• Journal of Pharmaceutical Investigation
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• 제36권2호
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• pp.83-87
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• 2006

Poly(acrylic acid) (PAA) was identified to possess good mucoadhesive properties ensuring its application to extend the retention times of the formulations at the oral cavity, intended route of administration using the polymer. In the noncross-linked state, PAA will swell and become eroded owing to the presence of salivary flow from the site of application. The formation of cross-links between the polymer chains will allow swelling but prevents the erosion of the dosage form. In the current study, cross-linking was achieved by esterification of the PAA chains with sucrose. The density of crosslinking was modified by changing sucrose concentration and the duration of cure time. The cross-linking density of the polymer hydrogel was assessed by equilibrium swelling studies. The mucoadhesion testing method allowed a comparative study of the hydrogels prepared. An inverse relationship between equilibrium swelling and peak detachment force showed that increased PAA chain density per unit area enhanced the mucoadhesive interaction.

• 비교문화연구
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• 제26권
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• pp.43-71
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• 2012

In this article, we recognize the cross-cultural communication between Greece and Spain through El Greco's pictures. The Greeks of Crete kept to their culture and continued to look to the declining Byzantine Empire for spiritual and political guidance. For two centuries after the conquest, the strength of the Byzantine tradition had become the moral and spiritual sustenance of the conquered in Crete. The basic contribution of Cretan intellectuals or artists such as El Greco of the fifteenth and sixteenth centuries was the forging of connecting links between the Hellenism of the old Byzantine East and the rising, youthful Hellenism of the Renaissance West. In this way, Crete served as an important halfway point between East and West. The saint Mary Magdalene was symbol of Christian penitence, which represents the penitential life personified and became widespread during the Counter Reformation, when new emphasis was put on the value of prayer and repentance in the forgiveness of sin. In Spain, the Penitent Magdalene was popular and El Greco painted many versions, which at the first time, were reflected by Tiziano, on the contrary, at the time of Toledo, were recreated by his own style. Although El Greco was converted to Catholic in Spain, his faith in Greek Orthodox Church influenced on his original painting world. El Greco had never painted a picture whose subject treat with the emphasis of identification between Mary Magdalene and Mary, younger sister of Martha.

• 한국경영과학회지
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• 제32권4호
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• pp.19-35
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• 2007

This study is for detecting the Braess Paradox by stable dynamics in general transportation networks. Stable dynamics, suggested by Nesterov and de Palma[18], is a new model which describes and provides a stable state of congestion in urban transportation networks. In comparison with user equilibrium model based on link latency function in analyzing transportation networks, stable dynamics requires few parameters and is coincident with intuitions and observations on the congestion. Therefore it is expected to be an useful analysis tool for transportation planners. The phenomenon that increasing capacity of a network, for example creating new links, may decrease its performance is called Braess Paradox. It has been studied intensively under user equilibrium model with link latency function since Braess[5] demonstrated a paradoxical example. However it is an open problem to detect the Braess Paradox under stable dynamics. In this study, we suggest a method to detect the Paradox in general networks under stable dynamics. In our model, we decide whether Braess Paradox will occur in a given network. We also find Braess links or Braess crosses if a network permits the paradox. We also show an example how to apply it in a network.

• Steel and Composite Structures
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• 제2권3호
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• pp.171-194
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• 2002

In this paper, the behaviour of axially loaded partially encased composite columns made with light welded H steel shapes is examined using ABAQUS finite element modelling. The results of the numerical simulations are compared to the response observed in previous experimental studies on that column system. The steel shape of the specimens has transverse links attached to the flanges to improve its local buckling capacity and concrete is poured between the flanges only. The test specimens included 14 stubcolumns with a square cross section ranging from 300 mm to 600 mm in depth. The transverse link spacing varied from 0.5 to 1 times the depth and the width-to-thickness ratio of the flanges ranged from 23 to 35. The numerical model accounted for nonlinear stress-strain behaviour of materials, residual stresses in the steel shape, initial local imperfections of the flanges, and allowed for large rotations in the solution. A Riks displacement controlled strategy was used to carry out the analysis. Plastic analyses on the composite models reproduced accurately the capacity of the specimens, the failure mode, the axial strain at peak load, the transverse stresses in the web, and the axial stresses in the transverse links. The influence of applying a typical construction loading sequence could also be reproduced numerically. A design equation is proposed to determine the axial capacity of this type of column.

