• Korean Journal of Clinical Pharmacy
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• v.16 no.2
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• pp.86-91
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• 2006

There are 3 different hypotheses on how statins may affect bones, through promoting bone formation, inhibiting bone resorption or through anti-inflammatory effect. In the 3 cross-sectional studies above, one showed increase BMD at hip and spine, one showed increase BMD only at mid-forearm and one showed that the risk reduction in fractures is not explained by the changes in BMD however, all 3 studies showed a decrease in risk of fracture associated with statins. In the 2 prospective cohort studies, one showed the use of statins was not associated with BMD at any skeletal site or decreasing the risk of fracture, and the other showed statins except pravastatin decreased in risk of vertebrate fracture but not affecting lumbar spine BMD. All of case-control studies indicated reduction in fracture risk but did not provide any data regarding BMD. 2 of the randomized, controlled studies showed no significant reduction in fracture risk as well as statins' effects on BMD. Finally, one longitudinal study showed statin use reduced fracture risk and increased BMD. Among the conflicting results shown above, even when statin use was shown to increase BMD, it does not seem to account for the reduction in fracture risk. There may be different ways that statins affect bone other than those hypotheses proposed above. Many studies seem to agree that pravastatin does not have any effect on bone. Some studies suggested that the reason statins did not achieve clinically significant increases in BMD in some studies, is due to the low affinity of statins on bone; statins are designed to act in the liver therefore their effective concentration in extrahepatic tissue is low. The limitations to those studies discussed above. Many studies did not account for the change of lifestyle while subjects' were on statins. Increases in weight bearing exercise and changes in diet might affect BMD and thus reduce risk of fractures. Mental alertness and vision acuity might prevent falls from occurring; many statin-users in the studies were young so the risk of fractures from falls would be decreased. Almost all of the studies failed exclude patients with neurological problems. During study periods, many subjects may have been started on drugs for diseases that usually occur with aging which could cause drowsiness and lead to falls. The sample sizes used in some of the trials were small and the duration of treatment and follow up might not have been long enough to see clinically relevant results.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.12 no.1
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• pp.16-22
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• 2009

Purpose: To update the epidemiologic information of hepatobiliary diseases in pediatric inpatients using cross-sectional survey data throughout the Republic of Korea. Methods: Nationwide cross-sectional survey was obtained from the 85 residency training hospitals in Korea to gather the final diagnosis on discharge. The surveyed periods were from 2004 to 2006. All the reports regarding the diagnosis were based on ICD-10 system. In this study, we focused on hepatobiliary diseases. Results: A total of 826,896 cases with discharge data were collected, of which 4,151 (5.0%) hepatobiliary cases were identified; 2,385 cases (57.4%) of hepatobiliary disease were hepatitis, which was the most common hepatobiliary disease. Other diseases included congenital hepatobiliary diseases (524 cases [12.6%]) and biliary diseases (315 cases [7.6%]). The prevalence of hepatobiliary disease according to age differed. Biliary atresia was the most common hepatobiliary disease in the neonatal period, whereas the prevalence of hepatitis increased in adolescents. The total number of hepatobiliary operations was 416 cases. With the comparison of annual data, there was no definite difference in the total number of hepatobiliary cases. The average duration of hospital stay appeared to decrease gradually. Conclusion: In this study, we have summarized the recent epidemiology of hepatobiliary disorders in Korean children based on discharge data. Hepatobiliary disorders in pediatric inpatient units consisted of diverse disorders with a low prevalence, so multi-center approaches should be considered to enhance the clinical and public health outcomes. To improve this nationwide survey, a new data collecting system should be developed.

• The Journal of Korean Society for School & Community Health Education
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• v.17 no.1
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• pp.89-99
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• 2016

