• Journal of the Optical Society of Korea
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• 제20권6호
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• pp.733-738
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• 2016

We calculate optical properties of guided modes of a hybrid-guiding photonic crystal fiber. The design and modeling of such hybrid-guiding PCF is made by replacing air holes with inserts of high refractive index material layer by layer in order. The optical properties such as mode intensity profile, mode dispersion, optical birefringence, confinement loss, and chromatic dispersion during transition of the guiding mechanism are analyzed and discussed. The guided modes in the hybrid-guiding region are also compared with those of reference index-guiding and bandgap-guiding photonic crystal fibers.

• Bulletin of the Korean Chemical Society
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• 제30권4호
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• pp.846-848
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• 2009

Two modifications of the ${\alpha}\;and\;{\beta}$ forms of propyl mercaptan nickel(II) cluster, [$Ni_6(SCH_2CH_2CH_3)_{12}$], have been synthesized and their crystal structures have been determined by single-crystal X-ray diffraction. The alkyl groups are away from $Ni_6$ ring in $\alpha$ form whereas they are near to the Ni atom in $\beta$ form. The distance of Ni-H in $\beta$ form [2.576(5) $\AA$] is much shorter than that in $\alpha$ form [3.101(2) $\AA$]. In the crystal lattice of $\beta$ form, the whole structure forms a flower shape.

• Archives of Pharmacal Research
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• 제19권2호
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• pp.160-162
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• 1996

The structural analysis of tolfenamic acid, 2-[(3-chloro-2-methylphenyl)-amino]benzoic acid, was performed by single crystal X-ray diffraction technique. The compound was recrystallized from a mixture of ether and toluene in triclinic, space group $P2_1/c, \;with\; \partial=3.914(1), \; b=22.\; 020(2), \; c=14.271(1)\;{\AA}, \beta.=94.68(1)^{\circ}, $ and Z=4. The calculated density is $1.418 g/cm^3$. The structure was solved by the direct method and refined by full matrix least-squares procedure to the final R value of 0.039 for 1773 independent reflections. In the molecule, carboxyl group at the anthranilic acid is coplanar to the phenyl ring. The dihedral angle between the two aromatic rings of the molecule is $44.2^{\circ}$ The molecules are dirnerized through the intermolecular hydrogen bonds at the carboxyl group in the crystal.

• KSBB Journal
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• 제13권4호
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• pp.337-342
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• 1998

Immunosensor for the determination of LDL(Low-Density Lipoprotein), a good indicator for the diagnosis of atherosclerosis and hypercholesterolemia, was developed by using quartz crystal microbalance(QCM). The immunosensor consists of flow-through cell, oscillating circuit, oscilloscope, and frequency counter. FIA(Flow Injection Analysis) was applied to the QCM system for the measurement of LDL in liquid phase. Antibody showing binding affinity against LDL was immobilized on the gold electrode of a quartz crystal by covalent coupling via polyethylenimine / glutaredehyde. LDL was injected and bound to the antibody immobilized on the QCM immunosensor. The response of the immunosensor (F0 - F1) was found to be proportional to the LDL concentration from 200 $\mu\textrm{g}$/ml to 800 $\mu\textrm{g}$/ml. Operational conditions for the operation of immunosensor were also investigated in terms of sensitivity and non-specific binding.

• 대한전기학회논문지
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• 제41권5호
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• pp.541-550
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• 1992

The fourth harmonic conversion(FHC) efficiency of high-power Nd laser pulse with wavelength of 1.054x10S0-6Tm using two KDP crystals(doubler adn quadrupler) was simulated numerically. Simulation results show that for the perfect phase-matching condition the FHC efficiency were 60-70% for several hundreds MW/cmS02T class and over 70% for GW/cmS02T class laser pulses. And the overall characteristics of FHC were discussed in terms of effects of input intensity, crystal length, and mismatch angle Δ$\theta$. Optimum method to FHC was type-II doubler & type-I quadrupler KDP crystal because type-II KDP doubler crystal has wide tolerance of acceptance matching-angle.

• Journal of the Optical Society of Korea
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• 제7권1호
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• pp.38-41
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• 2003

We present an analysis of highly-dispersive guided modes of two-dimensional photonic crystal waveguides. By the plane ave expansion method, band structures and mode profiles of two-dimensional photonic crystal waveguides are obtained. It is found that guided modes have very small group velocities and very large group velocity dispersions in the region near the f-point and in the region near the Brillouin zone edge. Especially, the group velocity dispersions are found to be millions of times larger than that of a conventional optical fiber. The contributions of the transverse resonance formed by two photonic band gap reflectors and the standing wave mode formed by periodic structures are discussed. We conclude that the highly-dispersive characteristics originate from the resonator-like aspect of the photonic crystal waveguide.

