• Radiation Oncology Journal
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• v.23 no.1
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• pp.51-60
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• 2005

Purpose : Selective inhibition of multiple molecular targets may improve the antitumor activity of radiation. Two specific inhibitors of selective cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) were combined with radiation on the HeLa cell line. To investigate cooperative mechanism with selective COX-2 inhibitor and EGFR blocker, in vitro experiments were done. Materials and Methods : Antitumor effect was obtained by growth inhibition and apoptosis analysis by annexin V-Flous method. Radiation modulation effects were determined by the clonogenic cell survival assay. Surviving fractions at 2 Gy ($SF_2$) and dose enhancement ratio at a surviving fraction of 0.25 were evaluated. To investigate the mechanism of the modulation of radiosensitivity, the cell cycle analyses were done by flow cytometry. The bcl-2 and bax expressions were analyzed by western blot. Results : A cooperative effect were observed on the apoptosis of the HeLa ceil line when combination of the two drugs, AG 1478 and NS 398 with radiation at the lowest doses, apoptosis of $22.70\%$ compare with combination of the one drug with radiation, apoptosis of $8.49\%$. In cell cycle analysis, accumulation of cell on $G_0/G_l$ phase and decrement of S phase fraction was observed from 24 hours to 72 hours after treatment with radiation, AG 1478 and NS 398. The combination of NS 398 and AG 1478 enhanced radiosensitivity on a concentration-dependent manner in HeLa cells with dose enhancement ratios of 3.00 and $SF_2$ of 0.12 but the combination of one drug with radiation was not enhanced radlosensitivity with dose enhancement ratios of 1.12 and SF2 of 0.68 (p=0.005). The expression levels of bcl-2 and bax were reduced when combined with AG 1478 and NS 398. Conclusion : Our results indicate that the selective COX-2 inhibitor and EGFR blocker combined with radiation have potential additive or cooperative effects on radiation treatment and may act through various mechanisms including direct inhibition of tumor cell proliferation, suppression of tumor cell cycle progression and inhibition of anti-apoptotic proteins.

• The KIPS Transactions:PartA
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• v.17A no.3
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• pp.159-166
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• 2010

In this paper, to obtain the Minimum Spanning Tree (MST) from the graph with several nodes having the same weight, I applied both Bor$\dot{u}$vka and Kruskal MST algorithms. The result came out to such a way that Kruskal MST algorithm succeeded to obtain MST, but not did the Prim MST algorithm. It is also found that an algorithm that chooses Inter-MSF MWE in the $2^{nd}$ stage of Bor$\dot{u}$vka is quite complicating. The $1^{st}$ stage of Bor$\dot{u}$vka has an advantage of obtaining Minimum Spanning Forest (MSF) with the least number of the edges, and on the other hand, Kruskal MST algorithm has an advantage of always obtaining MST though it deals with all the edges. Therefore, this paper suggests an Hybrid MST algorithm which consists of the merits of both Bor$\dot{u}$vka's $1^{st}$ stage and Kruskal MST algorithm. When applied additionally to 6 graphs, Hybrid MST algorithm has a same effect as that of Kruskal MST algorithm. Also, comparing the algorithm performance speed and capacity, Hybrid MST algorithm has shown the greatest performance Therefore, the suggested algorithm can be used as the generalized MST algorithm.

• Journal of KIISE:Software and Applications
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• v.26 no.9
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• pp.1073-1084
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• 1999

이동 컴퓨팅 환경에서 이동 호스트는 제한된 대역폭을 효율적으로 사용하고 이동 트랜잭션의 응답 시간을 향상시키기 위하여 캐쉬를 이용한다. 그리고 이동 호스트에 캐슁된 데이타가 이동 지구국에서 갱신되면 이동 호스트의 캐쉬 일관성을 유지하기 위하여 이동 지구국은 무효화 메시지를 방송한다. 그러나 이동 지구국에서 주기적으로 무효화 메시지를 방송하는 방법은 이동 트랜잭션의 빠른 처리를 위하여 이동 지구국으로부터 데이타를 즉시 캐슁하는 경우에 이동 트랜잭션의 직렬가능한 수행을 보장할 수 없는 경우가 발생한다. 본 연구에서는 캐슁된 데이타를 이용하여 이동 트랜잭션을 수행하는 경우에 록을 이용하여 이동 트랜잭션의 직렬가능한 수행을 보장하는 UCL-MT 방법과 록 관리 방법을 제안한다. 제안하는 UCL-MT 방법은 이동 트랜잭션을 완료하기 이전에 이동 트랜잭션이 접근한 데이타 정보를 이용하여 지구국에서 사이클을 탐지함으로써 이동 트랜잭션의 직렬가능한 수행을 보장한다. 또한 제안하는 록 관리 방법은 이용할 수 있는 대역폭의 크기에 따른 무효화 메시지 내용의 변화에 유연하게 적용될 수 있다. Abstract In mobile computing environments, a mobile host caches the data to use the narrow bandwidth efficiently and improve the response time of a mobile transaction. If the cached data in mobile host is updated at a mobile support station, the mobile support station broadcasts an invalidation message for maintaining the cache consistency of a mobile host. But when a mobile transaction accesses the data which is not in cache, if a mobile host caches the data immediately from a mobile support station for processing a mobile transaction rapidly, the method that a mobile support station broadcasts an invalidation message periodically, happens to the case that can not guarantee the serializable execution of a mobile transaction. In this paper, we propose the UCL-MT method and lock management method, as a mobile transaction is executed using cached data. Since, using the data a mobile transaction accessed, the UCL-MT method detects a cycle in a mobile support station before the completion of the mobile transaction, it guarantees the serializable execution of the mobile transaction. Also, proposing lock management method can be adapted flexibly at the change of invalidation message content, according to the available bandwidth.

