• Journal of Digestive Cancer Research
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• 제10권2호
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• pp.99-106
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• 2022

Clinical research ultimately aimed to promptly diagnose and prevent diseases through precise biomarker development. Finding the optimal cut-off point of a regularly measured biomarker can help its interpretation and ultimately help in disease investigation and diagnosis, more specifically in determining the presence of diseases. Therefore, this study aimed to use the characteristics of outcome variables in clinical research to explain how to determine the optimal cutoff point. The outcome variables can be divided into dichotomous, ordinal, and survival types. The optimal cut-off point can be determined by finding points that maximize the Youden index, extended Youden index, and log-rank statistics. This study will enable clinical researchers to accurately determine the optimal cut-off points for regularly measured biomarkers, thereby enabling prompt disease diagnosis for effective treatment.

• 한국환경보건학회지
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• 제47권4호
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• pp.320-329
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• 2021

Background: Smoking exposure may be objectively assessed through specific biomarkers. The most common biomarker for smoking is cotinine concentration in urine, and setting an optimal cut-off point can accurately classify smoking status. Such a cut-off point for Korean adolescents has never been studied. Objectives: The aim of this study was to determine a cut-off point for urinary cotinine concentration for the discrimination of smoking in adolescents. Methods: Participants were adolescents aged 13~18 years who participated in the third cycle of the Korean National Environmental Health Survey. We used urine samples to confirm the level of cotinine concentrations. Smoking status was determined by self-reported questionnaire. We identified the optimal cotinine cut-off point for discriminating smoking status using receiver operating characteristic curve analysis. Results: Of the 904 participants, 28 (3.1%) were smokers, among whom 20 (71.4%) were male. The median urinary cotinine concentrations in smokers was 218 ㎍/L (male: 215 ㎍/L, female: 303 ㎍/L), and that in non-smokers was 1.31 ㎍/L (male: 1.46 ㎍/L, female: 1.18 ㎍/L). We found significant differences in urinary cotinine concentration according to smoking status and sex (p<0.001). Urinary cotinine concentrations performed well for identifying smoking adolescents [area under the curve: 0.954 (male: 0.963, female: 0.908)]. The cut-off that optimally distinguished smokers from non-smokers was 39.85 ㎍/L (sensitivity: 89.3%, specificity: 97.4%). Male [39.85 ㎍/L (sensitivity: 90.0%, specificity: 94.9%)] had a different optimal cut-off point than female [26.26 ㎍/L (sensitivity: 87.5%, specificity: 99.6%)]. Conclusions: This study determined a cut-off point for urinary cotinine of 39.85 ㎍/L (male: 39.85 ㎍/L, female: 26.26 ㎍/L) to distinguish smokers from non-smokers in adolescents.

• 한국언어정보학회:학술대회논문집
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• 한국언어정보학회 2007년도 정기학술대회
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• pp.126-135
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• 2007

We propose and test several computational methods to automatically determine possible saliency cut-off points in Sketch Engine (Kilgarriff and Tugwell, 2001). Sketch Engine currently displays collocations in descending importance, as well as according to grammatical relations. However, Sketch Engine does not provide suggestions for a cut-off point such that any items above this cut-off point may be considered significantly salient. This proposal suggests improvement to the present Sketch Engine interface by calculating three different cut-off point methods, so that the presentation of results can be made more meaningful to users. In addition, our findings also contribute to linguistic analyses based on empirical data.

• 방송공학회논문지
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• 제15권6호
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• pp.845-852
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• 2010

클라이언트로부터의 요구메시지의 통계를 바탕으로 하여 방송 서버는 데이터 아이템에 대하여 최적의 컷오프 포인트를 이용하여 핫 아이템과 콜드 아이템으로 나눈다. 핫 아이템은 주기적으로 방송되는데 이 때, 방송 주기는 아이템들의 인기도, 즉 요구확률에 따라 정해진다. 핫 아이템이 방송되지 않은 빈 슬롯에는 적절한 콜드 아이템을 골라 방송하게 되는데, 이 때 대기시간과 대기 중인 요구 메시지의 수 등을 고려하여 콜드 아이템을 정한다. 최적의 컷오프 포인트를 해석적으로 구하기 위하여 평균 응답시간을 컷오프 포인트의 함수로 나타나도록 계산하였다. 요청 도착율과 아이템의 인기도를 변화하면서 수행한 시뮬레이션을 통하여 본 논문에서 제안한 방법이 기존의 방법들보다 더욱 우수한 성능을 나타냄을 보였다.

• 응용통계연구
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• 제27권3호
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• pp.501-512
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• 2014

상당수의 사업체 조사는 절사표본설계법을 사용하고 있다. 이는 절사표본설계법에서 얻은 전수층이 많은 정보를 포함하고 있어 전체 표본크기를 최소화 할 수 있는 장점이 있기 때문이다. 그러나 최근 전수층에 포함된 사업체들의 무응답률이 높아감에 따라 전수층이 가지고 있는 장점에 한계가 나타나고 있다. 이에 Lee (2011), Shin과 Lee (2013)는 표본설계 단계에서부터 주어진 허용오차를 만족하면서 전수층 규모를 최소화하는 연구를 실시하였다. 본 연구에서는 주어진 허용오차를 만족하고 Hidiroglou (1986)가 제안한 방법으로 산출 된 표본크기를 고정한 상태에서 표본층 분산에 알려진 함수를 적합하여 전수층 크기를 최소화하는 새로운 최적 절사점을 제안하였다. 또한 Hidiroglou (1986)와 Shin과 Lee (2013)가 제안한 절단분포를 이용한 방법과 본 연구에서 제안한 방법을 모의실험과 사례연구를 통해 비교하였다.

