
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• pp.353-364
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• 2014

Formaldehyde(HCHO) may have a damage effect on Korean traditional textiles, because concentration is high and occurrence frequency is frequent at the exhibition room and storage area. Total 20 specimens were prepared using 4 different materials (silk, cotton, ramie, hemp) after dyeing with 5 colors (undyed, red, yellow, blue, black). The specimens were exposed to HCHO gas in the test chamber. The gas acceleration test was conducted to identify the deterioration of Korean traditional textiles according to HCHO concentration(0.5, 1, 10, 100, 500ppm), to temperature-humidity condition at HCHO 500ppm, and deterioration conditions at HCHO 500ppm. Optical, chemical, and physical evaluation was carried out after the exposure. The results, color difference, grey scale rating, formate($HCO_2{^-}$) of some textiles increased at 500ppm, while pH decreased at 500ppm. Also, color difference, grey scale rating, formate($HCO_2{^-}$) of some textiles increased double damage at high temperatures & humidity, high humidity condition. But, damages of accelerated degradation textiles were slight, because of degradation degree and degradation products. The results suggest that determined the damage to the korean traditional textile, damage level, damage-weighted condition, damage to accelerated degradation textiles. In addition, formaldehyde damaged to yellowing of red textiles, bleaching of accelerated degradation textiles, formic acid damaged to bleaching of total 20 specimens.

• The Journal of the Korea Contents Association
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• v.21 no.4
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• pp.166-176
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• 2021

Due to urbanization and industrialization, the importance of large-scale fire prevention, management and measures is increasing day by day. However, the fire site arrival rate in Golden Time, which is a factor that can minimize large-scale fire damage, of Pohang, a large city with a population of over 500,000, is relatively low. So additional fire fighting power deployment and infrastructure investment are required. However, as budget and manpower are limited, it is necessary to selectively deploy fire fighting power and invest in infrastructure. Therefore, this study attempted to present a fire damage rating that can compare the level of fire damage, which is an index that can help selectively provide fire fighting services in Pohang and make related decisions. For the index, the OD cost matrix was used to predict fire vulnerable areas with a high probability of increasing the fire scale in the event of a fire. Also fire damage was measured by predicting the level of fire damage in the event of a fire according to population, building density, and access of fire trucks. It is expected that the fire damage rating will be able to help in various decisions related to fire fighting service deployment and services not only in Pohang city, but also in other regions.

• Structural Engineering and Mechanics
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• v.63 no.6
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• pp.825-835
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• 2017

Significant improvements to methodologies on structural damage detection (SDD) have emerged in recent years. However, many methods are related to inversion computation which is prone to be ill-posed or ill-conditioning, leading to low-computing efficiency or inaccurate results. To explore a more accurate solution with satisfactory efficiency, a PSO-INM algorithm, combining particle swarm optimization (PSO) algorithm and an improved Nelder-Mead method (INM), is proposed to solve multi-sample objective function defined based on Bayesian inference in this study. The PSO-based algorithm, as a heuristic algorithm, is reliable to explore solution to SDD problem converted into a constrained optimization problem in mathematics. And the multi-sample objective function provides a stable pattern under different level of noise. Advantages of multi-sample objective function and its superior over traditional objective function are studied. Numerical simulation results of a two-storey frame structure show that the proposed method is sensitive to multi-damage cases. For further confirming accuracy of the proposed method, the ASCE 4-storey benchmark frame structure subjected to single and multiple damage cases is employed. Different kinds of modal identification methods are utilized to extract structural modal data from noise-contaminating acceleration responses. The illustrated results show that the proposed method is efficient to exact locations and extents of induced damages in structures.

• Journal of the Korean Society of Fashion and Beauty
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• v.5 no.1 s.12
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• pp.71-77
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• 2007

This study attempted to comparative analysis about the physical and morphological damage degrees of hair according to the bleaching methods by $H_2O_2$ concentration. As a result of the changes in the physical characteristics of the hair according to the deceleration operation methods by 3-6-9% and 9% $H_2O_2$ concentration, the intensity of tension considerably decreased but the elongation was increased. And the more the damage of hair, the larger the degree of change. Regarding the method of deceleration operation, the 3-6-9% deceleration operation method was more damaging than the 9% single deceleration operation method. In the change of the characteristics of the form of the hair, the control group of the 5-level deceleration hair generally showed a smooth external appearance and regular and closely overlapped epidermis and undamaged cuticle were observed. But in the 3-6-9% deceleration operation method and 9% single deceleration operation method, damages such as the irregular form of the edge of the epidermis and the unclear boundary between the epidermis occurred.