• Journal of KIISE:Software and Applications
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• v.33 no.9
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• pp.776-786
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• 2006

This paper proposes XML based mobile information visualization system using rectangle layout to show effectively XML based information to user on mobile devices which do not have a rich display feature. We define XML schema that can describes information in graph with cycle as well as information in tree form. It suggests using rectangle layout method that is an improvement of the traditional method of the radial layout because the specificity of the mobile display should be considered when XML information is rendered on the screen. And then, it applies DOI of fisheye view algorithm to information on the rectangle layout to represent all and user interest information. And it also suggests an effective method considering capability of mobile devices to decrease user's confusion and improve awareness of user when a user Interest target selected. The proposed information visualization system in the form of focus+context supports an effective interface for information retrieval via mobile devices, such as PDA, cellular phone and smart phone, that usually have less power of CPU than that of PC and the constraints of display and memory. In this paper, it performs experiments and makes an evaluation comparing information visualization method between the traditional radial layout and the proposed rectangle layout.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.3
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• pp.100-109
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• 2019

Maintainability indicates the extent to which maintenance can be done easily and quickly. The consideration of maintainability is crucial to reduce the operation and support costs of weapon systems, but if the maintainability is evaluated after the prototype production is done and necessitates design changes, it may increase the cost and delay the schedule. The evaluation should verify whether maintenance work can be performed, and support the designers in developing a design to improve maintainability. In previous studies, the maintainability index was calculated using the graph theory at the early design phase, but evaluation accuracy appeared to be limited. Analyzing the methods of evaluating the maintainability using fuzzy logic and 3D modeling indicate that the design of a system with good maintainability should be done in an integrated manner during the whole system life cycle. This paper proposes a method to evaluate maintainability using SysML-based modeling and simulation technique and fuzzy logic. The physical design structure with maintainability attributes was modeled using SysML 'bdd' diagram, and the maintainability was represented by an AHP matrix for maintainability attributes. We then calculated the maintainability using AHP-based weighting calculation and fuzzy logic through the use of SysML 'par' diagram that incorporated MATLAB. The proposed maintainability model can be managed efficiently and consistently, and the state of system design and maintainability can be analyzed quantitatively, thereby improving design by early identifying the items with low maintainability.

• Journal of Dental Rehabilitation and Applied Science
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• v.38 no.2
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• pp.81-89
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• 2022

Purpose: Wireless endodontic handpieces (WEH) are widely used in dental clinics due to their convenience and portability. This study aimed to compare the vibration magnitudes and patterns generated by five WEH. Materials and Methods: Vibration acceleration of five WEH (X-Smart IQ, E connect S, Endo A Class, ENDOIT, and TRAUS ENDO) in the rotary and reciprocating motion was measured with accelerometer The average vibration acceleration was analyzed using the t-test, Welch's ANOVA test, and Dunnett T3 test at P < 0.05. Results: In all WEH, the average vibration acceleration in reciprocating motion was significantly higher than that in rotary motion (P < 0.001). In rotary motion, repeated vibration graphs of constant amplitude were obtained without sudden changes in the magnitude of vibration, and the average vibration acceleration value was high in the order of X Smart IQ, Endo A Class, ENDOIT, E Connect S, and TRAUS ENDO (P < 0.001), there was no statistically significant difference between X Smart IQ and Endo A Class. In reciprocating motion, a vibration graph was obtained in which large amplitude peaks appear at specific points within one cycle are repeated. The average vibration acceleration value was highest in the order of X Smart IQ, E Connect S, Endo A class, ENDOIT, and TRAUS ENDO (P < 0.001). Conclusion: Regardless of the type of WEH, greater vibration occurred in the reciprocating motion than in the rotary motion (P < 0.001). In the reciprocating motion, there was a difference in vibration for all handpieces (P < 0.001).

• Radiation Oncology Journal
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• v.9 no.1
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• pp.1-6
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• 1991

The effect of 2-deoxy-d-glucose (2-DDG) on $C_3H$ mouse fibrosarcoma(FSall) was studied. Metabolic status, especially for energy metabolism, was studied using in vivo $^{31}P$-MRS, proliferative capacity was observed on flow cytometry(FC) and growth rate was measured after transplantation of $10^6$ viable tumor cells in the dorsum of foot of $C_3Hf/Sed$ mice. One gram of 2-DDG Per kg of body weight was injected intraperitoneally on 12th day of implantation. Average tumor size on 12th day of implantion was $250mm^3$. Growth rate of Fsall tumor was measured by tumor doubling time and slope on semilog plot. After 2-DDG injection, growth rate slowed down. Tumor doubling time between tumor age 5-12 days was 0.84 days with slope 0.828 and tumor doubling time between tumor age 13-28 days was 3.2 days with slope 0.218 in control group. After 2-DDG injection, tumor doubling time was elongated to 5.1 days with slope 0.136. The effect of 2-DDG studied in vivo $^{31}P$-MRS suggested that the increase of phosphomonoester (PME) and inorganic phosphate (Pi) by increasing size of tumor, slowed down after 2-DDG injection. Flow cytometry showed significantly increased S-phase and $G_2+M$ phase fraction suggesting increased proliferative capacity of tumor cells in the presence of 2-DDG. Authors observed an interesting effect of 2-DDG on FSall tumor and attempt to utilize as an adjunct for radiotherapy.