• 한국유체기계학회 논문집
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• 제13권3호
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• pp.37-42
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• 2010

This study investigated on details of flow characteristics of a multi-blade fan for domestic ventilation. Experiments and analysis were carried out to describe on flow pattern with variations of cut-off angle near the scroll housing throat, which were performed by PIV measurement for the flow field and by total pressure probes. The stagnation point at cut-off region of the fan moves to the exit of the scroll housing as the cut-off angle increases. The movement of stagnation point and the variation of throat area of the scroll housing influence to the distribution of velocity magnitude at the exit of the fan. Furthermore, a large distortion of the velocity distribution at the scroll exit causes to increase mixing loss along the flow path.

• 한국멀티미디어학회논문지
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• 제21권7호
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• pp.772-778
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• 2018

We have previously proposed a preliminary cut-off indoor positioning scheme considering the reference point with the same signal similarity. This scheme estimates the position using the relative rank of the peak of received signal strength from the beacons around user. However, this scheme has a weak point with lower accuracy when there are more than one nearest reference points having the same signal similarity. In order to tackle this, we propose a weighted preliminary cut-off indoor positioning scheme. Firstly, if the above problem occurs, the similarity to the peak of signal strength is considered as well as the relative rank. Next, weights are assigned to the nearest reference points using the similarity to the peak of the received signal strength. Finally, the user's position is estimated by applying the weights. As a result, the weighted preliminary cut-off scheme improves the positioning accuracy by about 7.9% compared to the previous scheme.

• 한국멀티미디어학회논문지
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• 제20권1호
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• pp.74-81
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• 2017

In learning stage of the preliminary Cut-off indoor positioning scheme, RSSI and UUID data received from beacons at each reference point(RP) are stored in fingerprint map. The fingerprint map and real-time beacon information are compared to identify the nearest K reference points through which the user position is estimated. If the number of K is zero, this scheme cannot estimate user position. We have improved the preliminary Cut-off scheme to get the estimated user position even in the case. The improved scheme excludes the beacon of the weakest signal received by user mobile device and identifies neighborhood reference points using the other beacon information. This procedure are performed repetitively until K > 0. The simulation results confirm that the proposed scheme outperforms K-Nearest-Neighbor (KNN), Cluster KNN and the conventional Cut-off scheme in terms of accuracy while the constraints are guaranteed to be satisfied.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2011년도 제40회 동계학술대회 초록집
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• pp.200-200
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• 2011

Although the cut-off probe, a precise measurement method for the electron density, is widely used in the industry, the physics on the wave spectrum of the cut-off is not understood yet, only cut-off point frequency containing the information of electron density has been analyzed well. This paper analyzes the microwave frequency spectrum of the cut-off probe to see the physics behind using both microwave field simulation (CST Microwave Studio) and simplified circuit simulation. The result shows that the circuit model well reproduces the cut-off wave spectrum especially in the low frequency regime where the wavelength of the driving frequency is larger than the characteristic length and reveals the physics of transmission characteristics with frequency as resonances between vacuum, plasma and sheath. Furthermore, by controlling the time domain in solver of the microwave simulator, the cut-off like transmission peaks above the cut-off frequency which has been believed as cavity effect is verified as chamber geometry effect. The result of this paper can be used as the basis for the improvement of cut-off probe.

• 대한방사선기술학회지:방사선기술과학
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• 제26권2호
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• pp.63-69
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• 2003

영상재구성에 있어 잡음(noise)을 제거하고 공간 분해능과 대조도 분해능을 향상시킬 수 있는 filter에서 cut off 주파수 level에 따라 영상의 질에 영향을 미치는 경향을 반폭치(FWHM : full width at half maximum)측정방법을 이용하여 비교하였다. 선택한 filter의 종류는 Band-limited, Sheep-logan, Sheep-logan Hanning, Generalized Hamming, Low pass cosine, Parazen, 그리고 Butterworth filter이다. SPECT 영상을 기록하기 위한 점선원(point source)으로 방사성의약품 $^{99m}TcO_4$을 이용하였으며 점선원에 대하여 각각의 filter에서 cut off 주파수 준위별로 영상을 기록하고 axial transverse, coronal sagittal... fh의 section image의 profile 곡선에서 반폭치을 측정하여 비교하였다. 본 연구에서 사용한 filter들에 있어서는 cut off level에 따라 X, Y, 그리고 Z축 방향으로의 평균 FWHM의 길이가 $9.16\;mm{\sim}18.14\;mm$까지 측정되었는데 cut off level 0.7에서 Generalized Hamming filter와 Band limited filter의 경우 9.16 mm로 반폭치의 길이가 제일 짧은 것으로 나타났다.