• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7897-7907
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• 2014

Background: There is paucity of studies defining the prevalence of non-communicable disease (NCD) risk factors in Saudi Arabia despite the surging epidemic of obesity, change in dietary habits and sedentary lifestyle. Objectives: This cross-sectional study aimed to assess the prevalence of NCDs risk factors among employees at King Faisal University in Al Hassa, Saudi Arabia and to determine the possible correlates for clustering of NCDs risk factors among them. Materials and Methods: All employees were invited to participate; the World Health Organization STEPwise approach was used for data collection which consisted of a personal interview to collect socio-demographic characteristics, NCD history, tobacco use, vegetables and fruit consumption, and physical activity (PA), followed by anthropometric measurements namely weight, height and waist circumference and blood pressure measurements, subjects were finally subjected to biochemical tests with determination of fasting plasma glucose, serum triglycerides, cholesterol and high density lipoproteins. Results: Of the surveyed employees (n=691), daily current smokers accounted for 22.7%. 94.9%, 95.1% and 86% consumed < 5 servings per day of vegetables, fruits and both fruits and vegetables respectively, 73% were physically inactive, 64% were overweight or obese, 22.1% had hypertension, and 21.5% were diabetics. Elevated cholesterol levels were found in 36.6%, low high density lipoproteins in 36.8%, and elevated triglycerides in 36.1%. Only 3% had no NCD risk factors, and 57.6% had ${\geq}3$ factors. Multivariate logistic regression showed that gender (being male, adjusted odds ratio 'aOR'=1.51), aged ${\geq}50$ years (aOR=3.06), < college education (aOR=1.75), current smokers (aOR=2.37), being obese (aOR=6.96) and having a low PA level (aOR=4.59) were the significant positive predictors for clustering of NCD risk factors. Conclusions: Over fifty percent of the studied university's employees had multiple (${\geq}3$) NCD risk factors. Screening and health promotion initiatives should be launched at least targeting the modifiable factors to avert the excessive risk for cardiovascular disease, diabetes mellitus and several types of cancers.

• Journal of Dairy Science and Biotechnology
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• 제27권1호
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• pp.1-12
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• 2009

In 2008, baby formula containing melamine was found to be responsible for a large outbreak of renal failure in infants in China. A total of 294,000 infants were hospitalized, and at least 6 babies died due to ingestion of the tainted formula. Melamine contains high levels of nitrogen (>60%), which is used as an indicator of protein content. Therefore, high levels of melamine in infant formula were thought to be the result of deliberate contamination m an attempt to increase its apparent protein content. Following inspections by China's national inspection agency, assorted products from at least 22 dairy manufacturers across China were found to have varied levels of melamine (range: 0.096196.61 mg/kg). Melamine co-exposure with cyanuric acid can induce acute melamine-cyanurate crystal nephropathy, which can lead to renal failure at much lower doses than if either compound were ingested alone. However, currently, there are very few data on melamine analogues other than cyanuric acid. At an expert meeting of the WHO and FAO held to review toxicological aspects of melamine and cyanuric acid on December 14, 2008, a new tolerable daily intake (TDI) of melamine was established that could be applied to the entire population, including infants. Therefore, a risk assessment of the various theoretical melamine contamination levels in infant formula and selected representative foods (other than infant formula and sole-source nutrition products) is urgently needed for Korean babies and children up to 7 years of age. Although the undetectable level regulation for infant formula may be low enough to guarantee the safety of babies under the age of 1 year (including premature babies), the melamine standard of 2.5 ppm for foods other than baby formula could be insufficient to protect the 95th percentile population aged 1~2 years because of this demographic's high consumption of milk, yogurt, and soy milk (hazard index = 1.79). Because TDIs are chronic values intended to protect an individual over his/her lifetime, occasional modest ingestion in excess of the TDI is not likely to be a health concern. However, children aged 1~2 years may have renal systems that are comparatively more sensitive to the crystallization of melamine and its analogues. Therefore, governmental jurisdictions may need to practice more prudent management of food items that could raise the melamine exposure for this population.

