• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 춘계학술대회
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• pp.213-213
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• 1996

The effects of the anti-tumor agent, SDZ-y2434, on rat kidney were investigated to predict the toxicities of its derivatives and to develope less toxic derivatives. After adjusted in metabolic cages for 5 days, rats were treated SDZ-62434(acute : 25mg/kg, i.p, once and 50mg/kg, i.p., once; subacute ; 10mg/kg, i.p., daily for 7 days). Kidney weights and urine volume during the treatment were observed. Creatinine concentration, protein concentration and the activities of N-acetyl-${\beta}$-D-glucosaminidase (NAG), alanine aminopeptidase (AAP), ${\gamma}$-glutamyl transpeptidase (GGT) and lactate dehydrogenase(LDH) in 24 hr urine were also determined. The kidney weights after the acute and subacute administration didn't show any difference. Urine volume increased 5 days after the acute administration (50mg/kg) and 3 days after the subacute administration. The excretion of creatinine was increased 5 days after the acute (50mg/kg) and subacute administration. However, the protein excretion didn't show any change. NAG acivity declined 7 days after the subacute administration. AAP and GGT activites increased 3 days after the acute administration (50mg/kg) but, returned to the control value. LDH activity showed continuousely high value after the subacute administration. These results indicates that the acute administration of SDZ-62434 might damage on glomerulus and that the subacute administration might be cytotoxic to kidney cells.

• Journal of Korean Biological Nursing Science
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• 제22권2호
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• pp.139-147
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• 2020

Purpose: The purpose of this study was to determine the effects of different intensity of aerobic exercise for four weeks on cardiovascular risk factors, reactive oxygen, and antioxidant enzymes in old mice. Methods: Eighteen male C57BL/6 mice age 18 months were randomly classified into the control group (n= 6), the moderate intensity exercise group (n= 6), and the low intensity exercise group (n= 6). The training groups performed the aerobic exercise twice daily for 20 minutes, five days weekly for four weeks. Data were analyzed using descriptive statistics, analysis of variance (ANOVA), the Chi-square test, and the Tukey's test with the SPSSWIN 21.0 program. Results: In this study, among the risk factors of cardiovascular disease, blood sugar (BS) (p= .023) and total cholesterol (TC) (p= .001) were significantly different between the moderate intensity exercise group and the control group. Additionally, there were significant differences in the reactive oxygen malondialdehyde (MDA) (p= .001), the antioxidant enzymes superoxide dismutase (SOD) (p< .001) and glutathione reductase (GR) (p= .015) between the moderate intensity exercise group and the control group. Conclusion: This finding suggests that moderate intensity aerobic exercise promotes the activity of antioxidant enzymes and lowers cardiovascular risk factors in older mice.

• 한국보건간호학회지
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• 제14권1호
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• pp.26-40
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• 2000

This study was conducted to find out residential environment, mood states, ADL(Activity Daily Living) and nursing need of the elderly who live alone. The questionnaire survey was conducted on 154 single household elderly over 65years who live n D-city, Kangwon Province. The data were collected between September 1. 1999 and October 17, 1999 and analyzed by means of SPSS package. The results were as follows; 1. The percentage of the subjects who owned their house was no were than $13\%$., which showed that they still belonged to the economically vulnerable class. As for their residential environment, the average indoor temperature and humidity level were $16.45^{\circ}C\;and\;44.62\%$ respectively during the daytime between September and October, which proved to range within the standard scope. The average indoor illumination level was, however, 43.61 Lux, which showed that their illumination environment was very poor. 2. The average score of their mood states was 3.31. which turned out to be rather low. 3. The mean score of ADL was 1.69, which showed that they didn't have any serious inconveniences in their ordinary lives. 4. The mean score of their nursing need was 275, which proved to be close to the normal level. 5. The higher the room humidity was, the higher their nursing need increased. The higher the degree of illumination level was, the lower the degree of their nursing need was and the higher the level of ADL was. 6. The major factors influencing their moon status were the frequency of their contact with children and room humidity. These two factors could account for $22\%$ of the total mood status. These results suggest that the residential environment should be necessarily considered in the psychological nursing intervention for the elderly who live alone and they should be urgently supported in terms of health policy so that they can maintain the optimum level of illumination during the daytime.