• 대한화학회지
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• 제63권1호
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• pp.7-11
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• 2019

Olmutinib, N-[3-({2-[4-(4-methylpiperazine-1-yl)aniline]thieno[3,2-d]Pyrimidin-4-yl}oxy)phenyl]prop-2-enamide dihydrochloride monohydrate, $Olita^{TM}$ is an oral, third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) that was developed by Boehringer Ingelheim and Hanmi Pharmaceutical Co. Ltd for the treatment of non-small cell lung cancer (NSCLC). The aim of this work was to investigate the existence of polymorphs and pseudopolymorphs of olmutinib. Three crystal forms of olmutinib have been isolated by recrystallization and characterized by differential scanning calorimetry (DSC), thermogravimetric (TG) analysis and powder X-ray diffractometry (PXRD). From the DSC and TG data it was confirmed that Form 1 is monohydrate, Form 2 is dihydrate, Form 3 is 1.5 hydrate. The PXRD patterns of three crystal forms were different respectively. After storage of 1 month at $2^{\circ}C$, 24% RH (Relative Humidity), Form 1, Form 2, and Form 3 were not transformed.

• Restorative Dentistry and Endodontics
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• 제24권2호
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• pp.330-336
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• 1999

In biological systems, the mineral that forms hard tissue is of an apatitic nature, and hydroxyapatite($Ca_5OH(PO_4)_3$: HA) is generally considered as the prototype for such a mineral. Thus, the precipitation of HA, having biological implications, has been the subject of several investigations. Crystal growth studies using HA seeds in supersaturated solutions have enhanced our understanding of the process and mechanism involved in seeded crystal growth. From these studies, it has become apparent that the precipitation rate of HA onto the seed crystals depends on the various conditions, especially on the additives. The relation between the supersaturated solution containing fluoride and the process of HA crystal growth enhances the understanding of mechanism of HA crystal growth. Until recently, the studies have been on the crystal growth of enamel minerals and synthetic HA seeds in the supersaturated solution containing 1~2 ppm fluoride. The purpose of the present investigation is to study the effect that fluoride of high concentration has on the crystal growth kinetics of HA. In order to produce the composition found in the secretory enamel fluid, experimental solutions of 1mM Ca, 3mM P, and 100mM Tris as background electrolyte were used. Then this experimental solutions were added to 0, 2, 4, 6, 8, 10 ppm fluoride. The effect of fluoride at high concentrations on the precipitation was examined in a bench-top crystal growth model adopting a miniaturized reaction column. Chemical analysis was employed for characterization of working solutions before and after the experimentation. Remarkable findings were : 1) the amount of crystal growth was gradually accelerated as the fluoride concentration increased until 6 ppm, but decreased in 8 and 10 ppm fluoride; 2) the amount of fluoride ion consumed in crystal formation was constant despite the increase in fluoride concentration.

• 한국물환경학회지
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• 제21권1호
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• pp.59-65
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• 2005

A phosphate recovery system from artificial wastewater was developed using a completely mixed phosphorus crystallization reactor, in which powdered converter slag was used as a seeding crystal. In preliminary test, the optimal pH range for meta-stable hydroxyapatite crystallization for high phosphorus concentration was observed to be 6.0 to 7.0, which was different from the conventionally known pH range (8.0~9.5) for effective crystallization in relatively low phosphorus concentration less than 5 mg/L. The average phosphorus removal efficiency in a lab-scaled completely mixed crystallization system for artificial wastewater with about 100 mg/L of average $PO_4-P$ concentration was shown to be 60.9% for 40 days of lapsed time. XRD analysis exhibited that crystalline of hydroxyapatite formed on the surface of seed crystal, which was also observed in SEM analysis. In EDS mapping analysis, composition mole ratio (=Ca/P) of the crystalline was found to be 1.78, indicating the crystalline on the surface of seed crystal is likely to be hydroxyapatite. Particle size distribution analysis showed that average size of seed crystal increased from $28{\mu}m$ up to $50{\mu}m$, suggesting that phosphorus recycling from wastewater with high phosphorus concentration can be successfully obtained by using the phosphorus crystallization recovery system.

• 대한전자공학회논문지
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• 제12권3호
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• pp.13-19
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• 1975

CuCl, KDP 결정체를 이용한 지그재그형 진헹파 전기광학적 레이저 변조기에 대해 자세히 해석했다. 변조기와 크기와 대역폭은 변조용 결정체의 광학적 특성및 M/W유전특성에 의해 결정됨을 알수 있다. 더욱 광손실과 M/W손실의 영향, 입사각, 회절등의 영향을 규명했고 최적 설계법을 제시했다. 중요한 결과를 요약하면 다음과 같다. (1) CuCl, KDP로 10(GHz)이상의 대역폭에서 3(watt)이하의 변조전력으로 50%변조를 얻었다. (2) 변조주파수 한계의 상한은 레이저 빔폭에 의한 차단주파수로 인해 제한된다. A detailed analysis has been carried out of a zigzag traveling wave electro-optic laser modulator usin3 CuCl, KDP Crystal. The inclusion of such practical factors as M/W and optical loss results in an optimum design in which modulator dimensions and bandwidth limitation are uniquely determined by optical and M/W dielectic properties of modulating crystal. The main conclusion of the analysis are: (1) CuCl, KDP may be used to produce 50% modulation over bandwidth of 10(GHz) with less than (watt) of modulating power. (2) The upper modulation frequency limit is set by a cutoff frequency which arises from finite width of optical beam.