• 한국환경농학회지
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• 제28권3호
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• pp.310-325
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• 2009

동물용의약품은 가축의 질병예방 및 치료, 성장 촉진 등 생산성을 높이는 목적으로 사용되는 의약품임에도 불구하고 무분별하게 과용 또는 남용되면 축 수산물에 잔류하게 되고 장기간 노출될 경우 인체에 유해할 수 있기 때문에 관리가 필요한 물질이다. 국내 동물용의약품의 관리는 국립수의과학 검역원에서 국내 사용되는 동물용의약품의 허가를 담당하고 있으며, 식품의약품안전청은 해당 동물용의약품의 잔류자료, 일일섭취허용량, 식품섭취량 및 국민평균체중 등을 이용하여 위해평가를 실시하고 그에 알맞은 잔류허용기준을 고시하고 있다. 현재 국내의 동물용의약품에 대한 잔류허용기준은 116 개가 고시되어 있으며, 2009년 말까지 총 142종에 대하여 기준이 설정될 예정이다. 또한 2010년 1월 1일부터 축 수산물 (유, 알 포함) 및 벌꿀에서 기준 미설정 항생제 및 합성항균제가 검출될 경우 0.03 mg/kg의 일률기준을 적용함으로써 축 수산물에 대한 안전관리가 강화하게 된다. 현재 동물용의 약품의 기준관리는 이미 선진국 수준으로 운영되고 있으며, 잔류분석법도 또한 국제적 수준에 맞게 개선할 예정이다.

• 감성과학
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• 제19권1호
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• pp.71-82
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• 2016

소비자들은 구두를 단순히 발을 보호하고 편안하게 해주는 역할 뿐만 아니라 장식과 자아 이미지를 표현해주는 패션제품으로써 인지하는 경향이 있다. 온라인 시장 분석에서 구두가 소비자들의 일상생활에서 중요한 제품이라고는 하였지만 인터넷 구두 시장을 조사한 연구는 드물다. 본 연구는 인터넷 구두시장에서 구두 e-충동구매과정에 대한 쇼핑성향, 마케팅 자극, 소비자들이 인지하는 위험지각의 영향에 초점을 맞추어 조사하였다. 최근 6개월 동안 구두 e-충동구매를 경험한 적이 있는 대학생들 총 408명을 대상으로 자기기술형식의 자료를 수집하였다. 결과에 의하면, 쾌락적 쇼핑성향이나 브랜드 쇼핑성향이 높은 소비자들은 인터넷에서 제공하는 마케팅 자극(판매촉진 자극이나 제품자극)을 더 많이 인지하였고, 반면 경제적 쇼핑성향의 소비자들은 마케팅 자극을 더 낮게 인지하였으나 기능적인 위험은 더 높게 지각하는 것으로 나타났다. 구두의 경우, 마케팅 자극이 강할수록 e-충동구매는 증가하였으나 소비자들이 지각하는 위험은 e-충동구매에 아무런 영향을 미치지 않았다. 이러한 연구결과는 소비자의 쇼핑성향에 영향을 받는 마케팅 자극이 구두 e-충동구매를 유발하는데 중요한 요인임을 제안한다.

• 한국식품영양과학회지
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• 제42권4호
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• pp.600-607
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• 2013

본 연구는 김치 유래 유산균인 Leuc. citreum GR1의 안정성을 평가하고자 Leuc. citreum GR1을 SD 계통의 흰쥐에게 4주간 반복 경구투여를 통하여 장기투여에 의한 안전성을 확인하고자 식품의약품안전청의 의약품 등의 독성시험기준에 따라 실시하였다. SD 계열의 암수 흰쥐에 시험물질을 0, 500, 1,000 및 2,000 mg/kg/day의 용량으로 4주간 반복 경구투여 한 후 사망률, 일반증상, 체중변화, 사료섭취량, 수분섭취량, 부검소견, 장기무게의 변화, 혈액학적, 혈액생화학적 및 병리조직학적 검사를 실시하였다. 모든 시험군에서 시험기간 시험물질로 인한 일반증상 및 사망동물이 관찰되지 않았다. 전 시험기간 동안 Leuc. citreum GR1의 4주간의 경구투여 결과 체중이 지속적으로 증가되었지만 대조군과 유의성 있는 변화가 관찰되지 않았다. 또한 장기의 육안적 관찰, 장기 중량변화, 혈액학적, 혈액생화학적 및 병리조직학적 검사에서도 모든 시험물질 투여군이 대조군과 유의성이 있는 차이를 보이지 않았으며, 모두 정상 범위를 벗어나지 않아 시험물질에 기인하는 이상 소견을 발견할 수 없었다. 이상의 결과로 보아 4주 반복투여 독성시험 결과 김치 유산균인 Leuc. citreum GR1은 저독성의 안전한 물질로 판정되며, 본 시험물질의 무독성량은 암수 모두 2,000 mg/kg/day 이상을 상회하는 것으로 판단되었다.