Objectives: This cross-sectional study aims to investigate the prevalence and factors relating to handwashing with soap among Korean adults. Methods: Study subjects consist of 755 adults who have been contacted in September 2013 via telephone surveys. The data collected has been analyzed using descriptive statistics, a chi-square test and a logistic regression analysis. A primary purpose is to understand the prevalence of handwashing with soap more than 8 times daily and for 30 seconds per wash among adults. Independent variables include socioeconomic levels, the participants' perception and knowledge of handwashing and their educational experiences relating to handwashing. Results: The overall percentile of people who wash their hands with soap 8 time per day for 30 seconds or more per wash was 16.0%, which is 121 people out of 755 study subjects. In univariate analysis, age, education levels, monthly average income, handwashing habits, perceptions relate to the importance of handwashing, self-assessment of handwashing, environment of public toilet, and the completion of handwashing education shows significant result. Significant differences also appear (p<0.05) in logistic regression analysis on binary variables. There is a strong correlation between daily frequency of handwashing and willingness to wash hands while outside. For example, people who wash their hands very often while outside are 2.24 times (95% C.I. 1.29-3.87) more likely to practice handwashing with soap 8 times per day for 30 seconds or more per wash than those people who only intermittently wash their hands while outside. Furthermore, people with general unwillingness to wash their hands while outside are 4.61 times (95% C.I. 1.22-3.28) less likely to practice handwashing with soap 8 times per day for 30 seconds or more per wash than those with general willingness. Conclusions: This study has been carried out to identify the decision factors in practicing handwashing with soap for Korean adults. In univariate analysis, age, education level, monthly average income, handwashing habits, handwashing self-assessment, public toilet environment, completion of handwashing education and so forth have been identified to be the decision factors. This study result shows that the overall level of cleanliness of public toilet perceives to be poor and it suggests that the environment of public toilet needs to be enhanced. As the handwashing habits and handwashing-self assessment have been identified to be the significant decision factors for handwashing, there search and approach in these factors need to be developed further.

• Journal of Korea Water Resources Association
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• v.50 no.7
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• pp.455-465
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• 2017

Understanding of the two-dimensional velocity field is crucial in terms of analyzing various hydrodynamic and fluvial processes in the riverine environments. Until recently, many numerical models have played major roles of providing such velocity field instead of in-situ flow measurements, because there were limitations in instruments and methodologies suitable for efficiently measuring in the broad range of river reaches. In the last decades, however, the advent of modernized instrumentations started to revolutionize the flow measurements. Among others, acoustic Doppler current profilers (ADCPs) became very promising especially for accurately assessing streamflow discharge, and they are also able to provide the detailed velocity field very efficiently. Thus it became possible to capture the velocity field only with field observations. Since most of ADCPs measurements have been mostly conducted in the cross-sectional lines despite their capabilities, it is still required to apply appropriate interpolation methods to obtain dense velocity field as likely as results from numerical simulations. However, anisotropic nature of the meandering river channel could have brought in the difficulties for applying simple spatial interpolation methods for handling dynamic flow velocity vector, since the flow direction continuously changes over the curvature of the channel shape. Without considering anisotropic characteristics in terms of the meandering, therefore, conventional interpolation methods such as IDW and Kriging possibly lead to erroneous results, when they dealt with velocity vectors in the meandering channel. Based on the consecutive ADCP cross-sectional measurements in the meandering river channel. For this purpose, the geographic coordinate with the measured ADCP velocity was converted from the conventional Cartesian coordinate (x, y) to a curvilinear coordinate (s, n). The results from application of A-VIM showed significant improvement in accuracy as much as 41.5% in RMSE.

• Korean Journal of Materials Research
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• v.11 no.7
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• pp.556-561
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• 2001

We prepared a new a SOS(silicon-on-silicide) wafer pair which is consisted of Si(100)/1000$\AA$-NiSi Si (100) layers. SOS can be employed in MEMS(micro- electronic-mechanical system) application due to low resistance of the NiSi layer. A thermally evaporated $1000\AA$-thick Ni/Si wafer and a clean Si wafer were pre-mated in the class 100 clean room, then annealed at $300~900^{\circ}C$ for 15hrs to induce silicidation reaction. SOS wafer pairs were investigated by a IR camera to measure bonded area and probed by a SEM(scanning electron microscope) and TEM(transmission electron microscope) to observe cross-sectional view of Si/NiSi. IR camera observation showed that the annealed SOS wafer pairs have over 52% bonded area in all temperature region except silicidation phase transition temperature. By probing cross-sectional view with SEM of magnification of 30,000, we found that $1000\AA$-thick uniform NiSi layer was formed at the center area of bonded wafers without void defects. However we observed debonded area at the edge area of wafers. Through TEM observation, we found that $10-20\AA$ thick amourphous layer formed between Si surface and NiSix near the counter part of SOS. This layer may be an oxide layer and lead to degradation of bonding. At the edge area of wafers, that amorphous layer was formed even to thickness of $1500\AA$ during annealing. Therefore, to increase bonding area of Si NiSi ∥ Si wafer pairs, we may lessen the amorphous layers.