• 한국융합학회논문지
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• 제11권6호
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• pp.69-74
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• 2020

본 연구는 척수손상 작업치료 가이드라인의 개발에 앞서 척수손상환자에게 적용하고 있는 작업치료 실태와 임상에서 요구하는 가이드라인의 범위를 알아봄으로써 이에 따른 필요성의 제기 및 근거 기반 재활 중재 서비스 체계 구축을 위한 것으로 동일 분야 연구에 활용이 있을 것으로 사료 된다. 조사방법으로는 현재 작업치료사가 근무하는 기관을 중심으로 작업치료사 112명을 대상으로 2019년 10월 3일부터 17일 까지 총 15일간 설문조사 하였다. 그 결과 임상에서 주로 사용되는 중재방법에는 신체활동훈련 106명(94.6%), 일상생활동작훈련 96명(85.7%), 교육-카운슬링-정보제공 44명(39.3%), 보호자 교육 39명(34.8%)순으로 조사되었다. 연구결과를 통해 작업치료 가이드라인의 인식과 임상적 요구를 확인하였다.

• 한국환경과학회지
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• 제22권12호
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• pp.1643-1650
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• 2013

This study investigated water quality of effluents and stream from the sewage treatment plants located at Gumi Complex 4, Gumi, and Wonpyeong in Gumi. Downstream region was found to increase the concentration of nutrients for sewage treatment plant effluent. Both phosphorus and nitrogen were accounted most as soluble form. In particular, the high ratio of dissolved effluent of sewage treatment plants were investigated. In the streams, Phosphorus concentration was high during rainy season and nitrogen concentration was high in the dry season. Sewage treatment plant effluent was relatively less microbial activity and nutrient concentrations were higher in the winter. TN/TP ratio was the highest in the upstream region and the lowest in the sewage treatment plant effluent. The effect of the nutrient matter from a discharge of a sewage treatment plant on rivers varied depending on the size of the river and the treatment plant. However, the influence of the concentration was greater than that of flowrate. Sewage treatment plant effluent loads phosphorus, nitrogen accounted for 8% and 6% respectively at the point N3 of the Nakdong river.

• 한국가스학회지
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• 제10권2호
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• pp.22-26
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• 2006

본 연구에서는 하루 50 kg의 DME를 생산하기 위한 파일럿 플랜트를 Aspen Plus를 사용하여 전산모사 하였다. 전체 DME 분리공정의 모델링을 위하여 NRTL 액체 활동도계수 모델식을 사용하였으며 light 가스 성분의 용매의 용해도 추산을 위해서 Henry의 법칙을 사용하였으며 기상의 비이상성을 계산하기 위해서 SRK 상태방정식 모델식을 사용하였다. 전산모사 결과로 DME 분리탑의 중간 제품으로써 98 wt% 이상의 순도를 갖는 DME를 얻을 수 있었다.

• Industrial Engineering and Management Systems
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• 제7권2호
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• pp.171-181
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• 2008

Home care, known also as domiciliary care, is part of the community care service that is a responsibility of the local government authorities in the UK as well as many other countries around the world. The aim is to provide the care and support needed to assist people, particularly older people, people with physical or learning disabilities and people who need assistance due to illness to live as independently as possible in their own homes. It is performed primarily by care workers visiting clients' homes where they provide help with daily activities. This paper is concerned with the dispatching of care workers to clients in an efficient manner. The optimized routine for each care worker determines a schedule to achieve the minimum total cost (in terms of distance traveled) without violating the capacity and time window constraints. A collaborative population-based meta-heuristic called Particle Swarm Optimization (PSO) is applied to solve the problem. A particle is defined as a multi-dimensional point in space which represents the corresponding schedule for care workers and their clients. Each dimension of a particle represents a care activity and the corresponding, allocated care worker. The continuous position value of each dimension determines the care worker to be assigned and also the assignment priority. A heuristic assignment scheme is specially designed to transform the continuous position value to the discrete job schedule. This job schedule represents the potential feasible solution to the problem. The Earliest Start Time Priority with Minimum Distance Assignment (ESTPMDA) technique is developed for generating an initial solution which guides the search direction of the particle. Local improvement procedures (LIP), insertion and swap, are embedded in the PSO algorithm in order to further improve the quality of the solution. The proposed methodology is implemented, tested, and compared with existing solutions for some 'real' problem instances.