• Asian-Australasian Journal of Animal Sciences
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• 제12권2호
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• pp.203-208
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• 1999

An 8 week feeding trial was conducted with 864 ISA Brown laying hens, 48 weeks old, to determine if microbial phytase $(Natuphos^{(R)})$ supplementation can reduce non-phytate phosphorus (NPP) level in laying diets. The experiment consisted of four dietary treatments: T1, control diet with 0.26% NPP (0.55% total P) wand no supplementary phytase; T2, 0.21% NPP (0.50% total P) diet with 250 U of phytase/kg of diet; T3, 0.16% NPP (0.45% total P) diet with 250 U of phytase/kg of diet; and T4, 0.11% NPP (0.40% total P) diet with 250 U of phytase/kg of diet. T3 showed the highest egg production and egg weight and the lowest feed conversion while T4 gave the lowest egg production and the highest feed conversion and mortality. Daily feed consumption ranged from 130.4 g (T4) to 132.7 g (T2). T1 and T2 were not significantly different in the production parameters. Eggshell strength, egg specific gravity, and eggshell thickness were not significantly different among treatments. However, broken egg ratio was significantly lower in T2 and T4 than in T1. Retentions of Ca, P, Mg, and Cu were greater in phytase supplemented treatments (T2, T3, and T4) than the control (T1), and those in T3 and T4 were greater than in T2. Excretions of P in phytase supplemented treatments (T2, T3, and T4) were significantly (p<0.05) smaller than in T1 but excretions of N were not significantly different among the treatments. Contents of ash in tibiae were not significantly affected by treatments, but contents of Ca, P, Mg, and Zn was increased and that of Cu decreased by phytase supplementation. It is concluded that the NPP concentration in the diet of Brown layers consuming about 130 g/d of feed can be safely lowered from 0.26% (0.55% total P) to 0.16% (0.45% total P). The excretion of P was reduced by the inclusion of 250 U phytase/kg of diet.

• 대한한의학회지
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• 제38권2호
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• pp.15-30
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• 2017

Objectives: Hwangryunhaedok-tang (HHT; Huanglianjiedu-tang, Orengedoku-to), a traditional herbal formula, is used for treating inflammation, hypertension, gastritis, liver dysfunction, cerebrovascular diseases, dermatitis and dementia. The objective of this study was to assess the sub-acute toxicity of HHT in Sprague-Dawley (SD) rats, and its effect on the activities of human microsomal cytochrome P450s (CYP450s) and UDP-glucuronosyltransferases (UGTs). Methods: Male and female SD rats were orally administered HHT once daily at doses of 0, 500, 1000 and 2000 mg/kg for 4 weeks. We analyzed mortality, clinical observations, body weight, food consumption, organ weights, urinalysis, hematology, serum biochemistry, and histopathology. The activities of major human CYP450s (CYP1A2, CYP3A4, CYP2B6, CYP2C9, CYP2C19, CYP2D6, and CYP2E1) and UGTs (UGT1A1, UGT1A4, and UGT2B7) were assessed using in vitro fluorescence- and luminescence-based enzyme assays, respectively. Results: No toxicologically significant changes related to the repeated administration of HHT were observed in both male and female SD rats. The no observed adverse effect level (NOAEL) value was more than 2000 mg/kg/day for both sexes. HHT inhibited the activities of human microsomal CYP1A2, CYP2C19, CYP2D6, and CYP2E1, whereas it weakly inhibited the activities of CYP2B6, CYP2C9, CYP3A4, and UGT1A1. In addition, HHT negligibly inhibited the activities of human microsomal UGT1A4 and UGT2B7 with $IC_{50}$ values in excess of $1000{\mu}g/mL$. Conclusions: Our findings indicate that HHT may be safe for repeated administration up to 4 weeks. In addition, these findings provide information on the safety and effectiveness of HHT when co-administered with conventional drugs.

• 한국산학기술학회논문지
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• 제21권10호
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• pp.8-15
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• 2020

딥러닝을 사용한 예측 방법은 동일한 예측 모델과 파라미터를 사용한다 하더라도 데이터셋의 특성에 따라 결과가 일정하지 않다. 예를 들면, 데이터셋 A에 최적화된 예측 모델 X를 다른 특성을 가진 데이터셋 B에 적용하면 데이터셋 A와 같이 좋은 예측 결과를 기대하기 어렵다. 따라서 높은 정확도를 갖는 예측 모델을 구현하기 위해서는 데이터셋의 성격을 고려하여 예측 모델을 최적화하는 것이 필요하다. 본 논문에서는 하루 대학 캠퍼스 전력사용량을 1시간 단위로 예측하기 위해 데이터셋의 특성이 고려된 예측 모델이 도출되는 일련의 방법을 단계적으로 제시한다. 데이터 전처리 과정을 시작으로, 이상치 제거와 데이터셋 분류 과정 그리고 합성곱 신경망과 장기-단기 기억 신경망이 결합된 알고리즘(CNN-LSTM: Convolutional Neural Networks-Long Short-Term Memory Networks) 기반 하이퍼파라미터 튜닝 과정을 소개한다. 본 논문에서 제안하는 예측 모델은, 각 시간별 24개 포인트에서 2%의 평균 절대비율 오차(MAPE: Mean Absolute Percentage Error)를 보인다. 단순히 예측 알고리즘만을 적용한 모델과는 달리, 단계적 방법을 통해 최적화된 예측 모델을 사용하여 단일 전력 입력 변수만을 사용해서 높은 예측 정확도를 도출한다. 이 예측 모델은 모바일 에너지관리시스템(Energy Management System: EMS) 어플리케이션에 적용되어 관리자나 소비자에게 최적의 전력사용 방안을 제시할 수 있으며 전력 사용 효율 개선에 크게 기여할 것으로 기대된다.