• Childhood Kidney Diseases
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• v.13 no.1
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• pp.63-74
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• 2009

Purpose : The current nationally representative data on inpatient care are important to make the of the national public health policy because distributions and the prevalence of diseases among children and adolescents represent the socioeconomic status of the society. The prevalence of chronic disease is increasing now in Korea as the socioeconomic condition is improving. We analyzed a part of genitourinary tract disease of the cross-sectional hospital discharge survey data in Korea collected recently to delineate the trend of genitourinary tract diseases. Methods : Korean nationwide hospital discharge survey for pediatric inpatients in the period from 2004 to 2006 was analyzed. Diagnoses in the data were coded using ICD-10 classification. Totally 826,896 cases were collected from the 85 training hospitals. Selected data of genitourinary tract diseases (belonging to N00-N99 by ICD-10) among 826,896 cases of final inpatients data were analyzed for this study. Results : Among total patients of 826,896, diseases of the genitourinary system accounted for 4.1%. and four diagnostic categories accounted for 92.8%. These were other diseases of the urinary system (N30-39), 45.8%, disease of male genital organs (N40-51),19.1%, glomerular diseases (N00-08), 17.3%, renal tubulo-interstitial diseases (N10-16), 10.6%, respectively. Conclusion : Genitourinary tract disease in pediatric inpatient shows decreasing tendency but the prevalence of chronic diseases is increasing in Korea as the socioeconomic condition is improving. For further comprehensive analysis, regular and organized nationwide survey should be performed. Development of a new data collecting system will improve the performance of such nationwide survey.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.8
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• pp.3769-3776
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• 2016

Background: Breast cancer is the leading cause of cancer deaths among women worldwide. High breast cancer mortality has been attributed to lack of public awareness of the disease. Little is known about the level of knowledge of breast cancer in Central African Republic. This study aimed to investigate the knowledge of health professionals on breast cancer. Materials and Methods: This cross-sectional study was conducted among 158 health professionals (27 medical; 131 paramedical) in 17 hospitals in Bangui using a self-administered questionnaire. Descriptive statistical analysis, Person's ${\chi}^2$ test and ANOVA were applied to examine associations between variables with p < 0.05 being considered significant. Results: Data analyzed using SPSS version 20 indicates that average knowledge about breast cancer perception of the entire population was 47.6%, diagnosis method 45.5%, treatment 34.3% and risk factors 23.8%. Most respondents (65.8%) agreed that breast cancer is important in Central African Republic and that family history is a risk factor (44.3%). Clinical assessments and mammography were considered most suitable diagnostic methods, and surgery as the best treatment. The knowledge level was significantly higher among medical than paramedical staff with regard to risk factors, diagnosis and treatment. However the trainee group had very high significant differences of knowledge compared with all other groups. Conclusions: There is a very urgent need to update the various training programs for these professionals, with recommendations of retraining. Health authorities must create suitable structures for the overall management of cancer observed as a serious public health problem.

• Journal of Korean Society of Forest Science
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• v.84 no.2
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• pp.239-246
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• 1995

This research aimed at the contribution to obtaining the scientifical data which were required for planning she environmentally sound and sustainable management, particularly in the field of the logging road construction. Main natural environmental variables including natural vegetation, rainfall, soil runoff were measured in the logging road on-sites and analysed. This project was carried out at the (mt.)Paekunsan Research sorest of Seoul National University, located in Gwangyang, Chollanam-do in southern part of Korea, from 1993 to 1994. 1. The explanatory variables for erosion and sedimentation on logging road surface were accumulated rainfall, erosion distance, cross-sectional gradient, and soil hardness. The erosion and sedimentation on logging road was increasing positively in proportion to the accumulated rainfall, soil distance from starting point of the logging road, and cross-sectional gradient. 2. On cut-slope of logging road, cut-slope shape, part of the slope, plant coverage, soil hardness, sand content, accumulated rainfall, clay content, and silt content were effective factors. Cut-slope erosion and sedimentation on logging roam increased as with the lower plant coverage, the lower accumulated rainfall, the high sand content in the soil. 3. On fill-slope of logging road, there were three significant variables such as total rainfall and number of rainfall-storm. Fill-slope erosion and sedimentation had a positive correlation with the amount of rainfall, the number of rainfall, the soil hardness. 4. The total erosion and sedimentation on logging road were $5.04{\times}10^{-2}m^2/m^2$ in logging road construction year, $7.37{\times}10^{-2}m^2/m^2$ in next year. The erosion and sedimentation on logging road surface were 32.7% of total erosion and sedimentation on Logging road in construction year, and 57.1% in next year, respectively. The erosion and sedimentation on cut-slopes were 30.4% on logging road in construction year, fill-slopes of total erosion and sedimentation and 21.0% in next year, respectively. The erosion and sedimentation on fill-slopes were 36.9% on logging road in construction year, 21.9 in next year. To decrease the erosion and sedimentation at the logging road from the beginning stage of construction, the effective revegetation works should be implemented on the cut-slope and fill slopes, and erosion control measures such as optima. road design must be constructed on read surface.