• Journal of Korean Neurosurgical Society
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• 제56권5호
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• pp.375-382
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• 2014

Objective : To assess the effect of bone marrow mononuclear cells (BMMNCs) transplantation in the expression of nuclear factor-${\kappa}B$ (NF-${\kappa}B$) in spinal cord injury (SCI) in rats. Methods : BMMNCs were isolated from tibia and femur by a density gradient centrifugation. After establishment of acute transection SCI, rats were divided into experiment (BMMNCs), experiment control (0.1 M PBS infused) and sham surgery groups (laminectomy without any SCI). Locomotor function was assessed weekly for 5 weeks post-injury using BBB locomotor score and urinary bladder function daily for 4 weeks post-injury. Activity of NF-${\kappa}B$ in spinal cord was assessed by immunohistochemistry and reverse transcriptase polymerase chain reaction. Results : At each time point post-injury, sham surgery group had significantly higher Basso, Beattie, Bresnahan locomotor and urinary bladder function scores than experiment and experiment control group (p<0.05). At subsequent time interval there were gradual improvement in both experiment and experiment control group, but experiment group had higher score in comparison to experiment control group (p<0.05). Comparisons were also made for expression of activated NF-${\kappa}B$ positive cells and level of NF-${\kappa}B$ messenger RNA in spinal cord at various time points between the groups. Activated NF-${\kappa}B$ immunoreactivity and level of NF-${\kappa}B$ mRNA expression were significantly higher in control group in comparison to experiment and sham surgery group (p<0.05). Conclusion : BMMNCs transplantation attenuates the expression of NF-${\kappa}B$ in injured spinal cord tissue and thus helps in recovery of neurological function in rat models with SCI.

• Nutrition Research and Practice
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• 제11권3호
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• pp.198-205
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• 2017

BACKGROUND/OBJECTIVES: The anti-diabetic activity of pear through inhibition of ${\alpha}-glucosidase$ has been demonstrated. However, little has been reported about the effect of pear on insulin signaling pathway in obesity. The aims of this study are to establish pear pomace 50% ethanol extract (PPE)-induced improvement of insulin sensitivity and characterize its action mechanism in 3T3-L1 cells and high-fat diet (HFD)-fed C57BL/6 mice. MATERIALS/METHODS: Lipid accumulation, monocyte chemoattractant protein-1 (MCP-1) secretion and glucose uptake were measure in 3T3-L1 cells. Mice were fed HFD (60% kcal from fat) and orally ingested PPE once daily for 8 weeks and body weight, homeostasis model assessment of insulin resistance (HOMA-IR), and serum lipids were measured. The expression of proteins involved in insulin signaling pathway was evaluated by western blot assay in 3T3-L1 cells and adipose tissue of mice. RESULTS: In 3T3-L1 cells, without affecting cell viability and lipid accumulation, PPE inhibited MCP-1 secretion, improved glucose uptake, and increased protein expression of phosphorylated insulin receptor substrate 1 [p-IRS-1, ($Tyr^{632})$)], p-Akt, and glucose transporter type 4 (GLUT4). Additionally, in HFD-fed mice, PPE reduced body weight, HOMA-IR, and serum lipids including triglyceride and LDL-cholesterol. Furthermore, in adipose tissue, PPE up-regulated GLUT4 expression and expression ratio of p-IRS-1 ($Tyr^{632})/IRS$, whereas, down-regulated p-IRS-1 ($Ser^{307})/IRS$. CONCLUSIONS: Our results collectively show that PPE improves glucose uptake in 3T3-L1 cells and insulin sensitivity in mice fed a HFD through stimulation of the insulin signaling pathway. Furthermore, PPE-induced improvement of insulin sensitivity was not accompanied with lipid accumulation.

• The Journal of Korean Physical Therapy
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• 제26권5호
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• pp.351-357
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• 2014

Purpose: The purpose of this study was to investigate level of functioning in patients with stroke using Modified Bathel Index (MBI), World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0), and ICF core-set for stroke. Methods: Sixty-four patients with stroke were recruited for this study from nine medical institutes. The ICF core-set for stroke, WHODAS 2.0, and MBI were used to collect subjects' functional levels. ICF core-set was employed here as a standard frame to observe multi-dimension of functioning, that is physiological bodily function, activity and participation (AP) in daily life, and current environmental factors (EF) in patients with stroke. WHODAS 2.0 and MBI were also used in order to have a specific functioning level for subjects. The linkage of each item in WHODAS 2.0 and MBI into the ICF core-set for stroke was examined. Pearson correlation coefficient was used for analysis of their relationships. Results: Functioning level of participants showed moderate resulting from MBI and WHODAS 2.0 ($73.48{\pm}22.27$ and $35.55{\pm}12.53$, respectively). Strong relationship was observed between ICF core-set and WHODAS 2.0, and with MBI. Each item of disability scales was obtained its linkage into ICF in the domain of AP. However, lack of correlation between MBI and ICF in the domain of EF was found due to absence of related factors. Conclusion: MBI was found to be linked mainly into ICF in the domain of AP and to have limited linkage into EF. Therefore, it should be suggested that the ICF concept frame should be used as a multi-dimensional approach to patients with stroke.