• Coupled systems mechanics
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• 제9권2호
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• pp.183-200
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• 2020

Connection of adjacent buildings with stiff links is an efficient approach for seismic pounding mitigation. However, use of highly rigid links might alter the torsional response in asymmetric plans and although this was mentioned in the literature, no quantitative study has been done before to investigate the condition numerically. In this paper, the effect of rigid coupling on the elastic lateral-torsional response of two adjacent one-story column-type buildings has been studied by comparison to uncoupled structures. Three cases are considered, including two similar asymmetric structures, two adjacent asymmetric structures with different dynamic properties and a symmetric system adjacent to an adjacent asymmetric one. After an acceptable validation against the actual earthquake, the traditional random vibration method has been utilized for dynamic analysis under Ideal white noise input. Results demonstrate that rigid coupling may increase or decrease the rotational response, depending on eccentricities, torsional-to-lateral stiffness ratios and relative uncoupled lateral stiffness of adjacent buildings. Results are also discussed for the case of using identical cross section for all columns supporting eachplan. In contrast to symmetric systems, base shear increase in the stiffer building may be avoided when the buildings lateral stiffness ratio is less than 2. However, the eccentricity increases the rotation of the plans for high rotational stiffness of the buildings.

• Genomics & Informatics
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• 제8권2호
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• pp.63-69
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• 2010

Monofunctional biosynthetic peptidoglycan transglycosylase (MBPT) catalyzes the formation of the glycan chain in bacterial cell walls from peptidoglycan subunits: N-acetylglucosamine (NAG) and acetylmuramic acid (NAM). Bifunctional glycosyltransferases such as the penicillin binding protein (PBP) have peptidoglycan glycosyltransferase (PGT) on their C terminal end which links together the peptidoglycan subunits while transpeptidase (TP) on the N terminal end cross-links the peptide moieties on the NAM monosaccharide of the peptide subunits to create the bacterial cell wall. The singular function of MBPT resembles the C terminal end of PBP as it too contains and utilizes a similar PGT domain. In this article we analyzed the infectious and non infectious protein sequences of MBPT from 31 different strains of bacteria using a variety of bioinformatic tools. Motif analysis, dot-plot comparison, and phylogenetic analysis identified a number of significant differences between infectious and non-infectious protein sequences. In this paper we have made an attempt to explain, analyze and discuss these differences from an evolutionary perspective. The results of our sequence analysis may open the door for utilizing MBPT as a new target to fight a variety of infectious bacteria.

• 한국통신학회논문지
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• 제41권1호
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• pp.58-65
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• 2016

위성 통신은 넓은 지역에 통신 서비스를 제공하는 광역 네트워크이다. 하지만, 위성 통신은 대역폭이 제한되고 매우 긴 전파 지연 시간과 높은 BER(Bit Error Rate)로 인해 위성 통신을 고려하지 않은 TCP의 성능이 저하 된다. 본 논문에서는 위성 통신에서의 TCP 성능을 향상시키기 위해 DVB-RCS(Digital Video Broadcasting-Return Channel via Satellite) 네트워크 환경을 고려한 cross-layer 기반 PEP(Performance Enhancing Proxy) 기술을 제안한다. 제안하는 프로토콜은 TCP와 링크 계층 간 위성 자원 할당 정보를 정보 교환을 통해 최적의 TCP CWND(Congestion Window)를 설정한다. 제안한 프로토콜의 성능 평가를 위해 리눅스 기반의 PEP 테스트 베드를 구현하였다. 성능 평가 결과 다양한 BER에서 제안한 프로토콜은 위성 자원 할당 정보를 이용하여 최적의 TCP CWND 크기를 설정하기 때문에 단일 및 다중 세션 환경에서 기존 TCP 보다 제안한 프로토콜이 더 좋은 성능을 보여준다는 것을 확인할 수 있었다.