• 미술이론과 현장
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• 제7호
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• pp.7-36
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• 2009

This paper intends to examine the significance of the "Minjoong Misool(People's art)" of the 1980s emerged in Korea in its social, cultural, and art historical context. This paper also aims to provide an analysis of the meaning and form of the individual artist's works, which have been overlooked under the dominant discourse that has emphasized their political role as a collective group. In particular, this paper scrutinizes the work of "Critical Realists" by examining the way in which they perceived Korean society in the early 1980s and visualized their experiences of the period. The figurative art newly emerged in the early 1980s challenged the formalist Modernism, which was adopted into Korea and translated into monochrome paintings and the work of the conversative academicism of the 1970s. The figurative art encouraged a social communication and moreover it intended to criticize the conflicts in the political, economical, and social domains in Korea. The targets of its critique include the unavoidable results of the unprecedented development of economy, various social phenomena of the post-industrial society, and the growth of the commercialized kitsch culture. Along with Shin, Hak-chul's work that incorporates collage technique since the 1980s, the work of some members of "Reality and Utterance" and "Im- sul-nyun" exemplify their critical interests in disclosing the false dream of wealth and happiness by both referring to and drawing on the utopian fantasy manipulated and distributed by mass media and commercial advertisements. This paper pays particular attention to Nouvelle Figuration emerged in France and Europe during the 1960s, which is comparable to the new figurative art emerged in Korea during the 1980s. Nouvelle Figuration criticized the autonomy in art isolated itself from political and social reality after WWII, in particular the indifference of Informel and abstract art as well as American abstract art. Moreover it became rather politicized around May of 1968. Given that French Nouvelle Figuration was introduced in Korea in 1982 and made a significant contribution to the formation of figurative art in Korea, it should be noted that the new figurative art emerged in the 1980s in Korea cannot be categorized merely in relation to People's Art. This paper intends to critically redress the notion that People's art was formed in the particular political, economical, and cultural context of Korea independent of the contemporary artistic practices outside Korea. It will provide a critical examination and analysis of the content and form of the new figurative art, from which People's Art was germinated, in the global context.

• Journal of Power Electronics
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• 제11권4호
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• pp.408-417
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• 2011

The plug-in hybrid electric vehicles (PHEVs) are specialized hybrid electric vehicles that have the potential to obtain enough energy for average daily commuting from batteries. The PHEV battery would be recharged from the power grid at home or at work and would thus allow for a reduction in the overall fuel consumption. This paper proposes an integrated power electronics interface for PHEVs, which consists of a novel Eight-Switch Inverter (ESI) and an interleaved DC/DC converter, in order to reduce the cost, the mass and the size of the power electronics unit (PEU) with high performance at any operating mode. In the proposed configuration, a novel Eight-Switch Inverter (ESI) is able to function as a bidirectional single-phase AC/DC battery charger/ vehicle to grid (V2G) and to transfer electrical energy between the DC-link (connected to the battery) and the electric traction system as DC/AC inverter. In addition, a bidirectional-interleaved DC/DC converter with dual-loop controller is proposed for interfacing the ESI to a low-voltage battery pack in order to minimize the ripple of the battery current and to improve the efficiency of the DC system with lower inductor size. To validate the performance of the proposed configuration, the indirect field-oriented control (IFOC) based on particle swarm optimization (PSO) is proposed to optimize the efficiency of the AC drive system in PHEVs. The maximum efficiency of the motor is obtained by the evaluation of optimal rotor flux at any operating point, where the PSO is applied to evaluate the optimal flux. Moreover, an improved AC/DC controller based Proportional-Resonant Control (PRC) is proposed in order to reduce the THD of the input current in charger/V2G modes. The proposed configuration is analyzed and its performance is validated using simulated results obtained in MATLAB/ SIMULINK. Furthermore, it is experimentally validated with results obtained from the prototypes that have been developed and built in the laboratory based on TMS320F2808 DSP.