• Journal of Nutrition and Health
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• v.34 no.4
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• pp.401-408
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• 2001

The spontaneous frequency of genetic damage and the possible relationship of this damage to total radical-trapping antioxidant potential(TRAP) and antioxidant vitamins, including plasma levels of $\alpha$-carotene, $\beta$-carotene, cryptoxanthin, retinol, $\alpha$-tocopherol and ${\gamma}$-tocopherol in humans were investigated in 57 subjects using two indices of genetic damage, SCE & HFC frequency. The mean of SCE and HFC frequencies were weakly correlated with plasma TRAP(r=-0.305, p<0.1 for SCEs: r=-0.297, p<0.1 for HFCs, respectively), but those were strongly negatively correlated with plasma $\beta$-carotence(r=-0.385, p<0.01 for SCEs : r=-0.392, p<0.01 for HFCs) and cryptoxanthin(r=-0.312, p<0.05 for SCEs : r=0.335, p<0.05 for HFCs, respectively) levels in the subjects. However, those DNA damage markers including SCE and HFC did not correlate with either plasma $\alpha$-carotene, $\alpha$-tocopherol or retinol concentrations. The mean of SCE and HFC frequencies were positively correlated with plasma ${\gamma}$-tocopherol level(r=0.421, p<0.01 for SCEs : r=0.399, p<0.01 for HFCs, respectively). These findings indicate that increased cytogenetic DNA changes, as determined by SCE and HFC frequencies are possibly associated with generation of free radicals in lymphocytes and decreased plasma antioxidant vitamin($\beta$-carotene and cryptoxanthin) status in the subjects. (Korean J Nutrition 34(4) : 401~08, 2001)

• Structural Monitoring and Maintenance
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• v.7 no.1
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• pp.13-25
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• 2020

One of the most important aspects in structural health monitoring is the detection of fatigue damage. Structural components such as heavy-duty bolts work under high dynamic loads, and thus are prone to accumulate fatigue damage and cracks may originate. Those heavy-duty bolts are used, for example, in wind power generation and mining equipment. Therefore, the investigation of new and more effective monitoring technologies attracts a great interest. In this study the acoustic emission (AE) technology was employed to detect incipient damage during fatigue testing of a M36 bolt. Initial results showed that the AE signals have a high level of background noise due to how the load is applied by the fatigue testing machine. Thus, an advanced signal processing method in the time-frequency domain, the Hilbert-Huang Spectrum (HHS), was applied to reveal AE components buried in background noise in form of high-frequency peaks that can be associated with damage progression. Accordingly, the main contribution of the present study is providing insights regarding the detection of incipient damage during fatigue testing using AE signals and providing recommendations for further research.

• Journal of the Earthquake Engineering Society of Korea
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• v.17 no.5
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• pp.237-243
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• 2013

In the Korean Building Code (KBC), the Design Eccentricity involves the torsional amplification factor (TAF), and the inherent and accidental eccentricities. When a structure of less than 6-stories and assigned to seismic design category C or D is designed using equivalent static analysis method, both KBC-2006 and KBC-2009 use the TAF but apply different calculation methods for the of design eccentricity. The design eccentricity in KBC-2006 is calculated by multiplying the sum of inherent eccentricity and accidental eccentricity at each level by a TAF but that in KBC-2009 is calculated by multiplying only the accidental eccentricity by a TAF. In this paper, the damage indices of a building with planar structural irregularity designed by different design eccentricities are compared and the relationship between the earthquake damage and design eccentricity of the building is evaluated. On the basis of this study, the increment of design eccentricity results in the decrement of final eccentricity and global damage index of structure. It is observed that design eccentricity in KBC-2006 reduces the vulnerability of torsional irregular building compared to design eccentricity in KBC-2009.