• Journal of Korean Tunnelling and Underground Space Association
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• v.22 no.4
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• pp.347-365
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• 2020

In order to resolve traffic problems in urban areas and to increase the area of green spaces, tunnels in downtown areas are being increased. Additionally, the application of large port smoke extraction ventilation systems is increasing as a countermeasure to smoke extraction ventilation for tunnels with high potential for traffic congestion. It is known that the smoke extraction performance of the large port smoke extraction system is influenced not only by the amount of the extraction flow rate, but also by various factors such as the shape of the extraction port (damper) and the extraction air velocity through a damper. Therefore, in this study, the design standards and installation status of each country were investigated. When the extraction air flow rate was the same, the smoke extraction performance according to the size of the damper was numerically simulated in terms of smoke propagation distance, compared and evaluated, and the following results were obtained. As the cross-sectional area of the smoke damper increases, the extraction flow rate is concentrated in the damper close to the extraction fan, and the smoke extraction rate of the damper in downstream decreases, thereby increasing the smoke propagation distance on the downstream side. In order to prevent such a phenomenon, it is necessary to reduce the cross-sectional area of the smoke damper and increase the velocity of passing air through the damper so that the pressure loss passing through the damper increases, thereby reducing the non-uniformity of smoke extraction flow rate in the extraction section. In this analysis, it was found that when the interval distance of the extraction damper was 50 m, the air velocity passing through damper was 4.4 m/s or more, and when the interval distance of the extraction dampers was 100 m, the air velocity passing through damper was greater than 4.84 m/s, it was found to be advantageous to ensure smoke extraction performance.

• Management & Information Systems Review
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• v.34 no.2
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• pp.131-149
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• 2015

Recently many organizations have engaged in widespread restructuring as well as more flexible usage of labor in an attempt to cut costs and to increase profit. As a result of lays offs resulting from frequent restructuring, many people no longer consider their jobs as permanent positions. many employees have an increased feeling of job insecurity. There structuring and following downsizing have created an uncertain environment within creased fear offer ther job losses. therefore the study of job insecurity is significant. especially To understand the relationship between job security and union-relation behaviors on the industrial relations. The purpose of this study suggested the strategies to company and union. The purpose of this study is to examine how the union-relation behaviors are influenced by the job security. This study built a exploratory model that there is causal relationship of job security to union commitment, dual commitment, and labor related behaviors. For the verification of this study model, the regression analysis was applied to the surveys of 236 members of union that are located in Busan, Gyeongnam, Ulsan, and Pohang. The result of this research shows that the job insecurity is strongly related to the union commitment and union related behaviors. According to the research, the effect that the job security affects union commitment and union related behaviors are positive. With the research outputs, we have discussed about the academic and pragmatic viewpoint. We proposed comprehensive model to verify how the job insecurity affects the union-related behaviors, and objectively analyzed the model. The research result was opposite to what the existing theories have said that high job insecurity derives high union-related behaviors. This result is meaningful because it is concerned with the social issues-present situation of Korean company, low-employment, unstable employment and so on. Moreover, this research may contribute to expand the aspect of academic research on job insecurity as there are few research conducted in korea. This research also suggests the realistic alternative of union-related behaviors because it is proved that job security can contribute to innovation activities. Also, this research implies that the matter of job insecurity is the basic need of organizational individual and presents that job security is not a notion but the alternative by using of the positional stability and situational control power. The limitation of this research is that it is only utilized the cross-sectional study. To remedy the cross-sectional study, vertical, and serial method of research is needed. And there is no enough sample to secure more comprehensive data as the targets of the research is limited to Busan and Gyeongnam regions. Finally, the measurement tool for job security is needed to be suitably modified to by the South Korea's economic, linguistic, and cultural situation.