• 한국응용과학기술학회지
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• 제36권2호
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• pp.645-655
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• 2019

본 연구에서는 강도를 조절한 마이크로겔을 사용하여 다양한 점탄성을 갖는 콜로이드 마이크로겔을 제조하였다. 하이드로겔의 화학적 가교제의 함량이 증가할수록 팽윤비는 $2.0{\times}10^4%$에서 $6.0{\times}10^3%$까지 감소하였고, 강도는 22.2 kPa에서 99.7 kPa까지 증가하였다. 이를 $100{\mu}m$ 크기로 분쇄하여 마이크로겔을 제작하였고 이온성 가교결합을 유도하는 분산액과 혼합하여 콜로이드 마이크로겔을 제작하였다. 그 결과, 가교제의 가교도와 분산액에 따라 $10^{-1}rad/s$의 진동수에서 1.679 kPa.s에서 86.485 kPa.s까지 점도를 세밀하게 조절할 수 있었다. 본 연구에서는 콜로이드 마이크로겔의 물성을 제어하기 위해 하이드로겔의 가교도를 조절 또는 분산액의 종류와 함량을 조절하여 다양한 유변학적 거동을 갖는 콜로이드 마이크로겔을 제조하였다. 물성을 제어할 수 있는 콜로이드 마이크로겔을 사용하여 향후 콜로이드 현탁액 및 유화를 제조하는 화장품, 제약, 페인트 및 식품 산업에서 목적에 따라 적합한 물성을 갖는 콜로이드 마이크로겔을 제조할 수 있다.

• 한국멀티미디어학회논문지
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• 제13권6호
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• pp.849-864
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• 2010

This paper proposes a multipath routing protocol called cross-layer multipath AODV (CM-AODV) for wireless ad hoc networks, which selects multiple routes on demand based on the signal-to-interference plus noise ratio (SINR) measured at the physical layer. Note that AODV (Ad hoc On-demand Distance Vector) is one of the most popular routing protocols for mobile ad hoc networks. Each time a route request (RREQ) message is forwarded hop by hop, each forwarding node updates the route quality which is defined as the minimum SINR of serialized links in a route and is contained in the RREQ header. While achieving robust packet delivery, the proposed CM-AODV is amenable to immediate implementation using existing technology by neither defining additional packet types nor increasing packet length. Compared to the conventional multipath version of AODV (which is called AOMDV), CM-AODV assigns the construction of multiple paths to the destination node and makes it algorithmically simple, resulting in the improved performance of packet delivery and the less overhead incurred at intermediate nodes. Our performance study shows that CM-AODV significantly outperforms AOMDV in terms of packet delivery ratio and average end-to-end delay, and results in less routing overhead.

• 한국통신학회논문지
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• 제31권9A호
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• pp.856-867
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• 2006

This paper proposes a new algorithm for opportunistic scheduling that take advantage of both multiuser diversity and power control. Motivated by the multicast RTS and priority-based CTS mechanism of OSMA protocol, we propose an opportunistic packet scheduling with power control scheme based on IEEE 802.11 MAC protocol. The scheduling scheme chooses the best candidate receiver for transmission by considering the SINR at the nodes. This mechanism ensures that the transmission would be successful. The power control algorithm on the other hand, helps reduce interference between links and could maximize spatial reuse of the bandwidth. We then formulate a convex optimization problem for minimizing power consumption and maximizing net utility of the system. We showed that if a transmission power vector satisfying the maximum transmission power and SINR constraints of all nodes exist, then there exists an optimal solution that minimizes overall transmission power and maximizes utility of the system.